An Evaluation of Determinants that Influence Decisions to Adopt School-Based Dental Sealant Programs by Principals in Elementary Schools in Georgia that Predominantly Serve Low-income Children

About one in five children aged 5 to 11 years have at least one untreated, decayed tooth (Dye, Li, & Beltran-Aguilar, 2012) and tooth decay is the number one chronic disease in children (S. O. Griffin, Wei, Gooch, Weno, & Espinoza, 2016). More than 51 million school hours are lost each year due to dental health issues, making it the number one reason for missed school (Gift, Reisine, & Larach, 1992). Additionally, studies show that poor oral health is associated with lower school performance (Blumenshine, Vann, Gizlice, & Lee, 2008; National Maternal and Child Oral Health Resource Center/Georgetown University, 1996; Satcher, 2000). Conversely, school attendance and performance by children are positively affected by good oral health (S. O. Griffin, Shillpa, Scherrer, Patel, & Sajal, 2017; S. Griffin et al., 2016; Reisine & Reisine, 1985; Seirawan, Faust, & Mulligan, 2012; United States General Accounting Office, 2003). The American Academy of Pediatric Dentistry states that tooth decay is the most preventable disease in children (The American Academy of Pediatric Dentistry, 2014). Preventive oral health services such as sealants are a cost-effective intervention when compared to costs of treating caries (S. Griffin et al., 2016). Additionally, school-based sealant programs (SBSP) are cost-effective (S. Griffin et al., 2016; Zabos et al., 2002) and are a recommended delivery mechanism (The Guide to Community Preventive Services, 2017) for dental sealants. Despite these facts, most elementary schools in Georgia do not have school-based sealant programs. This study identified factors that influence the SBSP adoption decision by elementary school principals in Georgia. Semi-structured key informant interviews were conducted with 18 elementary school principals, six of whom hosted SBSP, and 12 of whom did not. Principals were found to be very aware of the needs of and were concerned with the well-being of the children they serve. In those principals not currently hosting SBSP, there was a total lack of awareness of SBSP, which was a critical barrier to adoption. The processes and authorities for program adoption decision-making include principals, but generally reside at or at a minimum include the school district. Public health is a major contributing factor to the presence of SBSP in elementary schools in Georgia.Doctor of Public Healt

Collective intelligence for translational medicine: Crowdsourcing insights and innovation from an interdisciplinary biomedical research community.

This is the author accepted manuscript. The final version is available from Taylor & Francis via http://dx.doi.org/10.3109/07853890.2015.1091945Translational medicine bridges the gap between discoveries in biomedical science and their safe and effective clinical application. Despite the gross opportunity afforded by modern research for unparalleled advances in this field, the process of translation remains protracted. Efforts to expedite science translation have included the facilitation of interdisciplinary collaboration within both academic and clinical environments in order to generate integrated working platforms fuelling the sharing of knowledge, expertise, and tools to align biomedical research with clinical need. However, barriers to scientific translation remain, and further progress is urgently required. Collective intelligence and crowdsourcing applications offer the potential for global online networks, allowing connection and collaboration between a wide variety of fields. This would drive the alignment of biomedical science with biotechnology, clinical need, and patient experience, in order to deliver evidence-based innovation which can revolutionize medical care worldwide. Here we discuss the critical steps towards implementing collective intelligence in translational medicine using the experience of those in other fields of science and public health

The Risk of West Nile Virus Infection Is Associated with Combined Sewer Overflow Streams in Urban Atlanta, Georgia, USA

BACKGROUND: At present, the factors favoring transmission and amplification of West Nile Virus (WNV) within urban environments are poorly understood. In urban Atlanta, Georgia, the highly polluted waters of streams affected by combined sewer overflow (CSO) represent significant habitats for the WNV mosquito vector Culex quinquefasciatus. However, their contribution to the risk of WNV infection in humans and birds remains unclear.\ud \ud OBJECTIVES: Our goals were to describe and quantify the spatial distribution of WNV infection in mosquitoes, humans, and corvids, such as blue jays and American crows that are particularly susceptible to WNV infection, and to assess the relationship between WNV infection and proximity to CSO-affected streams in the city of Atlanta, Georgia.\ud \ud MATERIALS AND METHODS: We applied spatial statistics to human, corvid, and mosquito WNV surveillance data from 2001 through 2007. Multimodel analysis was used to estimate associations of WNV infection in Cx. quinquefasciatus, humans, and dead corvids with selected risk factors including distance to CSO streams and catch basins, land cover, median household income, and housing characteristics.\ud \ud RESULTS: We found that WNV infection in mosquitoes, corvids, and humans was spatially clustered and statistically associated with CSO-affected streams. WNV infection in Cx. quinquefasciatus was significantly higher in CSO compared with non-CSO streams, and WNV infection rates among humans and corvids were significantly associated with proximity to CSO-affected streams, the extent of tree cover, and median household income.\ud \ud CONCLUSIONS: Our study strongly suggests that CSO-affected streams are significant sources of Cx. quinquefasciatus mosquitoes that may facilitate WNV transmission to humans within urban environments. Our findings may have direct implications for the surveillance and control of WNV in other urban centers that continue to use CSO systems as a waste management practice

New theropod dinosaur teeth from the Middle Jurassic of the Isle of Skye, Scotland

Appendix 3:Datasets of theropod crown measurements used in the discriminant analysis and result of the discriminant analysis. The Excel sheet includes an updated version of Hendrickx et al.'s (2015) dataset as well as Smith and Lamanna's (2006) and Gerke and Wings' (2016) datasets of theropod crown measurements, all used in the discriminant analysis

Effects of noise exposure on young adults with normal audiograms I: electrophysiology

Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction in amplitude of wave I of the auditory brainstem response (ABR) to high-level stimuli, whereas the response at threshold is unaffected. The aim of the present study was to determine if this disorder is prevalent in young adult humans with normal audiometric hearing. One hundred and twenty six participants (75 females) aged 18-36 were tested. Participants had a wide range of lifetime noise exposures as estimated by a structured interview. Audiometric thresholds did not differ across noise exposures up to 8 kHz, although 16- kHz audiometric thresholds were elevated with increasing noise exposure for females but not for males. ABRs were measured in response to high-pass (1.5 kHz) filtered clicks of 80 and 100 dB peSPL. Frequency-following responses (FFRs) were measured to 80 dB SPL pure tones from 240- 285 Hz, and to 80 dB SPL 4 kHz pure tones amplitude modulated at frequencies from 240-285 Hz (transposed tones). The bandwidth of the ABR stimuli and the carrier frequency of the transposed tones were chosen to target the 3-6 kHz characteristic frequency region which is usually associated with noise damage in humans. The results indicate no relation between noise exposure and the amplitude of the ABR. In particular, wave I of the ABR did not decrease with increasing noise exposure as predicted. ABR wave V latency increased with increasing noise exposure for the 80 dB peSPL click. High carrier-frequency (envelope) FFR amplitudes decreased as a function of noise exposure in males but not females. However, these correlations were not significant after the effects of age were controlled. The results suggest either that noise-induced cochlear synaptopathy is not a significant problem in young, audiometrically normal adults, or that the ABR and FFR are relatively insensitive to this disorder in young humans, although it is possible that the effects become more pronounced with age

Recirculating Aquaculture Systems (RAS) analysis: main issues on management and future challenges

The main issues for Recirculating Aquaculture Systems (RAS) are analyzed, in order to lead to better solutions for future managers, identifying possible areas for improvements and future challenges for the industry. RAS-based production companies, researchers, system suppliers and consultants were interviewed separately, in order to gain an overall understanding of those systems and what developments could assist, in a positive way. Answers and subsequent analysis identified as significant barriers: poor participation by the producers; a disincentive on sharing information; and a lack of communication between different parties. The main issues are poor designs of the systems, as many had been modified after a previous approach was unsuitable; and their poor management, due mainly to an absence of skilled people taking responsibility for water quality and mechanical problems. As RAS will play an important role within the future of aquaculture, their enhancement is needed. Key priorities are the necessity to improve equipment performance, through researching at a commercial scale and further work on the best combinations of devices for each particular situation. Additional recommendations are for a specialized platform, to share knowledge on RAS, together with a more indepth and distinctive education programme

Participatory modelling for stakeholder involvement in the development of flood risk management intervention options

Advancing stakeholder participation beyond consultation offers a range of benefits for local flood risk management, particularly as responsibilities are increasingly devolved to local levels. This paper details the design and implementation of a participatory approach to identify intervention options for managing local flood risk. Within this approach, Bayesian networks were used to generate a conceptual model of the local flood risk system, with a particular focus on how different interventions might achieve each of nine participant objectives. The model was co-constructed by flood risk experts and local stakeholders. The study employs a novel evaluative framework, examining both the process and its outcomes (short-term substantive and longer-term social benefits). It concludes that participatory modelling techniques can facilitate the identification of intervention options by a wide range of stakeholders, and prioritise a subset for further investigation. They can help support a broader move towards active stakeholder participation in local flood risk management

Phage Therapy and Photodynamic Therapy: Low Environmental Impact Approaches to Inactivate Microorganisms in Fish Farming Plants

Owing to the increasing importance of aquaculture to compensate for the progressive worldwide reduction of natural fish and to the fact that several fish farming plants often suffer from heavy financial losses due to the development of infections caused by microbial pathogens, including multidrug resistant bacteria, more environmentally-friendly strategies to control fish infections are urgently needed to make the aquaculture industry more sustainable. The aim of this review is to briefly present the typical fish farming diseases and their threats and discuss the present state of chemotherapy to inactivate microorganisms in fish farming plants as well as to examine the new environmentally friendly approaches to control fish infection namely phage therapy and photodynamic antimicrobial therapy

Formulation and Bioequivalence Testing of Fixed-Dose Combination Orally Disintegrating Tablets for the Treatment of Tuberculosis in the Paediatric Population

Tuberculosis (TB) is believed to affect around 10 million people worldwide. Treatment for TB includes isoniazid and rifampicin, with fixed-dose combination (FDC) recommended for improved patient compliance. Similarly, orally disintegrating tablets (ODTs) are an increasingly popular dosage form that aid compliance since they do not require swallowing. In this study ODTs of isoniazid and rifampicin, either as discrete or FDC doses, were formulated and bioequivalence between single and combination doses compared using in vitro and in silico approaches. Dissolution profiles were compared using FDA advised difference (f 1) and similarity (f 2) testing in biorelevant media. Rifampicin release from FDCs decreased by approximately 15% in fed-state media (failed f 1 and f 2), which was attributed to enhanced rifampicin degradation in the presence of isoniazid at lower pH. Apparent permeability (P app) values derived from Caco-2 transport studies were included alongside dissolution results into a physiologically based pharmacokinetic (PBPK) model, to simulate in vivo bioavailability in healthy subjects. Models showed no difference in bioavailability between formulations or dosing (fasted or fed) state, despite the failures in dissolution-based bioequivalence testing, highlighting shortcomings in f 1 and f 2 assessment and the strength of PBPK models