A Barrett nyelőcső klinikai és kísérletes vizsgálata = Clinical and experimental investigation of Barrett's esophagus

Klinikai vizsgálatok Megvizsgáltuk a laparoscopos Nissen féle fundoplicatio hatékonyságát Barrett-nyelőcső (BNY) miatt operált betegeken (n=78). A műtét után 64 beteg utánkövetése történt, átlagosan 42±16.19 hónapig. Vizsgálataink szerint a low-grade dysplasia kialakulásában szerepet játszik a súlyos epés reflux. A kontroll vizsgálatok 10 esetben mutatták a Barrett-metaplasia (BM) teljes regresszióját. Részleges regresszió 9 esetben volt, 34 betegnél nem volt progresszió, 11 esetben volt progresszió (cardiális vagy intestinális metaplasia kialakulása). Az antireflux műtétek a betegek nagy részében kontrollálják a reflux betegséget, megakadályozzák a BM progresszióját és elősegítik a BM regresszióját. In vitro vizsgálatok Kísérleti rendszert dolgoztunk ki, amely alkalmas a humán nyelőcső epitél sejtek (NYES) iontranszport folyamatainak karakterizálására és toxikus ágensek NYES kifejtett hatásának a vizsgálatára. Kidolgoztunk egy új módszert, melynek során nyelőcső biopsziás mintákból enzimatikus úton NYESeket tudunk izolálni, mikrofluorometriás módszerrel karakterizáltuk a Na+/H+ és a Cl-/HCO3- kicserélő és a Na+/HCO3- kotranszporter jelenlétét. Humán NYES vonalon kimutattuk a pH regulációs transzporterek jelenlétét, megvizsgáltuk az epesav terhelés hatását a sejtek intracelluláris pH-jára, összehasonlítottuk a NYES ion transzportját más gasztrointesztinális epitél sejtek működésével. | Clinical studies: We investigated the efficacy of laparoscopic Nissen fundoplication in patients with Barrett’s esophagus (BE) (n=78). We assessed effect of fundoplication on symptoms of reflux disease, the changes of Barrett’s metaplasia (BM) in these patients. Clinical follow-up was available in the case of 64 patients at a mean of 42±16.19 months after surgery. Check-up examination revealed total regression of BM in 10 patients. Partial regression was seen in 9 cases, no further progression in 34 patients, and progression into cardiac or intestinal metaplasia in 11 patients. No cases of dysplastic or malignant transformation were registered. Severe biliary reflux is presumed to be a factor in the development of low grade dysplasia.Antireflux surgery can appropriately control the reflux disease and it may inhibit the progression and induce the regression of BM in these patients. In vitro studies: We developed a system for the characterization of ion transport mechanisms of human oesophageal epithelial cells (HOEC) and to study the effects of toxic agents on them. We used a novel method for the isolation of HOEC from oesophageal biopsy samples and characterized the presence of Na+/H+, Cl-/HCO3- exchanger and Na+/HCO3- cotransporter on HOEC. We confirmed the presence of pH regulatory transporters in HOEC line. We studied the effect of bile acids on the intracellular pH of HOEC and compared the HCO3- transport mechanisms of HOEC to those of other epithelial cells

Ground accessibility to Montreal's international airports : a disaggregate analysis

Ground access to airports : problem or not? -- Solutions for improving airport access -- Functional components of an airport access system -- Factors affecting ground access modal choice -- Montreal's international airports -- Airport flight activity -- Airport ground transportation demand -- Analysis approaches for airport ground access -- Origin-destination surveys -- Methodological elements of a transportation survey -- Airport user surveys -- The 1993 O-D and modal choice survey of passengers and employees -- A comparison between the ADM and MUCTC-MTQ O-D surveys -- Examination of data samples -- Expansion factors for ADM databases -- Enrichment of trip information -- Extraction of airport access trips for further analysis -- Significance of survey samples -- Analysis of survey data -- Profile of passengers -- Passenger airport access trips -- Profile of passenger greeters -- Passenger greeter airport access trips -- Greeter trips from the MUCTC-MTQ data sample -- Simulation and analysis with mad(Strat)2 -- Simulation of airport access trips -- Accessibility of Dorval and mirabel airports

Colonic endometriosis: from subtotal bowel obstruction to malignant transformation - a case series and literature review

BACKGROUND: Colonic involvement due to endometriosis is a rare condition with a nonspecific clinical presentation. In rare instances, it may undergo malignant transformation, mimicking primary colorectal carcinoma and complicating clinical decision-making.; CASE PRESENTATION: We present two cases illustrating the diverse clinical manifestations of colonic endometriosis. In Case 1, a female patient underwent appendectomy for abdominal pain, but further evaluation revealed full-thickness endometriosis of the sigmoid colon, causing subtotal occlusion. In Case 2, sigmoid endometriosis was discovered during endoscopic evaluation prompted by positive occult fecal blood testing. Histopathological analysis revealed malignant transformation to endometrioid adenocarcinoma. In both cases, definitive treatment was achieved via laparoscopic sigmoid resection, highlighting the role of laparoscopic surgery in managing such conditions.; CONCLUSIONS: The potential for malignant transformation of colonic endometriosis and its tendency to mimic colorectal carcinoma underscore the importance of proper tissue sampling methods and histopathological confirmation. A high index of suspicion and appropriate surgical intervention are key to effective management. © 2025. The Author(s)

New act on the prevention and combating of money laundering and terrorist financing

The need for action of international level against money laundering was recognised by economically developed countries in the 80's. First of all, in order to establish a uniform requirement system against the recycling of funds originating from drug trade and organised crime into the legal economy, the Financial Action Task Force (FATF) was set up in 1989. As a key player in the fight against money laundering, this international organisation worked out recommendations and created standards that influence the legislation, the financial and economic sphere and the operation of the executive bodies in a given country, considering the fact that the objective of the recommendations is to unify the system of institutions against money laundering

Principles of Periodontology

Periodontal diseases are among the most common diseases affecting humans. Dental biofilm is a contributor to the etiology of most periodontal diseases. It is also widely accepted that immunological and inflammatory responses to biofilm components are manifested by signs and symptoms of periodontal disease. The outcome of such interaction is modulated by risk factors (modifiers), either inherent (genetic) or acquired (environmental), significantly affecting the initiation and progression of different periodontal disease phenotypes. While definitive genetic determinants responsible for either susceptibility or resistance to periodontal disease have yet to be identified, many factors affecting the pathogenesis have been described, including smoking, diabetes, obesity, medications, and nutrition. Currently, periodontal diseases are classified based upon clinical disease traits using radiographs and clinical examination. Advances in genomics, molecular biology, and personalized medicine may result in new guidelines for unambiguous disease definition and diagnosis in the future. Recent studies have implied relationships between periodontal diseases and systemic conditions. Answering critical questions regarding host‐parasite interactions in periodontal diseases may provide new insight in the pathogenesis of other biomedical disorders. Therapeutic efforts have focused on the microbial nature of the infection, as active treatment centers on biofilm disruption by non‐surgical mechanical debridement with antimicrobial and sometimes anti‐inflammatory adjuncts. The surgical treatment aims at gaining access to periodontal lesions and correcting unfavorable gingival/osseous contours to achieve a periodontal architecture that will provide for more effective oral hygiene and periodontal maintenance. In addition, advances in tissue engineering have provided innovative means to regenerate/repair periodontal defects, based upon principles of guided tissue regeneration and utilization of growth factors/biologic mediators. To maintain periodontal stability, these treatments need to be supplemented with long‐term maintenance (supportive periodontal therapy) programs