SS 433: Results of a Recent Multi-wavelength Campaign

We conducted a multi-wavelength campaign in September-October, 2002, to observe SS 433. We used 45 meter sized 30 dishes of Giant Meter Radio Telescope (GMRT) for radio observation, 1.2 meter Physical Research Laboratory Infra-red telescope at Mt Abu for IR, 1 meter Telescope at the State Observatory, Nainital for Optical photometry, 2.3 meter optical telescope at the Vainu Bappu observatory for spectrum and Rossi X-ray Timing Explorer (RXTE) Target of Opportunity (TOO) observation for X-ray observations. We find sharp variations in intensity in time-scales of a few minutes in X-rays, IR and radio wavelengths. Differential photometry at the IR observation clearly indicated significant intrinsic variations in short time scales of minutes throughout the campaign. Combining results of these wavelengths, we find a signature of delay of about two days between IR and Radio. The X-ray spectrum yielded double Fe line profiles which corresponded to red and blue components of the relativistic jet. We also present the broadband spectrum averaged over the campaign duration.Comment: 17 pages 10 figures MNRAS (submitted

Home Automation Using Arduino and ESP8266

With the advent of technology, life has become faster in pace and shorter in interactions, with others, as well as with the surroundings. In such a scenario, there is a need to have an endeavor to have everything at the push of a button away, and more importantly, automated. Home Automation is such an endeavor, in which, all the electrical appliances present at home are connected to each other, having interactions with sensors placed at strategic positions in a closed loop manner in order to perform meager tasks automatically, leaving less burden on the humans. With this project we are promoting the fact that Home Automation can greatly contribute to energy conservation too

The Impact of Urinary Urgency and Frequency on Health-Related Quality of Life in Overactive Bladder: Results from a National Community Survey

AbstractObjectivesOveractive bladder (OAB) is described as urinary urgency, with and without urge incontinence and usually with frequency and nocturia. Most attention to OAB's impact on health-related quality of life (HRQL), however, has focused on urge incontinence. The objective of this study was to evaluate the burden of OAB, specifically urinary urgency and frequency on HRQL.MethodsIn the National Overactive Bladder Evaluation Program (NOBLE), a computer-assisted telephone interview survey was conducted to assess the prevalence of OAB in the United States. Based on interview responses, respondents were classified into three groups: continent OAB, incontinent OAB, and controls. To evaluate the HRQL impact of OAB, HRQL questionnaires were mailed to all respondents with OAB and age- and sex-matched controls as a performed nested case–control study. Continuous data were compared using Student's t tests and analysis of variance with post hoc pairwise comparisons; results were adjusted for age, sex, and comorbid conditions. Multivariable regressions were performed to assess the impact of each urinary variable on symptom bother and HRQL.ResultsA total of 919 participants responded to the questionnaires (52% response rate) with a mean age of 54.2 years (SD 16.4 years); 70.4% were female and 85% were white. Continent OAB participants comprised 24.8% of the sample, incontinent OAB 18.3%, and controls 56.9%. In each regression analysis, urinary urge intensity accounted for the greatest variance for increases in symptom bother and decreases in HRQL.ConclusionsThe experience of urinary urgency has a significant negative effect on HRQL and increases symptom bother, an effect that, in this community sample, is greater than that of incontinence, frequency, or nocturia

Observation of multiple doubly degenerate bands in Tl-195

The High-spin states in 195Tl, populated through the 185,187Re(13C, xn) fusion evaporation reaction at the beam energy of 75 MeV, were studied using the Indian National Gamma Array (INGA). More than 50 new γ transitions have been placed in the proposed level scheme which is extended up to the excitation energy of ≈ 5.6 MeV and spin. Two pairs of degenerate bands based on two different quasi-particle configurations have been identified in this nucleus indicating the first observation of such bands in an odd-A nucleus in region and signify the first evidence of multiple chiral bands in a nucleus in this region. The total Routhian surface calculations predict triaxial shapes for both the configurations and thereby, support the experimental observation. The importance of multiple neutron holes in the orbital and the stability of shapes for these two configurations have been discussed.Financial support of Department of Science & Technology, Govt. of India for clover detectors of INGA (Grant No. IR/S2/PF-03/2003-II) is greatfully acknowledged. One of the authors (S. Bhattacharya) acknowledges with thanks the financial support received as Raja Ramanna Fellowship from the Department of Atomic Energy, Govt. of India. T.R and Md. A.A acknowledge with thanks the financial support received as research fellows from the Department of Atomic Energy (DAE), Govt. of India

Observation of multiple doubly degenerate bands in ¹⁹⁵Tl

The High-spin states in 195 Tl, populated through the 185,187 Re( 13 C, xn) fusion evaporation reaction at the beam energy of 75 MeV, were studied using the Indian National Gamma Array (INGA). More than 50 new γ transitions have been placed in the proposed level scheme which is extended up to the excitation energy of ≈ 5.6 MeV and spin =22.5ħ . Two pairs of degenerate bands based on two different quasi-particle configurations have been identified in this nucleus indicating the first observation of such bands in an odd- A nucleus in A∼190 region and signify the first evidence of multiple chiral bands in a nucleus in this region. The total Routhian surface calculations predict triaxial shapes for both the configurations and thereby, support the experimental observation. The importance of multiple neutron holes in the i13/2 orbital and the stability of shapes for these two configurations have been discussed.Financial support of Department of Science & Technology, Govt. of India for clover detectors of INGA (Grant No. IR/S2/PF-03/2003-II) is greatfully acknowledged. One of the authors (S. Bhattacharya) acknowledges with thanks the financial support received as Raja Ramanna Fellowship from the Department of Atomic Energy, Govt. of India. T.R and Md. A.A acknowledge with thanks the financial support received as research fellows from the Department of Atomic Energy (DAE), Govt. of India

An international prospective study of INICC analyzing the incidence and risk factors for catheter-associated urinary tract infections in 235 ICUs across 8 Asian Countries

Background: Identify urinary catheter (UC)-associated urinary tract infections (CAUTI) incidence and risk factors (RF) in 235 ICUs in 8 Asian countries: India, Malaysia, Mongolia, Nepal, Pakistan, the Philippines, Thailand, and Vietnam. Methods: From January 1, 2014, to February 12, 2022, we conducted a prospective cohort study. To estimate CAUTI incidence, the number of UC days was the denominator, and CAUTI was the numerator. To estimate CAUTI RFs, we analyzed 11 variables using multiple logistic regression. Results: 84,920 patients hospitalized for 499,272 patient days acquired 869 CAUTIs. The pooled CAUTI rate per 1,000 UC-days was 3.08; for those using suprapubic-catheters (4.11); indwelling-catheters (2.65); trauma-ICU (10.55), neurologic-ICU (7.17), neurosurgical-ICU (5.28); in lower- middle-income countries (3.05); in upper-middle-income countries (1.71); at public-hospitals (5.98), at private-hospitals (3.09), at teaching-hospitals (2.04). The following variables were identified as CAUTI RFs: Age (adjusted odds ratio [aOR] = 1.01; 95% CI = 1.01-1.02; P < .0001); female sex (aOR = 1.39; 95% CI = 1.21-1.59; P < .0001); using suprapubic-catheter (aOR = 4.72; 95% CI = 1.69-13.21; P < .0001); length of stay before CAUTI acquisition (aOR = 1.04; 95% CI = 1.04-1.05; P < .0001); UC and device utilization-ratio (aOR = 1.07; 95% CI = 1.01-1.13; P = .02); hospitalized at trauma-ICU (aOR = 14.12; 95% CI = 4.68-42.67; P < .0001), neurologic-ICU (aOR = 14.13; 95% CI = 6.63-30.11; P < .0001), neurosurgical-ICU (aOR = 13.79; 95% CI = 6.88-27.64; P < .0001); public-facilities (aOR = 3.23; 95% CI = 2.34-4.46; P < .0001). Discussion: CAUTI rate and risk are higher for older patients, women, hospitalized at trauma-ICU, neurologic-ICU, neurosurgical-ICU, and public facilities. All of them are unlikely to change. Conclusions: It is suggested to focus on reducing the length of stay and the Urinary catheter device utilization ratio, avoiding suprapubic catheters, and implementing evidence-based CAUTI prevention recommendations

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic

Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study

Background: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World Health Assembly Global Action Plan (WHA GAP) target of a 25% global reduction from 2010 to 2019 in avoidable vision impairment, defined as cataract and undercorrected refractive error. Methods: We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. We fitted hierarchical models to estimate prevalence (with 95% uncertainty intervals [UIs]) of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness (<3/60 or less than 10° visual field around central fixation) by cause, age, region, and year. Because of data sparsity at younger ages, our analysis focused on adults aged 50 years and older. Findings: Global crude prevalence of avoidable vision impairment and blindness in adults aged 50 years and older did not change between 2010 and 2019 (percentage change −0·2% [95% UI −1·5 to 1·0]; 2019 prevalence 9·58 cases per 1000 people [95% IU 8·51 to 10·8], 2010 prevalence 96·0 cases per 1000 people [86·0 to 107·0]). Age-standardised prevalence of avoidable blindness decreased by −15·4% [–16·8 to −14·3], while avoidable MSVI showed no change (0·5% [–0·8 to 1·6]). However, the number of cases increased for both avoidable blindness (10·8% [8·9 to 12·4]) and MSVI (31·5% [30·0 to 33·1]). The leading global causes of blindness in those aged 50 years and older in 2020 were cataract (15·2 million cases [9% IU 12·7–18·0]), followed by glaucoma (3·6 million cases [2·8–4·4]), undercorrected refractive error (2·3 million cases [1·8–2·8]), age-related macular degeneration (1·8 million cases [1·3–2·4]), and diabetic retinopathy (0·86 million cases [0·59–1·23]). Leading causes of MSVI were undercorrected refractive error (86·1 million cases [74·2–101·0]) and cataract (78·8 million cases [67·2–91·4]). Interpretation: Results suggest eye care services contributed to the observed reduction of age-standardised rates of avoidable blindness but not of MSVI, and that the target in an ageing global population was not reached. Funding: Brien Holden Vision Institute, Fondation Théa, The Fred Hollows Foundation, Bill & Melinda Gates Foundation, Lions Clubs International Foundation, Sightsavers International, and University of Heidelberg

Predicting Hospitalisation of Patients with Diabetes Mellitus: An Application of the Bayesian Discriminant Analysis

The objective of this study was to develop, and subsequently test, a Bayesian discrimination model for the purpose of identifying both the personal and the healthcare system characteristics predictive of hospitalisation for the treatment of patients with diabetes mellitus or commonly observed cormorbidities associated with the disease. First, a Bayesian classification framework was proposed. The model was then tested by using a logit regression technique in order to estimate the probability of one or more hospitalisation events among patients with diabetes. The study used claims data extracted from the Hawaii Medical Service Association (HMSA) Private Business Claims (PBS) files for the 1995 calendar year. Patients under 65 years were identified by paid claims with ICD-9-CM diagnosis codes of 250.xx which gave a sample size of 6841 patients. Age, gender, various pharmacotherapy variables, presence of hypertension, hyperlipidaemia, congestive heart failure, multiple cardiovascular diseases, any combination of commonly observed comorbidities, dialysis services and annual eye examination are highly predictive of 1 or more hospitalisation events. The model shows a predictive power of almost 90%. This study found that multivariate discriminant analysis using a logit regression model successfully identifies: 1. important explanatory variables predictive of hospitalisation; 2. assigns patients into 1 of 2 mutually exclusive classes; and 3. offers a benchmark for a comprehensive disease management strategy for patients with more complicated diabetes.Clinical-trial-design, Cost-analysis, Pharmacoeconomics, Hospitalisation, Modelling, Diabetes-mellitus