Clima organizacional y satisfacción laboral del personal que labora en la empresa distribuidora de celulares, Jaén, 2020-2021

El estudio tuvo como objetivo determinar la relación entre el clima organizacional y satisfacción laboral del personal que labora en la empresa distribuidora de celulares, Jaén 2020; para ello se aplicó un estudio de tipo descriptiva correlacional, con un diseño no experimental. La población que fue igual a la muestra lo conformaron 9 trabajadores de dicha entidad en estudio, a quienes se les dirigió dos cuestionarios que miden a la variable Clima organizacional y satisfacción laboral respectivamente. Los resultados dejaron en evidencia un nivel regular tanto para clima organizacional y satisfacción laboral, expresados en porcentajes del 88.9% y 77.8% respectivamente. También se encontró relación positiva y de grado muy alto entre las dimensiones: realización personal, involucramiento laboral, supervisión, comunicación y condiciones laborales con la satisfacción laboral (p<0.05). Se concluye que existe relación positiva muy alta entre clima organizacional y la satisfacción laboral del personal que labora en la empresa distribuidora de celulares, Jaén 2020.TesisComunicación y desarrollo human

Aversión al riesgo en ejecutivos de empresas peruanas

Esta investigación tiene como objeto evaluar el sesgo cognitivo de la aversión al riesgo utilizando la herramienta planteada por Holt &Laury(2002) en personas con cargos de responsabilidad a nivel estratégico y táctico en las empresas. Se realizó una revisión de literatura sobre los sesgos cognitivos y su incidencia a nivel de la administración de empresas. Kahneman y Tversky (1974) los precursores del enfoque definen los sesgos cognitivos como distorsiones en la observación de la realidad, que implica errores sistémicos al emitir un juicio. Estos sesgos cognitivos influyen en la toma de decisiones de los individuos que los pueden llevar a elegir opciones de menor beneficio, esto tiene una gran implicación a nivel de los tomadores de decisiones en las empresas ya que conllevan mayor responsabilidad y sus decisiones tiene mayor repercusión en la sostenibilidad de las compañías. El presente estudio se desarrolló bajo un enfoque cuantitativo fue de diseño no experimental y midió el grado de aversión al riesgo en un grupo de población peruana con las siguientes características tener cargos de responsabilidad a nivel estratégico y táctica en la empresa, con personal a cargo y que tomen decisiones estratégicas a nivel administrativo. La muestra fue no probabilística de tipo por conveniencia con un total de 285 participantes distribuidos en tres grupos A, B, C. La evaluación de la aversión al riesgo por método de Holt &Laury (2002) permite medir el sesgo de aversión al riesgo en un juego hipotético de loterías en una muestra de peruanos con cargos de responsabilidad a nivel estratégico y táctico en las empresas, la población del estudio mostró un mayor grado de aversión al riesgo respecto a los resultados del estudio de Holt &Laury (2002) clasificándolos en el rango relativo de aversión al riesgo, como aversos al riesgo. Para una evaluación más precisa y exacta de los sesgos cognitivos en contextos particulares se recomienda el desarrollo o búsqueda de herramientas específicas como las desarrolladas en la investigación de Manzanal (2017) en el cual se utilizó una adaptación de la herramienta de Holt &Laury (2002) para medir en empresarios PyMEs la presencia de heurísticas como lo referencia el autor. La revisión de literatura arroja que son muy poco los estudios de este tipo en países de habla hispana, y que los estudios de economía conductual o economía del comportamiento están apenas floreciendo en la investigación de estas disciplinas.This research aims to evaluate the cognitive bias of risk aversion using the tool proposed by Holt & Laury (2002) in people with positions of responsibility at a strategic and tactical level in companies. A literature review on cognitive biases and their incidence at the level of business administration was carried out. Kahneman and Tversky (1974) the precursors of the approach define cognitive biases as distortions in the observation of reality, which implies systemic errors when making a judgment. These cognitive biases influence the decision making of individuals that can lead them to choose options of lower benefit, this has a great implication at the level of decision makers in companies since they carry greater responsibility and their decisions have a greater impact on the sustainability of companies. The present study was developed under a quantitative approach, it was of a non-experimental design and it measured the degree of risk aversion in a Peruvian population group with the following characteristics: having positions of responsibility at a strategic and tactical level in the company, with personnel in charge and to make strategic decisions at the administrative level. The sample was non-probabilistic of the convenience type with a total of 285 participants distributed in three groups A, B, C. The evaluation of risk aversion by the method of Holt & Laury (2002) allows to measure the risk aversion bias in a hypothetical lottery game in a sample of Peruvians with positions of responsibility at the strategic and tactical level in companies, the population of the This study showed a higher degree of risk aversion compared to the results of the study by Holt & Laury (2002), classifying them in the relative range of risk aversion, as risk averse. For a more precise and accurate evaluation of cognitive biases in particular contexts, the development or search for specific tools such as those developed in the Manzanal (2017) research is recommended, in which an adaptation of the Holt & Laury (2002) tool was used. to measure in SME entrepreneurs the presence of heuristics as the author references. The literature review shows that there are very few studies of this type in Spanish-speaking countries, and that studies of behavioral economics or behavioral economics are barely flourishing in the research of these disciplines

FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Smith, J. A., Curry, E. G., Blue, R. E., Roden, C., Dundon, S. E. R., Rodríguez-Vargas, A., Jordan, D. C., Chen, X., Lyons, S. M., Crutchley, J., Anderson, P., Horb, M. E., Gladfelter, A. S., & Giudice, J. FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. Journal of Cell Biology, 219(4), (2020): e201911129, doi: 10.1083/jcb.201911129.Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; however, the mechanisms driving these phenotypes remain unclear. The FXR1 gene undergoes alternative splicing, producing multiple protein isoforms and mis-splicing has been implicated in disease. Furthermore, mutations that cause frameshifts in muscle-specific isoforms result in congenital multi-minicore myopathy. We observed that FXR1 alternative splicing is pronounced in the serine- and arginine-rich intrinsically disordered domain; these domains are known to promote biomolecular condensation. Here, we show that tissue-specific splicing of fxr1 is required for Xenopus development and alters the disordered domain of FXR1. FXR1 isoforms vary in the formation of RNA-dependent biomolecular condensates in cells and in vitro. This work shows that regulation of tissue-specific splicing can influence FXR1 condensates in muscle development and how mis-splicing promotes disease.We thank the A.S. Gladfelter and J. Giudice laboratories, Nancy Kedersha, and Silvia Ramos for critical discussions; Eunice Y. Lee for technical help; Dr. Stephanie Gupton (University of North Carolina at Chapel Hill, Chapel Hill, NC) for donation of WT C57BL/6J mouse embryos; and Marcin Wlizla and National Xenopus Resource (RRID:SCR_013731) for their help in maintaining adult frogs and other important technical support. This work has been funded by a University of North Carolina at Chapel Hill Junior Faculty Development Award (to J. Giudice); a Nutrition and Obesity Research Center, University of North Carolina at Chapel Hill, Pilot & Feasibility Research grant (P30DK056350 to J. Giudice); University of North Carolina at Chapel Hill startup funds (to J. Giudice); the March of Dimes Foundation (5-FY18-36, Basil O’Connor Starter Scholar Award to J. Giudice); and NCTraCs Pilot Grant (550KR181805) from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through Grant Award Number UL1TR002489 (to J. Giudice), National Institutes of Health National Institute of General Medical Sciences grants (R01-GM130866 to J. Giudice, R01-GM081506 to A.S. Gladfelter, R35-GM126901 to P. Anderson, K99-GM124458 to S.M. Lyons, R25-GM089569 and 2R25-GM055336-20 to E.G. Curry); Howard Hughes Medical Institute Faculty Scholars program (A.S. Gladfelter), and National Institute of Health grants R01-HD084409 and P40-OD010997 (to M.E. Horb). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.2020-09-1

Clima, variabilidad y cambio climático en la Vertiente Caribe de Costa Rica: Un estudio básico para la actividad bananera

informe de investigación -- Universidad de Costa Rica. Centro de Investigaciones Geofísicas, 2013. Forma de citar el trabajo: Amador, J. A., E. J. Alfaro, H. G. Hidalgo, F. J. Soley, F. Solano, J. L. Vargas, F. Sáenz, B. Calderón, P. M. Pérez, J. J. Vargas, R. Díaz, A. Goebel, A. Montero, J. L. Rodríguez, A. Salazar, P. Ureña, N. Mora, I. Rivera, C. Vega y C. Bojorge, 2013. Clima, variabilidad y cambio climático en la Vertiente Caribe de Costa Rica: Un estudio básico para la actividad bananera. Informe Final del Proyecto VI-805-B0-402. Centro de Investigaciones Geofísicas (CIGEFI), Vicerrectoría de Investigación y Escuela de Física, Universidad de Costa Rica y Corporación Bananera Nacional (CORBANA), Setiembre 2013, 225 pp.Este Informe Final (IF) describe en forma sintética, los alcances y productos del proyecto “Clima, variabilidad y cambio climático en la Vertiente Caribe de Costa Rica: Un estudio básico para la actividad bananera”, en relación con el cumplimiento, por parte del Centro de Investigaciones Geofísicas (CIGEFI) de la Universidad de Costa Rica (UCR), de las Especificaciones y Requisitos Técnicos (ERT) de la investigación contratada con la Corporación Bananera Nacional (CORBANA). Los ERT de CORBANA (ERTC) están contenidos en la Parte 7 de la Propuesta Original entregada a la Corporación en octubre de 2010. Los detalles de los productos son discutidos en las diferentes secciones del IF. En este sentido, se examinaron la Estructura y Funcionalidad de la Base de Datos (BANACLIMA) y la Red de Estaciones de la Corporación. Se destaca, entre otras cosas, la implementación, en colaboración con CORBANA, de una torre de observación meteorológica en Siquirres (CIGEFI_et) con instrumental de precipitación, temperatura, viento y humedad, instalado a 10, 20 y 30 m de altura, con complemento de presión, temperatura y humedad (del suelo) en superficie. Se generaron y entregaron, tanto en formato JPEG o similar y en un Sistema de Información Geográfica (SIG) productos de climatología regional derivados de la información de BANACLIMA y de bases de datos regionales. Los productos entregados en el SIG facilitan el uso aplicado de la información. Este proceso contempló la familiarización de personal con los productos generados y no formaba parte de los ERTC. Se entregan clasificaciones climáticas basadas en los métodos de Thornthwaite y Hargreaves, con amplias discusiones sobre su aplicación y limitaciones. Las climatologías generadas con base al modelo MM5 incluyen aspectos de variabilidad que toma en cuenta los modos globales de El Niño Oscilación del Sur (ENOS), la Oscilación Multidecadal del Atlántico (OMDA), ambos basados en índices de la temperatura superficial del océano como predictor de la variabilidad atmosférica regional. Se analizaron datos atmosféricos regionales para obtener indicativos del cambio climático observado para varias variables troposféricas, entre ellas temperatura superficial y precipitación. Un tema investigado en este proyecto y no contemplado tampoco en las ERTC, es la inclusión de algunas proyecciones futuras sobre el cambio climático en la región de interés, basado en resultados de modelos de circulación general (conocidos como 20c3m runs) para el Informe de 2010 del Panel Inter-Gubernamental para el Cambio Climático. Otro aspecto, no contemplado en las ERTC, es la recolección de importantes datos históricos sobre meteorología y el desarrollo institucional de la Corporación. Sobre este tema, el CIGEFI espera continuar investigando por su parte y de darse las condiciones de acceso requeridas, dotar en un futuro a CORBANA de un documento más completo sobre su historia y el desarrollo en la actividad bananera nacional. Personal de CORBANA participó en Mini-congresos, talleres y presentaciones del CIGEFI en relación con los temas e investigaciones realizadas para el proyecto. Personal del Centro participó en Congresos Bananeros, talleres y seminarios dando a conocer los resultados del proyecto con CORBANA. Un importante grupo de artículos han sido publicados, otros están en proceso, todos ellos mostrando los productos y resultados de la investigación. Con respecto a los diferentes aspectos que tiene que ver con las ERTC, se incorporaron recomendaciones específicas, en el Informe Primero (IP), de setiembre de 2011, en el Informe Segundo (IS), de mayo de 2012 y en el presente IF. En este IF se incorporan figuras o tablas que aparecen en el IP o en el IS, sin embargo, éstas fueron, en general, mejoradas tanto por el uso de información complementaria, cambio o mejoramiento del método de trabajo o para incorporar un periodo más extenso de datos.Corporación Bananera Nacional (CORBANA). Universidad de Costa Rica (UCR).UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones Geofísicas (CIGEFI

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p&lt;0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (&lt;1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (&lt;1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon

The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection