346 research outputs found
Association between footwear use and neglected tropical diseases: a systematic review and meta-analysis
- Author
- A Alemu
- A Liberati
- A Martinez Cardenas
- A Tremblay
- AK Mukerji
- B Yakob
- BH Singer
- BJ Marston
- C Bird
- CB Leal-Castellanos
- CP Douglin
- D Ayode
- D Humphries
- DM Sasaki
- E Marion
- E Price
- EC Strunz
- F Portaels
- G Davey
- G Davey
- G Tadesse
- Gail Davey
- GC Ilechukwu
- H Feldmeier
- H Kloos
- Hannah Clark
- HG Lacerda
- HO Ejere
- I Ali
- J Bartram
- J Bethony
- J Gutman
- J Landier
- J Lello
- J Utzinger
- J Utzinger
- JC Nmor
- Jeffrey Michael Bethony
- JM Behnke
- JO Alarcon
- JZ Killewo
- Jürg Utzinger
- K Deribe
- K Gunawardena
- K Modjarrad
- K Phiri
- K Ziegelbauer
- Kebede Deribe
- Khizar Rafique
- L Erosie
- M Albonico
- M Muehlen
- M Nuti
- M Thielecke
- M Yunus Khan
- MA Johnson
- MC Freeman
- ME Stocks
- MI Gamboa
- MR Sulong
- N Njau
- P Aimpun
- P Bovet
- P Hotez
- P Phraisuwan
- P Steinmann
- PJ Hotez
- PJ Hotez
- PL Raghunathan
- PM Emerson
- PP Yori
- PR Sanchez
- PW Woodburn
- R Anderson
- R Kurup
- RI Ejemot
- RJ Traub
- RL Pullan
- S Knopp
- S Mihrshahi
- Sara Tomczyk
- Simon J. Brooker
- Stefanie Knopp
- T Liabsuetrakul
- US Ugbomoiko
- V Chongsuvivatwong
- V Jiraanankul
- VJ Lee
- WG Smillie
- YB Molla
- YB Molla
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2014
- Field of study
BACKGROUND
The control of neglected tropical diseases (NTDs) has primarily focused on preventive chemotherapy and case management. Less attention has been placed on the role of ensuring access to adequate water, sanitation, and hygiene and personal preventive measures in reducing exposure to infection. Our aim was to assess whether footwear use was associated with a lower risk of selected NTDs.
METHODOLOGY
We conducted a systematic review and meta-analysis to assess the association between footwear use and infection or disease for those NTDs for which the route of transmission or occurrence may be through the feet. We included Buruli ulcer, cutaneous larva migrans (CLM), leptospirosis, mycetoma, myiasis, podoconiosis, snakebite, tungiasis, and soil-transmitted helminth (STH) infections, particularly hookworm infection and strongyloidiasis. We searched Medline, Embase, Cochrane, Web of Science, CINAHL Plus, and Popline databases, contacted experts, and hand-searched reference lists for eligible studies. The search was conducted in English without language, publication status, or date restrictions up to January 2014. Studies were eligible for inclusion if they reported a measure of the association between footwear use and the risk of each NTD. Publication bias was assessed using funnel plots. Descriptive study characteristics and methodological quality of the included studies were summarized. For each study outcome, both outcome and exposure data were abstracted and crude and adjusted effect estimates presented. Individual and summary odds ratio (OR) estimates and corresponding 95% confidence intervals (CIs) were calculated as a measure of intervention effect, using random effects meta-analyses.
PRINCIPAL FINDINGS
Among the 427 studies screened, 53 met our inclusion criteria. Footwear use was significantly associated with a lower odds of infection of Buruli ulcer (OR=0.15; 95% CI: 0.08-0.29), CLM (OR=0.24; 95% CI: 0.06-0.96), tungiasis (OR=0.42; 95% CI: 0.26-0.70), hookworm infection (OR=0.48; 95% CI: 0.37-0.61), any STH infection (OR=0.57; 95% CI: 0.39-0.84), strongyloidiasis (OR=0.56; 95% CI: 0.38-0.83), and leptospirosis (OR=0.59; 95% CI: 0.37-0.94). No significant association between footwear use and podoconiosis (OR=0.63; 95% CI: 0.38-1.05) was found and no data were available for mycetoma, myiasis, and snakebite. The main limitations were evidence of heterogeneity and poor study quality inherent to the observational studies included.
CONCLUSIONS/SIGNIFICANCE
Our results show that footwear use was associated with a lower odds of several different NTDs. Access to footwear should be prioritized alongside existing NTD interventions to ensure a lasting reduction of multiple NTDs and to accelerate their control and elimination.
PROTOCOL REGISTRATION
PROSPERO International prospective register of systematic reviews CRD42012003338
Systematic Reviews and Meta-Analyses of the Procedure-specific Risks of Thrombosis and Bleeding in General Abdominal, Colorectal, Upper Gastrointestinal, and Hepatopancreatobiliary Surgery
- Author
- Aaltonen R
- Ahopelto K
- Beilmann-Lehtonen I
- Blanker MH
- Cardenas JL
- Cartwright R
- Couban RJ
- Craigie S
- Devereaux PJ
- Elberkennou J
- Garcia-Perdomo HA
- Ge FZ
- Gomaa HA
- Guyatt GH
- Halme ALE
- Haukka J
- Karanicolas PJ
- Karjalainen PK
- Kilpelainen TP
- Kivela AJ
- Lampela H
- Lavikainen LI
- Lee Y
- Mattila AK
- Najafabadi BT
- Nykanen TP
- Pandanaboyana S
- Pourjamal N
- Ratnayake CBB
- Raudasoja A
- Sallinen VJ
- Singh T
- Tikkinen KAO
- Vernooij RWM
- Violette PD
- Wang Y
- Xiao Y
- Yao L
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/02/2024
- Field of study
\ua9 2024 Lippincott Williams and Wilkins. All rights reserved.Objective: To provide procedure-specific estimates of symptomatic venous thromboembolism (VTE) and major bleeding after abdominal surgery. Background: The use of pharmacological thromboprophylaxis represents a trade-off that depends on VTE and bleeding risks that vary between procedures; their magnitude remains uncertain. Methods: We identified observational studies reporting procedure-specific risks of symptomatic VTE or major bleeding after abdominal surgery, adjusted the reported estimates for thromboprophylaxis and length of follow-up, and estimated cumulative incidence at 4 weeks postsurgery, stratified by VTE risk groups, and rated evidence certainty. Results: After eligibility screening, 285 studies (8,048,635 patients) reporting on 40 general abdominal, 36 colorectal, 15 upper gastrointestinal, and 24 hepatopancreatobiliary surgery procedures proved eligible. Evidence certainty proved generally moderate or low for VTE and low or very low for bleeding requiring reintervention. The risk of VTE varied substantially among procedures: in general abdominal surgery from a median of <0.1% in laparoscopic cholecystectomy to a median of 3.7% in open small bowel resection, in colorectal from 0.3% in minimally invasive sigmoid colectomy to 10.0% in emergency open total proctocolectomy, and in upper gastrointestinal/hepatopancreatobiliary from 0.2% in laparoscopic sleeve gastrectomy to 6.8% in open distal pancreatectomy for cancer. Conclusions: VTE thromboprophylaxis provides net benefit through VTE reduction with a small increase in bleeding in some procedures (eg, open colectomy and open pancreaticoduodenectomy), whereas the opposite is true in others (eg, laparoscopic cholecystectomy and elective groin hernia repairs). In many procedures, thromboembolism and bleeding risks are similar, and decisions depend on individual risk prediction and values and preferences regarding VTE and bleeding
Infusing Sodium Bicarbonate Suppresses Hydrogen Peroxide Accumulation and Superoxide Dismutase Activity in Hypoxic-Reoxygenated Newborn Piglets
- Author
- AA van Alfen-van der Velden
- AN Ammari
- AR Laptook
- AU Khan
- B Halliwell
- B Kalyanaraman
- C Szabo
- C Szabó
- CS Berg
- David L. Bigam
- DB Medinas
- DJ Cooper
- EJ Dickey
- F Kette
- F Kette
- GL Squadrito
- H Zhang
- HC Lou
- JE Jung
- Jiang-Qin Liu
- JL Aschner
- L Lokesh
- LF Barbosa
- M-F Guo
- MG Bonini
- Mingzhu Yao
- Namdar Manouchehri
- NM Epperlein
- O Augusto
- OD Saugstad
- Olivier Baud
- P Pacher
- P Sáenz
- P Ypsilantis
- PD Hurn
- PJ Johnson
- Po-Yin Cheung
- PY Cheung
- RE Anderson
- RJ Martin
- RJ Reiter
- RM Uppu
- S Reesa
- SK Ma
- SN Weis
- TF Lee
- Tze-Fun Lee
- VA Kolla
- VJ Cardenas Jr
- W Shuangyan
- YW Peng
- Publication venue
- Public Library of Science
- Publication date
- 22/06/2012
- Field of study
The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates. The aim of the present study was to examine its effect on hemodynamic changes and hydrogen peroxide (H(2)O(2)) generation in the resuscitation of hypoxic newborn animals with severe acidosis.Newborn piglets were block-randomized into a sham-operated control group without hypoxia (n = 6) and two hypoxia-reoxygenation groups (2 h normocapnic alveolar hypoxia followed by 4 h room-air reoxygenation, n = 8/group). At 10 min after reoxygenation, piglets were given either i.v. SB (2 mEq/kg), or saline (hypoxia-reoxygenation controls) in a blinded, randomized fashion. Hemodynamic data and blood gas were collected at specific time points and cerebral cortical H(2)O(2) production was continuously monitored throughout experimental period. Plasma superoxide dismutase and catalase and brain tissue glutathione, superoxide dismutase, catalase, nitrotyrosine and lactate levels were assayed.Two hours of normocapnic alveolar hypoxia caused cardiogenic shock with metabolic acidosis (PH: 6.99 ± 0.07, HCO(3)(-): 8.5 ± 1.6 mmol/L). Upon resuscitation, systemic hemodynamics immediately recovered and then gradually deteriorated with normalization of acid-base imbalance over 4 h of reoxygenation. SB administration significantly enhanced the recovery of both pH and HCO(3-) recovery within the first hour of reoxygenation but did not cause any significant effect in the acid-base at 4 h of reoxygenation and the temporal hemodynamic changes. SB administration significantly suppressed the increase in H(2)O(2) accumulation in the brain with inhibition of superoxide dismutase, but not catalase, activity during hypoxia-reoxygenation as compared to those of saline-treated controls.Despite enhancing the normalization of acid-base imbalance, SB administration during resuscitation did not provide any beneficial effects on hemodynamic recovery in asphyxiated newborn piglets. SB treatment also reduced the H(2)O(2) accumulation in the cerebral cortex without significant effects on oxidative stress markers presumably by suppressing superoxide dismutase but not catalase activity
THAM reduces CO2-associated increase in pulmonary vascular resistance – an experimental study in lung-injured piglets
- Author
- A Larsson
- A Larsson
- A Nahum
- A Thorsteinsson
- AM Dessap
- Anders Larsson
- AR Elliott
- B Simma
- C Jonmarker
- C Marshall
- C Masterson
- D Osman
- D Young
- E Futier
- E Robertis De
- F Ketabchi
- Fernando Suarez-Sipmann
- GF Curley
- GG Nahas
- Göran Hedenstierna
- J Devaquet
- JB Gordon
- JL Benumof
- Joakim Engström
- João Batista Borges
- Kerstin M. Ahlgren
- M Stengl
- MD Schreiber
- MG Berger
- MH Holmdahl
- MM Ijland
- ND Ferguson
- PP Terragni
- R Core Team
- RH Kallet
- RK Lyrene
- S Brimioulle
- S Brimioulle
- S Brody
- S Höstman
- SM Caples
- Staffan Höstman
- T Bein
- T Weber
- T Wetterberg
- The Acute Respiratory Distress Syndrome Network
- VJ Cardenas Jr
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Gene Expression Profiling in Gastric Mucosa from Helicobacter pylori-Infected and Uninfected Patients Undergoing Chronic Superficial Gastritis
- Author
- A Rogstam
- A Rump
- A Ullrich
- AM Terrés
- AP Bhavsar
- AP Gobert
- AT Franco
- B Fubini
- BB Aggarwal
- C Lindholm
- CS Kaetzel
- D Dorjsuren
- DE Ayer
- DJ Evans Jr
- DM Bronte-Tinkew
- E Burstein
- E Takeshima
- ED Segal
- EE Mannick
- EJ Beswick
- EJ Woo
- G Eisenhofer
- G Nguyen
- GR Davies
- H Isomoto
- H Kitamura
- HJ Baek
- J Dedio
- J Dovhanj
- J Hisatsune
- J Kohroki
- J Yoon
- JL Huff
- JP Yuan
- K Kranzer
- KL Scott
- KM Taylor
- KM Taylor
- KP Garrett
- M de Bernard
- M Karin
- M Karin
- M Suzuki
- M Yamada
- MA Endsley
- MA Hamon
- MA Janjetic
- MM D'Elios
- MS Ladeira
- N Kim
- N Matsukura
- N Nameki
- N Tochio
- NA Hawkes
- ND Lewis
- Niyaz Ahmed
- NR Hussein
- O Coux
- O Galamb
- O Handa
- P Ek
- PJ Sansonetti
- PM Harrison
- R Simon
- R Takenaka
- S Backert
- S Maeda
- S Wen
- S Yokota
- SC Baik
- SE Calvano
- SH Chu
- ST Dorsam
- SZ Ding
- T Sasaki
- TG McDaneld
- TR Graham
- TS Gomez
- V Necchi
- VG Bhoj
- VJ Hofman
- VM Cardenas
- Wei-Wen Chen
- X Xing
- Y Zhao
- Y Zhu
- YA Luqmani
- YF Wang
- YH You
- Ying-Fang Wang
- YJ Crow
- YJ Ma
- YL Chen
- Ze-Min Yang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Helicobacter pylori infection reprograms host gene expression and influences various cellular processes, which have been investigated by cDNA microarray using in vitro culture cells and in vivo gastric biopsies from patients of the Chronic Abdominal Complaint. To further explore the effects of H. pylori infection on host gene expression, we have collected the gastric antral mucosa samples from 6 untreated patients with gastroscopic and pathologic confirmation of chronic superficial gastritis. Among them three patients were infected by H. pylori and the other three patients were not. These samples were analyzed by a microarray chip which contains 14,112 cloned cDNAs, and microarray data were analyzed via BRB ArrayTools software and Ingenuity Pathways Analysis (IPA) website. The results showed 34 genes of 38 differentially expressed genes regulated by H. pylori infection had been annotated. The annotated genes were involved in protein metabolism, inflammatory and immunological reaction, signal transduction, gene transcription, trace element metabolism, and so on. The 82% of these genes (28/34) were categorized in three molecular interaction networks involved in gene expression, cancer progress, antigen presentation and inflammatory response. The expression data of the array hybridization was confirmed by quantitative real-time PCR assays. Taken together, these data indicated that H. pylori infection could alter cellular gene expression processes, escape host defense mechanism, increase inflammatory and immune responses, activate NF-κB and Wnt/β-catenin signaling pathway, disturb metal ion homeostasis, and induce carcinogenesis. All of these might help to explain H. pylori pathogenic mechanism and the gastroduodenal pathogenesis induced by H. pylori infection
Characterization of Coastal Urban Watershed Bacterial Communities Leads to Alternative Community-Based Indicators
- Author
- A Chauhan
- A Moustafa
- AC Mosier
- AJ Scupham
- B McCune
- B Sercu
- BC Crump
- Bram Sercu
- C Lozupone
- CA Lozupone
- CE Nelson
- Ching-Hong Yang
- Cindy H. Wu
- D Daffonchio
- D Woebken
- DN Frank
- E Cardenas
- E Graneli
- E Smit
- E Urbach
- EE Geldreich
- EF DeLong
- EL Brodie
- EL Brodie
- Eoin L. Brodie
- FO Glockner
- G Bodtker
- Gary L. Andersen
- GL Andersen
- H Hirayama
- H Kaartokallio
- HW Paerl
- HY Dang
- HY Sun
- I Zrafi-Nouira
- II Ivanov
- J Evans
- J Nieman
- J Raes
- JA Fuhrman
- Jakk Wong
- JL Flanagan
- JR Lu
- JR Stewart
- K Cruz-Martinez
- K Roest
- KC Wrighton
- KE Nelson
- KG Field
- KH Wilson
- KM DeAngelis
- Laurie C. Van De Werfhorst
- LE Black
- LR Fogarty
- M Cotta
- M Hamady
- M Rajilic-Stojanovic
- M Troussellier
- M Zaballos
- MA Mahowald
- MJ Cox
- MM Williams
- MP Franklin
- MT La Duc
- N Masuda
- N Wery
- NJ West
- O Savichtcheva
- O Savichtcheva
- P Juteau
- P van der Wielen
- Patricia A. Holden
- PB Eckburg
- PW Mielke
- R Chouari
- R Chouari
- R Mei
- RA Wassel
- RE Ley
- RH Platt
- RJ Hawkins
- S Benlloch
- S Ishii
- S Juretschko
- SB Humayoun
- SC Goslee
- SE Dowd
- SG Acinas
- SL Isovitsch Parks
- T Shibata
- TC Hazen
- Terry C. Hazen
- TM LaPara
- TM Petersen
- Todd Z. DeSantis
- TZ DeSantis
- TZ DeSantis
- US Sagaram
- VJ Harwood
- VM Madrid
- WH Hartman
- Publication venue
- Public Library of Science
- Publication date
- 01/03/2010
- Field of study
BACKGROUND: Microbial communities in aquatic environments are spatially and temporally dynamic due to environmental fluctuations and varied external input sources. A large percentage of the urban watersheds in the United States are affected by fecal pollution, including human pathogens, thus warranting comprehensive monitoring. METHODOLOGY/PRINCIPAL FINDINGS: Using a high-density microarray (PhyloChip), we examined water column bacterial community DNA extracted from two connecting urban watersheds, elucidating variable and stable bacterial subpopulations over a 3-day period and community composition profiles that were distinct to fecal and non-fecal sources. Two approaches were used for indication of fecal influence. The first approach utilized similarity of 503 operational taxonomic units (OTUs) common to all fecal samples analyzed in this study with the watershed samples as an index of fecal pollution. A majority of the 503 OTUs were found in the phyla Firmicutes, Proteobacteria, Bacteroidetes, and Actinobacteria. The second approach incorporated relative richness of 4 bacterial classes (Bacilli, Bacteroidetes, Clostridia and alpha-proteobacteria) found to have the highest variance in fecal and non-fecal samples. The ratio of these 4 classes (BBC:A) from the watershed samples demonstrated a trend where bacterial communities from gut and sewage sources had higher ratios than from sources not impacted by fecal material. This trend was also observed in the 124 bacterial communities from previously published and unpublished sequencing or PhyloChip- analyzed studies. CONCLUSIONS/SIGNIFICANCE: This study provided a detailed characterization of bacterial community variability during dry weather across a 3-day period in two urban watersheds. The comparative analysis of watershed community composition resulted in alternative community-based indicators that could be useful for assessing ecosystem health
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
- Briant T
- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
- Brinkmann M
- Brisbois C
- Brisson V
- Brnzas H
- Brocato E
- Brockill P
- Broderick JW
- Broida JE
- Bron S
- Brooks AF
- Brooks D
- Brostean-Kaiser J
- Brout D
- Brown DA
- Brown DD
- Brown IS
- Bruijn R
- Brun F
- Brun P
- Brunett S
- Brunner J
- Bruun SH
- Bryan M
- Buchanan CC
- Buchholz P
- Buckley DAH
- Buckley-Geer E
- Budnev NM
- Buehler R
- Bueno A
- Bufano F
- Buffa F
- Buikema A
- Buitink S
- Bulgarelli A
- Bulger J
- Bulik T
- Bulik T
- Bulla M
- Bulten HJ
- Buonanno A
- Burgay M
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- Krger PP
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- Li XB
- Li XF
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
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- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
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- Abusleme Hoffman AC
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
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- Abildgaard MH
- Abudu YP
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV
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- Chou Y
- Chow YS
- Chowdhury T
- Christopher LD
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Cieri D
- Ciesla KM
- Cindro V
- Ciocio A
- Cirotto F
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- Clark A
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- Clawson SE
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- Cornell SD
- Corpe LD
- Corradi M
- Correia AMH
- Corrigan EE
- Corriveau F
- Costa MJ
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- Dam M
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- de Renstrom PAB
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- Dedovich DV
- Degens J
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- Deviveiros PO
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- Di Domenico A
- Di Donato C
- Di Girolamo A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
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