464 research outputs found
Cosmological Non-Linearities as an Effective Fluid
The universe is smooth on large scales but very inhomogeneous on small
scales. Why is the spacetime on large scales modeled to a good approximation by
the Friedmann equations? Are we sure that small-scale non-linearities do not
induce a large backreaction? Related to this, what is the effective theory that
describes the universe on large scales? In this paper we make progress in
addressing these questions. We show that the effective theory for the
long-wavelength universe behaves as a viscous fluid coupled to gravity:
integrating out short-wavelength perturbations renormalizes the homogeneous
background and introduces dissipative dynamics into the evolution of
long-wavelength perturbations. The effective fluid has small perturbations and
is characterized by a few parameters like an equation of state, a sound speed
and a viscosity parameter. These parameters can be matched to numerical
simulations or fitted from observations. We find that the backreaction of
small-scale non-linearities is very small, being suppressed by the large
hierarchy between the scale of non-linearities and the horizon scale. The
effective pressure of the fluid is always positive and much too small to
significantly affect the background evolution. Moreover, we prove that
virialized scales decouple completely from the large-scale dynamics, at all
orders in the post-Newtonian expansion. We propose that our effective theory be
used to formulate a well-defined and controlled alternative to conventional
perturbation theory, and we discuss possible observational applications.
Finally, our way of reformulating results in second-order perturbation theory
in terms of a long-wavelength effective fluid provides the opportunity to
understand non-linear effects in a simple and physically intuitive way.Comment: 84 pages, 3 figure
Non-Equilibrium Statistical Physics of Currents in Queuing Networks
We consider a stable open queuing network as a steady non-equilibrium system
of interacting particles. The network is completely specified by its underlying
graphical structure, type of interaction at each node, and the Markovian
transition rates between nodes. For such systems, we ask the question ``What is
the most likely way for large currents to accumulate over time in a network
?'', where time is large compared to the system correlation time scale. We
identify two interesting regimes. In the first regime, in which the
accumulation of currents over time exceeds the expected value by a small to
moderate amount (moderate large deviation), we find that the large-deviation
distribution of currents is universal (independent of the interaction details),
and there is no long-time and averaged over time accumulation of particles
(condensation) at any nodes. In the second regime, in which the accumulation of
currents over time exceeds the expected value by a large amount (severe large
deviation), we find that the large-deviation current distribution is sensitive
to interaction details, and there is a long-time accumulation of particles
(condensation) at some nodes. The transition between the two regimes can be
described as a dynamical second order phase transition. We illustrate these
ideas using the simple, yet non-trivial, example of a single node with
feedback.Comment: 26 pages, 5 figure
Effect of laser treatment on the attachment and viability of mesenchymal stem cell responses on shape memory NiTi alloy
The objectives of this study were to investigate the effect of laser-induced surface features on the morphology, attachment and viability of mesenchymal stem cells (MSCs) at different periods of time, and to evaluate the biocompatibility of different zones: laser-melted zone (MZ), heat-affected zone (HAZ) and base metal (BM) in laser-treated NiTi alloy. The surface morphology and composition were studied by scanning electron microscope (SEM) and X-ray photoemission spectroscopy (XPS), respectively. The cell morphology was examined by SEM while the cell counting and viability measurements were done by hemocytometer and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. The results indicated that the laser-induced surface features, such as surface roughening, presence of anisotropic dendritic pattern and complete surface Ni oxidation were beneficial to improve the biocompatibility of NiTi as evidenced by the highest cell attachment (4 days of culture) and viability (7 days of culture) found in the MZ. The biocompatibility of the MZ was the best, followed by the BM with the HAZ being the worst. The defective and porous oxide layer as well as the coarse grained structure might attribute to the inferior cell attachment (4 days of culture) and viability (7 days of culture) on the HAZ compared with the BM which has similar surface morphology. Ă© 2014 Elsevier B.V
Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma
A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to ÎČ-lactam cleavage in mouse plasma
Reading Ronaldo: contingent whiteness in the football media
Ever since his introduction to the first-Â-team at Manchester United FC, Cristiano Ronaldo Dos Santos Aveiro has been recognised as one of the footballing worldâs most stand-Â-out football players. In turn, Ronaldo has drawn the attention of scholars working across a number of disciplines. While sports economists and sociologists of sport, amongst others, have contributed to a growing literature about Ronaldo and the social implications of his on and off-Â-field behaviour, few critical analyses have considered the racialised aspects of Ronaldoâs representations, or how audiences make sense of his racialised or ethnic identity. Using images of Ronaldo, which we presented to and discussed with self-Â-identified physically active white British men, we explore what it is representations and audience interpretations of Ronaldo reveal about the complexities of white male identity formation. We do this to understand better how white male identities can be read and interpreted through and in the context of football. Facilitated by our conception of contingent whiteness, we argue that white British menâs interpretations of Ronaldoâs whiteness are inextricably linked to discourses of âraceâ, masculinities and football
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in âs = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fbâ1 of protonâproton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC
Measurements of inclusive jet suppression in heavy ion collisions at the LHC
provide direct sensitivity to the physics of jet quenching. In a sample of
lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated
luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with
a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the
transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the
anti-kt algorithm with values for the distance parameter that determines the
nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of
the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp.
Jet production is found to be suppressed by approximately a factor of two in
the 10% most central collisions relative to peripheral collisions. Rcp varies
smoothly with centrality as characterized by the number of participating
nucleons. The observed suppression is only weakly dependent on jet radius and
transverse momentum. These results provide the first direct measurement of
inclusive jet suppression in heavy ion collisions and complement previous
measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables,
submitted to Physics Letters B. All figures including auxiliary figures are
available at
http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02
The Structure of a Rigorously Conserved RNA Element within the SARS Virus Genome
We have solved the three-dimensional crystal structure of the stem-loop II motif (s2m) RNA element of the SARS virus genome to 2.7-Ă
resolution. SARS and related coronaviruses and astroviruses all possess a motif at the 3âČ end of their RNA genomes, called the s2m, whose pathogenic importance is inferred from its rigorous sequence conservation in an otherwise rapidly mutable RNA genome. We find that this extreme conservation is clearly explained by the requirement to form a highly structured RNA whose unique tertiary structure includes a sharp 90° kink of the helix axis and several novel longer-range tertiary interactions. The tertiary base interactions create a tunnel that runs perpendicular to the main helical axis whose interior is negatively charged and binds two magnesium ions. These unusual features likely form interaction surfaces with conserved host cell components or other reactive sites required for virus function. Based on its conservation in viral pathogen genomes and its absence in the human genome, we suggest that these unusual structural features in the s2m RNA element are attractive targets for the design of anti-viral therapeutic agents. Structural genomics has sought to deduce protein function based on three-dimensional homology. Here we have extended this approach to RNA by proposing potential functions for a rigorously conserved set of RNA tertiary structural interactions that occur within the SARS RNA genome itself. Based on tertiary structural comparisons, we propose the s2m RNA binds one or more proteins possessing an oligomer-binding-like fold, and we suggest a possible mechanism for SARS viral RNA hijacking of host protein synthesis, both based upon observed s2m RNA macromolecular mimicry of a relevant ribosomal RNA fold
Baryons: What, When and Where?
We review the current state of empirical knowledge of the total budget of
baryonic matter in the Universe as observed since the epoch of reionization.
Our summary examines on three milestone redshifts since the reionization of H
in the IGM, z = 3, 1, and 0, with emphasis on the endpoints. We review the
observational techniques used to discover and characterize the phases of
baryons. In the spirit of the meeting, the level is aimed at a diverse and
non-expert audience and additional attention is given to describe how space
missions expected to launch within the next decade will impact this scientific
field.Comment: Proceedings Review for "Astrophysics in the Next Decade: JWST and
Concurrent Facilities", ed. X. Tielens, 38 pages, 10 color figures. Revised
to address comments from the communit
- âŠ