Conflicts in the Metaphysical Foundations of Schopenhauer’s Ethics

Schopenhauer encourages us towards sympathy and empathy for others by holding that compassion is the foundation and essence of ethics; but when we turn to his philosophical system, we encounter conflicts that negate his ethics and in practice, compassion has no opportunity to manifest itself. Some of the conflicts are as follows: the negation of free will in his metaphysics, the evilness of will, the essentiality and immutability of personality (character) and the evilness of man’s essence. In his metaphysics he believes that everything in the world as determined by will, comes under the principle of sufficient reason, and time and space and necessarily becomes objective. As the foundation of ethics, the human will must also naturally come under the principle of sufficient reason and necessarily become objective; in this case, Schopenhauer’s ethics is fundamentally negated, because ethics requires freedom and to remain outside the realm of the principle of sufficient reason. Similarly, in believing in the evilness of will, the essentiality and immutability of personality and in the evilness of man’s essence, Schopenhauer’s ethics is negated – at least from the normative type, and one cannot visualize a positive place for it in his philosophical system

Executive functions and information processing in patients with type 2 diabetes in comparison to pre-diabetic patients

BACKGROUND: Diabetes is associated with cognitive decline or dementia. The purpose of this study was to assess the executive functions and information processing in patients with type 2diabetes in comparison to pre-diabetic patients and normal subjects in Endocrine and Metabolism Research Center of Isfahan City from April to July 2011. METHODS: The sample consisted of 32 patients with type 2 diabetes, 28 pre-diabetic patients and 30 healthy individuals. Executive functions were assessed by Wisconsin Card Sorting Test (WCST). Information processing was assessed by Paced Auditory Serial Addition Test (PASAT) and sub tests of Wechsler Adult Intelligence Scale-Revised (WAIS-R). RESULTS: There was a significant difference among 3 groups, after the variables of age, sex and academic status were controlled (p ≤ 0.001). The pairwise comparisons of executive functions among three groups suggest a significant difference between diabetic and normal groups in WCST (perseveration) p = 0.018, and significant difference between diabetic and pre-diabetic patient in WCST (perseveration) p = 0.019. But there was no difference between three groups in WCST (category) and WCST (conceptual responses). The pairwise comparisons of information processing among three groups, suggest a significant difference between diabetic and normal groups in PASAT3". PASAT2", and Symbol coding (P = 0.003, P = 0.009, and P = 0.001, respectively). There was a significant correlation between demographic variable (FBS, HbA1c) and Symbol coding p = 0.05, p = 0.01 respectively) and significant correlation between (cholesterol) and WCST (conceptual responses) p = 0.05. The other variables were not correlated. CONCLUSION: There were significant differences in executive function and information processing in patients with type 2 diabetic and normal individuals. Thus, monitoring neuropsychological status besides controlling levels of blood sugar in these patients is important

An exploration study on factors influencing on market orientation: A case study of tourism industry

During the past two decades, tourism industry has become popular among many researchers in developing countries. Tourism is able to attract substantial amount of investment to some areas where many investors are normally unwilling to invest in. This paper, presents important factors influencing market orientation in tourism industry based on the implementation of factor analysis. The proposed study designs a questionnaire and distributes it among 267 experts who are involved in tourism industry. Cronbach alpha has been calculated as 0.873, which validates the overall questionnaire. The results of factor analysis have indicated that six factors of market oriented, limiting rules and regulations, strategic competition, marketing planning culture, financial figures and top management

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

Among several attempts to integrate tissue engineering concepts into strategies to repair different parts of the human body, neuronal repair stands as a challenging area due to the complexity of the structure and function of the nervous system and the low efficiency of conventional repair approaches. Herein, electrospun polyvinyl alcohol (PVA)/chitosan nano-fibrous scaffolds have been synthesized with large pore sizes as potential matrices for nervous tissue engineering and repair. PVA fibers were modified through blending with chitosan and porosity of scaffolds was measured at various levels of their depth through an image analysis method. In addition, the structural, physicochemical, biodegradability, and swelling of the chitosan nanofibrous scaffolds were evaluated. The chitosan-containing scaffolds were used for in vitro cell culture in contact with PC12 nerve cells, and they were found to exhibit the most balanced properties to meet the basic required specifications for nerve cells. It could be concluded that addition of chitosan to the PVA scaffolds enhances viability and proliferation of nerve cells, which increases the biocompatibility of the scaffolds. In fact, addition of a small percentage of chitosan to the PVA scaffolds proved to be a promising approach for synthesis of a neural-friendly polymeric blend

Blood pressure percentiles by age and body mass index for adults

Since no comprehensive study has been conducted on blood pressure (BP) percentiles established upon nationally representative sample population of adults, the present study aimed to construct the blood pressure percentiles by age, sex and body mass index (BMI) of the subjects. Analyses were based on data collected in 2011 from 8,425 adults aged 25 to 69 years old. Data on demographic characteristics, anthropometric measurements, and blood pressure was recorded for each subject. Linear Regression analysis was used to assess the adjusted relationship of age-sex-specific standard deviation scores of BMI, height, and weight with blood pressure. Four separate models for systolic blood pressure (SBP) and diastolic blood pressure (DBP) of men and women were constructed for BP percentiles according to age and BMI. Blood pressure increased with the rise in BMI and weight, but showed a negative correlation with height. SBP and DBP rose steadily with increasing age, but the rise in SBP was greater than DBP. Overweight and obese population, seem to fall into the category of hypertensive. The findings of present study show that BP percentiles are steadily increased by age and BMI. In addition, most obese or overweight adults are hypertensive

Synthesis and characterization of a novel chemically designed (Globo)3–DTPA–KLH antigen

In recent years, many experiments have been conducted for the production and evaluation of anticancer glycoconjugated vaccines in developed countries and many achievements have been accomplished with Globo H derivatives. In the current experiment, a new chemically designed triplicate version of (Globo H)3–diethylenetriamine pentaacetic acid (DTPA)–KLH antigen was synthesized and characterized. Immunization with (Globo H)3-DTPA-KLH, a hexasaccharide that is a member of a family of antigenic carbohydrates that are highly expressed in various types of cancers conjugated with DTPA and KLH protein, induced a high level of antibody titer along with an elevated level of IL-4 in mice. Treatment of tumors with the collected sera from immunized mice decreased the tumor size in nude mice as well. None of the immunized mice illustrated any sign of tumor growth after injection of MCF-7 cells compared to the control animals. These findings, based on the newly presented structure of the Globo H antigen, lend exciting and promising evidence for clinical advancement in the development of a therapeutic vaccine in the future

ارزیابی ریسک نسبی اثرات تحریکی در تراشکاران مواجهه یافته با میست مایعات فلزکاری منتخب از شهر تهران

Background and Objectives: Occupational exposure to metalworking fluid mist causes respiratory irritation. This study aimed to assess the relative risk of irritating effects in occupational exposure to metalworking fluids of lathe process. Materials and Methods: Sixty-five subjects exposed to oil mist as exposed group and 65 administrative staff of the same industry as control group were selected. Health and Safety Executive/Health and Safety Laboratory (HSE/HSL) questionnaire was used for irritating effects. The US National Institutes of Health and Safety (NIOSH) method 5026 was used to monitoring respiratory exposure to oil mist. We also calculated the relative risk of irritating symptoms using MedCalc software. The study was approved by the ethics committee and conducted with the consent of participants. Results: The mean time-weighted exposure to mineral oil mist in lathe workers was 7.10±3.49 mg/m3. The amount of throat irritation in machinists was significantly higher than the control group (p-value = 0.044).The relative risk of irritating effects in the eyes, nose, mouth and throat in machinists is slightly higher than control subjects (p-value = 0.05). Conclusion: In this study, the occupational exposure in 67% of lathe workers is higher than recommended exposure limit in Iran. Subjects by oil mists exposure represented a risk of irritating effects in the respiratory tract, especially the throat. For this reason, continuous assessment and control of exposure is are needed to reduce the risk of chronic diseases.زمینه و اهداف: مواجهه شغلی با میست مایعات فلزکاری باعث بروز اثرات تحریکی در مجاری تنفسی می‌گردد. هدف مطالعه حاضر ارزیابی ریسک نسبی اثرات تحریکی در مواجهه شغلی با میست مایعات فلزکاری در تراشکاری است. مواد و روش­ها: در این مطالعه 65 نفر از تراشکاران مواجهه یافته با میست روغن به‌عنوان گروه مواجهه و 65 نفر از کادر اداری همان صنعت به‌عنوان گروه کنترل انتخاب گردیدند. جهت بررسی اثرات تحریکی میست روغن از پرسشنامه آژانس ایمني، بهداشت و محیط‌زیست/آزمایشگاه ایمني و بهداشت HSE/HSL و جهت پایش میزان مواجهه تنفسی با میست روغن از روش 5026 انستیتو ملی ایمنی و بهداشت آمریکا (NIOSH) استفاده شد. میزان ریسک نسبی علائم تحریکی نیز با استفاده از نرم­افزار MedCalc محاسبه شد. مطالعه حاضر دارای تاییدیه کمیته اخلاق بوده و با کسب رضایت از شرکت­کنندگان انجام‌شده است. یافته­ ها: میانگین مواجهه وزنی-زمانی با میست روغن معدنی در کارگران تراشکاری 49/3 ± 10/7 میلی‌گرم در مترمکعب ارزیابی شد. تحریک حلق در ماشینکاران به‌طور معناداری بالاتر از گروه شاهد است (044/0 p-value=). ریسک نسبی عوارض تحریک در چشم، بینی، دهان و حلق در ماشینکاران اندکی بالاتر از افراد گروه شاهد محاسبه شد (05/0 p-value=). نتیجه‌گیری: در این مطالعه مواجهه شغلی در 67٪ از کارگران تراشکاری بالاتر از حد توصیه‌شده در ایران است. ریسک اثرات تحریکی در مجاری تنفسی به‌ویژه حلق در ماشینکاران دارای مواجهه با میست مایعات فلزکاری نسبت به گروه کنترل بالاتر است. به همین دلیل ضرورت ارزیابی و کنترل مداوم مواجهه در جهت کاهش ریسک و پیشگیری از بروز بیماری‌های مزمن مدنظر قرار دارد

Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort

\ua9 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Individuals with rare kidney diseases account for 5–10% of people with chronic kidney disease, but constitute more than 25% of patients receiving kidney replacement therapy. The National Registry of Rare Kidney Diseases (RaDaR) gathers longitudinal data from patients with these conditions, which we used to study disease progression and outcomes of death and kidney failure. Methods: People aged 0–96 years living with 28 types of rare kidney diseases were recruited from 108 UK renal care facilities. The primary outcomes were cumulative incidence of mortality and kidney failure in individuals with rare kidney diseases, which were calculated and compared with that of unselected patients with chronic kidney disease. Cumulative incidence and Kaplan–Meier survival estimates were calculated for the following outcomes: median age at kidney failure; median age at death; time from start of dialysis to death; and time from diagnosis to estimated glomerular filtration rate (eGFR) thresholds, allowing calculation of time from last eGFR of 75 mL/min per 1\ub773 m2 or more to first eGFR of less than 30 mL/min per 1\ub773 m2 (the therapeutic trial window). Findings: Between Jan 18, 2010, and July 25, 2022, 27 285 participants were recruited to RaDaR. Median follow-up time from diagnosis was 9\ub76 years (IQR 5\ub79–16\ub77). RaDaR participants had significantly higher 5-year cumulative incidence of kidney failure than 2\ub781 million UK patients with all-cause chronic kidney disease (28% vs 1%; p<0\ub70001), but better survival rates (standardised mortality ratio 0\ub742 [95% CI 0\ub732–0\ub752]; p<0\ub70001). Median age at kidney failure, median age at death, time from start of dialysis to death, time from diagnosis to eGFR thresholds, and therapeutic trial window all varied substantially between rare diseases. Interpretation: Patients with rare kidney diseases differ from the general population of individuals with chronic kidney disease: they have higher 5-year rates of kidney failure but higher survival than other patients with chronic kidney disease stages 3–5, and so are over-represented in the cohort of patients requiring kidney replacement therapy. Addressing unmet therapeutic need for patients with rare kidney diseases could have a large beneficial effect on long-term kidney replacement therapy demand. Funding: RaDaR is funded by the Medical Research Council, Kidney Research UK, Kidney Care UK, and the Polycystic Kidney Disease Charity

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic

Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.publishedVersio