62 research outputs found

    Electoral reform in the former USSR and Russian Federation, 1989-1993: Continuity, contradiction and departure

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    Through an examination of the elections of the USSR Congress of People's Deputies and the elections to the Russian Federal Assembly and their deputy compositions, this dissertation argues that the elections held in the former Soviet Union and the contemporary Russian Federation from 1989-1993 have demonstrated elements of continuity, contradiction and departure compared to those elections held before Mikhail Gorbachev's tenure as General Secretary of the Communist Party of the Soviet Union (CPSU). There has been a continuity of a central, powerful institution interfering and designing the electoral system and largely influencing, encouraging and restricting their outcomes. This continuity can be interpreted as a contradiction between the regime's intention to implement democratic changes and its reform efforts. Notwithstanding these factors, with each successive election there have been numerous innovations, greater scope for candidate competition and subsequently public choice, improved possibilities for civic involvement in all stages of the election campaigns and the opportunity for civil society to become actively involved in political affairs. Therefore, this accumulation of these electoral reform measures has resulted in significant departures from the previous electoral system that existed in the USSR from 1937-late 1980s. These developments have changed the Soviet electoral system from a series of plebiscites in which there was no choice among candidates to elections in which citizens were offered a choice among candidates to, ultimately, multiparty elections

    Clinical, histopathological and molecular features of dedifferentiated melanomas:An EORTC Melanoma Group Retrospective Analysis

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    PURPOSE: Dedifferentiated melanoma (DedM) poses significant diagnostic challenges. We aimed to investigate the clinical, histopathological and molecular features of DedM. Methylation signature (MS) and copy number profiling (CNP) were carried out in a subgroup of cases.PATIENTS AND METHODS: A retrospective series of 78 DedM tissue samples from 61 patients retrieved from EORTC (European Organisation for Research and Treatment of Cancer) Melanoma Group centres were centrally reviewed. Clinical and histopathological features were retrieved. In a subgroup of patients, genotyping through Infinium Methylation microarray and CNP analysis was carried out.RESULTS: Most patients (60/61) had a metastatic DedM showing most frequently an unclassified pleomorphic, spindle cell, or small round cell morphology akin to undifferentiated soft tissue sarcoma, rarely associated with heterologous elements. Overall, among 20 successfully analysed tissue samples from 16 patients, we found retained melanoma-like MS in only 7 tissue samples while a non-melanoma-like MS was observed in 13 tissue samples. In two patients from whom multiple specimens were analysed, some of the samples had a preserved cutaneous melanoma MS while other specimens exhibited an epigenetic shift towards a mesenchymal/sarcoma-like profile, matching the histological features. In these two patients, CNP was largely identical across all analysed specimens, in line with their common clonal origin, despite significant modification of their epigenome.CONCLUSIONS: Our study further highlights that DedM represents a real diagnostic challenge. While MS and genomic CNP may help pathologists to diagnose DedM, we provide proof-of-concept that dedifferentiation in melanoma is frequently associated with epigenetic modifications.</p

    Rights to Land, Forests and Carbon in REDD+ : Insights from Mexico, Brazil and Costa Rica

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    Land tenure and carbon rights constitute critical issues to take into account in achieving emission reductions, ensuring transparent benefit sharing and determining non-permanence (or non-compliance) liabilities in the context of REDD+ strategies and projects. This is so because tenure systems influence who becomes involved in efforts to avoid deforestation and improve forest management, and that land tenure, carbon rights and liabilities may be linked or divorced with implications for rural development. This paper explores these issues by looking at tenure regimes and carbon rights issues in Mexico, Brazil and Costa Rica. It is effectively shown that complex bundles of rights over forest resources have distinct implications for REDD+ design and implementation, and that REDD+ strategies in selected countries have to date failed in procedurally addressing land-use conflicts and carbon rights entitlements and liabilities

    Dynamics and Mechanisms of DNA Methylation Reprogramming

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    The Beaker phenomenon and the genomic transformation of northwest Europe

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    From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions. However, migration had a key role in the further dissemination of the Beaker complex. We document this phenomenon most clearly in Britain, where the spread of the Beaker complex introduced high levels of steppe-related ancestry and was associated with the replacement of approximately 90% of Britain’s gene pool within a few hundred years, continuing the east-to-west expansion that had brought steppe-related ancestry into central and northern Europe over the previous centuries

    Promotion of Electric Mobility in the European Union—Overview of Project PROMETEUS from the Perspective of Cohesion through Synergistic Cooperation on the Example of the Catching-Up Region

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    This project report presents the rationale and the first results as regards the ongoing learning process of the PROMETEUS (PROMotion of EmobiliTy in EU regionS) project, co-financed by the Interreg Europe program, in the context of EU policies and programs dedicated to the promotion of sustainable mobility, and electric mobility in particular. Electric mobility, and in general low-carbon mobility, is one of the main targets of the European Union’s policies dedicated to a green transition. Despite continuous efforts, the number of electric cars in circulation remains low and the objectives of expanding the market for such vehicles by 2030 are still far from being fulfilled. Up until 2018, the share of electric vehicles was in fact only 1.5% of total car sales in the EU. Specifically, it has been noted that an increase in the uptake of electric vehicles in Europe is hampered by the presence of three main barriers: affordability, infrastructure availability, and lack of investments. In this context, project PROMETEUS has aimed at tackling the lacunae in the availability of infrastructures for a transition towards electric mobility in the partnership’s regions, namely, Carinthia in Austria, Castilla y León in Spain, Lazio in Italy, Malta, and Prešov in Slovakia, and at countering low awareness in the public through the improvement of policy instruments linked to structural funds. In order to approach and clarify the process of improvement of those policy instruments, we have summarized and presented the reference results and outputs from the Action Plans across the partners. Moreover, the report discusses in detail the output of the regional Action Plan of the one of project partners—the Prešov region, as the form of a model example—as the initial situation in terms of infrastructure development in the region posing as the biggest challenge for the project. Managerial as well as research summaries can be helpful in the implementation of similar projects; in the continuous improvement of policy instruments; and, last but not least, in the formulation of new challenges to improve awareness of sustainable forms of transport
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