23 research outputs found
Tipping the scales:Lessons from simple model systems on inositol imbalance in neurological disorders
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A thread of continuity spiritual journey through yarn in honor of Wixarika ancestors
In this thesis, I demonstrate how the market economy and tourism has influenced the crafting of ethnic identity for the Huichol people. Specifically, I examine how the re-imagination of sacred offerings as commercial art has resulted in a transformation in the cultural psychology of the Huichol people. Although some scholars maintain that the commodification of culture results in cultural degradation, I argue that it can result in cultural transformation which is positively regarded by indigenous actors. The meaningfulness of craft production, however, depends on the type of craft made, and idiosyncratic factors which influence the relationship Huichols have with the products of their labor. The cultural change, which has resulted from the commodification of culture, has had a heterogeneous effect on the Huichol people. For Huichols who make beaded figurines and jewelry, craft production is associated with economic hardship. For Huichol yarn painters, their practice is conceptualized in an agenic sense—a way to preserve ethnic identity in the face of poor socio-economic conditions compounded by infringements on traditional lands by external forces. Even though in the marketplace Huichol yarn paintings are sold to tourists as emblems of peyote-induced vision, Huichol yarn painters associate their practice with an imagined feeling of cultural continuity detached from the market value of the medium
Data from: Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory
In yeast and humans, previous experiences can lead to epigenetic transcriptional memory: repressed genes that exhibit mitotically heritable changes in chromatin structure and promoter recruitment of poised RNA polymerase II preinitiation complex (RNAPII PIC), which enhances future reactivation. Here, we show that INO1 memory in yeast is initiated by binding of the Sfl1 transcription factor to the cis-acting Memory Recruitment Sequence, targeting INO1 to the nuclear periphery. Memory requires a remodeled form of the Set1/COMPASS methyltransferase lacking Spp1, which dimethylates histone H3 lysine 4 (H3K4me2). H3K4me2 recruits the SET3C complex, which plays an essential role in maintaining this mark. Finally, while active INO1 is associated with Cdk8- Mediator, during memory, Cdk8+ Mediator recruits poised RNAPII PIC lacking the Kin28 CTD kinase. Aspects of this mechanism are generalizable to yeast and conserved in human cells. Thus, COMPASS and Mediator are repurposed to promote epigenetic transcriptional poising by a highly conserved mechanism
Light behind the curtain: photoregulation of nuclear architecture and chromatin dynamics in plants
Light is a powerful stimulus regulating many aspects of plant development and phenotypic plasticity. Plants sense light through the action of specialized photoreceptor protein families that absorb different wavelengths and intensities of light. Recent discoveries in the area of photobiology have uncovered photoreversible changes in nuclear organization correlated with transcriptional regulation patterns that lead to de-etiolation and photoacclimation. Novel signalling components bridging photoreceptor activation with chromatin remodelling and regulation of gene expression have been discovered. Moreover, coregulated gene loci have been shown to relocate to the nuclear periphery in response to light. The study of photoinduced changes in nuclear architecture is a flourishing area leading to major discoveries that will allow us to better understand how highly conserved mechanisms underlying genomic reprogramming are triggered by environmental and endogenous stimuli. This review aims to discuss fundamental and innovative reports demonstrating how light triggers changes in chromatin and nuclear architecture during photomorphogenesis