ZigBee Pulse Oximeter

This work presents a prototype to adapt a standard pulse oximeter by turning it into a wireless device using ZigBee. Patient’s data are extracted and transmitted to the server in real time through a Wireless Sensor Network. This Wireless Sensor Network is deployed using the mesh topology in order to reach the maximum reliability in the communications. The pulse oximeter is based on a Nellcor DS-100a probe and is controlled by an Arduino FIO with a XBee wireless modem. The amplifier circuit which is designed to extract the information of the pulse oximeter probe is included in this work

Multicolour photometry for exoplanet candidate validation

Context. The TESS and PLATO missions are expected to find vast numbers of new transiting planet candidates. However, only a fraction of these candidates will be legitimate planets, and the candidate validation will require a significant amount of follow-up resources. Radial velocity follow-up can be carried out only for the most promising candidates around bright, slowly rotating, stars. Thus, before devoting RV resources to candidates, they need to be vetted using cheaper methods, and, in the cases for which an RV confirmation is not feasible, the candidate's true nature needs to be determined based on these alternative methods alone. Aims. We study the applicability of multicolour transit photometry in the validation of transiting planet candidates when the candidate signal arises from a real astrophysical source. We seek to answer how securely can we estimate the true uncontaminated star-planet radius ratio when the light curve may contain contamination from unresolved light sources inside the photometry aperture when combining multicolour transit observations with a physics-based contamination model. Methods. The study is based on simulations and ground-based transit observations. The analyses are carried out with a contamination model integrated into the PyTransit v2 transit modelling package, and the observations are carried out with the MuSCAT2 multicolour imager installed in the 1.5 m TCS in the Teide Observatory. Results. We show that multicolour transit photometry can be used to estimate the amount of flux contamination and the true radius ratio. Combining the true radius ratio with an estimate for the stellar radius yields the true absolute radius of the transiting object, which is a valuable quantity in statistical candidate validation, and enough in itself to validate a candidate whose radius falls below the theoretical lower limit for a brown dwarf.Comment: Accepted to A&

Red Dots: A temperate 1.5 Earth-mass planet candidate in a compact multi-terrestrial planet system around GJ 1061

Abstract Small low-mass stars are favourable targets for the detection of rocky habitable planets. In particular, planetary systems in the solar neighbourhood are interesting and suitable for precise characterisation. The Red Dots campaigns seek to discover rocky planets orbiting nearby low-mass stars. The 2018 campaign targeted GJ 1061, which is the 20th nearest star to the Sun. For three consecutive months we obtained nightly, high-precision radial velocity measurements with the HARPS spectrograph. We analysed these data together with archival HARPS data. We report the detection of three planet candidates with periods of 3.204 ± 0.001, 6.689 ± 0.005 and 13.03 ± 0.03 days, which are close to 1:2:4 period commensurability. After several considerations related to the properties of the noise and sampling, we conclude that a 4th signal is most likely explained by stellar rotation, although it may be due to a planet. The proposed three-planet system (and the potential four-planet solution) is long-term dynamically stable. Planet-planet gravitational interactions are below our current detection threshold. The minimum masses of the three planets range from 1.4±0.2 to 1.8±0.3 M⊕. Planet d, with msin i = 1.64 ± 0.24M⊕, receives a similar amount of energy as Earth receives from the Sun. Consequently it lies within the liquid-water habitable zone of the star and has a similar equilibrium temperature to Earth. GJ 1061 has very similar properties to Proxima Centauri but activity indices point to lower levels of stellar activity

Are the hosts of Gamma-Ray Bursts sub-luminous and blue galaxies?

We present K-band imaging observations of ten Gamma-Ray Burst (GRB) host galaxies. We compare their observed and absolute K magnitudes as well as their R-K colours with those of other distant sources detected in various optical, near-infrared, mid-infrared and submillimeter deep surveys. We find that the GRB host galaxies, most of them lying at 0.5<z<1.5, exhibit very blue colours, comparable to those of the faint blue star-forming sources at high redshift. They are sub-luminous in the K-band, suggesting a low stellar mass content. We do not find any GRB hosts harbouring R- and K-band properties similar to those characterizing the luminous infrared/submillimeter sources and the extremely red starbursts. Should GRBs be regarded as an unbiased probe of star-forming activity, this lack of luminous and/or reddened objects among the GRB host sample might reveal that the detection of GRB optical afterglows is likely biased toward unobscured galaxies. It would moreover support the idea that a large fraction of the optically-dark GRBs occur within dust-enshrouded regions of star formation. On the other hand, our result might also simply reflect intrinsic properties of GRB host galaxies experiencing a first episode of very massive star formation and characterized by a rather weak underlying stellar population. Finally, we compute the absolute B magnitudes for the whole sample of GRB host galaxies with known redshifts and detected at optical wavelengths. We find that the latter appear statistically even less luminous than the sub-luminous blue sources which mostly contributed to the B-band light emitted at high redshift. This indicates that the formation of GRBs could be favoured in particular systems with very low luminosities and, therefore, low metallicities. (Abridged)Comment: 15 pages, 6 figures, accepted for publication in Astronomy & Astrophysic

Age at menopause in Latin America

OBJECTIVE: To assess the age at menopause (AM) in Latin America urban areas. DESIGN: A total of 17,150 healthy women, aged 40 to 59 years, accompanying patients to healthcare centers in 47 cities of 15 Latin American countries, were surveyed regarding their age, educational level, healthcare coverage, history of gynecological surgery, smoking habit, presence of menses, and the use of contraception or hormone therapy at menopause. The AM was calculated using logit analysis. RESULTS: The mean age of the entire sample was 49.4 ± 5.5 years. Mean educational level was 9.9 ± 4.5 years, and the use of hormone therapy and oral contraception was 22.1% and 7.9%, respectively. The median AM of women in all centers was 48.6 years, ranging from 43.8 years in Asuncion (Paraguay) to 53 years in Cartagena de Indias (Colombia). Logistic regression analysis determined that women aged 49 living in cities at 2,000 meters or more above sea level (OR = 2.0, 95% CI: 1.4-2.9, P less than 0.001) and those with lower educational level (OR = 1.9, 95% CI: 1.3-2.8, P less than 0.001) or living in countries with low gross national product (OR = 2.1, 95% CI: 1.5-2.9, P less than 0.001) were more prone to an earlier onset of menopause. CONCLUSIONS: The AM varies widely in Latin America. Lower income and related poverty conditions influence the onset of menopause. © 2006 by The North American Menopause Society

INFOGEST static in vitro simulation of gastrointestinal food digestion

peer-reviewedSupplementary information is available at http://dx.doi.org/10.1038/s41596-018-0119-1 or https://www.nature.com/articles/s41596-018-0119-1#Sec45.Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus developed by the COST INFOGEST network. The method is designed to be used with standard laboratory equipment and requires limited experience to encourage a wide range of researchers to adopt it. It is a static digestion method that uses constant ratios of meal to digestive fluids and a constant pH for each step of digestion. This makes the method simple to use but not suitable for simulating digestion kinetics. Using this method, food samples are subjected to sequential oral, gastric and intestinal digestion while parameters such as electrolytes, enzymes, bile, dilution, pH and time of digestion are based on available physiological data. This amended and improved digestion method (INFOGEST 2.0) avoids challenges associated with the original method, such as the inclusion of the oral phase and the use of gastric lipase. The method can be used to assess the endpoints resulting from digestion of foods by analyzing the digestion products (e.g., peptides/amino acids, fatty acids, simple sugars) and evaluating the release of micronutrients from the food matrix. The whole protocol can be completed in ~7 d, including ~5 d required for the determination of enzyme activities.COST action FA1005 INFOGEST (http://www.cost-infogest.eu/ ) is acknowledged for providing funding for travel, meetings and conferences (2011-2015). The French National Institute for Agricultural Research (INRA, www.inra.fr) is acknowledged for their continuous support of the INFOGEST network by organising and co-funding the International Conference on Food Digestion and workgroup meeting

Is there a role for melatonin in fibromyalgia?

Fibromyalgia, characterised by persistent pain, fatigue, sleep disturbance and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis. Heterogeneity of clinical expression of fibromyalgia with a multifactorial aetiology has made the development of effective therapeutic strategies challenging. Physiological properties of the neurohormone melatonin appear related to the symptom profile exhibited by patients with fibromyalgia and thus disturbance of it’s production would be compatible with the pathophysiology. Altered levels of melatonin have been observed in patients with fibromyalgia which are associated with lower secretion during dark hours and higher secretion during daytime. However, inconsistencies of available clinical evidence limit conclusion of a relationship between levels of melatonin and symptom profiles in patients with fibromyalgia. Administration of melatonin to patients with fibromyalgia has demonstrated suppression of many symptoms and an improved quality of life consistent with benefit as a therapy for the management of this condition. Further studies with larger samples, however, are required to explore the potential role of melatonin in the pathophysiology of fibromyalgia and determine the optimal dosing regimen of melatonin for the management of fibromyalgia

Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)

Background: This study provides a global overview of the management of patients with acute cholecystitis during the initial phase of the COVID-19 pandemic. Methods: CHOLECOVID is an international, multicentre, observational comparative study of patients admitted to hospital with acute cholecystitis during the COVID-19 pandemic. Data on management were collected for a 2-month study interval coincident with the WHO declaration of the SARS-CoV-2 pandemic and compared with an equivalent pre-pandemic time interval. Mediation analysis examined the influence of SARS-COV-2 infection on 30-day mortality. Results: This study collected data on 9783 patients with acute cholecystitis admitted to 247 hospitals across the world. The pandemic was associated with reduced availability of surgical workforce and operating facilities globally, a significant shift to worse severity of disease, and increased use of conservative management. There was a reduction (both absolute and proportionate) in the number of patients undergoing cholecystectomy from 3095 patients (56.2 per cent) pre-pandemic to 1998 patients (46.2 per cent) during the pandemic but there was no difference in 30-day all-cause mortality after cholecystectomy comparing the pre-pandemic interval with the pandemic (13 patients (0.4 per cent) pre-pandemic to 13 patients (0.6 per cent) pandemic; P = 0.355). In mediation analysis, an admission with acute cholecystitis during the pandemic was associated with a non-significant increased risk of death (OR 1.29, 95 per cent c.i. 0.93 to 1.79, P = 0.121). Conclusion: CHOLECOVID provides a unique overview of the treatment of patients with cholecystitis across the globe during the first months of the SARS-CoV-2 pandemic. The study highlights the need for system resilience in retention of elective surgical activity. Cholecystectomy was associated with a low risk of mortality and deferral of treatment results in an increase in avoidable morbidity that represents the non-COVID cost of this pandemic

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks