The prevalence of thumb problems in Australian physiotherapists is high: an observational study

QuestionWhat is the lifetime and current prevalence of thumb problems in Australian physiotherapists and what are the factors associated with thumb problems?DesignSurvey of a random cross-section of physiotherapists.Participants1562 (approximately 10% of the total) registered Australian physiotherapists.Outcome measuresGeneral questions covered demographic information, area of practice, hours worked per week, and years worked as a physiotherapist. Specific questions about thumb problems covered thumb affected, symptoms, onset of symptoms, treatment sought, relevance of work-related factors, and joint hypermobility.Results1102 (71%) questionnaires were returned and 961 (68%) completed. The lifetime prevalence of thumb problems was 65% and the current prevalence was 41%. Factors that were significantly associated with thumb problems included: working in orthopaedic outpatients (OR 3.2, 95% CI 1.8 to 5.8); using manual therapy (OR 2.3 to 3.4, 95% CI 1.7 to 5.1), trigger point therapy (OR 2.3, 95% CI 1.7 to 3.0) and massage (OR 2.1, 95% CI 1.6 to 2.8); having thumb joint hypermobility (OR 2.2 to 2.6, 95% CI 1.4 to 4.5); or an inability to stabilise the joints of the thumb whilst performing physiotherapy techniques (OR 4.2, 95% CI 2.9 to 5.9). Of those respondents who reported thumb problems, 19% had changed their area of practice and 4% had left the profession as a result of their thumb problems.ConclusionThe prevalence of thumb problems in Australian physiotherapists appears to be high and can be of sufficient severity to impact on careers

A star-forming galaxy at z= 5.78 in the Chandra Deep Field South

We report the discovery of a luminous z = 5.78 star-forming galaxy in the Chandra Deep Field South. This galaxy was selected as an ‘i-drop’ from the GOODS public survey imaging with the Hubble Space Telescope/Advanced Camera for Surveys (object 3 in the work of Stanway, Bunker & McMahon 2003). The large colour of (i′−z′)AB = 1.6 indicated a spectral break consistent with the Lyman α forest absorption shortward of Lyman α at z≈ 6. The galaxy is very compact (marginally resolved with ACS with a half-light radius of 0.08 arcsec, so rhl 5. Our spectroscopic redshift for this object confirms the validity of the i′-drop technique of Stanway et al. to select star-forming galaxies atz≈ 6

The Occupational Therapy Examination and Practice Preparation (OTepp) Program: Development, Implementation and Evaluation of an Educational Program for Internationally-Educated Occupational Therapists

This paper provides a chronological overview of the development, implementation, and evaluation of an educational initiative aimed at ensuring internationally-educated occupational therapists are prepared to enter practice in their new country, Canada. The three major phases of the program’s 12-year evolution are described, to distill the key lessons learned at each phase. Data related to the demographics of participants, program content, results of the national examination, registration, and employment outcomes are included. An enhanced understanding of the transition experience of internationally educated occupational therapists provides a strong foundation from which to support internationally-educated colleagues and strengthen the occupational therapy profession

The chemical basis of serine palmitoyltransferase inhibition by myriocin

Sphingolipids (SLs) are essential components of cellular membranes formed from the condensation of L-serine and a long-chain acyl thioester. This first step is catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent, enzyme serine palmitoyltransferase (SPT) which is a promising therapeutic target. The fungal natural product myriocin is a potent inhibitor of SPT and is widely used to block SL biosynthesis despite a lack of a detailed understanding of its molecular-mechanism. By combining spectroscopy, mass spectrometry, X-ray crystallography, and kinetics, we have characterized the molecular details of SPT inhibition by myriocin. Myriocin initially forms an external aldimine with PLP at the active site, and a structure of the resulting co-complex explains its nanomolar affinity for the enzyme. This co-complex then catalytically degrades via an unexpected 'retro-aldol-like' cleavage mechanism to a C18 aldehyde which in turn acts as a suicide inhibitor of SPT by covalent modification of the essential catalytic lysine. This surprising dual mechanism of inhibition rationalizes the extraordinary potency and longevity of myriocin inhibition.</p

Language endangerment and language documentation in Africa

Non peer reviewe