Albert Mayr (1868-1924)

The Bavarian philologist Albert Mayr visited Malta during the autumn and winter months of 1897/98 and a second time in spring 1907. He is considered to have been a pioneer in many ways. His scientific approach to archaeology, at a time when the discipline was just getting beyond the point of myths and fables, enabled him to lay down solid foundations for various parts of Malta's prehistory and history.peer-reviewe

ІНАКШІСТЬ: НЕОБХІДНІСТЬ ОБГОВОРЕННЯ АСПЕКТІВ ПОЛІКУЛЬТУРНОГО НАВЧАННЯ

The character of the publication lays the emphasis on some of the most important aspects of multicultural-learning seen by philosophical annotations of the pedagogical anthropology. By reflection and concise exposition of the material in line with Martin Buber’s fundamental ideas on I and You the Dialogue-Philosophy of Sigmund Freud’s topography, of the Other-hood (foreigners) of some of the most important fields of intercultural pedagogy and the ideas about «consciousness» of the Latin American Pedagogy (Paulo Freire) are touched and pointed out.В статье акцентировано внимание на некоторых наиболее важных аспектах поликультурного обучения изложенных в философских аннотациях педагогической антропологии. С помощью рефлексии и краткого изложения материала в русле основных взглядов Мартина Бубера на Я и Ты раскрыто и проанализировано философию диалога в топографии Зигмунда Фрейда, взгляды других представителей некоторых из наиболее важных отраслей кросскультурной педагогики, а также идеи о «сознании» латиноамериканской педагогики (Пауло Фрейре).У статті акцентовано увагу на найбільш важливих аспектах полікультурного навчання, викладених у філософських анотаціях педагогічної антропології. За допомогою рефлексії та стислого викладу матеріалу в руслі основоположних поглядів Мартіна Бубера на Я і Ти розкрито і проаналізовано філософію діалогу в топографії Зигмунда Фройда, погляди інших представників деяких із найбільш важливих галузей кроскультурної педагогіки, а також ідеї про «свідомість» латиноамериканської педагогіки (Пауло Фрейре)

Ghajn Klieb, (Rabat, Malta)

Between October and December 1999 a team of local and foreign undergraduates from the University of Malta carried out a survey of the site at Ghajn Klieb outside Rabat. The exercise constituted the practical part of a unit on the Principles of Archaeological Surveying directed by Dr Nicholas Vella of the Department of Classics & Archaeology. For the survey the team was joined by Hanna Stager, a graduate of the same department, who also researched some of the references used in this article. Initial reconnaissance of the site was carried out on 15 October 1999 with Nathaniel Cutajar and Michelle B uhagiar, Curator and Assistant Curator respectively at the National Museum of Archaeology. The scatter of surface ceramics and the existence of previously known and unknown features revealed the extent and potential of the site. It was decided that the locality of Ghajn Klieb warranted systematic study that could be carried out in various stages, with the longterm aim being an assessment of human activity and cultural behaviour at the site. The Museums Department gave the go-ahead for this project, and permission to collect the surface ceramics was granted. This short report is intended to give an outline of the work undertaken to date. Emphasis is placed on the field methods adopted and on the presentation of what we believe to be worth talking about at this stage. An effort is here made by the senior author to unravel the collaborative nature of the exercise by lending weight to individual thoughts and interpretations that arose while work progressed in the field.peer-reviewe

Pulmonary DWCNT Exposure Causes Sustained Local and Low-Level Systemic Inflammatory Changes in Mice

Carbon nanotubes (CNTs) represent promising vectors to facilitate cellular drug delivery and to overcome biological barriers, but some types may also elicit persistent pulmonary inflammation based on their fibre characteristics. Here, we show the pulmonary response to aqueous suspensions of block copolymer dispersed, double-walled carbon nanotubes (DWCNT, length 1–10 lm) in mice by bronchoalveolar lavage (BAL) analysis, and BAL and blood cytokine and lung antioxidant profiling. The intratracheally instilled dose of 50 lg DWCNT caused significant pulmonary inflammation that was not resolved during a 7- day observation period. Light microscopy investigation of the uptake of DWCNT agglomerates revealed no particle ingestion for granulocytes, but only for macrophages. Accumulating macrophage, multinucleated macrophage and lymphocyte numbers in the alveolar region further indicated ineffective resolution with chronification of the inflammation. The local inflammatory impairment of the lung was accompanied by pulmonary antioxidant depletion and haematological signs of systemic inflammation. While the observed inflammation during its acute phase was dominated by neutrophils and neutrophil recruiting cytokines, the contribution of macrophages and lymphocytes with related cytokines became more significant after day 3 of exposure. This study confirms that acute pulmonary toxicity can occur on exposure of high doses of DWCNT agglomerates and offers further insight for improved nanotube design parameters to avoid potential long-term toxicity

Russell-like bodies in plant seeds share common features with prolamin bodies and occur upon recombinant protein production

Although many recombinant proteins have been produced in seeds at high yields without adverse effects on the plant, endoplasmic reticulum (ER) stress and aberrant localization of endogenous or recombinant proteins have also been reported. The production of murine interleukin-10 (mIL-10) in Arabidopsis thaliana seeds resulted in the de novo formation of ER-derived structures containing a large fraction of the recombinant protein in an insoluble form. These bodies containing mIL-10 were morphologically similar to Russell bodies found in mammalian cells. We confirmed that the compartment containing mIL-10 was enclosed by ER membranes, and 3D electron microscopy revealed that these structures have a spheroidal shape. Another feature shared with Russell bodies is the continued viability of the cells that generate these organelles. To investigate similarities in the formation of Russell-like bodies and the plant-specific protein bodies formed by prolamins in cereal seeds, we crossed plants containing ectopic ER-derived prolamin protein bodies with a line accumulating mIL-10 in Russell-like bodies. This resulted in seeds containing only one population of protein bodies in which mIL-10 inclusions formed a central core surrounded by the prolamin-containing matrix, suggesting that both types of protein aggregates are together removed from the secretory pathway by a common mechanism. We propose that, like mammalian cells, plant cells are able to form Russell-like bodies as a self-protection mechanism, when they are overloaded with a partially transport-incompetent protein, and we discuss the resulting challenges for recombinant protein production

Size distribution of FeNiB nanoparticles

Two samples of amorphous nanoparticles FeNiB, one of them with SiO2 sheath around the core and one without, were investigated by transmission electron microscopy and magnetic measurements. The coating gives mean particle diameters of 4.3 nm compared to 7.2 nm for the uncoated particles. Magnetic measurements prove superparamagnetic behaviour above 160 K (350 K) for the coated (uncoated) sample. With use of effective anisotropy constant Keff – determined from hysteresis loops – size distributions are determined both from ZFC curves, as well as from relaxation measurements. Both are in good agreement and are very similar for both samples. Comparison with the size distribution determined from TEM pictures shows that magnetic clusters consist of only few physical particles

Інформаційне законодавство. Основні нормативні акти

Наведено основні нормативні акти з регулювання інформаційних відносин, зокрема, у сфері інформації, інформаційних агентств, телекомунікації, радіочастотного ресурсу України, інформатизації, телебачення тощо. Розраховано на студентів, які здобувають вищу освіту в галузях знань "Право", "Інформаційна безпека", "Комп'ютерні науки", "Телекомунікації"

Policies for an Ageing Workforce Work-life balance, working conditions and equal opportunities 2019

At a time of rapid population ageing, a key means of sustaining current welfare states is to extend the length of working lives. In 2050, the share of people over the age of 75 years will be the same as the share over 65 years today. And just as not all are able to work to the age of 65 now, not everyone will be able to work to the age of 75 in 2050; even if future older workers will in all likelihood be healthier and have better working aids at their disposal. Extending average working lives by 10 years, and at the same time ensuring an adequate social safety net for those unable to work into their late 60s and 70s, is a major social policy challenge for the coming decades. And because people are much more likely to work late in life if they had stable careers before reaching 60, tackling this policy challenge means pulling on many more social policy levers than just pension policy. While being keenly aware of these issues and how they relate to the overall agenda of active ageing, Commissioner Thyssen also reminds us in her Foreword that marked increases in life expectancy – both past and in the future – represent enormous social progress. The Commissioner makes the point that older people too contribute to society. And more so with lifelong learning and investment in skills

Errors in the bisulfite conversion of DNA: modulating inappropriate- and failed-conversion frequencies

Bisulfite treatment can be used to ascertain the methylation states of individual cytosines in DNA. Ideally, bisulfite treatment deaminates unmethylated cytosines to uracils, and leaves 5-methylcytosines unchanged. Two types of bisulfite-conversion error occur: inappropriate conversion of 5-methylcytosine to thymine, and failure to convert unmethylated cytosine to uracil. Conventional bisulfite treatment requires hours of exposure to low-molarity, low-temperature bisulfite (‘LowMT’) and, sometimes, thermal denaturation. An alternate, high-molarity, high-temperature (‘HighMT’) protocol has been reported to accelerate conversion and to reduce inappropriate conversion. We used molecular encoding to obtain validated, individual-molecule data on failed- and inappropriate-conversion frequencies for LowMT and HighMT treatments of both single-stranded and hairpin-linked oligonucleotides. After accounting for bisulfite-independent error, we found that: (i) inappropriate-conversion events accrue predominantly on molecules exposed to bisulfite after they have attained complete or near-complete conversion; (ii) the HighMT treatment is preferable because it yields greater homogeneity among sites and among molecules in conversion rates, and thus yields more reliable data; (iii) different durations of bisulfite treatment will yield data appropriate to address different experimental questions; and (iv) conversion errors can be used to assess the validity of methylation data collected without the benefit of molecular encoding