9 research outputs found
Teaching in a multicultural environment:understanding teacher competence in finnish preparatory education
- Author
- Publication venue
- University of Oulu
- Publication date
- 03/05/2022
- Field of study
Abstract. As multiculturalism becomes an increasingly significant part of the Finnish school environment, the ability of teachers to encounter different cultures and to teach pupils with an immigrant background has attracted attention and the need for research. Preparatory education teachers are a fairly new professional group that consists of various educational professionals. Their eligibility requirements and training are, however, in many ways deficient.
The competences found in this study that preparatory education teachers need in their daily work include encountering pupils from different cultural backgrounds with understanding and respect, differentiation and teaching Finnish as a second language skills as well as flexibility and the ability to identify learning difficulties from insufficient language skills.
There may be differences as to which educational background would correspond to the work of a preparatory education teacher the best. The teachers, however, agree on the need for further training when it comes to multicultural implementation of education and the fact that their educational background has not provided enough knowledge for them to acquire the competences needed in the work
A case study of Oulu Universityâs teacher studentsâ understanding of inclusive education and their sense of self-efficacy to implement inclusive education in their future work
- Publication venue
- University of Oulu
- Publication date
- 22/08/2023
- Field of study
Abstract. Inclusive education has been a prevalent value in Finnish educational context since the 1990s. However, teacher education has not sufficiently adapted to the policy changes regarding inclusive education in schools. Previous research shows that teacher students feel that their education has not given them sufficient competence to implement inclusive education. Additionally, in order to implement inclusive education successfully, inclusive education must be understood as a right of every student to quality education.
Firstly, the purpose of this research is to examine and describe how masterâs level classroom and special education teacher students understand the concept of inclusive education. Secondly, the research aims to gain an in-depth understanding of teacher studentsâ sense of self-efficacy to implement inclusive education in their future work. Lastly, we examine how teacher education has developed the teacher studentsâ sense of self-efficacy.
The theoretical framework of our research considers inclusive education as a concept, different approaches to the implementation of it and its state particularly in the Finnish context. Additionally, we will discuss sense of self-efficacy especially according to Bandura. The research is a qualitative case study situated at the University of Oulu. The data was collected through an anonymous online questionnaire. The chosen analysis method is qualitative content analysis.
The research findings reveal that overall teacher students understand inclusive education to consider all students and reflect values of equality and participation. However, some define inclusive education through the concept of integration. Special education teacher studentsâ self- efficacy was found higher than that of the classroom teacher students. Practicality of the studies and discussions were found most meaningful for the strengthening of their sense of self-effi- cacy. Additionally, special education teacher students are more satisfied with their studies regarding inclusive education. The research highlights that inclusive education must be considered more in teacher education.Tapaustutkimus Oulun yliopiston opettajaopiskelijoiden ymmaÌrryksestaÌ inklusiivisesta koulu- tuksesta ja heidaÌn minaÌpystyvyydestaÌaÌn toteuttaa inklusiivista koulutusta tulevassa tyoÌssaÌaÌn. TiivistelmĂ€. Inklusiivisuus on ollut keskeinen arvo suomalaisessa koulutuksessa 1990-luvulta laÌhtien. SiitaÌ huolimatta opettajakoulutus ei ole riittaÌvaÌsti mukautunut linjauksiin, joita on tehty inklusiiviseen koulutukseen liittyen kouluissa. Aiempi tutkimus osoittaa, ettaÌ opettajaopiskelijat kokevat, ettei heidaÌn koulutuksensa ole tukenut tarpeeksi minaÌpystyvyyden tunnetta inklusiivisen koulutuksen toteuttamiseen. LisaÌksi, jotta inklusiivista koulutusta voidaan toteuttaa onnistuneesti, ymmaÌrryksen siitaÌ tulee painottaa jokaisen oppilaan oikeutta laadukkaaseen opetukseen.
TaÌmaÌn tutkimuksen tarkoituksena on ensinnaÌkin tutkia ja kuvailla, kuinka maisterivaiheen luokanopettaja- ja erityisopettajaopiskelijat ymmaÌrtaÌvaÌt inklusiivisen koulutuksen. LisaÌksi tutkimuksen tavoitteena on luoda kattava kaÌsitys opettajaopiskelijoiden minaÌpystyvyydestaÌ toteuttaa inklusiivista koulutusta tulevassa tyoÌssaÌaÌn. Lopuksi tarkastelemme, kuinka opettajakoulutus on vaikuttanut opiskelijoiden minaÌpystyvyyteen.
Tutkimuksemme teoreettinen viitekehys tarkastelee inklusiivisen koulutuksen kaÌsitettaÌ, erilaisia laÌhestymistapoja sen toteutukseen sekaÌ sen tilaa erityisesti suomalaisessa kontekstissa. LisaÌksi kaÌsitelemme minaÌpystyyden kaÌsitettaÌ etenkin Banduran teorian mukaan. Tutkimus on kvalitatiivinen tapaustutkimus Oulun yliopistossa. Aineisto keraÌttiin anonyymin verkkokyselyn kautta. Analyysimetodina on kaÌytetty laadullista sisaÌlloÌnanalyysia.
Tutkimustuloksemme osoittavat, ettaÌ yleisesti opettajaopiskelijat ymmaÌrtaÌvaÌt inklusiivisen koulutuksen koskevan kaikkia oppilaita ja ymmaÌrrys seuraa tasa-arvon ja osallisuuden arvoja. Kuitenkin jotkut opettajaopiskelijat maÌaÌrittelevaÌt inklusiivisen koulutuksen integraation kaÌsitteen kautta. Erityisopettajaopiskelijoiden minaÌpystyvyys havaittiin tutkimuksessamme vahvemmaksi kuin luokanopettajaopiskelijoiden. KaÌytaÌnnoÌnlaÌheisyys ja keskustelut koettiin merkittaÌvimmiksi osa-alueiksi minaÌpystyvyyden vahvistamiseksi. LisaÌksi tutkimus osoittaa, ettaÌ erityisopettajaopiskelijat ovat tyytyvaÌisempiaÌ opintoihinsa inklusiivisesta koulutuksesta. Tutkimus painottaa, ettaÌ inklusiivinen koulutus tulisi huomioida paremmin opettajakoulutuksessa
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso InĂȘs
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
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- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
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- Burnett Mary Susan
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- Cambien Francois
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- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
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- Chatterjee Nilanjan
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- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
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- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
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- Elosua Roberto
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- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
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- Fischer Marcus
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- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
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- Fu Mao
- Gaget Stefan
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- Gieger Christian
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- Goddard Michael E.
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- Griffin Simon
- Groop Leif
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- Groves Christopher J.
- Grundberg Elin
- GrĂ€Ăler JĂŒrgen
- Grönberg Henrik
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- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
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- Hall Per
- Halperin Eran
- Hammond Christopher J.
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- Hamsten Anders
- Han Chen
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- Haritunians Talin
- Harris Tamara B.
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- MAGIC [Unknown]
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- Mallick Nadeem
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- Wells George A.
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- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
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- Willemsen Gonneke
- Willenborg Christina
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- Wilson James F.
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- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Ăhrvik John
- Ăstenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired ÎČ-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of âŒ2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 Ă 10(-4)), improved ÎČ-cell function (P = 1.1 Ă 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- AasarĂžd Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso InĂȘs
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- BlĂŒher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
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- Bouatia-Naji Nabila
- Bouchard Claude
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- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
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- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ărnlöv Johan
- Ăsterholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (PÂ <Â 5Â ĂÂ 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Author
- A David Smith
- Aaltonen L.
- Aaltonen V.
- Aarno Palotie
- Aarsland D.
- Aavikko M.
- Abalos M. S.
- Abdelnour C.
- Abner E.
- Abraham R.
- Ad Adarmes-GĂłmez
- Adam Boxer
- Adam Ziemann
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- Adams P. M.
- Adarmes-GĂłmez A.
- Adarmes-GĂłmez A. D.
- Adriana Gamboa
- Adrienne L Cupples
- Adrienne Tin
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Agustina Legaz
- Ahmad S.
- Aimee Pierce
- Aino Salminen
- Airi Jussila
- Aisha Khaleeq
- Aki Havulinna
- Akinyemi R. O.
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- Alan B Stevens
- Alan Lerner
- AlarcĂłn-MartĂn E.
- Albert M. S.
- Alberto Benussi
- Albin R. L.
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- Aldo Saenz
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- Yeunjoo E Song
- Yi Zhao
- Ying Wu
- Yoav Ben-Shlomo
- Yogen Patel
- Younkin S. G.
- Yu C. -E.
- Yu L.
- Yuanchao Zhang
- Yuk Yee Leung
- Yunfeng Huang
- Yunju Yang
- Zare H.
- Zdenka Pausova
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
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- Ziemann A.
- Zoia C. P.
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- Zulaica M.
- Zulma Sevillano
- Ălvarez V.
- Ă sa Hedman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
- Author
- Abecasis Goncalo R.
- Aben K K
- Absher D
- Adair L S
- Adair Linda S
- Adeyemo Adebowale
- Ahmadi Kourosh R.
- Ala-Korpela Mika
- Alavere H
- Albrecht E
- Alexander Myriam
- Alizadeh Behrooz Z.
- Almgren P
- Altmaier E L
- Altshuler D
- Amin N
- An P
- Ardlie K
- Ardlie K G
- Ariyurek Y
- Arking Dan E
- Arnold A M
- Arora Pankaj
- Artigas Maria Soler
- Aspelund T
- Aspelund Thor
- Assimes T L
- Atwood Larry D.
- Aulchenko Y S
- Aulchenko Yurii
- Bakker Stephan J L
- Balkau B
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- Balmforth A J
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- Bandinelli Stefania
- Barbalic M
- Barroso Ines
- Barroso InĂȘs
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- Baumeister Sebastian E.
- Beckmann J S
- Beckmann Jacques S
- Beilby J P
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- Bengtsson Boström Kristina
- Bennett A J
- Bennett Amanda J
- Bergman R N
- Bergman Richard N
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- Bergmann Sven
- Berndt S I
- Bhangale T
- Bis J C
- Bis Joshua C
- Blagieva Roza
- Bochud M
- Boehm Bernhard O
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- Boerwinkle E
- Bolton Judith A Hoffman
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- Borecki Ingrid B.
- Bornstein S R
- Bornstein Stefan R
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- Whincup Peter H
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- Wichmann H. Erich
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- Willemsen Gonneke
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- Wolffenbuttel Bruce H R
- Wong Andrew
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- Wong Tien Y
- Wood A R
- Workalemahu T
- Wright A F
- Wright Alan F
- Wu Guanming
- Wu Ying
- Wurz Peter
- WĂŒrtz Peter
- Xu Chun
- Xu J
- Yajnik Chittaranjan S
- Yang J
- Yao Jie
- Yarnell J W
- Yerges-Armstrong Laura M.
- Young J H
- Yuan Xin
- Zabena C
- Zagato L
- Zee R Y
- Zeggini E
- Zelenika D
- Zethelius B
- Zgaga L
- Zhai G
- Zhang Feng
- Zhang Weihua
- Zhao J H
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Ziegler A
- Zillikens M C
- Zitting P
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
- Abecasis G. (Goncalo)
- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Absher D. (Devin)
- Absher D. (Devin)
- Aherrahrou Z. (Zouhair)
- Ahlqvist E. (Emma)
- Ahmadi K.R. (Kourosh)
- Ahmed N. (Nabeel)
- Alavere H. (Helene)
- Alibrandi M.T.S. (Maria)
- Allayee H. (Hooman)
- Allen H.L.
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- Altshuler D. (David)
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- Johnson P. (Paul)
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- Johnson T. (Toby)
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- Jones G.T. (Gregory)
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- Marre M. (Michel)
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- McCarroll S.A. (Steven)
- McCarthy A. (Anne)
- McCarthy M. (Mark)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
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- Montgomery G.W. (Grant)
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- Morgan T. (Thomas)
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- Myers R.H. (Richard)
- MĂ€gi R. (Reedik)
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- Ngwa J.S.
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- Penninx B.W.J.H.
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- Peto R. (R.)
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- Pichler I. (Irene)
- Pietilainen K.H. (Kirsi Hannele)
- Platou C. (Carl)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Potter S.C. (Simon)
- Pramstaller P.P. (Peter P.)
- Preuss M. (Michael)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Purcell S. (Shaun)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quyyumi A.A. (Arshed)
- Rader D.J. (Daniel)
- Rafelt S. (Suzanne)
- Raitakari O. (Olli)
- Raitakari O.T. (Olli T.)
- Rallidis L.S. (Loukianos)
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- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (N. William)
- Rayner N.W. (Nigel William)
- Reilly M.P. (Muredach P.)
- Reinehr T. (Thomas)
- RidderstrÄle M. (Martin)
- Ridker P.M. (Paul)
- Rij A.M. (Andre) van
- Ripatti S. (Samuli)
- Rissanen A. (Aila)
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- Shi J. (Jianxin)
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- Shuldiner A.R. (Alan)
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- Sijbrands E. (Eric)
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- Sinisalo J. (Juha)
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- Sladek R. (Rob)
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- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith T.B. (Tamara B.)
- Snoep J.D. (Jaapjan)
- Soranzo N. (Nicole)
- SparsĂž T. (Thomas)
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- Speliotes E.K. (Elizabeth)
- Spertus J.A. (John)
- StanÄcĂĄkovĂĄ A. (Alena)
- Stark K. (Klaus)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Stephens J. (Jonathan)
- Stewart A.F. (Alexandre F.)
- Stirrups K. (Kathy)
- Stoll M. (Monika)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Strawbridge R.J. (Rona)
- Strawbridge R.J. (Rona)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
- Swift A.J. (Amy)
- SyvÀnen A.C.
- Tammesoo M.L.
- Taneera J. (Jalal)
- Tang W. (W.)
- Tardif J.-C. (Jean-Claude)
- Tennstedt S. (Stephanie)
- Teslovich T.M. (Tanya M.)
- Thiering E. (Eelisabeth)
- Thiering E. (Elisabeth)
- Thompson J.R. (John)
- Thomson B. (Brian)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorgeirsson G. (Gudmundur)
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- Travers M.E. (Mary E.)
- Travers M.E. (Mary)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Turrini F. (Fabiola)
- Tyrer J.P. (Jonathan)
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- Valle T.T. (Timo T.)
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- van't Hooft F. (Ferdinand)
- Van't Hooft F. (Ferdinand)
- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
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- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
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- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
- Wild S.H. (Sarah)
- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Ăhrvik J. (John)
- Ăstenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 Ă 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
- Author
- Aaltonen Lauri A.
- Aapro Matti
- Abbas Mohammed
- Adab Fawzi
- Adams Richard Alexander
- Ahmad Athar
- Ahmad Rizvana
- Ahmad Rizvana
- Al-Mishlab Talib
- Al-Salihi Omar
- Alexander Emma
- Ali Nasim
- Alsab Heidar
- Andersson Magnus
- Anjarwalia Salim
- Anthoney David A.
- Ashford Richard
- Askill Colin
- Astras George
- Atherton Philip J.
- Azam Faisal A.
- Azzabi Ashraf
- Bale Catherine
- Ballereau Stephane
- Barclay Ella
- Barlow Hilary
- Barnes Anne
- Basu Devyanee
- Bateman Adrian
- Baughan Christopher
- Beall Sarah
- Beech Darren
- Beesley Sharon
- Begent Richard
- Benstead Kim
- Bessell Eric Michael
- Birtle Alison
- Bishop Timothy
- Biswas Ashoke
- Blesing Claire
- Bliss Peter
- Braconi Chiara
- Bradley Chris
- Breathnach Oscar
- Brewer Carole
- Brewster A. E.
- Bridgewater John
- Bridgewater John
- Bridgewater John
- Broderick Peter
- Broughton Mary
- Brown Julia
- Butt Mohammad
- Bystricky Brano
- Calvert Paula
- Campbell Harry
- Carney Desmond
- Carpenter Sue
- Carvajal-Carmona Luis G.
- Casey Graham
- Cassidy James
- Cassidy James
- Cazier Jean-Baptiste
- Chakrabarti Amitabha
- Chakraborti Prabir
- Chander Ian
- Chau Ian
- Cheadle Jeremy Peter
- Clark Peter I.
- Cleator Susan
- Cleator Susan
- Clement Louise
- Clenton Susan
- Clive Sally
- Cogill Geoffrey
- Conn Andrew
- Conti David
- Cook Jaqueline
- Cooper Rachel
- Corrie Philippa
- Cottrill Christopher
- Courtney Cheryl
- Creak Antonia
- Crellin Adrian
- Crown John
- Cummins Sebastian
- Cunningham David
- Dalén Johan
- Daniel Francis
- Danwata Falalu
- Davidson Rosemarie
- Dawson Lesley
- Deary Ian
- Dent Jo
- Dhadda Amandeep
- Dhadda Amandeep
- Dickinson Peter D.
- Dobbins Sara E.
- Dobrowsky Werner
- Domingo Enric
- Donaldson Alan
- Duggan David J.
- Dunlop Malcolm G.
- Dunn Grainne
- Easton Douglas
- Eatock Martin
- Edler David
- Ekelund Susanne
- El-deeb Hany
- Ellis Richard
- Essapen Sharadah
- Evans Gareth
- Falk Stephen
- Falk Stephen
- Farrington Susan Mary
- Farrugia David
- Farrugia David
- Fennelly David
- Fisher David
- Ford Hugo
- Ford Victoria
- Frampton Matthew
- Freebairn Alice
- Fuller C.
- Furniss Debra
- Gallagher Madalena
- Gallinger Steven
- Gaya Andres
- Gaya Andrew
- Geh Ian
- Geh Ju Ian
- Genton M.
- Gidden Fiona
- Gildersleve James
- Giridharan Selvaraj
- Glaholm John
- Glynne-Jones Robert
- Gollins Simon
- Gopi Kakumudi
- Goriah Sonia
- Gorman Maggie
- Gracie Richard
- Green Andrew
- Greenhalge Lynn
- Griffiths Gareth O.
- Grimes Graeme
- Grogan Liam
- Gupta Rajnish
- Haites Neva
- Hall Julia
- Hall Viriginia
- Halliday Dorothy
- Hamid Abdel
- Hamid Abdel
- Harper Lynda
- Harper-Wynne Catherine
- Harrison Mark
- Hartley Andrew
- Hassan Sharma
- Haylock Brain
- Henderson Alex
- Henrion Marc
- Henry Paul
- Hickish Tamas
- Hill Mark
- Hindley Andrew
- Hjern Fredrik
- Hochhauser Daniel
- Hodgkinson Elizabeth
- Hodgson Shirley
- Hofmann Uschi
- Holm Jörn
- Homfray Tessa
- Hopkins Kirstin
- Hopper John
- Hornbuckle Joanne
- Houlston Richard S.
- Houston Russell
- Hughes Rob
- Iqbal Mussawar I.
- Iveson Timothy John
- Izatt Louise
- James Rodger D.
- Janson Martin
- Jenkins Mark A.
- Jephcott Catherine
- Jodrell Duncan
- Joffe Johnathan K.
- Johnson Patrick
- Johnston Patrick
- Jones Adam
- Jones Amanda
- Jones Angela M.
- Joseph Shibu
- Kaplan Rick
- Karp Stephen
- Kay Edward
- Keane Maccon
- Kelly Kay
- Kennedy James
- Kennedy James
- Kenny Sarah
- Kerr David J.
- Kirac Iva
- Kovacevi Dujo
- Kulkarni Rajendra
- Kumar Satish
- Langley Ruth
- Ledermann Jonathan
- Lenander Claes
- Leonard Gregory
- Leslie Martin
- Levine Edward
- Lindblom Annika
- Lindforss Ulrik
- Liu Tao
- Lloyd Amy
- Lo Nangi
- Lofts Fiona Jane
- Lowdell Charles
- Lowndes Sarah
- Lubbe Steven
- Lucassen Anneke
- Lundqvist Nils
- Ma Yusanne P.
- MacDonald Graham
- Macgregor Carol
- Mack Paul
- Macmillan Craig
- Madi Ayman
- Maher Eamonn
- Maisey Nicholas
- Maisey Nicholas
- Maraveyas Anthony
- Marks Christopher
- Marshall Ernest
- Martin Lynn
- Mason Malcolm David
- Matsuda Koichi
- Maughan Tim
- Maughan Timothy Stanley
- Mawdsley Suzannah
- Mayer Astrid
- McAdam Karen
- McCaffrey John
- McDermott Ray
- McDonald Alec
- McGovern Ursula
- McKinna Fiona
- McKinna Fiona
- McLean Catriona
- Meade Angela
- Mecklin Jukka-Pekka
- Medisetti Aruna
- Melcher Alan
- Melcher Lucinda
- Meyer Timothy
- Middleton Gary
- Midgley Rachel
- Mitchell Jena
- Mohammed Nazia
- Moody Anne Margeret
- Morrison Patrick
- Mort Diana
- Mukherjee Somnath
- Mullamitha Saifee
- Mullard Anna
- Murday Victoria
- Murphy Claire
- Murray Phillip
- Muthuramalingam Sethupathi
- Myint Arthur S.
- Nakamura Yusuke
- Narayana Priya
- Neal Janet
- Neupane Rekha
- Newcomb Polly
- Nichols Laura
- Nicoll Jonathan
- Northover John
- O'Callaghan Anne
- O'Hagan Julie
- O'Hara Richard
- O'Neill Paul
- O'Reilly Seamus
- Okada Yukinori
- Olsson Louise
- Olver Bianca
- Ooi Li-Yin
- Osborne Richard
- Osborne Richard
- Palles Claire
- Palmer Cheryl
- Palmer Cheryl
- Palmer Dan
- Parker Chris
- Parmar Mahesh
- Patel Kinnari
- Paterson Joan
- Pedley Ian
- Penegar Steven
- Pharoah Paul
- Phillips Hamish Andrew
- Pledge Simon
- Polychronis Andrew
- Pope Malcolm
- Potter Vanessa
- Prejbisz Jan
- Prendergast James
- Propper David
- PĂ„hlman Lars
- Raine Anne
- Raj Sanjay
- Reed Nicholas
- Rees Charlotte
- Renkonen-Sinisalo Laura
- Riddle Philippa
- Rogers Penny
- Ross Paul
- Roy Raj
- Rudan Igor
- Rudd Robin
- Rudman Sarah
- Samuel Leslie M.
- Saunders Mark
- Scarffe John H.
- Schumacher Fredrick
- Semple Colin
- Sevitt Timothy
- Seymour Matthew
- Seymour Matthew
- Sgouros Joseph
- Shah Mitul
- Shah Riyaz
- Shankland K.
- Sharif Sahid
- Shepherd Stephen
- Sheridan Eamonn
- Sherwin Elizabeth
- Side Lucy
- Sizer Bruce
- Smedh Kennet
- Smillie Claire
- Smith Chris
- Smith David
- Smith David
- Soomal Rabinder
- Spain Sarah
- Sparrow Geoff
- Starr John M.
- Steven Neil
- Stewart Jill
- Stout Ronald
- Strauss Sandra
- Stuart Nicholas
- Summers Jeffrey
- Suri Mohnish
- Susnerwala Shabbir
- Susnerwala Shabbir
- Sydes Benjamin
- Tahir Saad
- Talbot Toby
- Tan Li Tee
- Tenesa Albert
- Teo Mark
- Theodoratou Evropi
- Thomas Huw
- Thomas Robert
- Thompson Lindsay
- Tighe Mary
- Tomkins Susan
- Tomlinson Ian P.
- Tomlinson Marjorie
- Topham Claire
- Toy Elizabeth
- Tsang David
- Twelves Chris
- Törnqvist Anders
- Valle Juan
- Van der Voet Johannes
- Vigneswaran Vallipuram
- Vijayakrishnan Jayaram
- Wadd Nicholas J.
- Wadsley Jonathan
- Wagstaff John
- Walker Lisa
- Walshe Janice
- Walther Julie
- Wasan Harpreet
- Wasan Harpreet S.
- Waterston Ashita
- Weaver Andrew
- Webb Andrew
- Webb Andrew
- West Hannah
- Whelan Jeremy
- Whiffin Nicola
- Whillis David
- White Jeff
- Wilkins Margeret
- Wilkins Marie
- Williams Rachel
- Wilson Charles
- Wilson David
- Wilson Gregory
- Wilson Richard
- Wilson Richard
- Wise Marcus
- Wright Kathryn
- Wrigley Jessica
- Yosef Hosney
- Zgaga Lina
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/05/2012
- Field of study
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 Ă 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 Ă 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 Ă 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.</p
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-GĂłmez Ad
- Adarmes-GĂłmez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- AlarcĂłn-MartĂn Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso MarĂa Dolores
- Alonso MarĂa Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- AntĂșnez Carmen
- Aparicio Hugo J.
- Apostolova Liana G.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola
- Armstrong Nicola J.
- Arnold Steven E.
- Arosio Beatrice
- Arvas Mikko
- Assogna Francesca
- Asthana Sanjay
- Athanasiu Lavinia
- Atwood Craig S.
- Auge Franck
- Auranen Annika
- Auvinen PĂ€ivi
- Awaisa Ghazal
- Ayres Gayle
- Bacha Juan Ignacio
- Bahadori Maryam
- Bahrami Shahram
- Bailly Henri
- Baldwin Clinton T.
- Banaj Nerisa
- Baquero Miquel
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Barral Sandra
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Becker James T.
- Becker Tim
- Beecham Gary W.
- Beekly Duane
- Behrens Tim
- Beiser Alexa
- Belezhanska Diyana
- Bellenguez CĂ©line
- Below Jennifer E.
- Below Jennifer E.
- Ben-Shlomo Yoav
- Benchek Penelope
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Benussi Alberto
- Benussi Luisa
- Bergh Sverre
- Bernardo-Harrington Mateus
- Berr Claudine
- Bertelson John
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- Bessi Valentina
- Betts Jo
- Bhangale Tushar
- Biessels Geert Jan
- Binetti Giuliano
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- Bird Thomas D.
- Bis Joshua C.
- Biswas Shameek
- Bizarro Alessandra
- Bjerke Maria
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- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- BossĂč Paola
- Bowen James D.
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- Brayne Carol
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- Brewer James
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- Brodaty Henry
- Broeckhoven Christine Van
- Bronson Paola
- Brookes KJ
- Brown Kristelle
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- Brusco Luis Ignacio
- BrÄthen Geir
- Buendia Mar
- Buiza-Rueda Dolores
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- Chasman Daniel
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- Chatelain Clement
- Chauhan Ganesh
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- Clarimon Jordi
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- Close David
- Collinge John
- Comic Hata
- Conti Elisa
- Cores Valeria
- Corma-GĂłmez AnaĂŻs
- Costa Marcos R.
- Costantini Emanuele
- Cox Simon
- Craft Suzanne
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- Cullum Munro
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- Custodero Carlo
- Daian Delphine
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- Davies Chloe
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- Davis Barbara
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- de Mendonça Alexandre
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- della Briotta Parola Pietro
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- Deloukas Panagiotis
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- Denning Nicola
- Deramecourt Vincent
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- DeStefano Anita
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- Escott-Price Valentina
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- Fulton-Howard Brian
- Fulton-Howard Brian
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- Garcia-Tabuenca Javier
- GarcĂa-Alberca Jose Maria
- GarcĂa-GonzĂĄlez Pablo
- Garrote-Espina L.
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- Haapasalo Annakaisa
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- Harold Denise
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- Hartmann Annette M.
- Harvima Ilkka
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- Hausner Lucrezia
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- Helisalmi Seppo
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- Hendolin Minna
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- PirilÀ Laura
- Pisanu Claudia
- PitkÀranta Anne
- Piñol-Ripoll Gerard
- Plenge Robert
- Podgornaia Anna
- Polak Thomas
- Politis Daniel G.
- Polk Marsha
- Poon Wayne W.
- Popovic Relja
- Popp Julius
- Posthuma Danielle
- Potter Huntington
- Powell John
- Powell John F.
- Preckler Silvia
- Prestia Federico Ariel
- Priller Josef
- Proitsi Petra
- Prokic Ivana
- Psaty Bruce M.
- Puerta Raquel
- Pulford David
- Pulkki Kari
- Pussinen Pirkko
- PylkÀs Katri
- PĂ€rn Kalle
- PĂ©rez-CordĂłn Alba
- PĂ©rez-Tur Jordi
- Qu Liming
- Quarless Danjuma
- Quenez Olivier
- Quiceno Mary
- Quinn Joseph F.
- Quintela Inés
- Rahimov Fedik
- Raikkonen-Talvitie Katri
- Rainero Innocenzo
- Raj Ashok
- Raj Towfique
- Rajabli Farid
- Rajpal Deepak
- Rajula Reddy
- Ramakers Inez
- Ramirez Alfredo
- Raskind Murray
- Rathinakannan Venkat Subramaniam
- Real de AsĂșa Diego
- Real Luis M.
- Reeve Mary Pat
- Reiman Eric M.
- Reinders Marcel J. T.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Remes Anne
- Reyes-Dumeyer Dolly
- Riaz Moeen
- Rice David
- Rich Stephen
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Riley-Gillis Bridget
- Ringman John M.
- Rinne Juha
- Rios Mario
- Ripatti Samuli
- Ritari Jarmo
- Rivas Manuel
- Roberson Erik D.
- Roberto Natalia
- Rodrigo Silvia
- Rodrigo-Herrero Silvia
- Rodriguear Monica
- Rodriguez-Rodriguez Eloy
- RodrĂguez Carmen MartĂnez
- Roeck Ellen De
- Rogaeva Ekaterina
- Rojo Matias
- Romero Jose
- Rongve Arvid
- Rosen Howard J.
- Rosenberg Roger N.
- Rosende-Roca Maitée
- Roshchupkin Gena
- Rossi Giacomina
- Rossi Paolo Dionigi
- Rossor Martin
- Rossor Martin
- Rotter Jerome
- Roveta Fausto
- Royall Donald R.
- Royo Jose Luis
- Rubino Elisa
- Rubinsztein David C.
- Ruiz AgustĂn
- Rujescu Dan
- Runz Heiko
- Ryan Natalie S.
- Ryan Nathalie
- RĂĄbano Alberto
- RĂŒeger Sina
- Saba Yasaman
- Sachdev Perminder
- Saenz Aldo
- Sager Mark A.
- Sakka Paraskevi
- Sala Gessica
- Salmi Teea
- Salminen Aino
- Salo Tuula
- Salomaa Veikko
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria Ăngela
- Sanchez-Garcia Florentino
- Sando Sigrid B.
- Sano Mary
- Sargurupremraj Murali
- Sarnowski Chloé
- Sastre Isabel
- Satizabal Claudia L.
- Saykin Andrew J.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schleutker Johanna
- Schmid Matthias
- Schmidt Helena
- Schmidt Reinhold
- Schneider Anja
- Schneider Julie A.
- Schneider Lon S.
- Schott Jonathan M.
- Schutzman Jennifer
- SchĂŒrmann Britta
- Seeley William W.
- Seitsonen Sanna
- Sekhar Hema
- SelbĂŠk Geir
- Selnes Per
- Seripa Davide
- Serpente Maria
- Serpi Raisa
- Serrano Manuel
- Seshadri Sudha
- Sevillano Zulma
- Sha Jin
- Shadrin Alexey A.
- Shaikho Elmutaz
- Shaw Christopher E.
- Shcherban Anastasia
- Shin Jean
- Shofany Jacob
- Shulman Joshua M.
- Siirtola Harri
- Simino Jeannette
- Sims Rebecca
- Sinisalo Juha
- Sipeky Csilla
- SipilÀ Kirsi
- SipilÀ Timo P.
- Siponen Maria
- Sistonen Tuuli
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Slifer Susan H.
- Sliz Eeva
- Small Scott
- Smaoui Nizar
- Smith A. David
- Smith Amanda G.
- Smith Janet P.
- Smith Jennifer
- Snijders Gijsje J. L.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Yeunjoo
- Song Yeunjoo E.
- Sonnen Joshua A.
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spina Salvatore
- Spottke Annika
- Squassina Alessio
- Stern Robert A.
- Stevens Alan B.
- Stordal Eystein
- Strandberg Timo
- Strauss Erich
- Strittmatter Stephen M.
- StÄhlbom Anne Kinhult
- Sultzer David
- Suominen Liisa
- Sussams Rebecca
- Swerdlow Russell H.
- SĂĄez MarĂa Eugenia
- SĂĄnchez-Arjona MarĂa Bernal
- SĂĄnchez-Valle Raquel
- Takalo Mari
- Tanzi Rudolph E.
- Tartan Juan Pablo
- Tasanen Kaisa
- Taskinen Marja-Riitta
- Teipel Stefan
- Teng Edmond
- TesĂ Niccolo
- Teumer Alexander
- Thalamuthu Anbupalam
- Thomas Alvin
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg HĂ„kan
- Tienari Pentti
- Tilson Jeffrey L.
- Tin Adrienne
- Todd Stephen
- Toso Carlos Reyes
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Trojanowski John Q.
- Troncoso Juan C.
- Tsai Ellen
- Tsolaki Anthoula
- Tsolaki Magda
- Tsuang Debby W.
- Tsuo Kristin
- Tucker-Drob Elliot
- Tukiainen Taru
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tuovila Outi
- Turpeinen Miia
- Turton James
- Turunen Joni A.
- TybjĂŠrg-Hansen Anne
- Tzourio Christophe
- TĂĄrraga LluĂs
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Uphill James
- Usiskin Keith
- Uusitalo Hannu
- Uusitalo-JĂ€rvinen Hannele
- Vacca Alessandro
- Vainio Seppo
- Valero Sergi
- Valladares Otto
- Valladares Otto
- van Adelsberg Janet
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- van Duijn Cornelia M.
- van Eldik Linda J.
- van Lent Debora Melo
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vargas Liliana
- Vassar Robert
- Verhey Frans
- Vicente Maria Pilar
- Vidal Jean-SĂ©bastien
- Vigo-Ortega R.
- Vigo-Ortega Rosario
- Vilas Raquel Huerto
- Vinters Harry V.
- Virolainen Petri
- Vivancos Liliana
- Vogelgsang Jonathan
- Vojinovic Dina
- Vonsattel Jean-Paul
- Voutilainen Markku
- Vyhnalek Martin
- Wadhawan Samir
- Wagner Michael
- Wallon David
- Wang Clarence
- Wang Li-San
- Wang Ruiqi
- Wang Yanbing
- Warden Donald
- Waring Jeff
- Waring Jeffrey
- Warner Nick
- Warren Jason D.
- Waterworth Dawn
- Weber Heike
- Weinhold Leonie
- Weinstein Galit
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Ălvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele