494 research outputs found
Miniature standoff Raman probe for neurosurgical applications
- Publication venue
- 'SPIE-Intl Soc Optical Eng'
- Publication date
- Field of study
Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease
- Author
- Aarnoud Huissoon
- Abigail Furnell
- Adrian Thrasher
- Alan Greenhalgh
- Alasdair Parker
- Alba Sanchis-Juan
- Alba Sanchis-Juan
- Alex Richter
- Alice Gardham
- Allan Lawrie
- Aman Sohal
- Amanda Creaser-Myers
- Amy Frary
- Andreas Greinacher
- Andrew Mumford
- Andrew Peacock
- Andrew Webster
- Andrew R. Webster
- Angela F. Brady
- Angie Brady
- Ania Koziell
- Ania Manson
- Anita Chandra
- Anke Hensiek
- Anna Maw
- Anne M. Kelly
- Anthony Moore
- Anthony T. Moore
- Anton Vonk Noordegraaf
- Antony Attwood
- Archana Herwadkar
- Arno
- Auton
- Ba-Abbad
- Beaulieu
- Belkadi
- Benjamini
- Berger
- Braun
- Bruce Furie
- Carmen Treacy
- Carolyn M. Millar
- Carrock Sewell
- Catherine Roughley
- Catherine Titterton
- Catherine Williamson
- Charaka Hadinnapola
- Charu Deshpande
- Chen
- Cheng
- Cheng-Hock Toh
- Chiang
- Chiara Bacchelli
- Chilamakuri
- Chris Patch
- Chris Van Geet
- Christine Bryson
- Christopher J. Penkett
- Christopher J. Rhodes
- Christopher Penkett
- Claire Bethune
- Claire Booth
- Claire Lentaigne
- Coleen McJannet
- Colin Church
- Consugar
- Crina Samarghitean
- Csaba Halmagyi
- Daniel Gale
- Daniel Greene
- Daniel Hart
- David Allsup
- David Bennett
- David Edgar
- David J. Perry
- David Keeling
- David Kiely
- Debbie Shipley
- Deborah Whitehorn
- Debra Fletcher
- Deepa Krishnakumar
- den Hollander
- Desmet
- Detelina Grozeva
- Detelina Grozeva
- Dinakantha Kumararatne
- Dorothy A. Thompson
- Dorothy Thompson
- Dragana Josifova
- Dragana Josifova
- Eamonn Maher
- Eisenberger
- Elaine Murphy
- Elaine Murphy
- Eleanor Dewhurst
- Eleanor Dewhurst
- Elisabeth Rosser
- Elisabeth Rosser
- Elizabeth Chalmers
- Elizabeth Drewe
- Elizabeth McDermott
- Ellen Thomas
- Ellingford
- Ellingford
- Emily Staples
- Emma Clement
- Emma Clement
- Emma Wakeling
- Emma Wakeling
- Eric Oksenhendler
- Ernest Turro
- Evan Reid
- Evangeline Wassmer
- F. Lucy Raymond
- F. Lucy Raymond
- Fengyuan Hu
- Fiona Kennedy
- Fitzgerald
- Frances Flinter
- Gary Polwarth
- Gautum Ambegaonkar
- Gavin Arno
- Gavin Arno
- Genevieve Wright
- Geoffrey Woods
- Gerry Coghlan
- Gilissen
- Grant Hayman
- Gururaj Arumugakani
- Hana Alachkar
- Hana Lango Allen
- Hans Stauss
- Harald Schulze
- Harm Boggard
- Helen Baxendale
- Helen Firth
- Henderson
- Hilary Longhurst
- Hoischen
- Huang
- Hugh S. Markus
- Hugh Watkins
- Hull
- Ilenia Simeoni
- Irene Roberts
- Isabella Quinti
- Ivy Wanjiku
- James C. Fox
- James Thaventhiran
- Jane Hurst
- Jane Hurst
- Jay Suntharalingam
- Jeanette Payne
- Jecko Thachil
- Jennifer Martin
- Jenny Carmichael
- Jenny Carmichael
- Jesmeen Maimaris
- Joan Paterson
- Joan Paterson
- Joanna Pepke-Zaba
- Johan W.M. Heemskerk
- John Davis
- John Pasi
- John R. Bradley
- John Wharton
- John Wort
- Jonathan Stephens
- Jonathan Stephens
- Julia Rankin
- Julie Anderson
- Julie Vogt
- Julie von Ziegenweldt
- Karola Rehnstrom
- Karyn Megy
- Karyn Megy
- Kate Talks
- Kathelijne Peerlinck
- Kathleen Freson
- Kathleen Stirrups
- Kathleen Stirrups
- Keith Gomez
- Kenneth Smith
- Keren Carss
- Keren J. Carss
- Kevin Rue-Albrecht
- Khan
- Kimberley Gilmour
- Kircher
- Larahmie Masati
- Laura Southgate
- Lek
- Lelieveld
- Liew
- Lisa Devlin
- Lisa Willcocks
- Lorena Lorenzo
- Louise Allen
- Louise Allen
- Louise Daugherty
- Manali Chitre
- Manali Chitre
- Manju Kurian
- Marc Humbert
- Marc Tischkowitz
- Maria Bitner-Glindzicz
- Maria Bitner-Glindzicz
- Marie Erwood
- Marie Erwood
- Marie Scully
- Marijke Veltman
- Mark Caulfield
- Mark Ponsford
- Mark Toshner
- Marta Bleda
- Martin Wilkins
- Mary Mathias
- Matthew Brown
- Matthew Rondina
- Matthias Haimel
- Mayer
- McRae
- Melissa Lees
- Michael A. Laffan
- Michael Browning
- Michael Gattens
- Michael Richards
- Michel Michaelides
- Michel Michaelides
- Michele P. Lambert
- Minka De Vries
- Moira Thomas
- Muriel Holder
- Naomi Clements-Brod
- Natalie Canham
- Natalie Dormand
- Nathalie Kingston
- Neeti Ghali
- Nichola Cooper
- Nicholas Morrell
- Nigel Yeatman
- Olga Shamardina
- O’Sullivan
- Paquita Nurden
- Patel
- Patrick Chinnery
- Patrick Deegan
- Patrick Yong
- Patwardhan
- Paul Calleja
- Paul Gissen
- Paula Bolton-Maggs
- Pavandeep K. Ghataorhe
- Pavel Gordins
- Penelope Stein
- Peter Collins
- Peter Kelleher
- Ping Yu
- Purcell
- Pusch
- R. Campbell Tait
- Rachel Linger
- Rainer Doffinger
- Rajiv Machado
- Rashid Kazmi
- Ravishankar Sargur
- Reese
- Remi Favier
- Ri Liesner
- Richard Antrobus
- Richard H. Scott
- Richard Sandford
- Richard Scott
- Richard Trembath
- Rob Mackenzie
- Robert E. MacLaren
- Robert H.H. Henderson
- Robert Henderson
- Robert MacLaren
- Roberta Rizzo
- Roger James
- Rohit Ghurye
- Rosa DaCosta
- Rosie Hague
- Rutendo Mapeta
- Ruth Armstrong
- Ruth Armstrong
- Sadia Noorani
- Sai Murng
- Saikat Santra
- Salih Tuna
- Samantha Malka
- Sangermano
- Sara Lear
- Sarah Goddard
- Sarah Hull
- Sarah Mangles
- Sarah Westbury
- Sarju Mehta
- Scott Hackett
- Sergey Nejentsev
- Shahin Moledina
- Shahnaz Bibi
- Sharon Meehan
- Simon Gibbs
- Simon Holden
- Simon Staines
- Sinisa Savic
- Siobhan Burns
- Sofia Grigoriadou
- Sofia Papadia
- Sofie Ashford
- Sol Schulman
- Sonia Ali
- Soo-Mi Park
- Sophie Davies
- Sophie Stock
- Sri V.V. Deevi
- Stavropoulos
- Stefan Gräf
- Stenson
- Stephen Jolles
- Steve Austin
- Steve Welch
- Stuart Meacham
- Stuart Rankin
- Suranjith Seneviratne
- Susan Holder
- Suthesh Sivapalaratnam
- Sylvia Richardson
- Taco W. Kuijpers
- Tadbir K. Bariana
- Tamam Bakchoul
- Tamara Everington
- Thorvaldsdóttir
- Tim Young
- Timothy Aitman
- Timothy Q. Warner
- Tiwari
- Tracey Hammerton
- Turner
- Vaché
- Val Pollock
- van den Hurk
- Vera Matser
- Vincent Plagnol
- Virginia Clowes
- Walter
- Waseem Qasim
- Wendy N. Erber
- Westbury
- Willem H. Ouwehand
- Willem H. Ouwehand
- William Astle
- William Egner
- Wojciech Turek
- Wright
- Yang
- Yang
- Yvonne Henskens
- Yvonne Tan
- Zarrei
- Publication venue
- American Journal of Human Genetics
- Publication date
- 29/12/2016
- Field of study
Inherited retinal disease is a common cause of visual impairment and represents a highly heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals with inherited retinal disease, who have had whole-genome sequencing (n = 605), whole-exome sequencing (n = 72), or both (n = 45) performed, as part of the NIHR-BioResource Rare Diseases research study. We identified pathogenic variants (single-nucleotide variants, indels, or structural variants) for 404/722 (56%) individuals. Whole-genome sequencing gives unprecedented power to detect three categories of pathogenic variants in particular: structural variants, variants in GC-rich regions, which have significantly improved coverage compared to whole-exome sequencing, and variants in non-coding regulatory regions. In addition to previously reported pathogenic regulatory variants, we have identified a previously unreported pathogenic intronic variant in CHM in two males with choroideremia. We have also identified 19 genes not previously known to be associated with inherited retinal disease, which harbor biallelic predicted protein-truncating variants in unsolved cases. Whole-genome sequencing is an increasingly important comprehensive method with which to investigate the genetic causes of inherited retinal disease.This work was supported by The National Institute for Health Research England (NIHR) for the NIHR BioResource – Rare Diseases project (grant number RG65966). The Moorfields Eye Hospital cohort of patients and clinical and imaging data were ascertained and collected with the support of grants from the National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital, National Health Service Foundation Trust, and UCL Institute of Ophthalmology, Moorfields Eye Hospital Special Trustees, Moorfields Eye Charity, the Foundation Fighting Blindness (USA), and Retinitis Pigmentosa Fighting Blindness. M.M. is a recipient of an FFB Career Development Award. E.M. is supported by UCLH/UCL NIHR Biomedical Research Centre. F.L.R. and D.G. are supported by Cambridge NIHR Biomedical Research Centre
Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
- Author
- Aalfs C.M. (Cora)
- Adenis C. (Claude)
- Adlard J.W. (Julian)
- Agata S. (Simona)
- Agnarsson B.A. (Bjarni)
- Aittomäki K. (Kristiina)
- Andersen M.K. (Mette)
- Andrulis I.L. (Irene)
- Angelakos M. (Maggie)
- Antoniou A.C. (Antonis)
- Ardern-Jones A. (Audrey)
- Ardnor C.E. (Christina Edwinsdotter)
- Arnold N. (Norbert)
- Arun B.K. (Banu)
- Arver B. (Brita Wasteson)
- Asperen C.J. (Christi) van
- Attard V. (Virginia)
- Ausems M.G.E.M. (Margreet)
- Bacot F. (Francois)
- Bae-Jump V.L. (Victoria L.)
- Balmana J. (Judith)
- Bancroft E.K. (Elizabeth)
- Bardsley C. (Cathryn)
- Barjhoux L. (Laure)
- Barkardottir R.B. (Rosa)
- Barouk-Simonet E. (Emmanuelle)
- Barrowdale D. (Daniel)
- Barton D.E. (David)
- Barwell J. (Julian)
- Beattie M.S. (Mary)
- Belotti M. (Muriel)
- Benítez J. (Javier)
- Berlin C. (Cheryl)
- Berthet P. (Pascaline)
- Bignon Y.-J. (Yves-Jean)
- Bignon Y.-J. (Yves-Jean)
- Blanco I. (Ignacio)
- Blank S.V. (Stephanie)
- Blok M.J. (Marinus)
- Bock G.H. (Geertruida) de
- Bonadona V. (Valérie)
- Bonnani B. (Bernardo)
- Bonnet F. (Françoise)
- Borg Å. (Åke)
- Bourdon V. (Violaine)
- Bradshaw N. (Nicola)
- Brady A.F. (Angela)
- Bressac-de Paillerets B. (Brigitte)
- Brewer C. (C.)
- Brewer C. (Carole)
- Brice G. (Glen)
- Bronner M. (Myriam)
- Brunet J. (Joan)
- Bubien V. (Virginie)
- Buecher B. (Bruno)
- Bustinza G.B.
- Buys S.S. (Saundra)
- Caldes T. (Trinidad)
- Calender A. (Alain)
- Caligo M.A. (Maria)
- Campbell I. (Ian)
- Caron O. (Olivier)
- Castera L. (Laurent)
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- Claber O. (Oonagh)
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- Cohn D.E. (David)
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- Devilee P. (Peter)
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- Dunning A.M. (Alison)
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- Durán M. (Mercedes)
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- Tollenaar R.A.E.M. (Rob)
- Toulas C. (Christine)
- Tripathi V. (Vishakha)
- Tung N. (Nadine)
- Uhrhammer N. (Nancy)
- Varesco L. (Liliana)
- Varon-Mateeva R. (Raymonda)
- Vaszko T. (Tibor)
- Vennin P. (Philippe)
- Verhoef S.
- Verhoef S. (S.)
- Verny-Pierre C. (Carole)
- Viel A. (Alessandra)
- Vijai J. (Joseph)
- Vincent D. (Daniel)
- Volorio S. (Sara)
- Vénat-Bouvet L. (Laurence)
- Wachenfeldt A. (Anna) von
- Waisfisz Q. (Quinten)
- Walker L.J. (Lisa)
- Walsh C.S. (Christine)
- Wang C. (Chen)
- Wang X. (Xianshu)
- Wapenschmidt B. (Barbara)
- Watt C. (Catherine)
- Weaver J. (JoEllen)
- Weber B.H.F. (Bernhard)
- Weitzel J.N. (Jeffrey)
- Wiggins J. (Jennifer)
- Wijnen J.T. (Juul)
- Wijnen J.T. (Juul)
- Winchester L. (Lizzie)
- Yannoukakos D. (Drakoulis)
- Złowocka-Perłowska E. (Elzbieta)
- Öfverholm A. (Anna)
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 15/04/2013
- Field of study
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
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- Andeen Timothy
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- de Asmundis Riccardo
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- Xu Wenhao
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- Yacoob Sahal
- Yamaguchi Daiki
- Yamaguchi Yohei
- Yamamoto Akira
- Yamamoto Shimpei
- Yamanaka Takashi
- Yamane Fumiya
- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yigitbasi Efe
- Yildirim Eda
- Yorita Kohei
- Yoshihara Keisuke
- Young Charles
- Young Christopher
- Yu Jaehoon
- Yu Jie
- Yuen Stephanie
- Yusuff Imran
- Zabinski Bartlomiej
- Zacharis Georgios
- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- Artía Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- Balaña-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- Bognár Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
- Bowman Gregory R.
- Bradley Robert K.
- Bradshaw William J.
- Brady-Kalnay Susann M.
- Breton Hairol E.
- Bruning John B.
- Bruning John Burt
- Bryant-Friedrich Amanda
- Buckner Frederick S.
- Buroni Silvia
- Butler Brittany
- Byrne Lee J.
- Byun Soo Young
- Caflisch Amedeo
- Cakir Isin
- Caliandro Ileana
- Caljon Guy
- Cann Andrew B.
- Caporali Andrea
- Capuzzi Stephen J.
- Caroleo Maria Cristina
- Cathcart Ann M.
- Celano Stephanie L.
- Cerna Mark Vincent C. dela
- Chadni Somaia Haque
- Champion Matthew M.
- Chan Nei-Li
- Chapman Carly J.
- Chaton Catherine T.
- Chatterjee Arnab K.
- Chaudhuri Dipayan
- Chauhan Shefali
- Chaytow Helena
- Chen Daniel
- Chen Lifeng
- Chen Yicheng
- Chern Ting-Rong
- Chini Andrea
- Chou Tristan
- Chou Tsui-Fen
- Christensen Emily M.
- Christodoulides Myron
- Chu Shaoyou
- Chua Benjamin Soon Kai
- Chuah Janelle
- Chung Zara
- Chuong Patrick
- Ciccia Alberto
- Cildir Gökhan
- Cione Erika
- Clayton W. Brent
- Coles John G.
- Colomba Audrey
- Colotti Gianni
- Conn Graeme L.
- Conticello Silvestro G.
- Contreras Stephanie
- Cools Julie
- Coombe Deirdre R.
- Corson Timothy W.
- Cortopassi Gino
- Corvo Ileana
- Costoya Jose A.
- Cowen Leah E.
- Cox Bryan D.
- Cuddihy Andrew R.
- Cullinane Ryan T.
- Cunningham Kathryn A.
- Dahal Gopal
- Dallman Sydney
- Dame Remus T.
- Davtyan Aram
- De Keulenaer Gilles
- De Luise Monica
- de Oliveira Aldo Sena
- de Oliveira Saulo
- de Sousa Alessandra Mara
- de Souza Guilherme Eduardo
- Debonsi Hosana Maria
- Degterev Alexei
- DeHaan Nicholas
- Del Rio Flores Antonio
- Dempsey Garrett
- Desai Umesh R.
- Diallo Bakary N’tji
- Dickhout Jeffrey
- Dickinson Bryan C.
- Dieck Chelsea L.
- Dirksen Dorian
- do Monte-Neto Rubens Lima
- Dolce Vincenza
- Donaldson William A.
- Douville Renée N.
- Dowling David J.
- Drewry David H.
- Duggan Brendan M.
- Duncan Dustin
- Dymock Brian W.
- Dzhumaev Sergei
- D’Antuono Anna
- Ebright Richard H.
- Eckert Sam
- Edelman Benjamin L.
- Eitzen Gary
- ElSheikh Assmaa
- Englinger Bernhard
- Escaffre Olivier
- Espinoza Stefano
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- Young Matthew A.
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- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
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- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
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- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
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- Arabi Yaseen
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- Leaver Susannah
- Leblond Julie
- Lee Kelvin
- Lee Stephanie
- Leparco Cécile
- Lesona Eden
- Leszkoven János
- Lewis Roger
- Lewis Roger J
- Lewis Sarah
- León López Rafael
- Limb James
- Linstrum Kelsey
- Linstrum Kelsey
- Litton Ed
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- Litton Edward
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- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
- Lowrey Julie
- Luis David
- Luk Tracy
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- Mackay Euan
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- Maselli Astrid
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- Mateo López Maria Isabel
- Matsa Ramprasad
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- McArthur Colin
- McArthur Colin
- McAuley Daniel
- McAuley Daniel
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- McDyer John
- McGhee Christopher
- McGlothin Anna
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGuigan Peter
- McGuinness Shay
- McGuinness Shay
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- McLachlan Danielle
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- McNamara Robert
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- McVerry Bryan
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- Montague Laura
- Montgomery Stephanie
- Montgomery Stephanie
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- Moreno Cuesta Jeronimo
- Morgan Matt
- Morpeth Susan
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- Morrison Lynette
- Mouncey Paul
- Mouncey Paul
- Moviat M
- Mullan Dee
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- Munt Sheila
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- Murthy Srinivas
- Murthy Srinivas
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- O’Neill Aisling
- Page Valerie
- Paling A
- Panwar Rakshit
- Paramasivam Elankumaran
- Parekh Dhruv
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- Parke Rachael
- Parker Jane
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- Patch Sarah
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- Patel Kamal
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- Pellicano Annamaria
- Pereira Sousa Bastos Joana Margarida
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- Phalod Gunjan
- Philbin Jennifer
- Phillips Barbara
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- Pletz Mathias
- Plumb Benjamin
- Pogreban Tatiana
- Pogson David
- Polderman F
- Polgarova Petra
- Pomeroy Fiona
- Porteous Rebecca
- Porter David
- Potter Alison
- Pourcine Franck
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- Powell Matthew
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- Pulletz Mark
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- Quinn Kevin
- Qureshi Hafiz
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- Rees Tabitha
- Reeve Brenda
- Regli Adrian
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- Rengers Els
- Reschreiter Henrik
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- Reynolds John
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- Richards-Belle Alvin
- Ricketts Daniel
- Rietveld Ilse
- Ristimäki Sanna
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- Robert Alain
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- Robinson Philip
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- Roedl Kevin
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- Rose Steve
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- Rowan Kathryn
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- Roynon-Reed Anna
- Rozendaal Wim
- Russell Robert
- Ryalls Kim
- Ryan Lucy
- Sagnier Anne
- Salazar Degracia Anna
- Salerno Tania
- Salet A
- Salisbury Sarah
- Sall Jas
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- Sandhu Gyan
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- Sanil Ashish
- Santamaria John
- Santos Filipa
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- Santos Marlene
- Saull Michelle
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- Saunders Christina
- Schischka Livia
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- Seymour Christopher
- Shah Asim
- Shakih Arif
- Shankar-Hari Manu
- Shaw David
- Shaw Joanne
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- Sheffield Jonathan
- Shehabi Yahya
- Shovelton Charmaine
- Shrestha Tapaswi
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- Siami Shidasp
- Silversides Jon
- Sim Malcolm
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- Simons Koen
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- Simpson Scott
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- Singleton Jo
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- Sundaran Dhinesh
- Sutherland Helen
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- Sweet Katie
- Szakmany Tamas
- Szigligeti Gábor
- Szőke Viktória
- Tallott Mandy
- Tatham Kate Colette
- Templeton Maie
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- Thomas Matthew
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Tilney Emma
- Tinmouth Alan
- Tong Steve
- Tooley Joe
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- Trask Kara
- Triulzi Darrell
- Trodd Dawn
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- Tully Redmond
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- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija Brajković Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
- Author
- Abbas Rezaianzadeh
- Abdonas Tamosiunas
- Abdul Basit
- Abdullah Alkandari
- Abdullatif Husseini
- Adolfo Rubinstein
- Afshin Ostovar
- Agustinus Soemantri
- Ahmad A Zainuddin
- Ahmad Faudzi Yusoff
- Ahmed A Madar
- Aida Pilav
- Aïcha Soumaré
- Akaninyene Otu
- Akihiro Yoshihara
- Akram Pourshams
- Alain Morejon
- Albertino Damasceno
- Alberto Barceló
- Aleksander Giwercman
- Aleksandra Gomula
- Aleksandra Piwonska
- Alessandro Gialluisi
- Alexandre C Pereira
- Alfonso Sousa-Poza
- Ali Ahmadi
- Ali Akbar Shayesteh
- Ali Esmaeili
- Ali Ghanbari
- Ali Reza Safarpour
- Alibek Mereke
- Alice Bonilla-Vargas
- Aline P Batista
- Alireza Ansari-Moghaddam
- Alireza Khosravi
- Alireza Moslem
- Alireza Sadjadi
- Alisha N Wade
- Almaz Sharman
- Altan Onat
- Amalia De Curtis
- Amanda G Thrift
- Amaneh Shayanrad
- Ambady Ramachandran
- Amir Houshang Mehrparvar
- Amirabbas Momenan
- Ana B Crujeiras
- Ana Jelaković
- Ana Maria B Menezes
- Ana Paula C Cândido
- Anar Dushpanova
- Anders Grøntved
- Andre P Kengne
- Andrea Gazzinelli
- Andrea R V R Horimoto
- Andrea Y Rodríguez
- Andreia N Pizarro
- Andrew Kingston
- Andrew Wong
- Andrzej Więcek
- Angel R Gonzalez
- Anil Poudyal
- Anjani Kumar Jha
- Anna Bugge
- Anna G Iannone
- Annamari Lundqvist
- Anne Taylor
- Anneke Blokstra
- Annika Rosengren
- Anselmo J Mc Donald Posso
- Anthony Kafatos
- Antonio Bernabe-Ortiz
- Antonio Cabrera de León
- Antonis Zampelas
- Antonisamy Belavendra
- Anu Mishra
- Anup Ghimire
- Anwar M Batieha
- Archie W Rayner
- Areti Triantafyllou
- Ari Voutilainen
- Aristides M Machado-Rodrigues
- Arsalan Khaledifar
- Aryeh D Stein
- Asher Fawwad
- Augustin F Beybey
- Augustine N Odili
- Aung Soe Htet
- Avula Laxmaiah
- Axel C Carlsson
- Aya Mostafa
- Aye Aye Sein
- Azaliia M Tuliakova
- Azim Nejatizadeh
- Badreya Al-Lahou
- Bagher Larijani
- Bahareh Kheiri
- Bahman Cheraghian
- Bakary Jallow
- Balkish M Naidu
- Batyrbek Assembekov
- Beatriz D Schaan
- Behrooz Hamzeh
- Bekbolat Zholdin
- Ben Schöttker
- Benoit Salanave
- Bernard Maire
- Bernardo L Horta
- Bert-Jan van den Born
- Bharathi Viswanathan
- Bihungum Bista
- Bill Stavreski
- Bin Zhou
- Bogdan Wojtyniak
- Bojan Jelaković
- Calvin Ke
- Carl Lachat
- Carlo Maria Barbagallo
- Carlos A Aguilar-Salinas
- Carolina B Tarqui-Mamani
- Caroline H Fall
- Carsten O Schmidt
- Catherine Kyobutungi
- Catterina Ferreccio
- Cecilia Björkelund
- Cézane P Reuter
- Charles Agyemang
- Charles K Mondo
- Charlotte B Ottendahl
- Charmaine A Duante
- Chiara Donfrancesco
- Chinwuba Ijoma
- Chongjian Wang
- Chris Cowell
- Chris J Paciorek
- Christa Scheidt-Nave
- Christin Heidemann
- Christina Howitt
- Christophe Tzourio
- Chung T Nguyen
- Cihangir Erem
- Claudia Hormiga
- Cláudia S Minderico
- Clicerio González-Villalpando
- Clive Osmond
- Cyrus Cooper
- Daan Kromhout
- Dalia Luksiene
- Damian K Francis
- Daniel A Rangel Reina
- Daniel Fernández-Bergés
- Daniel Lemogoum
- David A Gonzalez-Chica
- David Flood
- David Goltzman
- Davide Noto
- Davood Khalili
- Deena Al Asfoor
- Deepak N Amarapurkar
- Demetre Labadarios
- Denise Eldemire-Shearer
- Dénes Molnár
- Diana A Santos
- Diane T Meto
- Dianna J Magliano
- Diego Augusto Santos Silva
- Diego Vanuzzo
- Dirk Vanderschueren
- Dolores S Andrade
- Dominique Hange
- Dušan Grafnetter
- Duygu Islek
- Dwi Hapsari Tjandrarini
- Ebrahim Eftekhar
- Ebrahim Ghaderi
- Edith J M Feskens
- Eduardo Capuano
- Edward F Fottrell
- Edward Janus
- Edward W Gregg
- Eero O Kajantie
- Elaine Dennison
- Eldridge Ferrer
- Eleonora d'Orsi
- Elisabeth M van Zutphen
- Elisabetta L Romeo
- Ellina M Iakupova
- Ellis Owusu-Dabo
- Ellisiv B Mathiesen
- Elnaz Faramarzi
- Elysée Claude Bika Lele
- Elzbieta Dziankowska-Zaborszczyk
- Eman Aly
- Emanuel Zitt
- Emily B Wong
- Emmanuel Cohen
- Emmanuella Magriplis
- Enguerran Macia
- Enzo Manzato
- Erfan Ghasemi
- Eric Monterrubio-Flores
- Erik J Timmermans
- Eruke E Egbagbe
- Espen Bjertness
- Esther Lopez-Garcia
- Eugène Sobngwi
- Eunice Ugel
- Evangelia Tzala
- Fabián Méndez
- Fadi J Charchar
- Fadia AlBuhairan
- Farahnaz Joukar
- Farbod Alinezhad
- Farhad Moradpour
- Farhad Pourfarzi
- Farhad Zamani
- Fariborz Mansour-Ghanaei
- Farid Najafi
- Farshad Farzadfar
- Fatemeh Malekzadeh
- Felipe F Casanueva
- Felipe V Cureau
- Felix K Assah
- Fereidoun Azizi
- Fernando Rigo
- Fernando Rodríguez-Artalejo
- Flavio Nervi
- Flora A M Ukoli
- Flora Bacopoulou
- Francesco Gianfagna
- Francesco Panza
- Francisco J Felix-Redondo
- François F Kaze
- Frank Buntinx
- Frank Claessens
- Freda Pitakaka
- Frederic Gottrand
- Frederick C Wu
- G K Mini
- Gabriel M Leung
- Gabriele Nagel
- Garry Jennings
- Garry R Brian
- Georg Lappas
- George L L Machado-Coelho
- Giovanni de Gaetano
- Giuseppina Imperatore
- Gladys E Maestre
- Glen Gironella
- Godsent C Isiguzo
- Gonzalo Valdivia
- Goodarz Danaei
- Gowri Mahasampath
- Graziella D'Arrigo
- Grazyna Jasienska
- Gretchen A Stevens
- Guanghui Dong
- Guillermo Frontera
- Gul Ergor
- Gustavo Velasquez-Melendez
- Günay Can
- Gyulli M Kazakbaeva
- Habiba Ben Romdhane
- Haiquan Xu
- Hajer Aounallah-Skhiri
- Halima Al-Hinai
- Hamid Hakimi
- Hamideh Sabbaghi
- Hana Shimizu-Furusawa
- Hanan F Abdul Rahim
- Hanna K Tolonen
- Hanno Ulmer
- Hannu M T Uusitalo
- Hans Concin
- Haroldo S Ferreira
- Harshpal S Sachdev
- Hashem Y Jaddou
- Heba M Fouad
- Hedley K Quintana
- Heidi Klakk
- Helen Gonçalves
- Heloísa Bettiol
- Herman Borghs
- Hermann Brenner
- Hiep Hoang Phan
- Hoang Van Minh
- Holger Theobald
- Hossein Poustchi
- Hsien-Ho Lin
- Huashuai Chen
- Husam F Alomirah
- Hyeon Chang Kim
- Hynek Pikhart
- Ian R Hambleton
- Ildar Fakhradiyev
- Ilona Nenko
- Ilpo Tapani Huhtaniemi
- Imelda A Agdeppa
- Imperia Brajkovich
- Indah S Widyahening
- Indrapal I Meshram
- Inge Huybrechts
- Iraj Mohebbi
- Iraj Nabipour
- Irene G M van Valkengoed
- Irfan Nuhoğlu
- Ivan Pećin
- J Jaime Miranda
- Jaakko Mursu
- Jacek Jóźwiak
- Jacqueline Ramke
- Jakub Stokwiszewski
- Jalila El Ati
- James E Bennett
- Jan A Staessen
- Jana Klanova
- Jana Námešná
- Jane D P Renner
- Janne S Tolstrup
- Jardena J Puder
- Jari J Jokelainen
- Javad Aghazadeh-Attari
- Javad Harooni
- Jawad A Al-Lawati
- Jean Claude N Mbanya
- Jean Dallongeville
- Jelena Kos
- Jeremy M Jacobs
- Jerzy Chudek
- Jesus D Melgarejo
- Jesus Vioque
- Jie Hao
- Joany Mariño
- João M Pedro
- Jochanan Stessman
- Johan G Eriksson
- Johan Sundström
- Johan Van der Heyden
- Johann Willeit
- Johanna A Otero
- John Tuitele
- Jolanta Slowikowska-Hilczer
- Jonathan E Shaw
- Jorge Motta
- Jose G Boggia
- Jose Sánchez-Abanto
- Josep Redon
- José Eugenio Lozano
- José María Huerta
- José R Banegas
- Josipa Josipović
- Jost B Jonas
- Jostein Steene-Johannessen
- Jouko L Saramies
- Juan Francisco Miquel
- Juan J Cruz
- Juan P González-Rivas
- Judith Simons
- Juha Auvinen
- Jukka T Salonen
- Julie Taylor
- Julio Zuñiga Cisneros
- Jun Hata
- Jussi Kauhanen
- Jürgen König
- Jyrki K Virtanen
- K M Venkat Narayan
- K R Thankappan
- Kai-Uwe Saum
- Kairat Davletov
- Kamarul Imran Musa
- Kamel Ajlouni
- Karen Morgan
- Karen Sparrenberger
- Karen Webster-Kerr
- Karien Stronks
- Karl-Heinz Herzig
- Karl-Heinz Jöckel
- Kate E Sheffer
- Katia V Bloch
- Kazem Mohammad
- Kazi M Jamil
- Kelias P Msyamboza
- Kenneth James
- Khairil Si-Ramlee
- Khem B Karki
- Kirsten Mehlig
- Kishwar Azad
- Ko Ko Zaw
- Kodavanti Mallikharjuna Rao
- Krishna K Aryal
- Kurt Widhalm
- Kyungwon Oh
- Lachmie Lall
- Larissa Pruner Marques
- Lars Bo Andersen
- Lars Lind
- Laura A Rodríguez-Villamizar
- Laura Censi
- Laura Gutierrez
- Laura Torres-Collado
- Lauren Lissner
- Leanne M Riley
- Leila Houti
- Lekhraj Rampal
- Lena Barrera
- Lenie van Rossem
- Leo D Westbury
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- Shahla AlDhukair
- Shalkar Adambekov
- Sheikh Mohammed Shariful Islam
- Shelly R McFarlane
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- Silvia Plata
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- Stefaan De Henauw
- Stefaan Demarest
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- Stefan Savin
- Stefan Söderberg
- Stefania Maggi
- Stephen T McGarvey
- Stephen Vander Hoorn
- Sudhir Kowlessur
- Susi Kriemler
- Suyeon Park
- Suzanne N Morin
- Sylvain Sebert
- Tahir Aris
- Tajana Zeljkovic Vrkic
- Takafumi Ishida
- Take Naseri
- Takuro Furusawa
- Tamara R Santos
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- Tania Lopez
- Tania Tello
- Terence W O'Neill
- Teresa Shamah-Levy
- Terho Lehtimäki
- Thaliane Mayara Pessôa Dos Prazeres
- Thein Thein Htay
- Thet Thet Mu
- Tiffany K Gill
- Tiina Laatikainen
- Tiina Lankila
- Till Ittermann
- Tint Swe Latt
- Tom Wilsgaard
- Tomas Vega
- Tomasz Grodzicki
- Tomasz Zdrojewski
- Tomi-Pekka Tuomainen
- Toshiharu Ninomiya
- Tran Quoc Bao
- Trevor S Ferguson
- Tuija Jääskeläinen
- Tze Pin Ng
- Ulla Roggenbuck
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- Valérie Deschamps
- Vasiliki Efthymiou
- Vera Lanska
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- Vinay B Nangia
- Vincent DeGennaro Jr
- Vincenzo Capuano
- Vincenzo Solfrizzi
- Viswanathan Mohan
- Viviane C Cardoso
- Wan Mohamad Wan Bebakar
- Wan Nazaimoon Wan Mohamud
- Weili Yan
- Wen-Harn Pan
- Wenbin Wei
- Wichai Aekplakorn
- Willem A Hanekom
- Wilma M Hopman
- Wojciech Drygas
- Xenophon Theodoridis
- Xiaotian Liu
- Ximena Berrios Carrasola
- Xinyi Gwee
- Ya Xing Wang
- Yajaira Briceño
- Yannis Manios
- Yanping Li
- Yi Zeng
- Ying-Wei Wang
- Yong Du
- Yosef Farzi
- Youcef Laid
- Young-Ho Khang
- Yousef Saleh Khader
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- Yuan Lu
- Yunjiang Yu
- Zahra Mohammadi
- Zbigniew Gaciong
- Zhanna Kalmatayeva
- Zhen-Yu Zhang
- Zivka Dika
- Publication venue
- Publication date
- 01/11/2023
- Field of study
Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
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- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era
- Author
- Aaij Roel
- Adeva Bernardo
- Adinolfi Marco
- Aidala Christine Angela
- Ajaltouni Ziad
- Akar Simon
- Albicocco Pietro
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Ali Suvayu
- Alkhazov Georgy
- Alvarez Cartelle Paula
- Alves Jr Antonio Augusto
- Amato Sandra
- Amerio Silvia
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andreassi Guido
- Andreotti Mirco
- Andrews Jason
- Appleby Robert
- Archilli Flavio
- Arnau Romeu Joan
- Artamonov Alexander
- Artuso Marina
- Arzymatov Kenenbek
- Aslanides Elie
- Atzeni Michele
- Bachmann Sebastian
- Back John
- Baker Sophie
- Balagura Vladislav
- Baldini Wander
- Baranov Alexander
- Barlow Roger
- Barsuk Sergey
- Barter William
- Baryshnikov Fedor
- Batozskaya Varvara
- Batsukh Baasansuren
- Battista Vincenzo
- Bay Aurelio
- Beddow John
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Bel Lennaert
- Beliy Nikita
- Bellee Violaine
- Belloli Nicoletta
- Belous Konstantin
- Belyaev Ivan
- Ben-Haim Eli
- Bencivenni Giovanni
- Benson Sean
- Beranek Sarah
- Berezhnoy Alexander
- Bernet Roland
- Berninghoff Daniel
- Bertholet Emilie
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bettler Marc-Olivier
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bifani Simone
- Billoir Pierre
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- Bjørn Mikkel
- Blago Michele Piero
- Blake Thomas
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- Blusk Steven
- Bobulska Dana
- Bocci Valerio
- Boente Garcia Oscar
- Boettcher Thomas
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- Wishahi Julian
- Wislicki Wojciech
- Witek Mariusz
- Wormser Guy
- Wotton Stephen
- Wyllie Kenneth
- Xiao Dong
- Xie Yuehong
- Xu Ao
- Xu Menglin
- Xu Qingnian
- Xu Zehua
- Xu Zhirui
- Yang Zhenwei
- Yang Zishuo
- Yao Yuezhe
- Yeomans Lauren Emma
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Yushchenko Oleg
- Zarebski Kristian Alexander
- Zavertyaev Mikhail
- Zhang Dongliang
- Zhang Liming
- Zhang Wen Chao
- Zhang Yanxi
- Zhelezov Alexey
- Zheng Yangheng
- Zhu Xianglei
- Zhukov Valery
- Zonneveld Jennifer Brigitta
- Zucchelli Stefano
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2×1034
cm−2s−1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b → sl+l−and b → dl+l− transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 → μ+μ−)/B(Bs → μ+μ−). Probing charm CP violation at the 10−5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier
LHCb upgrade software and computing : technical design report
- Author
- Aaij Roel
- Adeva Bernardo
- Adinolfi Marco
- Aidala Christine Angela
- Ajaltouni Ziad
- Akar Simon
- Albicocco Pietro
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Ali Suvayu
- Alkhazov Georgy
- Alvarez Cartelle Paula
- Alves Jr Antonio Augusto
- Amato Sandra
- Amerio Silvia
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andreassi Guido
- Andreotti Mirco
- Andrews Jason
- Appleby Robert
- Archilli Flavio
- Arnau Romeu Joan
- Artamonov Alexander
- Artuso Marina
- Arzymatov Kenenbek
- Aslanides Elie
- Atzeni Michele
- Bachmann Sebastian
- Back John
- Baker Sophie
- Balagura Vladislav
- Baldini Wander
- Baranov Alexander
- Barlow Roger
- Barsuk Sergey
- Barter William
- Baryshnikov Fedor
- Batozskaya Varvara
- Batsukh Baasansuren
- Battista Vincenzo
- Bay Aurelio
- Beddow John
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Bel Lennaert
- Beliy Nikita
- Bellee Violaine
- Belloli Nicoletta
- Belous Konstantin
- Belyaev Ivan
- Ben-Haim Eli
- Bencivenni Giovanni
- Benson Sean
- Beranek Sarah
- Berezhnoy Alexander
- Bernet Roland
- Berninghoff Daniel
- Bertholet Emilie
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bettler Marc-Olivier
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bifani Simone
- Billoir Pierre
- Birnkraut Alex
- Bizzeti Andrea
- Bjørn Mikkel
- Blago Michele Piero
- Blake Thomas
- Blanc Frederic
- Blusk Steven
- Bobulska Dana
- Bocci Valerio
- Boente Garcia Oscar
- Boettcher Thomas
- Bondar Alexander
- Bondar Nikolay
- Borghi Silvia
- Borisyak Maxim
- Borsato Martino
- Bossu Francesco
- Boubdir Meriem
- Bowcock Themistocles
- Bozzi Concezio
- Braun Svende
- Brodski Michael
- Brodzicka Jolanta
- Brossa Gonzalo Arnau
- Brundu Davide
- Buchanan Emma
- Buonaura Annarita
- Burr Christopher
- Bursche Albert
- Buytaert Jan
- Byczynski Wiktor
- Cadeddu Sandro
- Cai Hao
- Calabrese Roberto
- Calladine Ryan
- Calvi Marta
- Calvo Gomez Miriam
- Camboni Alessandro
- Campana Pierluigi
- Campora Perez Daniel Hugo
- Capriotti Lorenzo
- Carbone Angelo
- Carboni Giovanni
- Cardinale Roberta
- Cardini Alessandro
- Carniti Paolo
- Carson Laurence
- Carvalho Akiba Kazuyoshi
- Casse Gianluigi
- Cassina Lorenzo
- Cattaneo Marco
- Cavallero Giovanni
- Cenci Riccardo
- Chamont David
- Chapman Matthew George
- Charles Matthew
- Charpentier Philippe
- Chatzikonstantinidis Georgios
- Chefdeville Maximilien
- Chekalina Viktoriia
- Chen Chen
- Chen Shanzhen
- Chitic Stefan-Gabriel
- Chobanova Veronika
- Chrzaszcz Marcin
- Chubykin Alexsei
- Ciambrone Paolo
- Cid Vidal Xabier
- Ciezarek Gregory
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- Cliff Harry
- Closier Joel
- Coco Victor
- Coelho Joao A B
- Cogan Julien
- Cogneras Eric
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- Colombo Tommaso
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- Contu Andrea
- Coombs George
- Coquereau Samuel
- Corti Gloria
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- Couturier Benjamin
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- Crocombe Andrew
- Cruz Torres Melissa Maria
- Currie Robert
- D'Ambrosio Carmelo
- d'Argent Philippe
- Da Cunha Marinho Franciole
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- Dall'Occo Elena
- Dalseno Jeremy
- Danilina Anna
- Davis Adam
- De Aguiar Francisco Oscar
- De Bruyn Kristof
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- De Cian Michel
- De Miranda Jussara
- De Paula Leandro
- De Serio Marilisa
- De Simone Patrizia
- de Vries Jacco
- Dean Cameron Thomas
- Decamp Daniel
- Del Buono Luigi
- Delaney Blaise
- Dembinski Hans Peter
- Demmer Moritz
- Dendek Adam
- Derkach Denis
- Deschamps Olivier
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- Dettori Francesco
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- Di Nezza Pasquale
- Didenko Sergey
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- Dordei Francesca
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- dos Reis Alberto
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- Douglas Lauren
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- Dreimanis Karlis
- Dufour Laurent
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- Durante Paolo
- Durham John Matthew
- Dutta Deepanwita
- Dzhelyadin Rustem
- Dziewiecki Michal
- Dziurda Agnieszka
- Dzyuba Alexey
- Easo Sajan
- Egede Ulrik
- Egorychev Victor
- Eidelman Semen
- Eisenhardt Stephan
- Eitschberger Ulrich
- Ekelhof Robert
- Eklund Lars
- Ely Scott
- Ene Alexandru
- Escher Stephan
- Esen Sevda
- Evans Timothy
- Falabella Antonio
- Farley Nathanael
- Farry Stephen
- Fazzini Davide
- Färber Christian
- Federici Luca
- Fernandez Declara Placido
- Fernandez Gerard
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- Ferreira Rodrigues Fernando
- Ferro-Luzzi Massimiliano
- Féo Mauricio
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- Fiorini Massimiliano
- Firlej Miroslaw
- Fitzpatrick Conor
- Fiutowski Tomasz
- Fleuret Frederic
- Fontana Marianna
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- Forty Roger
- Franco Lima Vinicius
- Frank Markus
- Frei Christoph
- Fu Jinlin
- Funk Wolfgang
- Gabriel Emmy
- Gallas Torreira Abraham
- Galli Domenico
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- Gan Yuyue
- Gandelman Miriam
- Gandini Paolo
- Gao Yuanning
- Garcia Martin Luis Miguel
- Garcia Plana Beatriz
- García Pardiñas Julián
- Garra Tico Jordi
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- Gascon David
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- Gerick David
- Gersabeck Evelina
- Gersabeck Marco
- Gershon Timothy
- Gerstel Dawid
- Ghez Philippe
- Gianì Sebastiana
- Gibson Valerie
- Girard Olivier Göran
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- Gizdov Konstantin
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- Hadavizadeh Thomas
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- Hansmann-Menzemer Stephanie
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- Kuonen Axel Kevin
- Kvaratskheliya Tengiz
- Lacarrere Daniel
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- Leflat Alexander
- Lefrançois Jacques
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- Li Pei-Rong
- Li Tenglin
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- Lindner Rolf
- Lionetto Federica
- Lisovskyi Vitalii
- Liu Xuesong
- Loh David
- Loi Angelo
- Longstaff Iain
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- Lovell George Holger
- Lucchesi Donatella
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- Lupato Anna
- Luppi Eleonora
- Lupton Oliver
- Lusiani Alberto
- Lyu Xiao-Rui
- Machefert Frederic
- Maciuc Florin
- Macko Vladimir
- Mackowiak Patrick
- Maddrell-Mander Samuel
- Maev Oleg
- Maguire Kevin
- Maisuzenko Dmitrii
- Majewski Maciej Witold
- Malde Sneha
- Malecki Bartosz
- Malinin Alexander
- Maltsev Timofei
- Manca Giulia
- Mancinelli Giampiero
- Marangotto Daniele
- Maratas Jan
- Marchand Jean François
- Marconi Umberto
- Marin Benito Carla
- Marinangeli Matthieu
- Marino Pietro
- Marks Jörg
- Marshall Phillip John
- Martellotti Giuseppe
- Martin Morgan
- Martinelli Maurizio
- Martinez Santos Diego
- Martinez Vidal Fernando
- Massafferri André
- Materok Marcel
- Matev Rosen
- Mathad Abhijit
- Mathe Zoltan
- Matteuzzi Clara
- Mauri Andrea
- Maurice Emilie
- Maurin Brice
- Mazurov Alexander
- McCann Michael
- McNab Andrew
- McNulty Ronan
- Mead James Vincent
- Meadows Brian
- Meaux Cedric
- Meier Frank
- Meinert Nis
- Melnychuk Dmytro
- Merk Marcel
- Merli Andrea
- Michielin Emanuele
- Milanes Diego Alejandro
- Millard Edward James
- Minard Marie-Noelle
- Minzoni Luca
- Mitzel Dominik Stefan
- Mogini Andrea
- Molina Rodriguez Josue
- Mombächer Titus
- Monroy Igancio Alberto
- Monteil Stephane
- Morandin Mauro
- Morello Gianfranco
- Morello Michael Joseph
- Morgunova Olga
- Moron Jakub
- Morris Adam Benjamin
- Mountain Raymond
- Mödden Antje
- Muheim Franz
- Mulder Mick
- Murphy Colm Harold
- Murray Donal
- Müller Dominik
- Müller Janine
- Müller Katharina
- Müller Vanessa
- Naik Paras
- Nakada Tatsuya
- Nandakumar Raja
- Nandi Anita
- Nanut Tara
- Nasteva Irina
- Needham Matthew
- Neri Nicola
- Neubert Sebastian
- Neufeld Niko
- Neuner Max
- Nguyen Thi Dung
- Nguyen-Mau Chung
- Nieswand Simon
- Niet Ramon
- Nikitin Nikolay
- Nogay Alla
- O'Hanlon Daniel Patrick
- Oblakowska-Mucha Agnieszka
- Obraztsov Vladimir
- Ogilvy Stephen
- Oldeman Rudolf
- Onderwater Gerco
- Ossowska Anna
- Otalora Goicochea Juan Martin
- Owen Patrick
- Oyanguren Maria Aranzazu
- Pais Preema Rennee
- Palano Antimo
- Palutan Matteo
- Panshin Gennady
- Papanestis Antonios
- Pappagallo Marco
- Pappalardo Luciano
- Parker William
- Parkes Christopher
- Passaleva Giovanni
- Pastore Alessandra
- Patel Mitesh
- Patrignani Claudia
- Pearce Alex
- Pellegrino Antonio
- Penso Gianni
- Pepe Altarelli Monica
- Perazzini Stefano
- Pereima Dmitrii
- Perret Pascal
- Pescatore Luca
- Petridis Konstantinos
- Petrolini Alessandro
- Petrov Aleksandr
- Petrucci Stefano
- Petruzzo Marco
- Pietrzyk Boleslaw
- Pietrzyk Guillaume
- Pikies Malgorzata
- Pili Martina
- Pinci Davide
- Pinzino Jacopo
- Pisani Flavio
- Piucci Alessio
- Placinta Vlad-Mihai
- Playfer Stephen
- Plews Jonathan
- Plo Casasus Maximo
- Polci Francesco
- Poli Lener Marco
- Poluektov Anton
- Polukhina Natalia
- Polyakov Ivan
- Polycarpo Erica
- Pomery Gabriela Johanna
- Ponce Sebastien
- Popov Alexander
- Popov Dmitry
- Poslavskii Stanislav
- Potterat Cédric
- Price Eugenia
- Prisciandaro Jessica
- Prouve Claire
- Pugatch Valery
- Puig Navarro Albert
- Pullen Hannah Louise
- Punzi Giovanni
- Qian Wenbin
- Qin Jia-Jia
- Quagliani Renato
- Quintana Boris
- Rachwal Bartlomiej
- Rademacker Jonas
- Rama Matteo
- Ramos Pernas Miguel
- Rangel Murilo
- Ratnikov Fedor
- Raven Gerhard
- Ravonel Salzgeber Melody
- Reboud Meril
- Redi Federico
- Reichert Stefanie
- Reiss Florian
- Remon Alepuz Clara
- Ren Zan
- Renaudin Victor
- Ricciardi Stefania
- Richards Sophie
- Rinnert Kurt
- Robbe Patrick
- Robert Arnaud
- Rodrigues Ana Barbara
- Rodrigues Eduardo
- Rodriguez Lopez Jairo Alexis
- Roehrken Markus
- Rogozhnikov Alexey
- Roiser Stefan
- Rollings Alexandra Paige
- Romanovskiy Vladimir
- Romero Vidal Antonio
- Rotondo Marcello
- Rudolph Matthew Scott
- Ruf Thomas
- Ruiz Vidal Joan
- Saborido Silva Juan Jose
- Sagidova Naylya
- Saitta Biagio
- Salustino Guimaraes Valdir
- Sanchez Gras Cristina
- Sanchez Mayordomo Carlos
- Sanmartin Sedes Brais
- Santacesaria Roberta
- Santamarina Rios Cibran
- Santimaria Marco
- Santovetti Emanuele
- Sarpis Gediminas
- Sarti Alessio
- Satriano Celestina
- Satta Alessia
- Saur Miroslav
- Savrina Darya
- Schael Stefan
- Schellenberg Margarete
- Schiller Manuel
- Schindler Heinrich
- Schmelling Michael
- Schmelzer Timon
- Schmidt Burkhard
- Schneider Olivier
- Schopper Andreas
- Schreiner HF
- Schubiger Maxime
- Schune Marie Helene
- Schwemmer Rainer
- Sciascia Barbara
- Sciubba Adalberto
- Semennikov Alexander
- Sepulveda Eduardo Enrique
- Sergi Antonino
- Serra Nicola
- Serrano Justine
- Sestini Lorenzo
- Seuthe Alex
- Seyfert Paul
- Shapkin Mikhail
- Shcheglov Yury
- Shears Tara
- Shekhtman Lev
- Shevchenko Vladimir
- Shmanin Evgenii
- Siddi Benedetto Gianluca
- Silva Coutinho Rafael
- Silva de Oliveira Luiz Gustavo
- Simi Gabriele
- Simone Saverio
- Skidmore Nicola
- Skwarnicki Tomasz
- Smeaton John Gordon
- Smith Eluned
- Smith Iwan Thomas
- Smith Mark
- Soares Lavra Lais
- Soares Marcelo
- Sokoloff Michael
- Soler Paul
- Souza De Paula Bruno
- Spaan Bernhard
- Spradlin Patrick
- Stagni Federico
- Stahl Marian
- Stahl Sascha
- Stefko Pavol
- Stefkova Slavomira
- Steinkamp Olaf
- Stemmle Simon
- Stenyakin Oleg
- Stepanova Margarita
- Stevens Holger
- Stone Sheldon
- Storaci Barbara
- Stracka Simone
- Stramaglia Maria Elena
- Straticiuc Mihai
- Straumann Ulrich
- Strokov Sergey
- Sun Jiayin
- Sun Liang
- Swientek Krzysztof
- Syropoulos Vasileios
- Szumlak Tomasz
- Szymanski Maciej Pawel
- T'Jampens Stephane
- Tang Zhipeng
- Tayduganov Andrey
- Tekampe Tobias
- Tellarini Giulia
- Teubert Frederic
- Thomas Eric
- Tilley Matthew James
- Tisserand Vincent
- Tolk Siim
- Tomassetti Luca
- Tou Da Yu
- Tourinho Jadallah Aoude Rafael
- Tournefier Edwige
- Traill Murdo
- Tran Minh Tâm
- Trisovic Ana
- Tsaregorodtsev Andrei
- Tully Alison
- Tuning Niels
- Ukleja Artur
- Usachov Andrii
- Ustyuzhanin Andrey
- Uwer Ulrich
- Vacca Claudia
- Vagner Alexander
- Vagnoni Vincenzo
- Valassi Andrea
- Valat Sebastien
- Valenti Giovanni
- van Beuzekom Martinus
- van Herwijnen Eric
- van Tilburg Jeroen
- van Veghel Maarten
- Vazquez Gomez Ricardo
- Vazquez Regueiro Pablo
- Vázquez Sierra Carlos
- Vecchi Stefania
- Velthuis Jaap
- Veltri Michele
- Veneziano Giovanni
- Venkateswaran Aravindhan
- Verlage Tobias Anton
- Vernet Maxime
- Veronesi Michele
- Veronika Naomi
- Vesterinen Mika
- Viana Barbosa Joao Vitor
- Vieira Daniel
- Vieites Diaz Maria
- Viemann Harald
- Vilasis-Cardona Xavier
- Vitkovskiy Arseniy
- Vitti Marcela
- Volkov Vladimir
- Vollhardt Achim
- Voneki Balazs
- Vorobyev Alexey
- Vorobyev Vitaly
- Waldi Roland
- Walsh John
- Wang Jianchun
- Wang Mengzhen
- Wang Yilong
- Wang Zhenzi
- Ward David
- Wark Heather Mckenzie
- Watson Nigel
- Websdale David
- Weiden Andreas
- Weisser Constantin
- Whitehead Mark
- Wicht Jean
- Wilkinson Guy
- Wilkinson Michael
- Williams Ifan
- Williams Mark Richard James
- Williams Mike
- Williams Timothy
- Wilson Fergus
- Wimberley Jack
- Winn Michael Andreas
- Wishahi Julian
- Wislicki Wojciech
- Witek Mariusz
- Wormser Guy
- Wotton Stephen
- Wyllie Kenneth
- Xiao Dong
- Xie Yuehong
- Xu Ao
- Xu Menglin
- Xu Qingnian
- Xu Zehua
- Xu Zhirui
- Yang Zhenwei
- Yang Zishuo
- Yao Yuezhe
- Yeomans Lauren Emma
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Yushchenko Oleg
- Zarebski Kristian Alexander
- Zavertyaev Mikhail
- Zhang Dongliang
- Zhang Liming
- Zhang Wen Chao
- Zhang Yanxi
- Zhelezov Alexey
- Zheng Yangheng
- Zhu Xianglei
- Zhukov Valery
- Zonneveld Jennifer Brigitta
- Zucchelli Stefano
- Publication venue
- Publication date
- 01/01/2018
- Field of study
This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis
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