Radial Bargmann representation for the Fock space of type B

Let $\nu_{\alpha,q}$ be the probability and orthogonality measure for the $q$-Meixner-Pollaczek orthogonal polynomials, which has appeared in \cite{BEH15} as the distribution of the $(\alpha,q)$-Gaussian process (the Gaussian process of type B) over the $(\alpha,q)$-Fock space (the Fock space of type B). The main purpose of this paper is to find the radial Bargmann representation of $\nu_{\alpha,q}$. Our main results cover not only the representation of $q$-Gaussian distribution by \cite{LM95}, but also of $q^2$-Gaussian and symmetric free Meixner distributions on $\mathbb R$. In addition, non-trivial commutation relations satisfied by $(\alpha,q)$-operators are presented.Comment: 13 pages, minor changes have been mad

Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium

AbstractWe aimed to evaluate mineralocorticoid receptor (MR) expression in rat bladder and the physiological role of the MR-epithelial sodium channel (ENaC) pathway in controlling bladder function in 10–12-week-old, male Sprague–Dawley rats. First, we examined the mRNA expression of MR and localization of MR and ENaC-α proteins in the urinary bladder. MR mRNA expression was observed in untreated-rat urinary bladders, and MR and ENaC-α proteins were localized in the epithelium. Next, rats were treated with vehicle (controls) or fludrocortisone (an MR agonist) for 3 days, and ENaC-α protein expression levels and bladder function were evaluated on day 4. ENaC-α protein expression was significantly higher in fludrocortisone-treated rats than in controls. In addition, cystometry was performed during intravesical infusion of saline and amiloride (an ENaC inhibitor). While intercontraction intervals (ICIs) during saline infusion were significantly shorter in the fludrocortisone group than in the controls, infusion of amiloride normalized the ICIs in the fludrocortisone group. However, no intra- or inter-group differences in maximum intravesical pressure were observed. Taken together, MR protein is localized in the rat urinary bladder epithelium, and may regulate ENaC expression and bladder afferent input. The MR-ENaC pathway may be a therapeutic target for ameliorating storage symptoms

プロサッカーリーグにおける得点機会獲得のための攻撃プレーの分析 : パスプレーに着目して

In football it is necessary to score more goals than one’s opponents in order to win the game. One strategy for gaining goals and scoring opportunities is attacking through the gap between an opposing defender (DF) and a midfielder (MF) (the DF-MF gap). However, research on this form of attack has revealed that it is merely more likely to lead to scoring and scoring opportunities than other forms of attack. In the present study, therefore, through a comparison between the Japanese J League (JL) and the German Bundesliga (BL), we examined the features of DF-MF attack play in the JL and BL and differences between them, in order to clarify the challenges in the JL for creating scoring opportunities. We determined the number of passes into the DF-MF gap, the number of passes from players receiving the ball in the DF-MF gap, and the relationship between receiving the ball in the DF-MF gap and the opposing DF. The sample used for analysis was a total of 40 games: 20 in the JL (2015 season) and 20 in the BL (2015/2016 season). For statistical analysis, independent t test and chi-squared test were conducted. In comparison to the BL, the rate of penetration into the DF-MF gap was lower in the JL. In addition, it became clear that in the JL there was a lower proportion of scoring opportunities such as penetration into the PA and shots when penetrating into the DF-MF gap than was the case in the BL. This was considered to be due to the fact that in the JL, the number of balls received in the DF-MF gap in the direction of goal was lower than that in the BL. Furthermore, in the JL, when the ball was received in the DF-MF gap, the proportion of moves defended from the opponent goal side was higher than in the BL, suggesting a problem in how the ball is received. These findings suggest that in the JL it is necessary to increase the opportunity for scoring by making it easier for the ball to advance in a goalward direction by receiving the ball when separated from the opponent DF

サッカーにおける相手ディフェンダーとミッドフィルダーとの間のスペースを利用した攻撃の有効性の検討およびJ リーグとブンデスリーガにおける攻撃様相の比較

One of the most important factors for winning football matches is to score goals. At the field level, one important attack strategy is to use the gap between the opposing defender (DF) and midfielder (MF) (DFMF gap). An attack strategy using the DF-MF gap is one of the challenges of Japanese football, but little research on this strategy has been done and its effectiveness is currently unknown. In the present study, therefore, using notational game performance analysis, we aimed to clarify the effectiveness of attacks using the DF-MF gap, and the characteristics of this strategy in the J League (JL) and the German Bundesliga (BL). The sample consisted of a total of 20 games: 10 in the JL (2015 season) and 10 in the BL (2015/2016 season). For statistical analysis, independent t test and chi-squared tests were conducted. In both the JL and BL, it was observed that for attacks using the DF–MF gap, the frequencies of shots, penalty area intrusions, and scoring were higher than for side attacks, suggesting that attacks using the DF–MF gap were more effective. Furthermore, a lower ratio of attacks using the DF-MF gap was observed in the JL than in the BL. Also, the success rate of play in the DF-MF gap and the occurrence rate of play in a “forward” direction was significantly lower for the JL than for the BL. These observations suggest that the difference between the JL and BL lies in the frequency of attacks using the DF–MF gap and in play within it. One of the challenges for the JL is to increase the frequency of play that carries the ball forward into the DF–MF gap without losing possession, in order to increase the occurrence rate of play in that area, and eventually the success rate of attacks using the DF–MF gap

The ASTRO-H X-ray Observatory

The joint JAXA/NASA ASTRO-H mission is the sixth in a series of highly successful X-ray missions initiated by the Institute of Space and Astronautical Science (ISAS). ASTRO-H will investigate the physics of the high-energy universe via a suite of four instruments, covering a very wide energy range, from 0.3 keV to 600 keV. These instruments include a high-resolution, high-throughput spectrometer sensitive over 0.3-2 keV with high spectral resolution of Delta E < 7 eV, enabled by a micro-calorimeter array located in the focal plane of thin-foil X-ray optics; hard X-ray imaging spectrometers covering 5-80 keV, located in the focal plane of multilayer-coated, focusing hard X-ray mirrors; a wide-field imaging spectrometer sensitive over 0.4-12 keV, with an X-ray CCD camera in the focal plane of a soft X-ray telescope; and a non-focusing Compton-camera type soft gamma-ray detector, sensitive in the 40-600 keV band. The simultaneous broad bandpass, coupled with high spectral resolution, will enable the pursuit of a wide variety of important science themes.Comment: 22 pages, 17 figures, Proceedings of the SPIE Astronomical Instrumentation "Space Telescopes and Instrumentation 2012: Ultraviolet to Gamma Ray

Hitomi (ASTRO-H) X-ray Astronomy Satellite

The Hitomi (ASTRO-H) mission is the sixth Japanese x-ray astronomy satellite developed by a large international collaboration, including Japan, USA, Canada, and Europe. The mission aimed to provide the highest energy resolution ever achieved at E  >  2  keV, using a microcalorimeter instrument, and to cover a wide energy range spanning four decades in energy from soft x-rays to gamma rays. After a successful launch on February 17, 2016, the spacecraft lost its function on March 26, 2016, but the commissioning phase for about a month provided valuable information on the onboard instruments and the spacecraft system, including astrophysical results obtained from first light observations. The paper describes the Hitomi (ASTRO-H) mission, its capabilities, the initial operation, and the instruments/spacecraft performances confirmed during the commissioning operations for about a month

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements