Los vinos de mora de M\ue9rida son una buena fuente de antioxidantes

Fue evaluada la actividad antioxidantes de 12 vinos de mora fabricados artesanalmente en el P\ue1ramo La Culata (M\ue9rida, Venezuela) a trav\ue9s de la inhibici\uf3n de la formaci\uf3n del ani\uf3n super\uf3xido y radical hidroxilo, y el m\ue9todo de la Actividad Antioxidante (AOA). Adem\ue1s, fue determinado el contenido de fenoles y de prote\uednas de acuerdo al procedimiento de Folin- Ciocalteu. En lo que se refiere al efecto de los diferentes vinos de mora en la generaci\uf3n del ani\uf3n super\uf3xido y el radical hidroxilo, se obtuvieron los mayores porcentajes de inhibici\uf3n por las muestras 2, 4, 9, 11 y 12, siendo en muchos casos los porcentajes de inhibici\uf3n superiores a los observados con melatonina y vitamina E. En relaci\uf3n a los valores de AOA, se encontr\uf3 que las muestras de vino de mora presentaron valores de AOA entre 0.80- 0.95 mM, siendo en casi todos los casos superiores o similares a los presentados por la melatonina y la vitamina E. En todos los casos existi\uf3 una correlaci\uf3n lineal entre la capacidad antioxidante y el contendido de fenoles de las muestras en estudio, representado por valores de correlaci\uf3n (R2) entre 0.988 y 0.997 y valores de P entre 0.005 y 0.021. Se ha demostrado que los vinos de mora producidos artesanalmente en M\ue9rida (Venezuela) analizados en este estudio son una buena fuente de antioxidantes naturales. ABSTRACT The antioxidative activity of a total of 12 mulberry wines was examined by inhibition of superoxide anion and hydroxyl radical generation, and antioxidant activity method (AOA) autoxidation of methyl linoleate. The content of total phenolics in the samples was determined spectrometrically according to the Folin-Ciocalteu procedure. In relation to the effect of differet mulberry wines in superoxide anion and hydroxyl radical generatio, were founded the hights inhibition percentages for samples 2, 4, 9, 11 and 12, being in some cases bigers that those founded with melatonin and vitamin E.On the other hand, was founded tha mulberry wine simples had AOA values between 0.80-0.95 mM, being in all cases bigger or similar to those founded with melatonin and vitamin E. In all cases, there was a lineal relation between antioxidant capacity and phenol content of samples, represented by correlation values (R2) between 0.988 y 0.997 and P values between 0.005 and 0.021. Has been demosntrated that mulberry wines produced in M\ue9rida (Venezuela) assayed in this studyare a good source of natural antioxidants

Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family.

Fibroblast growth factor receptor 1 (FGFR1) is known to be activated by homodimerization in the presence of both the FGF agonist ligand and heparan sulfate glycosaminoglycan. FGFR1 homodimers in turn trigger a variety of downstream signaling cascades via autophosphorylation of tyrosine residues in the cytoplasmic domain of FGFR1. By means of Bioluminescence Energy Resonance Transfer (BRET) as a sign of FGFR1 homodimerization, we evaluated in HEK293T cells the effects of all known FGF agonist ligands on homodimer formation. A significant correlation between BRET(2) signaling and ERK1/2 phosphorylation was observed, leading to a further characterization of the binding and signaling properties of the FGF subfamilies. FGF agonist ligand-FGFR1 binding interactions appear as the main mechanism for the control of FGFR1 homodimerization and MAPK signaling which demonstrated a high correlation. The bioinformatic analysis demonstrates the interface of the two pro-triplets SSS (Ser-Ser-Ser) and YGS (Tyr-Gly-Ser) located in the extracellular and intracellular domain of the FGFR1. These pro-triplets are postulated participate in the FGFR1 homodimerization interface interaction. The findings also reveal that FGF agonist ligands within the same subfamily of the FGF gene family produced similar increases in FGFR1 homodimer formation and MAPK signaling. Thus, the evolutionary relationship within this gene family appears to have a distinct functional relevance

Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis

Background More than 10 years have elapsed since human papillomavirus (HPV) vaccination was implemented. We did a systematic review and meta-analysis of the population-level impact of vaccinating girls and women against human papillomavirus on HPV infections, anogenital wart diagnoses, and cervical intraepithelial neoplasia grade 2+ (CIN2+)to summarise the most recent evidence about the effectiveness of HPV vaccines in real-world settings and to quantify the impact of multiple age-cohort vaccination.Methods In this updated systematic review and meta-analysis, we used the same search strategy as in our previous paper. We searched MEDLINE and Embase for studies published between Feb 1, 2014, and Oct 11, 2018. Studies were eligible if they compared the frequency (prevalence or incidence) of at least one HPV-related endpoint (genital HPV infections, anogenital wart diagnoses, or histologically confirmed CIN2+) between pre-vaccination and post-vaccination periods among the general population and if they used the same population sources and recruitment methods before and after vaccination. Our primary assessment was the relative risk (RR) comparing the frequency (prevalence or incidence) of HPV-related endpoints between the pre-vaccination and post-vaccination periods. We stratified all analyses by sex, age, and years since introduction of HPV vaccination. We used random-effects models to estimate pooled relative risks.Findings We identified 1702 potentially eligible articles for this systematic review and meta-analysis, and included 65 articles in 14 high-income countries: 23 for HPV infection, 29 for anogenital warts, and 13 for CIN2+.After 5\u20138 years of vaccination, the prevalence of HPV 16 and 18 decreased significantly by 83% (RR 0\ub717, 95% CI 0\ub711\u20130\ub725) among girls aged 13\u201319 years, and decreased significantly by 66% (RR 0\ub734, 95% CI 0\ub723\u20130\ub749) among women aged 20\u201324 years. The prevalence of HPV 31, 33, and 45 decreased significantly by 54% (RR 0\ub746, 95% CI 0\ub733\u20130\ub766) among girls aged 13\u201319 years. Anogenital wart diagnoses decreased significantly by 67% (RR 0\ub733, 95% CI 0\ub724\u20130\ub746) among girls aged 15\u201319 years, decreased significantly by 54% (RR 0\ub746, 95% CI 0.36\u20130.60) among women aged 20\u201324 years, and decreased significantly by 31% (RR 0\ub769, 95% CI 0\ub753\u20130\ub789) among women aged 25\u201329 years. Among boys aged 15\u201319 years anogenital wart diagnoses decreased significantly by 48% (RR 0\ub752, 95% CI 0\ub737\u20130\ub775) and among men aged 20\u201324 years they decreased significantly by 32% (RR 0\ub768, 95% CI 0\ub747\u20130\ub798). After 5\u20139 years of vaccination, CIN2+ decreased significantly by 51% (RR 0\ub749, 95% CI 0\ub742\u20130\ub758) among screened girls aged 15\u201319 years and decreased significantly by 31% (RR 0\ub769, 95% CI 0\ub757\u20130\ub784) among women aged 20\u201324 years.Interpretation This updated systematic review and meta-analysis includes data from 60 million individuals and up to 8 years of post-vaccination follow-up. Our results show compelling evidence of the substantial impact of HPV vaccination programmes on HPV infections and CIN2+ among girls and women, and on anogenital warts diagnoses among girls, women, boys, and men. Additionally, programmes with multi-cohort vaccination and high vaccination coverage had a greater direct impact and herd effects

Strange particle production in proton-proton collisions at s=0.9\sqrt{s}=0.9 TeV with ALICE at the LHC

The production of mesons containing strange quarks (K$^0_s$, $\phi$) and both singly and doubly strange baryons ($\Lambda$, Anti-$\Lambda$, and $\Xi$+Anti-$\Xi$) are measured at central rapidity in pp collisions at $\sqrt{s}$ = 0.9 TeV with the ALICE experiment at the LHC. The results are obtained from the analysis of about 250 k minimum bias events recorded in 2009. Measurements of yields (dN/dy) and transverse momentum spectra at central rapidities for inelastic pp collisions are presented. For mesons, we report yields () of 0.184 $\pm$ 0.002 stat. $\pm$ 0.006 syst. for K$^0_s$ and 0.021 $\pm$ 0.004 stat. $\pm$ 0.003 syst. for $\phi$. For baryons, we find = 0.048 $\pm$ 0.001 stat. $\pm$ 0.004 syst. for $\Lambda$, 0.047 $\pm$ 0.002 stat. $\pm$ 0.005 syst. for Anti-$\Lambda$ and 0.0101 $\pm$ 0.0020 stat. $\pm$ 0.0009 syst. for $\Xi$+Anti-$\Xi$. The results are also compared with predictions for identified particle spectra from QCD-inspired models and provide a baseline for comparisons with both future pp measurements at higher energies and heavy-ion collisions.Comment: 33 pages, 21 captioned figures, 10 tables, authors from page 28, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/387

Cross-Scale Vulnerability Assessment for Smallholder Farming: A Case Study from the Northeast of Brazil

Climate change heavily impacts smallholder farming worldwide. Cross-scale vulnerability assessment has a high potential to identify nested measures for reducing vulnerability of smallholder farmers. Despite their high practical value, there are currently only limited examples of cross-scale assessments. The presented study aims at assessing the vulnerability of smallholder farmers in the Northeast of Brazil across three scales: regional, farm and field scale. In doing so, it builds on existing vulnerability indices and compares results between indices at the same scale and across scales. In total, six independent indices are tested, two at each scale. The calculated indices include social, economic and ecological indicators, based on municipal statistics, meteorological data, farm interviews and soil analyses. Subsequently, indices and overlapping indicators are normalized for intra- and cross-scale comparison. The results show considerable differences between indices across and within scales. They indicate different activities to reduce vulnerability of smallholder farmers. Major shortcomings arise from the conceptual differences between the indices. We therefore recommend the development of hierarchical indices, which are adapted to local conditions and contain more overlapping indicators for a better understanding of the nested vulnerabilities of smallholder farmers

Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics

A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance of b-tagging and the trigger. The physics potential for a variety of interesting physics processes, within the Standard Model and beyond, is examined. The study comprises a series of notes based on simulations of the detector and physics processes, with particular emphasis given to the data expected from the first years of operation of the LHC at CERN

LA GERENCIA DEL TALENTO HUMANO PARA UN LIDERAZGO GERENCIAL EN LA GESTION UNIVERSITARIA

La Gerencia se refiere a las organizaciones que efect\ufaan actividades de planificaci\uf3n, organizaci\uf3n, direcci\uf3n y control a objeto de utilizar sus recursos humanos, f\uedsicos y financieros con la finalidad de alcanzar objetivos. Cuando las organizaciones asumen la participaci\uf3n activa de sus empleados como pr\ue1ctica com\ufan en el desarrollo de sus actividades normales, convirti\ue9ndola en pilar fundamental de su \ue9xito institucional, est\ue1n asumiendo una actitud de aprender y mejorar en forma participativa. El personal, en este caso, al sentirse motivado e identificado con el servicio que brinda, logra cubrir las expectativas del cliente mejorando as\ued la eficiencia de la organizaci\uf3n, ofreciendo productos y/o servicios de calidad. En el caso de las Organizaciones Virtuales, el talento humano debe tener mayor motivaci\uf3n y estrategias de participaci\uf3n activa en los procesos que desarrolle dicha organizaci\uf3n. Palabras Claves del Autor: Gerencia, Gesti\uf3n Universitaria, Talento Humano. ABSTRACT Management refers to the organizations that carry out activities of planning, organization, direction and control in order to use its human, physical and financial resources in order to achieve objectives. When organizations assume the active participation of its employees as a common practice in the development of its normal activities, making fundamental pillar of its institutional success, are assuming an attitude of learning and improve in a participatory manner. The staff, in this case, the feel is motivated and identified with the service that provides, manages to meet the expectations of the customer thus improving the efficiency of the Organization, offering products and services of quality. In the case of virtual organizations, human talent must have greater motivation and strategies for active participation in the processes that develop this organization. Key words: Management, university Management, Human Talent<br

Predictors of choice of initial antifungal treatment in intraabdominal candidiasis

Intraabdominal candidiasis (IAC) is the second most frequent form of invasive candidiasis, and is associated with high mortality rates. This study aims to identify current practices in initial antifungal treatment (IAT) in a real-world scenario and to define the predictors of the choice of echinocandins or azoles in IAC episodes. Secondary analysis was performed of a multinational retrospective cohort at 13 teaching hospitals in four countries (Italy, Greece, Spain and Brazil), over a 3-year period (2011\u20132013). IAC was identified in 481 patients, 323 of whom received antifungal therapy (classified as the treatment group). After excluding 13 patients given amphotericin B, the treatment group was further divided into the echinocandin group (209 patients; 64.7%) and the azole group (101 patients; 32.3%). Median APACHE II scores were significantly higher in the echinocandin group (p 0.013), but IAT did not differ significantly with regard to the Candida species involved. Logistic multivariate stepwise regression analysis, adjusted for centre effect, identified septic shock (adjusted OR (aOR) 1.54), APACHE II > 15 (aOR 1.16) and presence in surgical ward at diagnosis (aOR 1.16) as the top three independent variables associated with an empirical echinocandin regimen. No differences in 30-day mortality were observed between groups. Echinocandin regimen was the first choice for IAT in patients with IAC. No statistical differences in mortality were observed between regimens, but echinocandins were administered to patients with more severe disease. Some disagreements were identified between current clinical guidelines and prescription of antifungals for IAC at the bedside, so further educational measures are required to optimize therapies

Search for vectorlike B quarks in events with one isolated lepton, missing transverse momentum, and jets at √s = 8 TeV with the ATLAS detector

A search has been performed for pair production of heavy vectorlike down-type (B) quarks. The analysis explores the lepton-plus-jets final state, characterized by events with one isolated charged lepton (electron or muon), significant missing transverse momentum, and multiple jets. One or more jets are required to be tagged as arising from b quarks, and at least one pair of jets must be tagged as arising from the hadronic decay of an electroweak boson. The analysis uses the full data sample of pp collisions recorded in 2012 by the ATLAS detector at the LHC, operating at a center-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 20.3 fb −1 . No significant excess of events is observed above the expected background. Limits are set on vectorlike B production, as a function of the B branching ratios, assuming the allowable decay modes are B → Wt/Zb/Hb. In the chiral limit with a branching ratio of 100% for the decay B → Wt, the observed (expected) 95% C.L. lower limit on the vectorlike B mass is 810 GeV (760 GeV). In the case where the vectorlike B quark has branching ratio values corresponding to those of an SU(2) singlet state, the observed (expected) 95% C.L. lower limit on the vectorlike B mass is 640 GeV (505 GeV). The same analysis, when used to investigate pair production of a colored, charge 5/3 exotic fermion T 5/3 , with subsequent decay T 5/3 → Wt, sets an observed (expected) 95% C.L. lower limit on the T 5/3 mass of 840 GeV (780 GeV)

Determination of fatty acids ethyl esters in virgin olive oils: proposals to enhance the EU official method

Fatty acids ethyl esters (FAEEs) are markers for virgin olive oils obtained from olives of poor quality or not adequately stored before being processed. FAEEs can also be considered as indirect markers in detecting the illegal treatment of soft deodorization that can be applied to slightly defective olive oils, as they are difficult to be removed from the oils at the conditions reached during this technological process. The official FAEEs determination (EU Reg. 61/2011) suffers some drawbacks in terms of amount of solvents and long time of analysis, linked with the preparative procedure to isolate these compounds. The aim of this work is to study the application of an HPLC-UV as a rapid alternative approach to the traditional liquid chromatography applied in the preparative phase. After the set up of the most appropriate working conditions (eg. mobile phase, flow, injection volume), some validation parameters (eg. precision, accuracy, LOD and LOQ, recovery) have been evaluated, in order to check the effectiveness of the proposed method. Moreover, considering the GC-FID step, the use of a PTV (programmed temperature vaporizer) injector as an alternative of the on-column one was evaluated. This work is developed in the context of the project OLEUM \u201cAdvanced solutions for assuring authenticity and quality of olive oil at global scale\u201c, funded by the European Commission within the Horizon 2020 Programme (2014\u20132020, GA no. 635690). The information expressed in this abstract reflects the authors\u2019 views; the EC is not liable for the information contained therein