The effect of a complex of active metabolites of vitamin D3 with vikasol on the periodontal state of rats

Purpose of the study. The study of the periodontoprotective properties of the complex of a mixture of active metabolites of cholecalciferol - 1,25 (OH)2D3 and 24,25(OH)2D3 with a synthetic analogue of vitamin K - vikasol in experimental periodontitis in rats. Materials and methods The study was carried out on 18 white male rats for 1.5 months. age, divided into 3 groups. Group 1 (4 individuals) comprised intact rats. In the rats of the 2nd and 3rd groups (7 individuals each), the parodontitis model was reproduced by oral administration of a 10% solution of pelentane, and also by replacing drinking water with a 2% solution of EDTA ad libitum. In group 3, rats were injected daily with a mixture of hormonal forms of vitamin D3 (1,25 (OH)2D3 and 24,25(OH)2D3) against a background of combined effects of pelentane and EDTA. The duration of the experiment was 60 days. Results and conclusions. It is established that the complex of a mixture of two hormonal-active forms of cholecalciferol with vikasol has significant periodontoprotective properties. The obtained data substantiate the inclusion of vitamin D3 in the composition of perioodontoprotective agents in the treatment of periodontitis

Using MUAC tapes for screening assessment of nutrition status in children

The aim of the study – to conduct a screening diagnosis of nutritional status disorders in children.Цель исследования - провести скрининговую диагностику нарушений нутритивного статуса детей

Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans

Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report that heterozygous KO mice haploinsufficient for Nbea have higher body weight due to increased adipose tissue mass. In several feeding paradigms, heterozygous KO mice consumed more food than wild-type (WT) controls, and this consumption was primarily driven by calories rather than palatability. Expression analysis of feeding-related genes in the hypothalamus and brainstem with real-time PCR showed differential expression of a subset of neuropeptide or neuropeptide receptor mRNAs between WT and Nbea+/− mice in the sated state and in response to food deprivation, but not to feeding reward. In humans, we identified two intronic NBEA single-nucleotide polymorphisms (SNPs) that are significantly associated with body-mass index (BMI) in adult and juvenile cohorts. Overall, data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits. Our study emphasizes the importance of neural mechanisms in body weight control and points out NBEA as a potential risk gene in human obesity

HE-LHC: The High-Energy Large Hadron Collider – Future Circular Collider Conceptual Design Report Volume 4

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries

Опыт диагностики и лечения болезни Кавасаки в клинике Санкт-Петербургского государственного педиатрического медицинского университета и Д етской городской больнице №1 Санкт-Петербурга

Kawasaki disease (KD) is acute systemic vasculitis of unknown etiology. Approximately 20–25% of untreated patients develop coronary artery changes with a range of severity from asymptomatic coronary artery dilatation to giant coronary artery aneurysms with thrombosis, myocardial infarction, and sudden death. To date there is no official data on the incidence of KD in Russia. In Russia, the disease is not enough known now to a wide circle of physicians and often masks other more common diseases. Since 2010, the detection rate of KD has dramatically increased in Saint-Petersburg.Objective: to analyze the experience in diagnosing and treating KD in two largest hospitals of Saint Petersburg.Patients and methods. The retrospective study included data on 30 children (18 boys, 12 girls) who were hospitalized with a diagnosis of KD in the Saint-Petersburg State Pediatric Medical University Clinic and Children’s Hospital One (Saint Petersburg) between January 2011 and September 2016. Data are represented by median and extreme values. The age of the children was 2.8 (0.2; 4.6) years; of them 5 (16.7%) patients were under the age of 1 year. The children were hospitalized on 5 (1; 14) days of disease onset; KD was diagnosed on 9 (3; 52) day of the disease.Results. Immediately after diagnosis, 27 (90%) children received aspirin. In early stages (before 10 days of the disease), intravenous immunoglobulin (IVIG) therapy was performed in 15 (50%) children, one of them received IVIG before disease day 5 (on day 3), but without effect. On disease days 11-20 (immediately after diagnosis), 10 (33.3%) children were prescribed with IVIG; thereafter fever was abolished in all the patients. Their body temperature became normal on day 11 (6; 23). Ultrasonography revealed coronary artery lesions in 13 (43.3%) patients. Out of the 30 children followed up, one baby who fell ill at the age of 3 months and received IVIG died on day 30 of the disease.Conclusion. Currently, there continues to be a delayed diagnosis of KD. IVIG therapy was effective, especially in cases of timely diagnosis. It is necessary to increase awareness of KD among clinicians and ultrasound diagnosticians.Болезнь Кавасаки (БК) – остро протекающий системный васкулит неизвестной этиологии. Примерно у 20–25% не получивших лечения больных развиваются изменения коронарных артерий различной степени тяжести – от бессимптомной дилатации до гигантских аневризм, тромбоза, инфаркта миокарда и внезапной смерти. До настоящего времени официальных данных о заболеваемости БК в России нет. В нашей стране БК недостаточно известна широкому кругу врачей и часто проходит под маской других более распространенных заболеваний. В Санкт-Петербурге после 2010 г. резко возросла выявляемость БК.Цель исследования – проанализировать опыт диагностики и лечения БК в двух крупных стационарах Санкт-Петербурга.Пациенты и методы. В ретроспективное исследование были включены данные о 30 детях (18 мальчиков, 12 девочек), находившихся на стационарном лечении с диагнозом БК в клинике Санкт-Петербургского государственного педиатрического медицинского университета и Детской городской больнице №1 Санкт-Петербурга с января 2011 г. по сентябрь 2016 г. Данные представлены медианой и крайними значениями. Возраст детей составил 2,8 [0,2; 4,6] года, из них 5 (16,7%) пациентов были в возрасте до 1 года. Дети были госпитализированы на 5-е [1; 14] сутки болезни, диагноз БК установлен на 9-й [3; 52] день болезни.Результаты. Сразу после установления диагноза получили аспирин 27 детей (90%). В ранние сроки (до 10-го дня болезни) терапия внутривенным иммуноглобулином (ВВИГ) проводилась у 15 (50%) пациентов, из них 1 получил ВВИГ ранее 5-го дня болезни (на 3-й день), однако без эффекта. На 11–20-й день болезни (сразу после установления диагноза) ВВИГ назначен 10 (33,3%) детям, после чего лихорадка была купирована у всех пациентов. Температура тела нормализовалась на 11-й [6; 23] день. Поражение коронарных артерий при УЗИ выявлено у 13 (43,3%) пациентов. Из 30 находившихся под наблюдением детей у 1 ребенка, заболевшего в возрасте 3 мес и получившего ВВИГ на 30-й день болезни, зафиксирован летальный исход.Выводы. В настоящее время БК продолжает диагностироваться с опозданием. Терапия ВВИГ была эффективной, особенно в случаях своевременного установления диагноза. Необходимо повышение осведомленности клиницистов и врачей ультразвуковой диагностики о БК

FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2

In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics

FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1

We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics

HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries

FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries