Considering the role of Murine double minute 2 in the cardiovascular system

The E3 ubiquitin ligase Murine double minute 2 (MDM2) is the main negative regulator of the tumor protein p53 (TP53). Extensive studies over more than two decades have confirmed MDM2 oncogenic role through mechanisms both TP53-dependent and TP53-independent oncogenic function. These studies have contributed to designate MDM2 as a therapeutic target of choice for cancer treatment and the number of patents for MDM2 antagonists has increased immensely over the last years. However, the question of the physiological functions of MDM2 has not been fully resolved yet, particularly when expressed and regulated physiologically in healthy tissue. Cardiovascular complications are almost an inescapable side-effect of anti-cancer therapies. While several MDM2 antagonists are entering phase I, II and even III of clinical trials, this review proposes to bring awareness on the physiological role of MDM2 in the cardiovascular system.York University Librarie

Towards the Model-Driven Engineering of Secure yet Safe Embedded Systems

We introduce SysML-Sec, a SysML-based Model-Driven Engineering environment aimed at fostering the collaboration between system designers and security experts at all methodological stages of the development of an embedded system. A central issue in the design of an embedded system is the definition of the hardware/software partitioning of the architecture of the system, which should take place as early as possible. SysML-Sec aims to extend the relevance of this analysis through the integration of security requirements and threats. In particular, we propose an agile methodology whose aim is to assess early on the impact of the security requirements and of the security mechanisms designed to satisfy them over the safety of the system. Security concerns are captured in a component-centric manner through existing SysML diagrams with only minimal extensions. After the requirements captured are derived into security and cryptographic mechanisms, security properties can be formally verified over this design. To perform the latter, model transformation techniques are implemented in the SysML-Sec toolchain in order to derive a ProVerif specification from the SysML models. An automotive firmware flashing procedure serves as a guiding example throughout our presentation.Comment: In Proceedings GraMSec 2014, arXiv:1404.163

MHD simulations of the solar photosphere

We briefly review the observations of the solar photosphere and pinpoint some open questions related to the magnetohydrodynamics of this layer of the Sun. We then discuss the current modelling efforts, addressing among other problems, that of the origin of supergranulation.Comment: 10 pages, 6 figures; 4th French-Chinese Meeting on Solar Physics Understanding Solar Activity: Advances and Challenges, 4th French-Chinese, Nice, Franc

Model the System from Adversary Viewpoint: Threats Identification and Modeling

Security attacks are hard to understand, often expressed with unfriendly and limited details, making it difficult for security experts and for security analysts to create intelligible security specifications. For instance, to explain Why (attack objective), What (i.e., system assets, goals, etc.), and How (attack method), adversary achieved his attack goals. We introduce in this paper a security attack meta-model for our SysML-Sec framework, developed to improve the threat identification and modeling through the explicit representation of security concerns with knowledge representation techniques. Our proposed meta-model enables the specification of these concerns through ontological concepts which define the semantics of the security artifacts and introduced using SysML-Sec diagrams. This meta-model also enables representing the relationships that tie several such concepts together. This representation is then used for reasoning about the knowledge introduced by system designers as well as security experts through the graphical environment of the SysML-Sec framework.Comment: In Proceedings AIDP 2014, arXiv:1410.322

Tracking granules on the Sun's surface and reconstructing horizontal velocity fields: I. the CST algorithm

Determination of horizontal velocity fields on the solar surface is crucial for understanding the dynamics of structures like mesogranulation or supergranulation or simply the distribution of magnetic fields. We pursue here the development of a method called CST for coherent structure tracking, which determines the horizontal motion of granules in the field of view. We first devise a generalization of Strous method for the segmentation of images and show that when segmentation follows the shape of granules more closely, granule tracking is less effective for large granules because of increased sensitivity to granule fragmentation. We then introduce the multi-resolution analysis on the velocity field, based on Daubechies wavelets, which provides a view of this field on different scales. An algorithm for computing the field derivatives, like the horizontal divergence and the vertical vorticity, is also devised. The effects from the lack of data or from terrestrial atmospheric distortion of the images are also briefly discussed.Comment: in press in Astronomy and Astrophysics, 9 page

Mesogranulation and the solar surface magnetic field distribution

The relation of the solar surface magnetic field with mesogranular cells is studied using high spatial (~ 100 km) and temporal (~ 30 sec) resolution data obtained with the IMaX instrument aboard SUNRISE. First, mesogranular cells are identified using Lagrange tracers (corks) based on horizontal velocity fields obtained through Local Correlation Tracking. After ~ 20 min of integration, the tracers delineate a sharp mesogranular network with lanes of width below about 280 km. The preferential location of magnetic elements in mesogranular cells is tested quantitatively. Roughly 85% of pixels with magnetic field higher than 100 G are located in the near neighborhood of mesogranular lanes. Magnetic flux is therefore concentrated in mesogranular lanes rather than intergranular ones. Secondly, magnetic field extrapolations are performed to obtain field lines anchored in the observed flux elements. This analysis, therefore, is independent of the horizontal flows determined in the first part. A probability density function (PDF) is calculated for the distribution of distances between the footpoints of individual magnetic field lines. The PDF has an exponential shape at scales between 1 and 10 Mm, with a constant characteristic decay distance, indicating the absence of preferred convection scales in the mesogranular range. Our results support the view that mesogranulation is not an intrinsic convective scale (in the sense that it is not a primary energy-injection scale of solar convection), but also give quantitative confirmation that, nevertheless, the magnetic elements are preferentially found along mesogranular lanes.Comment: Accepted for publication in ApJ Letters, 16 pages, 5 figure

Tracking granules at the Sun's surface and reconstructing velocity fields. II. Error analysis

The determination of horizontal velocity fields at the solar surface is crucial to understanding the dynamics and magnetism of the convection zone of the sun. These measurements can be done by tracking granules. Tracking granules from ground-based observations, however, suffers from the Earth's atmospheric turbulence, which induces image distortion. The focus of this paper is to evaluate the influence of this noise on the maps of velocity fields. We use the coherent structure tracking algorithm developed recently and apply it to two independent series of images that contain the same solar signal. We first show that a k-\omega filtering of the times series of images is highly recommended as a pre-processing to decrease the noise, while, in contrast, using destretching should be avoided. We also demonstrate that the lifetime of granules has a strong influence on the error bars of velocities and that a threshold on the lifetime should be imposed to minimize errors. Finally, although solar flow patterns are easily recognizable and image quality is very good, it turns out that a time sampling of two images every 21 s is not frequent enough, since image distortion still pollutes velocity fields at a 30% level on the 2500 km scale, i.e. the scale on which granules start to behave like passive scalars. The coherent structure tracking algorithm is a useful tool for noise control on the measurement of surface horizontal solar velocity fields when at least two independent series are available.Comment: in press in Astronomy and Astrophysics, 9 page

Relation between trees of fragmenting granules and supergranulation evolution

Context: The determination of the underlying mechanisms of the magnetic elements diffusion over the solar surface is still a challenge. Understanding the formation and evolution of the solar network (NE) is a challenge, because it provides a magnetic flux over the solar surface comparable to the flux of active regions at solar maximum. Aims: We investigate the structure and evolution of interior cells of solar supergranulation. From Hinode observations, we explore the motions on solar surface at high spatial and temporal resolution. We derive the main organization of the flows inside supergranules and their effect on the magnetic elements. Method: To probe the superganule interior cell, we used the Trees of Fragmenting Granules (TFG) evolution and their relations to horizontal Results: Evolution of TFG and their mutual interactions result in cumulative effects able to build horizontal coherent flows with longer lifetime than granulation (1 to 2 hours) over a scale up to 12\arcsec. These flows clearly act on the diffusion of the intranetwork (IN) magnetic elements and also on the location and shape of the network. Conclusions: From our analysis during 24 hours, TFG appear as one of the major elements of the supergranules which diffuse and advect the magnetic field on the Sun's surface. The strongest supergranules contribute the most to magnetic flux diffusion in the solar photosphere.Comment: 13 pages, 17 figures, accepted in Astronomy and Astrophysics movie : http://www.lesia.obspm.fr/perso/jean-marie-malherbe/Hinode2007/hinode2007.htm

Polar cap magnetic field reversals during solar grand minima: could pores play a role?

We study the magnetic flux carried by pores located outside active regions with sunspots and investigate their possible contribution to the reversal of the global magnetic field of the Sun. We find that they contain a total flux of comparable amplitude to the total magnetic flux contained in polar caps. The pores located at distances of 40--100~Mm from the closest active region have systematically the correct sign to contribute to the polar cap reversal. These pores can predominantly be found in bipolar magnetic regions. We propose that during grand minima of solar activity, such a systematic polarity trend, akin to a weak magnetic (Babcock-Leighton-like) source term could still be operating but was missed by the contemporary observers due to the limited resolving power of their telescopes.Comment: 11 pages, 9 figures, accepted for publication in Astronomy&Astrophysic