When Packaged Food Pollutes our Body and Earth: Plastic Packaged Food Consumption and Waste Disposal Practices in the Himalayas

The purpose of our field study project is to examine current waste disposal practices and food preferences in rural Himalayan agricultural communities and to communicate the results, as well as our own outside research, to the villagers in Sikkim. We hope to promote safe disposal practices of packaged plastic, to offer responsible alternatives to packaged waste disposal, and to encourage the consumption of organic, homegrown food for all ages to benefit both human and environmental well-being

Environmental Management in Richmond, Virginia: A Case Study of Reedy Creek

This report analyzes the Reedy Creek restoration project through four distinct lenses and aims to achieve a fuller understanding of the factors influencing the project’s success or failure. We hope this report contributes to a greater appreciation of the complex and vast amount of decisions both cities and stakeholders make when complying with environmental regulations. Moreover, we hope to provide invaluable learning opportunities for future environmental projects undertaken in the City of Richmond. Paper prepared for the Environmental Studies Senior Seminar/Geography Capstone.Faculty Advisor: Dr. David Salisbur

Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia

The Birt–Hogg–Dubé (BHD) disease is a genetic cancer syndrome. The responsible gene, BHD, has been identified by positional cloning and thought to be a novel tumor suppressor gene. BHD mutations cause many types of diseases including renal cell carcinomas, fibrofolliculomas, spontaneous pneumothorax, lung cysts, and colonic polyps/cancers. By combining Gateway Technology with the Ksp-Cre gene knockout system, we have developed a kidney-specific BHD knockout mouse model. BHDflox/flox/Ksp-Cre mice developed enlarged kidneys characterized by polycystic kidneys, hyperplasia, and cystic renal cell carcinoma. The affected BHDflox/flox/Ksp-Cre mice died of renal failure at approximate three weeks of age, having blood urea nitrogen levels over tenfold higher than those of BHD flox/+/Ksp-Cre and wild-type littermate controls. We further demonstrated that these phenotypes were caused by inactivation of BHD and subsequent activation of the mTOR pathway. Application of rapamycin, which inhibits mTOR activity, to the affected mice led to extended survival and inhibited further progression of cystogenesis. These results provide a correlation of kidney-targeted gene inactivation with renal carcinoma, and they suggest that the BHD product FLCN, functioning as a cyst and tumor suppressor, like other hamartoma syndrome–related proteins such as PTEN, LKB1, and TSC1/2, is a component of the mTOR pathway, constituting a novel FLCN-mTOR signaling branch that regulates cell growth/proliferation

PTF1 J082340.04+081936.5: A Hot Subdwarf B Star with a Low-mass White Dwarf Companion in an 87-minute Orbit

We present the discovery of the hot subdwarf B star (sdB) binary PTF1 J082340.04+081936.5. The system has an orbital period of P_(orb) = 87.49668(1) minutes (0.060761584(10) days), making it the second-most compact sdB binary known. The light curve shows ellipsoidal variations. Under the assumption that the sdB primary is synchronized with the orbit, we find a mass of M_(sdB) = 0.45_(-0.07)^(+0.09) M_⊙, a companion white dwarf mass of M_(WD) = 0.46_(-0.09)^(+0.12) M_⊙, and a mass ratio of q = M_(WD)/M_(sdB) = 1.03_(-0.08)^(+0.10). The future evolution was calculated using the MESA stellar evolution code. Adopting a canonical sdB mass of M_(sdB) = 0.47 M_⊙, we find that the sdB still burns helium at the time it will fill its Roche lobe if the orbital period was less than 106 minutes at the exit from the last common envelope (CE) phase. For longer CE exit periods, the sdB will have stopped burning helium and turned into a C/O white dwarf at the time of contact. Comparing the spectroscopically derived log g and T_(eff) with our MESA models, we find that an sdB model with a hydrogen envelope mass of 5 x 10^(-4) M_⊙ matches the measurements at a post-CE age of 94 Myr, corresponding to a post-CE orbital period of 109 minutes, which is close to the limit to start accretion while the sdB is still burning helium

Exploring Beethoven: An All Beethoven Gala Concert

Program listing performers and works performe

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research