El arte una estrategia para descubrir el mundo interior del ni?o

388 p. Recurso Electr?nicoLa investigaci?n realizada ?El arte una estrategia para descubrir el mundo interior del ni?o?, tuvo como prop?sito la transformaci?n de las pr?cticas que circulan en las aulas, generando procesos significativos en los ni?os de 4 a 5 a?os. En la investigaci?n se expuso la est?tica y la art?stica, como uno de los medios que lleva al estudiante a pensar, a crear, a expresarse espont?neamente, percibir, pensar, expresar sus inquietudes y dar puntos de vista sobre lo que ve y lo que piensa. La investigaci?n fue posible por medio de la intervenci?n de tres n?cleos denominados la pintura, el paisaje y la escena, cada uno de estos con subactividades, que permitieron aflorar sentimientos en los ni?os, los cuales se hac?an evidentes en el placer que demostraban al ejecutarlas y al observar sus rostros de asombro frente a las creaciones y producciones realizadas por ellos mismos los cuales formulaban preguntas encaminadas al enriquecimiento de su imaginaci?n, curiosidad y creatividad. Esta propuesta fue realizada teniendo en cuenta la metodolog?a investigaci?n- acci?n- participaci?n de corte etnogr?fico, la cual, promueve y facilita la generaci?n de impacto, la transformaci?n de realidades inmediatas y la resoluci?n de problemas cotidianos teniendo en cuenta la participaci?n activa, la reflexi?n y la construcci?n colectiva de saberes.The investigation is called "The art as a strategy to discover the inner world of the child" which aims the transformation of the practices that circulate in classrooms generating significant processes in children 4-5 years old. In this research the aesthetic and artistic as one of the means that leads the student to think, to create, to express themselves spontaneously, perceive, think, express their concerns and give views on what he sees is exposed and what you think. The research was made possible through the intervention of three cores called the painting, the landscape and the scene with each of these sub-activities, which allowed out feelings in children, which were evident pleasure in showing to execute and observe their faces with astonishment at the creations and productions by themselves which formulated questions designed to enrich their imagination, curiosity and creativity. This proposal was made according the research-action-participation methodology ethnographic, which promotes and facilitates the generation of the impact, the transformation of immediate realities and solving everyday problems taking into account the active participation, reflection and the collective construction of knowledge. Keywords: research, aesthetic, artistic, thinking, painting, scene, scenery, imagination, creativity, action, participation

Atributos que determinan la elecci?n de viviendas por adultos j?venes de 25 a 35 a?os en Lima Metropolitana

En este estudio se investiga los atributos que determinan la elecci?n de vivienda por parte de los jovenes adultos entre los 25 a. 35 a?os en Lima Metropolitana. En primera instancia, los atributos que se consideraron se recogieron de literatura existente en trabajos de investigaci?n de pa?ses europoeos y del medio oriente; los cuales se filtraron con la realidad peruana, obteni?ndose un total de quince atributos con dos niveles que se categorizan en atributos b?sicos, adicionales y de entorno. La herramienta utilizada para la investigaci?n es el an?lisis conjunto, la muestra depurada es de 144 encuestados a los cuales se les pregunt? su nivel de preferencias por determinado perfil, obteniendose un total de 2304 perfiles evaluados. Los resultados obtenidos muestran la mayor utilidad de atributos como ?rea, precio, cercan?a al trabajo y estacionamiento. Tambi?n podemos decir que el comportamiento de individuos con caracter?sticas sociodemogr?ficas homog?neos no necesariamente son similares, mediante el cruce de los atributos y el perfil sociodemogr?fico, incluso, al analizar la muestra se puede observar que los comportamientos del individuo se extrapolan en los dos niveles siguiendo preferencias en sentidos contrarios incluso con perfil homog?neos en base al cual los expertos del sector desarrollan los productos inmobiliarios

New flavonoid \u2013 N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer\ub4s disease endowed with neurogenic properties

The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for complex pathologies. MTDLs that combine neuro-repair properties and block the first steps of neurotoxic cascades could be the so long wanted remedies to treat neurodegenerative diseases (NDs). By linking two privileged scaffolds with well-known activities in ND-targets, the flavonoid and the N,N-dibenzyl(N-methyl)amine (DBMA) fragments, new CNS-permeable flavonoid \u2013 DBMA hybrids (1\u201313) were obtained. They were subjected to biological evaluation in a battery of targets involved in Alzheimer\u2019s disease (AD) and other NDs, namely human cholinesterases (hAChE/hBuChE), \u3b2-secretase (hBACE-1), monoamine oxidases (hMAO-A/B), lipoxygenase-5 (hLOX-5) and sigma receptors (\u3c31R/\u3c32R). After a funnel-type screening, 6,7-dimethoxychromone \u2013 DBMA (6) was highlighted due to its neurogenic properties and an interesting MTD-profile in hAChE, hLOX-5, hBACE-1 and \u3c31R. Molecular dynamic simulations showed the most relevant drug-protein interactions of hybrid 6, which could synergistically contribute to neuronal regeneration and block neurodegeneration

Strange particle production in proton-proton collisions at s=0.9\sqrt{s}=0.9 TeV with ALICE at the LHC

The production of mesons containing strange quarks (K$^0_s$, $\phi$) and both singly and doubly strange baryons ($\Lambda$, Anti-$\Lambda$, and $\Xi$+Anti-$\Xi$) are measured at central rapidity in pp collisions at $\sqrt{s}$ = 0.9 TeV with the ALICE experiment at the LHC. The results are obtained from the analysis of about 250 k minimum bias events recorded in 2009. Measurements of yields (dN/dy) and transverse momentum spectra at central rapidities for inelastic pp collisions are presented. For mesons, we report yields () of 0.184 $\pm$ 0.002 stat. $\pm$ 0.006 syst. for K$^0_s$ and 0.021 $\pm$ 0.004 stat. $\pm$ 0.003 syst. for $\phi$. For baryons, we find = 0.048 $\pm$ 0.001 stat. $\pm$ 0.004 syst. for $\Lambda$, 0.047 $\pm$ 0.002 stat. $\pm$ 0.005 syst. for Anti-$\Lambda$ and 0.0101 $\pm$ 0.0020 stat. $\pm$ 0.0009 syst. for $\Xi$+Anti-$\Xi$. The results are also compared with predictions for identified particle spectra from QCD-inspired models and provide a baseline for comparisons with both future pp measurements at higher energies and heavy-ion collisions.Comment: 33 pages, 21 captioned figures, 10 tables, authors from page 28, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/387

Particle-yield modification in jet-like azimuthal di-hadron correlations in Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76 TeV

The yield of charged particles associated with high-$p_{\rm T}$ trigger particles ($8 < p_{\rm T} < 15$ GeV/$c$) is measured with the ALICE detector in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV relative to proton-proton collisions at the same energy. The conditional per-trigger yields are extracted from the narrow jet-like correlation peaks in azimuthal di-hadron correlations. In the 5% most central collisions, we observe that the yield of associated charged particles with transverse momenta $p_{\rm T}> 3$ GeV/$c$ on the away-side drops to about 60% of that observed in pp collisions, while on the near-side a moderate enhancement of 20-30% is found.Comment: 15 pages, 2 captioned figures, 1 table, authors from page 10, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/350

Elliptic flow of charged particles in Pb-Pb collisions at 2.76 TeV

We report the first measurement of charged particle elliptic flow in Pb-Pb collisions at 2.76 TeV with the ALICE detector at the CERN Large Hadron Collider. The measurement is performed in the central pseudorapidity region (|$\eta$|<0.8) and transverse momentum range 0.2< $p_{\rm T}$< 5.0 GeV/$c$. The elliptic flow signal v$_2$, measured using the 4-particle correlation method, averaged over transverse momentum and pseudorapidity is 0.087 $\pm$ 0.002 (stat) $\pm$ 0.004 (syst) in the 40-50% centrality class. The differential elliptic flow v$_2(p_{\rm T})$ reaches a maximum of 0.2 near $p_{\rm T}$ = 3 GeV/$c$. Compared to RHIC Au-Au collisions at 200 GeV, the elliptic flow increases by about 30%. Some hydrodynamic model predictions which include viscous corrections are in agreement with the observed increase.Comment: 10 pages, 4 captioned figures, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/389

Suppression of charged particle production at large transverse momentum in central Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}} = 2.76 TeV

Inclusive transverse momentum spectra of primary charged particles in Pb-Pb collisions at $\sqrt{s_{_{\rm NN}}}$ = 2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0-5% and 70-80% of the hadronic Pb-Pb cross section. The measured charged particle spectra in $|\eta|<0.8$ and $0.3 < p_T < 20$ GeV/$c$ are compared to the expectation in pp collisions at the same $\sqrt{s_{\rm NN}}$, scaled by the number of underlying nucleon-nucleon collisions. The comparison is expressed in terms of the nuclear modification factor $R_{\rm AA}$. The result indicates only weak medium effects ($R_{\rm AA} \approx$ 0.7) in peripheral collisions. In central collisions, $R_{\rm AA}$ reaches a minimum of about 0.14 at $p_{\rm T}=6$-7GeV/$c$ and increases significantly at larger $p_{\rm T}$. The measured suppression of high-$p_{\rm T}$ particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb-Pb collisions at the LHC.Comment: 15 pages, 5 captioned figures, 3 tables, authors from page 10, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/98

Two-pion Bose-Einstein correlations in central Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76 TeV

The first measurement of two-pion Bose-Einstein correlations in central Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV at the Large Hadron Collider is presented. We observe a growing trend with energy now not only for the longitudinal and the outward but also for the sideward pion source radius. The pion homogeneity volume and the decoupling time are significantly larger than those measured at RHIC.Comment: 17 pages, 5 captioned figures, 1 table, authors from page 12, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/388

Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx

Background: Genomic studies of endangered species provide insights into their evolution and demographic history, reveal patterns of genomic erosion that might limit their viability, and offer tools for their effective conservation. The Iberian lynx (Lynx pardinus) is the most endangered felid and a unique example of a species on the brink of extinction. Results: We generate the first annotated draft of the Iberian lynx genome and carry out genome-based analyses of lynx demography, evolution, and population genetics. We identify a series of severe population bottlenecks in the history of the Iberian lynx that predate its known demographic decline during the 20th century and have greatly impacted its genome evolution. We observe drastically reduced rates of weak-to-strong substitutions associated with GC-biased gene conversion and increased rates of fixation of transposable elements. We also find multiple signatures of genetic erosion in the two remnant Iberian lynx populations, including a high frequency of potentially deleterious variants and substitutions, as well as the lowest genome-wide genetic diversity reported so far in any species. Conclusions: The genomic features observed in the Iberian lynx genome may hamper short- and long-term viability through reduced fitness and adaptive potential. The knowledge and resources developed in this study will boost the research on felid evolution and conservation genomics and will benefit the ongoing conservation and management of this emblematic species

Large Magnetoresistance of Isolated Domain Walls in La2/3Sr1/3MnO3 Nanowires

Generation, manipulation, and sensing of magnetic domain walls are cornerstones in the design of efficient spintronic devices. Half-metals are amenable for this purpose as large low field magnetoresistance signals can be expected from spin accumulation at spin textures. Among half metals, La1−xSrxMnO3 (LSMO) manganites are considered as promising candidates for their robust half-metallic ground state, Curie temperature above room temperature (Tc = 360 K, for x = 1/3), and chemical stability. Yet domain wall magnetoresistance is poorly understood, with large discrepancies in the reported values and conflicting interpretation of experimental data due to the entanglement of various source of magnetoresistance, namely, spin accumulation, anisotropic magnetoresistance, and colossal magnetoresistance. In this work, the domain wall magnetoresistance is measured in LSMO cross-shape nanowires with single-domain walls nucleated across the current path. Magnetoresistance values above 10% are found to be originating at the spin accumulation caused by the mistracking effect of the spin texture of the domain wall by the conduction electrons. Fundamentally, this result shows the importance on non-adiabatic processes at spin textures despite the strong Hund coupling to the localized t2g electrons of the manganite. These large magnetoresistance values are high enough for encoding and reading magnetic bits in future oxide spintronic sensors. © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.G.O. and D.S.-M. contributed equally to this work. The authors ac-knowledge received funding from the project To2Dox of FlagERA ERA-NET Cofund in Quantum Technologies implemented within the Euro-pean Union’s Horizon 2020 Program. This work was supported by Span-ish AEI through grants, PID2020-118078RB-I00, PID2020-11556RB-100and PID2020-117024GB-C43 and by Regional Government of MadridCAM through SINERGICO project Y2020/NMT-6661 CAIRO-CM. S.R.-G.also gratefully acknowledges the financial support of the Alexander vonHumboldt foundation. Work at CNRS/Thales supported by French ANR-22CE30-0020 "SUPERFAST". J.J.R was supported by the CSIC program forthe Spanish Recovery, Transformation and Resilience Plan funded by the Recovery and Resilience EU Facility EU regulation 2020/2094. The authorsthank the Helmholtz-Zentrum Berlin für Materialien und Energie for theallocation of synchrotron radiation beamtime.Open access funding enabled and organized by Projekt DEAL.Supporting InformationPeer reviewe