2,438 research outputs found
Sequential Deliberation for Social Choice
In large scale collective decision making, social choice is a normative study
of how one ought to design a protocol for reaching consensus. However, in
instances where the underlying decision space is too large or complex for
ordinal voting, standard voting methods of social choice may be impractical.
How then can we design a mechanism - preferably decentralized, simple,
scalable, and not requiring any special knowledge of the decision space - to
reach consensus? We propose sequential deliberation as a natural solution to
this problem. In this iterative method, successive pairs of agents bargain over
the decision space using the previous decision as a disagreement alternative.
We describe the general method and analyze the quality of its outcome when the
space of preferences define a median graph. We show that sequential
deliberation finds a 1.208- approximation to the optimal social cost on such
graphs, coming very close to this value with only a small constant number of
agents sampled from the population. We also show lower bounds on simpler
classes of mechanisms to justify our design choices. We further show that
sequential deliberation is ex-post Pareto efficient and has truthful reporting
as an equilibrium of the induced extensive form game. We finally show that for
general metric spaces, the second moment of of the distribution of social cost
of the outcomes produced by sequential deliberation is also bounded
Risk Factors for Nonsynchronous Second Primary Malignancy and Related Death in Patients with Differentiated Thyroid Carcinoma
BACKGROUND: Differentiated thyroid cancer (DTC) survivors are at increased risk of developing nonsynchronous second primary malignancy (NSPM). This study aims to examine possible risk factors leading to occurrence of NSPM as well as risk factors leading to NSPM-related death in patients with DTC. METHODS: Of the 1,106 patients with DTC managed at our institution, 92 (8.3%) patients developed NSPM and 40 (3.6%) patients died of NSPM. All causes of death were confirmed by medical record, autopsy report or death certificate. Clinicopathological variables were compared between those without NSPM and with NSPM as well as between those who died of NSPM and did not die of NSPM. Significant variables on univariate analysis were entered into a Cox proportional hazards model. RESULTS: The median latency period from diagnosis of DTC to NSPM was 142.7 (range 16.8-511.0) months. For occurrence of NSPM, age at DTC diagnosis >/=50 years old [relative risk (RR) = 2.35], cumulative radioactive iodine (RAI) activity 3.0-8.9 GBq (RR = 2.38), and external local radiotherapy (ERT) (RR = 1.95) were significant risk factors. For NSPM-related death, age at DTC diagnosis >/=50 years old (RR = 3.32) and nonbreast cancer (RR = 5.76) were significant risk factors. CONCLUSIONS: NSPM accounted for 18.7% of all deaths in DTC, but mortality was high (43.5%). Age at DTC diagnosis >/=50 years old, cumulative RAI activity 3.0-8.9 GBq, and ERT were significant risk factors for occurrence of NSPM, whereas age at DTC diagnosis >/=50 years old and the diagnosis of nonbreast cancer were significant risk factors for NSPM-related death.published_or_final_versionSpringer Open Choice, 21 Feb 201
Mechanisms of Esophago-Pharyngeal Acid Regurgitation in Human Subjects
Esophago-pharyngeal regurgitation is implicated in various otolaryngologic and respiratory disorders. The pathophysiological mechanisms causing regurgitation are still largely unknown
Complete larval development of the hermit crabs Clibanarius aequabilis and Clibanarius erythropus (Decapoda : Anomura : Diogenidae), under laboratory conditions, with a revision of the larval features of genus Clibanarius
The complete larval development (four zoeae and one megalopa) of Clibanarius aequabilis and C. erythropus, reared under laboratory conditions, is described and illustrated. The larval stages of the two northeastern Atlantic Clibanarius species cannot be easily differentiated. Their morphological characters are compared with those of other known Clibanarius larvae. The genus Clibanarius is very homogeneous with respect to larval characters. All Clibanarius zoeae display a broad and blunt rostrum, smooth abdominal segments and an antennal scale without a terminal spine. Beyond the second zoeal stage, the fourth telson process is present as a fused spine, and the uropods are biramous. In the fourth larval stage all species display a mandibular palp. The Clibanarius megalopa presents weakly developed or no ocular scales, symmetrical chelipeds, apically curved corneous dactylus in the second and third pereiopods, and 5-11 setae on the posterior margin of the telson. Apart from the number of zoeal stages, Clibanarius species may be separated, beyond the second zoeal stage, by the telson formula and the morphology of the fourth telson process.info:eu-repo/semantics/publishedVersio
Belowground DNA-based techniques: untangling the network of plant root interactions
Contains fulltext :
91591.pdf (publisher's version ) (Closed access)7 p
Sensory Electrical Stimulation Improves Foot Placement during Targeted Stepping Post-Stroke
Proper foot placement is vital for maintaining balance during walking, requiring the integration of multiple sensory signals with motor commands. Disruption of brain structures post-stroke likely alters the processing of sensory information by motor centers, interfering with precision control of foot placement and walking function for stroke survivors. In this study, we examined whether somatosensory stimulation, which improves functional movements of the paretic hand, could be used to improve foot placement of the paretic limb. Foot placement was evaluated before, during, and after application of somatosensory electrical stimulation to the paretic foot during a targeted stepping task. Starting from standing, twelve chronic stroke participants initiated movement with the non-paretic limb and stepped to one of five target locations projected onto the floor with distances normalized to the paretic stride length. Targeting error and lower extremity kinematics were used to assess changes in foot placement and limb control due to somatosensory stimulation. Significant reductions in placement error in the medial–lateral direction (p = 0.008) were observed during the stimulation and post-stimulation blocks. Seven participants, presenting with a hip circumduction walking pattern, had reductions (p = 0.008) in the magnitude and duration of hip abduction during swing with somatosensory stimulation. Reductions in circumduction correlated with both functional and clinical measures, with larger improvements observed in participants with greater impairment. The results of this study suggest that somatosensory stimulation of the paretic foot applied during movement can improve the precision control of foot placement
Heart rate variability and target organ damage in hypertensive patients
Background:
We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD).
Methods:
A retrospective analysis was performed including 200 patients registered in the Regione Campania network (aged 62.4 ± 12, male 64%). HRV analysis was performed by 24-h holter ECG. Renal damage was assessed by estimated glomerular filtration rate (eGFR), vascular damage by carotid intima-media thickness (IMT), and cardiac damage by left ventricular mass index.
Results:
Significantly lower values of the ratio of low to high frequency power (LF/HF) were found in the patients with moderate or severe eGFR (p-value < 0.001). Similarly, depressed values of indexes of the overall autonomic modulation on heart were found in patients with plaque compared to those with a normal IMT (p-value <0.05). These associations remained significant after adjustment for other factors known to contribute to the development of target organ damage, such as age. Moreover, depressed LF/HF was found also in patients with left ventricular hypertrophy but this association was not significant after adjustment for other factors.
Conclusions:
Depressed HRV appeared to be associated with vascular and renal TOD, suggesting the involvement of autonomic imbalance in the TOD. However, as the mechanisms by which abnormal autonomic balance may lead to TOD, and, particularly, to renal organ damage are not clearly known, further prospective studies with longitudinal design are needed to determine the association between HRV and the development of TOD
Collective emotions online and their influence on community life
E-communities, social groups interacting online, have recently become an
object of interdisciplinary research. As with face-to-face meetings, Internet
exchanges may not only include factual information but also emotional
information - how participants feel about the subject discussed or other group
members. Emotions are known to be important in affecting interaction partners
in offline communication in many ways. Could emotions in Internet exchanges
affect others and systematically influence quantitative and qualitative aspects
of the trajectory of e-communities? The development of automatic sentiment
analysis has made large scale emotion detection and analysis possible using
text messages collected from the web. It is not clear if emotions in
e-communities primarily derive from individual group members' personalities or
if they result from intra-group interactions, and whether they influence group
activities. We show the collective character of affective phenomena on a large
scale as observed in 4 million posts downloaded from Blogs, Digg and BBC
forums. To test whether the emotions of a community member may influence the
emotions of others, posts were grouped into clusters of messages with similar
emotional valences. The frequency of long clusters was much higher than it
would be if emotions occurred at random. Distributions for cluster lengths can
be explained by preferential processes because conditional probabilities for
consecutive messages grow as a power law with cluster length. For BBC forum
threads, average discussion lengths were higher for larger values of absolute
average emotional valence in the first ten comments and the average amount of
emotion in messages fell during discussions. Our results prove that collective
emotional states can be created and modulated via Internet communication and
that emotional expressiveness is the fuel that sustains some e-communities.Comment: 23 pages including Supporting Information, accepted to PLoS ON
Very Cold Gas and Dark Matter
We have recently proposed a new candidate for baryonic dark matter: very cold
molecular gas, in near-isothermal equilibrium with the cosmic background
radiation at 2.73 K. The cold gas, of quasi-primordial abundances, is condensed
in a fractal structure, resembling the hierarchical structure of the detected
interstellar medium.
We present some perspectives of detecting this very cold gas, either directly
or indirectly. The H molecule has an "ultrafine" structure, due to the
interaction between the rotation-induced magnetic moment and the nuclear spins.
But the lines fall in the km domain, and are very weak. The best opportunity
might be the UV absorption of H in front of quasars. The unexpected cold
dust component, revealed by the COBE/FIRAS submillimetric results, could also
be due to this very cold H gas, through collision-induced radiation, or
solid H grains or snowflakes. The -ray distribution, much more
radially extended than the supernovae at the origin of cosmic rays
acceleration, also points towards and extended gas distribution.Comment: 16 pages, Latex pages, crckapb macro, 3 postscript figures, uuencoded
compressed tar file. To be published in the proceeedings of the
"Dust-Morphology" conference, Johannesburg, 22-26 January, 1996, D. Block
(ed.), (Kluwer Dordrecht
Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae
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