2,230 research outputs found
Neuroprotective effects of carnitinoid compounds in rodent cellular and in vivo models of mitochondrial complex I dysfunction
Rotenone-mediated mitochondrial complex I inhibition was used to model Parkinson’s disease-like syndrome in Lewis rats. Tyrosine hydroxylase immunolabeling demonstrated a decrease in the number of dopaminergic neurons as well as aberrant morphology in surviving neurons. Administration of carnitinoid compounds (synthetic lipoylcarnitine or butyrylcarnitine compounds) reduced dopaminergic neuronal cell loss with characteristic morphology observed in surviving neurons. In a rat primordial hippocampal cell line (H19-7/IGF-IR), rotenone treatment resulted in increased ROS and reduced cellular ATP, while co-treatment with lipoylcarnitine maintained ROS and ATP at control levels. These results illustrate the therapeutic potential of small-molecule carnitinoids in treating neurodegenerative diseases associated with mitochondrial dysfunction.https://mesford.ca/journals/cab/articles-on-biotechnology/neuroprotective-effects-of-carnitinoid-compounds-in-rodent-cellular-and-in-vivo-models-of-mitochondrial-complex-i-dysfunction/Published versio
A Generalized Framework for Virtual Substitution
We generalize the framework of virtual substitution for real quantifier
elimination to arbitrary but bounded degrees. We make explicit the
representation of test points in elimination sets using roots of parametric
univariate polynomials described by Thom codes. Our approach follows an early
suggestion by Weispfenning, which has never been carried out explicitly.
Inspired by virtual substitution for linear formulas, we show how to
systematically construct elimination sets containing only test points
representing lower bounds
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