Значение традиционных нравственно-эстетических ценностей в формировании духовного мира ребенка в произведениях Эмиля Амита

Предлагаемый вниманию материал посвящён значению традиционных нравственно-эстетических ценностей в формировании духовного мира подрастающего поколения. Обращение к испокон веков ценимым ценностям под пером автора обретает особое звучание.Пропонований увазі матеріал присвячений проблемі еволюції морального ідеалу в творчості Е.Аміт. Традиційні споконвічні ціності під пером автора набувають особливого звучання.The material which is proposed to you dedicated to a problem of the evolution of the moral ideal in the creation of A Rmit

Деградация человеческого потенциала как фактор латентной составляющей деятельности высшей школы Украины

Рассмотрены проблемы тенизации и коррупционности функционирования украин-ской высшей школы на фоне вектора развития показателей потенциала населения страны.Розглянуті проблеми тінізації і коррупційності функціонування української вищої школи на тлі вектору розвитку показників потенціалу населення країни

The ocean sampling day consortium

Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world’s oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits

The phenotype of Floating-Harbor syndrome: Clinical characterization of 52 individuals with mutations in exon 34 of SRCAP

Background: Floating-Harbor syndrome (FHS) is a rare condition characterized by short stature, delays in expressive language, and a distinctive facial appearance. Recently, heterozygous truncating mutations in SRCAP were determined to be disease-causing. With the availability of a DNA based confirmatory test, we set forth to define the clinical features of this syndrome. Methods and results. Clinical information on fifty-two individuals with SRCAP mutations was collected using standardized questionnaires. Twenty-four males and twenty-eight females were studied with ages ranging from

The Ocean Sampling Day Consortium

Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world’s oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

Synthesis-Structure-Performance Relationships for Supported Metal Catalysts

Heterogeneous catalysts, which consist of many metal nanoparticles supported on highly porous, mechanically strong and chemically inert supports, are at the center of many existing as well as new and more sustainable processes, such as energy conversion and storage, nanoelectronics and the catalytic production of fuels and chemicals. For rational development of these materials, a comprehensive understanding of the processes that play a role during their synthesis is of utmost importance. Moreover, degradation of such materials by growth of nanoparticles under process conditions is detrimental for their functionality. Therefore, understanding the method of degradation and devising strategies to prevent these is paramount. The synthesis of heterogeneous catalysts can be done in many different ways. However, the more complicated the technique, the more difficult and expensive they become to perform on a large scale, which is necessary if the catalyst is ever to be used on an industrial scale. The method of impregnation and drying is often preferred, whereby a metal precursor dissolved in water is impregnated onto a premade porous support, which is subsequently dried to remove the solvent and calcined to decompose the precursor into the desired metal (oxide). Metal nitrate precursors, which generally have a high solubility in water, are used to obtain high loadings in a single step. Moreover, by impregnating only the pores of the support, no filtration or waste water is produced. Unfortunately, the resulting size and distribution of the metal nanoparticles are often difficult to control, with large particles or small particles clumped together into large aggregates often the result. Catalysts that suffer from aggregation are those used in the conversion of syngas, a mixture of H2 and CO, to more useful products. In the Fischer-Tropsch synthesis, syngas is converted into long hydrocarbon chains for the production of clean and more sustainable transportation fuels and lubricants from feedstocks other than crude oil. Cobalt is the desired metal for Fischer-Tropsch synthesis, and is commonly prepared on an industrial scale via impregnation of a porous support with cobalt nitrate solution. However, aggregates of cobalt nanoparticles are often reported, although their effect on the activity, selectivity and stability of the catalyst performance is not well understood. Alternatively, syngas can be converted into methane known as the methanation reaction, used to clean up the hydrogen feed for industrial ammonia plants and for the production of synthetic natural gas. This reaction is performed over nickel catalysts, which exhibit a high activity but suffer from Ostwald ripening via nickel carbonyl species, leading to rapid deactivation. The present work focuses on the synthesis of cobalt and nickel catalysts from their respective metal nitrate precursors via impregnation. Of main interest was to achieve control over the degree of aggregation and the particle size by studying the synthesis, in particular the drying step, and to elucidate the effects of particle size and nanoscale distribution on the performance of the Fischer-Tropsch and methanation reactions