Primeiro registro de Platyembia tessellata Ross, 2003 (Embioptera: Anisembiidae) para o estado de Rondônia, Brasil

Embioptera is one of the less studied insect groups. About 400 species have been recorded worldwide, but in Brazil, where five families have been reported to occur, the group is still poorly known. The Amazon is particularly important, insofar as it harbors a great biodiversity, although many species from its entomofauna remain unreported. We report here, for the first time, the occurrence of Platyembia tessellata Ross, 2003 in Rondônia state, northern Brazil. Specimens were collected from a tree trunk near the Jaci Paraná river. An adult male was identified based on its terminalia morphology, following the species original description.Os embiópteros constituem um dos grupos de insetos menos estudados atualmente. São registradas mais de 390 espécies no mundo todo e são pouco conhecidos no Brasil, onde ocorrem quatro famílias. A Amazônia é especialmente importante pois abriga uma grande biodiversidade e muitas espécies da entomofauna carecem de registro. O objetivo deste estudo é registrar a primeira ocorrência de Platyembia tessellata Ross, 2003 para o Estado de Rondônia, Brasil. As coletas foram realizadas em tronco de árvore próxima ao Rio Jaci Paraná. A identificação com base na morfologia da genitália de um macho adulto foi realizada de acordo com a descrição original da espécie. Os resultados mostram uma população brasileira da espécie sendo aqui registrada apenas pela segunda vez após a descoberta de Ross em 2003

Efeitos do extrato supercrítico de Melia azedarach (Meliaceae) no controle de Sitophilus zeamais Motschulsky, 1855 (Coleoptera, Curculionidae)

This study aimed to test the efficiency of the Melia azedarach supercritical extract in controlling Sitophilus zeamais through tarsal contact. The survival of insects was observed every 24 h after the experiment started. A higher mortality of insects was found during the first 72 h. The treatment that had the best performance considering the action time and the number of dead insects was that at 200 μL mL-1 concentration. The mean lethal concentration that kills 50% of the population (LC50) obtained after 96 h treatment was 165.52 µL ml-1, showing that the higher dose can be reduced with satisfactory results for the conditions used in this study. The extract of M. azedarach was effective in controlling S. zeamais under laboratory conditions.O presente estudo teve como objetivo testar a eficiência do extrato supercrítico de Melia azedarach no controle de Sitophilus zeamais por meio do contato tarsal. Observou-se a sobrevivência dos insetos a cada 24 h após o início do experimento. Constatou-se que houve maior mortalidade de insetos nas primeiras 72 h. O tratamento que teve melhor desempenho considerando-se a relação tempo de ação e número de insetos mortos foi o de concentração 200 μL mL-1. A concentração letal média que mata 50% da população (CL50) obtida após 96 h do tratamento foi de 165,52 μL mL-1, indicando que a maior dose pode ser reduzida com resultados satisfatórios para as condições empregadas no estudo. O extrato de M. azedarach revelou-se efetivo no controle de S. zeamais em condições de laboratório

Impact of gamma radiation dose on sterility and quality parameters of Anastrepha fraterculus (Diptera: Tephritidae)

Anastrepha fraterculus (Wiedemann, 1830) (Diptera: Tephritidae) is a major fruit pest, which is basicaly controlled using insecticides, which represents a risk to benefi cial arthropods, human health and food contamination. The sterile insect technique (SIT) is a potential alternative tool for the management of this pest, however, only confl icting data is found regarding the optimal dose to achieve sterility. Thus, this study evaluated the effect of gamma radiation doses (0, 40, 50, 60 and 70 Gy) on male and female reproductive sterility, gonads morphometry, emergence, fl ight ability, and longevity under nutritional stress of A. fraterculus. Full female sterility was achieved at 50 Gy, while full male sterility was achieved at 70 Gy. Both ovarian and testicular sizes were affected by irradiation, while no infl uence was observed on the quality parameters evaluated. Our results suggest that 70 Gy applied 48 h before adult emergence can be used to sterilize A. fraterculus in a SIT programme

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Generalidades sobre o quadro clínico da Rinossinusite: uma revisão narrativa de literatura: Generalities about the clinical picture of Rhinosinusitis: a narrative literature reviewv

A rinossinusite é um processo inflamatório da mucosa dos seios paranasais e da cavidade nasal. O sistema nasossinusal é responsável pelo balanço adequado entre a fabricação e o clearence de muco nas cavidades paranasais. A fisiologia deste é de vital importância para a proteção das vias aéreas superiores. No advém, determinados fatores podem acarretar um desbalanço nesse complexo, consequentemente um processo inflamatório. Qualquer fator que altere a drenagem, seja por obstrução, maior produção ou espessamento do muco, como processo infecciosos ou alérgicos, haverá uma impactação de secreções e a facilitação de colonização bacteriana, dando início ao processo infeccioso. A identificação da inflamação do nariz e seios paranasais é basicamente clínica. A suspeição desta ocorre através da manifestação de dois ou mais sintomatologias. As quais são o bloqueio ou obstrução nasal, a descarga nasal, pressão ou dor facial e redução ou perda do olfato. De modo geral, é essencial à prevenção básica das rinossinusites agudas é barrar a infecção viral. O suporte inclui medidas gerais de higiene, alimentação e hidratação, imunização para o combate de vírus respiratórios , administração de fármacos para turbinar o sistema imune se necessário