New Strategies for Latino Voter Mobilization: The Nevada Democratic Caucus as a Case Study

Describes the 2008 Democratic caucus in Nevada with a focus on the large Hispanic/Latino population. Reviews earlier efforts to raise historically low voter participation rates and the role of the media and suggests new models for voter mobilization

Frontloading the Primaries: African Americans No Longer Marginalized

Outlines how holding Democratic primaries early might affect the representation of African-American voters in a process long dominated by Iowa and New Hampshire. Considers the potential impact on policy issues as well as ways to maximize participation

Quantifying the Effects of Protests on Voter Registration and Turnout - Study II of "Protests, Politics, and Power: Exploring the Connections Between Youth Voting and Youth Movements"

Youth activism and participation in social movements has been one of the defining features of civic life in the past several years: from the anti-gun violence protests after the Parkland school shooting in 2018, to the nationwide actions for racial justice following George Floyd's murder in 2020. Both of those were also election years in which young people achieved historic or near-historic levels of voter turnout. But what, exactly, was the relationship between young people's participation in the streets and at the ballot box?To answer that question, the Center for Information & Research on Civic Learning and Engagement (CIRCLE) joined a team of researchers to produce Protests, Politics, and Power: Exploring the Connections Between Youth Voting and Youth Movements. This research encompasses two studies that tackled this question with different but complementary perspectives and approaches. The Role of Electoral Engagement in Youth Social Movements is a qualitative study based on interviews and supplemental surveys with young leaders and participants in social movements. The second study, Quantifying the Effects of Protests on Voter Registration and Turnout, uses quantitative methods to study changes in electoral participation in areas where protests took place

The Role of Electoral Engagement in Youth Social Movements - Study I of "Protests, Politics, and Power: Exploring the Connections Between Youth Voting and Youth Movements"

Youth activism and participation in social movements has been one of the defining features of civic life in the past several years: from the anti-gun violence protests after the Parkland school shooting in 2018, to the nationwide actions for racial justice following George Floyd's murder in 2020. Both of those were also election years in which young people achieved historic or near-historic levels of voter turnout. But what, exactly, was the relationship between young people's participation in the streets and at the ballot box?To answer that question, the Center for Information & Research on Civic Learning and Engagement (CIRCLE) joined a team of researchers to produce Protests, Politics, and Power: Exploring the Connections Between Youth Voting and Youth Movements. This research encompasses two studies that tackled this question with different but complementary perspectives and approaches. The Role of Electoral Engagement in Youth Social Movements is a qualitative study based on interviews and supplemental surveys with young leaders and participants in social movements. The second study, Quantifying the Effects of Protests on Voter Registration and Turnout, uses quantitative methods to study changes in electoral participation in areas where protests took place

Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity

Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null fat cells to that in cells reconstituted for caveolae by caveolin-1 re-expression. We find that the Cav1-null cells have a modestly enhanced rate of lipolysis and reduced cellular integrity compared with reconstituted cells as determined by the release of lipid metabolites and lactic dehydrogenase, respectively, into the media. There are no apparent differences in the levels of lipolytic enzymes or hormonally stimulated phosphorylation events in the two cell lines. In addition, acute fasting, which dramatically raises circulating fatty acid levels in vivo, causes a significant upregulation of caveolar protein constituents. These results are consistent with the hypothesis that caveolae protect fat cells from the lipotoxic effects of elevated levels fatty acids, which are weak detergents at physiological pH, by virtue of the property of caveolae to form detergentresistant membrane domains

Weighted gene coexpression network analysis strategies applied to mouse weight

Systems-oriented genetic approaches that incorporate gene expression and genotype data are valuable in the quest for genetic regulatory loci underlying complex traits. Gene coexpression network analysis lends itself to identification of entire groups of differentially regulated genes—a highly relevant endeavor in finding the underpinnings of complex traits that are, by definition, polygenic in nature. Here we describe one such approach based on liver gene expression and genotype data from an F2 mouse intercross utilizing weighted gene coexpression network analysis (WGCNA) of gene expression data to identify physiologically relevant modules. We describe two strategies: single-network analysis and differential network analysis. Single-network analysis reveals the presence of a physiologically interesting module that can be found in two distinct mouse crosses. Module quantitative trait loci (mQTLs) that perturb this module were discovered. In addition, we report a list of genetic drivers for this module. Differential network analysis reveals differences in connectivity and module structure between two networks based on the liver expression data of lean and obese mice. Functional annotation of these genes suggests a biological pathway involving epidermal growth factor (EGF). Our results demonstrate the utility of WGCNA in identifying genetic drivers and in finding genetic pathways represented by gene modules. These examples provide evidence that integration of network properties may well help chart the path across the gene–trait chasm

Towards a Muon Collider

A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work.Comment: 118 pages, 103 figure

Towards a muon collider

A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements