Star Formation and AGN Activity in Galaxy Clusters from z=1−2z=1-2: a Multi-wavelength Analysis Featuring HerschelHerschel/PACS

We present a detailed, multi-wavelength study of star formation (SF) and AGN activity in 11 near-infrared (IR) selected, spectroscopically confirmed, massive ($\gtrsim10^{14}\,\rm{M_{\odot}}$) galaxy clusters at $1<z<1.75$. Using new, deep $Herschel$/PACS imaging, we characterize the optical to far-IR spectral energy distributions (SEDs) for IR-luminous cluster galaxies, finding that they can, on average, be well described by field galaxy templates. Identification and decomposition of AGN through SED fittings allows us to include the contribution to cluster SF from AGN host galaxies. We quantify the star-forming fraction, dust-obscured SF rates (SFRs), and specific-SFRs for cluster galaxies as a function of cluster-centric radius and redshift. In good agreement with previous studies, we find that SF in cluster galaxies at $z\gtrsim1.4$ is largely consistent with field galaxies at similar epochs, indicating an era before significant quenching in the cluster cores ($r<0.5\,$Mpc). This is followed by a transition to lower SF activity as environmental quenching dominates by $z\sim1$. Enhanced SFRs are found in lower mass ($10.1< \log \rm{M_{\star}}/\rm{M_{\odot}}<10.8$) cluster galaxies. We find significant variation in SF from cluster-to-cluster within our uniformly selected sample, indicating that caution should be taken when evaluating individual clusters. We examine AGN in clusters from $z=0.5-2$, finding an excess AGN fraction at $z\gtrsim1$, suggesting environmental triggering of AGN during this epoch. We argue that our results $-$ a transition from field-like to quenched SF, enhanced SF in lower mass galaxies in the cluster cores, and excess AGN $-$ are consistent with a co-evolution between SF and AGN in clusters and an increased merger rate in massive haloes at high redshift.Comment: 26 pages, 14 figures, 6 tables with appendix, accepted for publication in the Astrophysical Journa

Holding and restraining children for clinical procedures within an acute care setting: an ethical consideration of the evidence

This critical reflection on the ethical concerns of current practice is underpinned by a systematic synthesis of current evidence focusing on why and how children are held or restrained for clinical procedures within acute care and the experiences of those present when a child is held against their wishes. Empirical evidence from a range of clinical settings internationally demonstrates that frequently children are held for procedures to be completed; younger children and those requiring procedures perceived as urgent are more likely to be held. Parents and health professionals express how holding children for procedures can cause feelings of moral distress expressed as uncertainty, guilt and upset and that this act breaches the trusting and protective relationship established with children. Despite this, children’s rights and alternatives to holding are not always respected or explored. Children’s experiences and perceptions are absent from current literature. Children and young people have a moral right to have their voice and protests heard and respected and for these to inform judgements of their best interests and the actions of health professionals. Without robust evidence, debate and recognition that children are frequently held against their wishes in clinical practice for procedures which may not be urgent, children’s rights will continue to be compromised

The timing of basaltic volcanism at the Apollo landing sites

Precise crystallisation ages have been determined for a range of Apollo basalts from Pb-Pb isochrons generated using Secondary Ion Mass Spectrometry (SIMS) analyses of multiple accessory phases including K-feldspar, K-rich glass and phosphates. The samples analysed in this study include five Apollo 11 high-Ti basalts, one Apollo 14 high-Al basalt, seven Apollo 15 low-Ti basalts, and five Apollo 17 high-Ti basalts. Together with the samples analysed in two previous similar studies, Pb-Pb isochron ages have been determined for all of the major basaltic suites sampled during the Apollo missions. The accuracy of these ages has been assessed as part of a thorough review of existing age determinations for Apollo basalts, which reveals a good agreement with previous studies of the same samples, as well as with average ages that have been calculated for the emplacement of the different basaltic suites at the Apollo landing sites. Furthermore, the precision of the new age determinations helps to resolve distinctions between the ages of different basaltic suites in more detail than was previously possible. The proposed ages for the basaltic surface flows at the Apollo landing sites have been reviewed in light of these new sample ages. Finally, the data presented here have also been used to constrain the initial Pb isotopic compositions of the mare basalts, which indicate a significant degree of heterogeneity in the lunar mantle source regions, even among the basalts collected at individual landing sites

Gender identity and future thinking about parenthood: a qualitative analysis of focus group data with transgender and non-binary people in the UK

The idea that people who are transgender or non-binary are not interested in becoming parents has been refuted by several studies. However, both medical unknowns and cisnormativity surround the process of becoming a parent for transgender or non-binary people, with little known about the psychosocial impact on the family formation dilemmas of transgender and non-binary adults. Employing Life Course Theory as our theoretical framework, three focus group interviews were conducted with eleven transgender or non-binary adults. Qualitative data analysis of focus group interview transcripts was conducted through Thematic Analysis. Four overarching interlinked themes were identified concerning the dilemmas perceived by the nine participants who contemplated future parenthood: (i) Balancing a desire for parenthood and desires for other life goals; (ii) Feeling that who I am doesn’t fit into the cisgender system of accessing fostering, adoption or fertility services; (iii) Experiencing the conjoined challenges of gender and fertility embodiment as I see them; (iv) Searching for a non-binary or gender appropriate self and the need for flexible future planning centered on reproductive capacity. Overall, thoughts about gender transition were often interwoven with parenthood plans and in a dialectical fashion the desire and intention to have, or not have, children was implicated in satisfaction with gender transition. The significance of these themes is discussed in relation to how hopes for parenthood could be realized without jeopardizing gender identity and the need for a future focused, flexible, and open-minded approach on the part of fertility and adoption services

IL-10 Suppression of NK/DC Crosstalk Leads to Poor Priming of MCMV-Specific CD4 T Cells and Prolonged MCMV Persistence

IL-10 is an anti-inflammatory cytokine that regulates the extent of host immunity to infection by exerting suppressive effects on different cell types. Herpes viruses induce IL-10 to modulate the virus-host balance towards their own benefit, resulting in prolonged virus persistence. To define the cellular and molecular players involved in IL-10 modulation of herpes virus-specific immunity, we studied mouse cytomegalovirus (MCMV) infection. Here we demonstrate that IL-10 specifically curtails the MCMV-specific CD4 T cell response by suppressing the bidirectional crosstalk between NK cells and myeloid dendritic cells (DCs). In absence of IL-10, NK cells licensed DCs to effectively prime MCMV-specific CD4 T cells and we defined the pro-inflammatory cytokines IL-12, IFN-γ and TNF-α as well as NK cell activating receptors NKG2D and NCR-1 to regulate this bidirectional NK/DC interplay. Consequently, markedly enhanced priming of MCMV-specific CD4 T cells in Il10-/-mice led to faster control of lytic viral replication, bu

Are publicly available internet resources enabling women to make informed fertility preservation decisions before starting cancer treatment: an environmental scan?

Background To identify publicly available internet resources and assess their likelihood to support women making informed decisions about, and between, fertility preservation procedures before starting their cancer treatment. Methods A survey of publically available internet resources utilising an environmental scan method. Inclusion criteria were applied to hits from searches of three data sources (November 2015; repeated June 2017): Google (Chrome) for patient resources; repositories for clinical guidelines and projects; distribution email lists to contact patient decision aid experts. The Data Extraction Sheet applied to eligible resources elicited: resource characteristics; informed and shared decision making components; engagement health services. Results Four thousand eight hundred fifty one records were identified; 24 patient resources and 0 clinical guidelines met scan inclusion criteria. Most resources aimed to inform women with cancer about fertility preservation procedures and infertility treatment options, but not decision making between options. There was a lack of consistency about how health conditions, decision problems and treatment options were described, and resources were difficult to understand. Conclusions Unless developed as part of a patient decision aid project, resources did not include components to support proactively women’s fertility preservation decisions. Current guidelines help people deliver information relevant to treatment options within a single disease pathway; we identified five additional components for patient decision aid checklists to support more effectively people’s treatment decision making across health pathways, linking current with future health problems

From the rhetoric to the real: a critical review of how the concepts of recovery and social inclusion may inform mental health nurse advanced level curricula – the eMenthe project

Objectives This critical review addresses the question of how the concepts of recovery and social inclusion may inform mental health nurse education curricula at Master’s level in order to bring about significant and positive change to practice. Design This is a literature-based critical review incorporating a modified rapid review method. It has been said that if done well, this approach can be highly relevant to health care studies and social interventions, and has substantial claims to be as rigorous and enlightening as other, more conventional approaches to literature (Rolfe, 2008). Data sources In this review, we have accessed contemporary literature directly related to the concepts of recovery and social inclusion in mental health. Review methods We have firstly surveyed the international literature directly related to the concepts of recovery and social inclusion in mental health and used the concept of emotional intelligence to help consider educational outcomes in terms of the required knowledge, skills and attitudes needed to promote these values-based approaches in practice. Results A number of themes have been identified that lend themselves to educational application. International frameworks exist that provide some basis for the developments of recovery and social inclusion approaches in mental health practice, however the review identifies specific areas for future development. Conclusions This is the first article that attempts to scope the knowledge, attitudes and skills required to deliver education for Master’s level mental health nurses based upon the principles of recovery and social inclusion. Emotional intelligence theory may help to identify desired outcomes especially in terms of attitudinal development to promote the philosophy of recovery and social inclusive approaches in advanced practice. Whilst recovery is becoming enshrined in policy, there is a need in higher education to ensure that mental health nurse leaders are able to discern the difference between the rhetoric and the reality