Recovery mechanisms and formation influencing factors of miscible CO2 huff-n-puff processes in shale oil reservoirs: A systematic review

Shale oil production is vital for meeting the rising global energy demand, while primary recovery rates are poor due to the ultralow permeability. CO2 huff-n-puff can boost yields by enabling key enhanced oil recovery mechanisms. This review examines the recent research on mechanisms and formation factors influencing CO2 huff-n-puff performance in shale liquid reservoirs. During the soaking period, oil swelling, viscosity reduction and CO2-oil miscibility occur through molecular diffusion into shale nanopores. The main recovery mechanism during the puff period is depressurization with oil desorption and elastic energy release. The interplay between matrix permeability and fracture network directly determines the CO2 huff-n-puff performance. Nanopore confinement, wettability alterations, and heterogeneity also significantly impact the huff-n-puff processes, with controversial effects under certain conditions. This work provides an integrated discussion on the mechanistic insights and formation considerations essential for the advancement of CO2 huff-n-puff application in shale reservoirs. By synthesizing the recent research findings, we aim to spotlight the key challenges and opportunities in considering reservoirs for this process, thereby contributing to the advancement of CO2 huff-n-puff applications for enhanced oil recovery.Ducument Type: Invite reviewCites as: Wan, Y., Jia, C., Lv, W., Jia, N., Jiang, L., Wang, Y. Recovery mechanisms and formation influencing factors of miscible CO2 huff-n-puff processes in shale oil reservoirs: A systematic review. Advances in Geo-Energy Research, 2024, 11(2): 88-102. https://doi.org/10.46690/ager.2024.02.0

Reducing toxicity and increasing efficiency: aconitine with liquiritin and glycyrrhetinic acid regulate calcium regulatory proteins in rat myocardial cell

Background: Compatibility of Radix Aconiti Carmichaeli and Liquorice is known to treat heart diseases such as heart failure and cardiac arrhythmias. This work answers the question that whether the active components (Aconitine, Liquiritin and Glycyrrhetinic Acid) of Radix Aconiti Carmichaeli and Liquorice could result in regulating intracellular calcium homeostasis and calcium cycling, and thereby verifies the therapeutic material basis.Materials and Methods: The myocardial cells were divided into twelve groups randomly as control group, Aconitine group, nine different dose groups that orthogonal combined with Aconitine, Liquiritin and Glycyrrhetinic Acid, and Verapamil group. The myocardial cellular survival rate and morphology were assessed. The expression of calcium regulation protein(RyR2、NCX1、DHPR-a1) in the myocardial cell by Western-blotting.Results: The results exhibited that Aconitine (120 uM) significantly damaged on myocardial cell, decreased the survival rate and expression of Na+/Ca2+ exchangers (NCX1) and dihydropteridine reducta-α1 (DHPR-a1), and increased the expression of ryanodine receptor type2 (RyR2) obviously. The compatibility groups (Aconitine, Liquiritin and Glycyrrhetinic Acid) all could against the damage on the myocardial cell by Aconitine at different levels.Conclusion: Aconitine with Liquiritin and Glycyrrhetinic Acid may regulate the expression of calcium-regulated proteins to protect myocardial cells from damage.Keywords: Aconitine, Liquiritin, Glycyrrhetinic Acid, myocardial cell, calcium regulator

Genistein-Inhibited Cancer Stem Cell-Like Properties and Reduced Chemoresistance of Gastric Cancer

Key Projects of Fujian Province Technology [2010D026]; China Postdoctoral Science Foundation [2012M521279]; Medical innovations Topic in Fujian Province [2012-CXB-9]; projects of Xiamen scientific and technological plan [3502Z20124018, 3502Z20134011]Genistein, the predominant isoflavone found in soy products, has exerted its anticarcinogenic effect in many different tumor types in vitro and in vivo. Accumulating evidence in recent years has strongly indicated the existence of cancer stem cells in gastric cancer. Here, we showed that low doses of genistein (15 M), extracted from Millettia nitida Benth var hirsutissima Z Wei, inhibit tumor cell self-renewal in two types of gastric cancer cells by colony formation assay and tumor sphere formation assay. Treatment of gastric cancer cells with genistein reduced its chemoresistance to 5-Fu (fluorouracil) and ciplatin. Further results indicated that the reduced chemoresistance may be associated with the inhibition of ABCG2 expression and ERK 1/2 activity. Furthermore, genistein reduced tumor mass in the xenograft model. Together, genistein inhibited gastric cancer stem cell-like properties and reduced its chemoresistance. Our results provide a further rationale and experimental basis for using the genistein to improve treatment of patients with gastric cancer

Characteristics of fine particulate matter and its sources in an industrialized coastal city, Ningbo, Yangtze River Delta, China

Chemical information is essential in understanding the characteristics of airborne particles, and effectively controlling airborne particulate matter pollution, but it remains unclear in some regions due to the scarcity of measurement data. In the present study, 92 daily PM2.5 (particulate matter with an aerodynamic diameter ≤ 2.5 μm) samples as well as historical observation data of air pollutants were collected in urban Ningbo, one of important industrial cities in the coastal area of the Yangtze River Delta, China in autumn and winter (from Nov. 2014 to Feb. 2015). Various chemical species in PM2.5 were determined including water soluble ions, organic and elemental carbon and elements. Positive matrix factorization model, cluster analysis of back trajectories, potential source contribution function (PSCF) model and concentration-weighted trajectory (CWT) model were used for identifying sources, apportioning contributions from each source and tracking potential areas of sources. The results showed the PM2.5 concentration has been reducing; nonetheless, the concentrations of PM2.5 are still much higher than the World Health Organization guideline with high PM2.5 concentrations observed in autumn and winter for the past few years. During the sampling period, the average PM2.5 mass concentration was 77 μg/m3 with the major components of OC, NO3−, SO42 −, NH4+ and EC, accounting for 24.7, 18.8, 14.5, 11.8 and 6.4% in the total mass concentration, respectively. When the aerosol pollution got worse during the sampling period, the NO3−, SO42 − and NH4+ concentrations increased accordingly and NO3− appeared to increase at fastest rate. SO42 − transported from industrial areas led to slight difference in spatial distribution of SO42 − in Ningbo. More secondary organic carbon was formed and the enrichment factor values of Cu, Ag, Cd, Sn and Pb increased with the degradation of air quality. Ten types of sources were identified for PM2.5 in the autumn and winter of Ningbo, which are metallurgical industry, biomass burning and waste incineration, manufacturing related with Mo, chlor-alkli chemical industry, oil combustion, vehicular emission, secondary source, soil dust, road dust and manufacturing related with Cr, accounting for 9.4, 4.8, 9.4, 7.6, 8.1, 18.7, 27.6, 2, 7.1 and 5.2% of the total sources, respectively. There were five groups of air parcels arriving in Ningbo, of which inland air masses originating from Shandong province were associated with the highest PM2.5 concentrations. Despite the slight differences, it was obvious that the north of Jiangxi, east of Anhui, west of Jiangsu, south of Shandong were identified as major potential sources-areas of SO42 −, NO3−, NH4+, Cl−, OC and EC by both PSCF and CWT models

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

Peer reviewe

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

Measurement of the top quark mass using charged particles in pp collisions at root s=8 TeV

Peer reviewe