596 research outputs found
Using food-web theory to conserve ecosystems
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/11/2015
- Field of study
© 2016, Nature Publishing Group. All rights reserved.Food-web theory can be a powerful guide to the management of complex ecosystems. However, we show that indices of species importance common in food-web and network theory can be a poor guide to ecosystem management, resulting in significantly more extinctions than necessary. We use Bayesian Networks and Constrained Combinatorial Optimization to find optimal management strategies for a wide range of real and hypothetical food webs. This Artificial Intelligence approach provides the ability to test the performance of any index for prioritizing species management in a network. While no single network theory index provides an appropriate guide to management for all food webs, a modified version of the Google PageRank algorithm reliably minimizes the chance and severity of negative outcomes. Our analysis shows that by prioritizing ecosystem management based on the network-wide impact of species protection rather than species loss, we can substantially improve conservation outcomes
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
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- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
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- Sulin VV
- Sullivan MJ
- Sultan DMS
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- Sumida T
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- Suruliz K
- Suster CJE
- Sutton MR
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- Svatos M
- Swiatlowski M
- Swift SP
- Swirski T
- Sydorenko A
- Sykora I
- Sykora M
- Sykora T
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- Talyshev AA
- Tame ZPA
- Tamir NM
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- Tariq K
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- Tartarelli GF
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- Tasevsky M
- Tashiro T
- Tassi E
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- Tayalati Y
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- Taylor GN
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- Tehrani FS
- Teixeira-Dias P
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- Terashi K
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- Teuscher RJ
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- Thiele F
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- Thomas JO
- Thomas JP
- Thompson PD
- Thomsen LA
- Thomson E
- Thorpe EJ
- Tikhomirov VO
- Tikhonov YA
- Timoshenko S
- Tipton P
- Tisserant S
- Tobon CAM
- Todome K
- Todorova-Nova S
- Todt S
- Tojo J
- Tokar S
- Tokushuku K
- Tolley E
- Tomiwa KG
- Tomoto M
- Tompkins L
- Tong B
- Tornambe P
- Toro RC
- Torrence E
- Torres H
- Torres RET
- Tosciri C
- Toth J
- Tovey DR
- Traeet A
- Treado CJ
- Trefzger T
- Tresoldi F
- Tricoli A
- Trigger IM
- Trincaz-Duvoid S
- Trischuk DA
- Trischuk W
- Trocme B
- Trofymov A
- Troncon C
- Trovato F
- Truong L
- Trzebinski M
- Trzupek A
- Tsai F
- Tseng JC-L
- Tsiareshka P
- Tsirigotis A
- Tsiskaridze V
- Tskhadadze EG
- Tsopoulou M
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tu Y
- Tudorache A
- Tudorache V
- Tulbure TT
- Tuna AN
- Turchikhin S
- Turgeman D
- Turner RJ
- Turra RT
- Tuts PM
- Tzamarias S
- Tzovara E
- Ucchielli G
- Uchida K
- Ukegawa F
- Unal G
- Undrus A
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- Ungaro FC
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- Urban J
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- Usai G
- Uysal Z
- Vacek V
- Vachon B
- Vadla KOH
- Vaidya A
- Valderanis C
- Vale MAB
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- Valentinetti S
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- Van Daalen TR
- Van Gemmeren P
- Van Vulpen I
- Vanadia M
- Vandelli W
- Vandenbroucke M
- Vandewall ER
- Vaniachine A
- Vannicola D
- Vari R
- Varnes EW
- Varni C
- Varol T
- Varouchas D
- Varvell KE
- Vasile ME
- Vasquez GA
- Vazeille F
- Vazquez Furelos D
- Vazquez CJB
- Vazquez JGP
- Veatch J
- Vecchio V
- Veen MJ
- Veloce LM
- Veloso F
- Veneziano S
- Ventura A
- Venturi N
- Vera AMR
- Verbytskyi A
- Vercesi V
- Verducci M
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- Verkerke W
- Vermeulen AT
- Vermeulen JC
- Verzini MJA
- Vetterli MC
- Viaux Maira N
- Vickey T
- Viehhauser GHA
- Vigani L
- Villa M
- Vilucchi E
- Vincter MG
- Virdee GS
- Vishwakarma A
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- Vivarelli I
- Vogel M
- Vokac P
- von Buddenbrock SE
- Von Toerne E
- Vorobel V
- Vorobev K
- Vos M
- Vossebeld JH
- Vozak M
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wagner-Kuhr J
- Wahdan S
- Wahlberg H
- Walbrecht VM
- Walder J
- Walker R
- Walker SD
- Walkowiak W
- Wallangen V
- Wang AM
- Wang AZ
- Wang C
- Wang F
- Wang H
- Wang J
- Wang P
- Wang Q
- Wang R
- Wang R-J
- Wang SM
- Wang W
- Wang WT
- Wang WX
- Wang Y
- Wang Z
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Warrack N
- Washbrook A
- Watson AT
- Watson MF
- Watts G
- Waugh BM
- Webb AF
- Webb S
- Weber C
- Weber MS
- Weber SA
- Weber SM
- Weidberg AR
- Weingarten J
- Weirich M
- Weiser C
- Wells PS
- Wenaus T
- Wengler T
- Wenig S
- Wermes N
- Werner MD
- Wessels M
- Weston TD
- Whalen K
- Whallon NL
- Wharton AM
- White A
- White AS
- White MJ
- Whiteson D
- Whitmore BW
- Wiedenmann W
- Wiel C
- Wielers M
- Wieseotte N
- Wiglesworth C
- Wiik-Fuchs LAM
- Wilkens HG
- Wilkins LJ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wingerter-Seez I
- Winkels E
- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf A
- Wolf TMH
- Wolff R
- Wolker R
- Wollrath J
- Wolter MW
- Wolters H
- Wong VWS
- Woods NL
- Worm SD
- Wosiek BK
- Wozniak KW
- Wraight K
- Wu SL
- Wu X
- Wu Y
- Wyatt TR
- Wynne BM
- Xella S
- Xi Z
- Xia L
- Xiao X
- Xiotidis I
- Xu D
- Xu H
- Xu L
- Xu T
- Xu W
- Xu Z
- Yabsley B
- Yacoob S
- Yajima K
- Yallup DP
- Yamaguchi N
- Yamaguchi Y
- Yamamoto A
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang HJ
- Yang HT
- Yang S
- Yang T
- Yang X
- Yang Y
- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye H
- Ye J
- Ye S
- Yeletskikh I
- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yuan R
- Yue X
- Zaazoua M
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
The Ischemic Stroke Genetics Study (ISGS) Protocol
- Author
- A Catto
- A Catto
- A Furlan
- A Sommerville
- AJ Catto
- AJ Catto
- AJ Catto
- AM Carter
- AM Carter
- AM Carter
- AM Carter
- Antiplatelet Trialists' Collaboration
- B Jennett
- BB Worrall
- BB Worrall
- BP Fuller
- Bradford Burke Worrall
- C Collin
- C Kessler
- CA Lewandowski
- CJ Johnson
- Collaborators North American Symptomatic Carotid
- D Shinar
- DM Heywood
- DW Hosmer Jr
- Executive Committee for the Asymptomatic Carotid Atherosclerosis Study
- G Gambaro
- GJ Annas
- GJ del Zoppo
- H Schmidt
- HP Adams Jr
- HP Adams Jr
- HP Adams Jr
- HS Markus
- I Martinelli
- J Bamford
- J Botkin
- J Corral
- James F Meschia
- JF Meschia
- JF Meschia
- JF Meschia
- JF Meschia
- JF Meschia
- JF Meschia
- JG van der Bom
- JM Bamford
- John Hardy
- José G Merino
- JR Gulcher
- JR Marler
- K Kontula
- KP Madden
- LA Goodman
- LE Carlsson
- LE Carlsson
- M Zuber
- Michael Frankel
- MO McCarron
- MW Foster
- P Lyden
- PM Ridker
- PM Ridker
- PM Ridker
- R Gonzalez-Conejero
- R Roberts
- RD Press
- RG Hart
- Richard JP Crook
- RL Sacco
- Robert D Brown
- S Nishiuma
- SA Miller
- Scott Silliman
- SR Poort
- Stephen S Rich
- The Ad Hoc Committee on Genetic Testing/Insurance Issues
- The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
- Thomas G Brott
- WHO MONICA Project Principal Investigators
- WJ Jones
- WM Halbmayer
- WT Longstreth Jr
- Publication venue
- BioMed Central
- Publication date
- 01/01/2003
- Field of study
BACKGROUND: The molecular basis for the genetic risk of ischemic stroke is likely to be multigenic and influenced by environmental factors. Several small case-control studies have suggested associations between ischemic stroke and polymorphisms of genes that code for coagulation cascade proteins and platelet receptors. Our aim is to investigate potential associations between hemostatic gene polymorphisms and ischemic stroke, with particular emphasis on detailed characterization of the phenotype. METHODS/DESIGN: The Ischemic Stroke Genetic Study is a prospective, multicenter genetic association study in adults with recent first-ever ischemic stroke confirmed with computed tomography or magnetic resonance imaging. Patients are evaluated at academic medical centers in the United States and compared with sex- and age-matched controls. Stroke subtypes are determined by central blinded adjudication using standardized, validated mechanistic and syndromic classification systems. The panel of genes to be tested for polymorphisms includes β-fibrinogen and platelet glycoprotein Ia, Iba, and IIb/IIIa. Immortalized cell lines are created to allow for time- and cost-efficient testing of additional candidate genes in the future. DISCUSSION: The study is designed to minimize survival bias and to allow for exploring associations between specific polymorphisms and individual subtypes of ischemic stroke. The data set will also permit the study of genetic determinants of stroke outcome. Having cell lines will permit testing of future candidate risk factor genes
Endothelial Stomatal and Fenestral Diaphragms in Normal Vessels and Angiogenesis
- Author
- Apkarian RP
- Baluk P
- Bankston PW
- Bendayan M
- Bradbury MW
- Braet F
- Breier G
- Chen J
- Clarijs R
- Connolly DT
- Desaki J
- Dvorak AM
- Feng D
- Ferrara N
- Front D
- Gautier A
- Gerber HP
- Grunstein J
- Hallmann R
- Hashizume H
- Hnasko R
- Hnasko R
- Holden CA
- Inai T
- Ioannidou S
- Kasantikul V
- Kawanami O
- Kohn S
- Lampugnani MG
- Llena JF
- Lombardi T
- Lombardi T
- Madden SL
- Madigan MC
- McDonald DM
- Naito M
- Nielsen BS
- Oberling C
- Paavonen K
- Palade GE
- Palade GF
- Penn PE
- Pino RM
- R.V. Stan
- Roberts WG
- Roberts WG
- Roberts WG
- Roberts WG
- Rosenberg RD
- Ruiter DJ
- Sauter B
- Schlingemann RO
- Schlingemann RO
- Schnitzer JE
- Shibata S
- Snyder DH
- Stan RV
- Stan RV
- Stan RV
- Stan RV
- Sundberg C
- Vasile E
- Vasile E
- Vittet D
- Wallow IH
- Weninger W
- Wisse E
- Witmer AN
- Yamada E
- Publication venue
- Dartmouth Digital Commons
- Publication date
- 01/01/2007
- Field of study
Vascular endothelium lines the entire cardiovascular system where performs a series of vital functions including the control of microvascular permeability, coagulation inflammation, vascular tone as well as the formation of new vessels via vasculogenesis and angiogenesis in normal and disease states. Normal endothelium consists of heterogeneous populations of cells differentiated according to the vascular bed and segment of the vascular tree where they occur. One of the cardinal features is the expression of specific subcellular structures such as plasmalemmal vesicles or caveolae, transendothelial channels, vesiculo-vacuolar organelles, endothelial pockets and fenestrae, whose presence define several endothelial morphological types. A less explored observation is the differential expression of such structures in diverse settings of angiogenesis. This review will focus on the latest developments on the components, structure and function of these specific endothelial structures in normal endothelium as well as in diverse settings of angiogenesis
The Siblings With Ischemic Stroke Study (SWISS) Protocol
- Author
- A Berger
- A Catto
- A Joutel
- BB Worrall
- BK Suarez
- CD Liapis
- CL Hanis
- CS Kidwell
- D Liao
- DK Kiely
- EC Haley Jr
- ER Hauser
- F Coria
- FP D'Armiento
- FR Rosendaal
- FR Rosendaal
- GC Ebers
- GJ Annas
- GW Petty
- H Basun
- H Chabriat
- H Schmidt
- HG Rubinstein
- HJ Barnett
- HP Adams Jr
- HS Markus
- HS Markus
- HS Markus
- I Vauhkonen
- IJ Perry
- J Chapman
- J Chataway
- J Kuusisto
- J Pedro-Botet
- JD Pickard
- JF Merz
- JF Meschia
- JF Meschia
- JF Meschia
- JG Davis
- JJ Rogus
- JK Mellies
- JL Davies
- JL Haines
- K Kontula
- KP Madden
- KR Wagner
- L Ferrucci
- L Kruglyak
- LE Carlsson
- LM Brass
- M Margaglione
- M Margaglione
- M Natowicz
- MA Pericak-Vance
- MM Ruchoux
- MO McCarron
- MW Foster
- N Risch
- N Risch
- N Risch
- NJ Cox
- P Holmans
- P Jousilahti
- P Kehoe
- P Sharma
- PL Kolominsky-Rabas
- PM Gaffney
- PM Ridker
- R Couderc
- R Roberts
- RD Press
- S Rubattu
- S Sawcer
- T Tatlisumak
- The Ad Hoc Committee on Genetic Testing/Insurance Issues
- The Collaborative Study on the Genetics of Asthma
- W Lalouschek
- WHO MONICA Project Principal Investigators
- WJ Jones
- WS Wu
- WT Longstreth Jr
- Publication venue
- BioMed Central
- Publication date
- 01/02/2002
- Field of study
BACKGROUND: Family history and twins studies suggest an inherited component to ischemic stroke risk. Candidate gene association studies have been performed but have limited capacity to identify novel risk factor genes. The Siblings With Ischemic Stroke Study (SWISS) aims to conduct a genome-wide scan in sibling pairs concordant or discordant for ischemic stroke to identify novel genetic risk factors through linkage analysis. METHODS: Screening at multiple clinical centers identifies patients (probands) with radiographically confirmed ischemic stroke and a family history of at least 1 living full sibling with stroke. After giving informed consent, without violating privacy among other family members, the proband invites siblings concordant and discordant for stroke to participate. Siblings then contact the study coordinating center. The diagnosis of ischemic stroke in potentially concordant siblings is confirmed by systematic centralized review of medical records. The stroke-free status of potentially discordant siblings is confirmed by validated structured telephone interview. Blood samples for DNA analysis are taken from concordant sibling pairs and, if applicable, from 1 discordant sibling. Epstein-Barr virus-transformed lymphoblastoid cell lines are created, and a scan of the human genome is planned. DISCUSSION: Conducting adequately powered genomics studies of stroke in humans is challenging because of the heterogeneity of the stroke phenotype and the difficulty of obtaining DNA samples from clinically well-characterized members of a cohort of stroke pedigrees. The multicentered design of this study is intended to efficiently assemble a cohort of ischemic stroke pedigrees without invoking community consent or using cold-calling of pedigree members
Methanogens, sulphate and heavy metals: a complex system
- Author
- A Gupta
- A Karlsson
- A Mudhoo
- A Rinzema
- A Visser
- AH Kaksonen
- AH Veeken
- Alfons J. M. Stams
- AM Saleh
- AO Olaniran
- AW Khan
- B Demirel
- B Sancey
- BC Hard
- BD Bennett
- BH Houten van
- C Park
- C Plugge
- C-Y Lin
- C-Y Lin
- C-Y Lin
- C-Y Lin
- CM Park
- CM Plugge
- CY Lin
- D Fortin
- D Liu
- DB Kosolapov
- DG Capone
- DH Nies
- Diana Z. Sousa
- DK Villa-Gomez
- DM McCartney
- DM McCartney
- E Colleran
- E Colleran
- E Lira-Silva
- E Lira-Silva
- E Rodriguez
- F Fu
- F Omil
- F Widdel
- G Gadd
- G Haferburg
- G Muyzer
- G Zayed
- GF Parkin
- GF Parkin
- GH Booth
- GM Gadd
- GM Gadd
- H Mu
- HF Castro
- HI Abdel-Shafy
- HL Ehrlich
- HP Fang
- HTQ Kieu
- I Colussi
- IP Pankhania
- IW Koster
- J Gonzalez-Estrella
- J Gonzalez-Estrella
- J Gustavsson
- J Gustavsson
- J Zhang
- J Zhang
- JA Lemire
- JA Oleszkiewicz
- JL Chen
- JL Huisman
- K Kida
- K Mori
- KB Chipasa
- KF Jarrell
- Lara M. Paulo
- M Karvelas
- M Luna-del Risco
- M Sarioglu
- MA Reis
- MH Wong
- MN Hughes
- P Chellapandi
- P Madden
- PA Loka Bharathi
- PNL Lens
- PP Karhadkar
- R Hammack
- R Singh
- RE Speece
- S Dar
- S Fetzer
- S Hirano
- S Karri
- S Oude Elferink
- S Srivastava
- SJWH Oude Elferink
- SK Bhattacharya
- SK Bhattacharya
- SR Poulson
- T Schmidt
- TD Hayes
- V O’Flaherty
- V O’Flaherty
- V O’Flaherty
- VP Utgikar
- VP Utgikar
- XM Feng
- Y Chen
- Y Tuo
- Y Zhang
- YE Collins
- YM Krishnanand
- Z Isa
- Z Isa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Anaerobic digestion (AD) is a well-established technology used for the treatment of wastes and wastewaters with high organic content. During AD organic matter is converted stepwise to methane-containing biogasa renewable energy carrier. Methane production occurs in the last AD step and relies on methanogens, which are rather sensitive to some contaminants commonly found in wastewaters (e.g. heavy metals), or easily outcompeted by other groups of microorganisms (e.g. sulphate reducing bacteria, SRB). This review gives an overview of previous research and pilot-scale studies that shed some light on the effects of sulphate and heavy metals on methanogenesis. Despite the numerous studies on this subject, comparison is not always possible due to differences in the experimental conditions used and parameters explained. An overview of the possible benefits of methanogens and SRB co-habitation is also covered. Small amounts of sulphide produced by SRB can precipitate with metals, neutralising the negative effects of sulphide accumulation and free heavy metals on methanogenesis. Knowledge on how to untangle and balance sulphate reduction and methanogenesis is crucial to take advantage of the potential for the utilisation of biogenic sulphide as a metal detoxification agent with minimal loss in methane production in anaerobic digesters.The research was financially supported by the People Program (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007-2013 under REA agreement 289193
The Biochemistry, Ultrastructure, and Subunit Assembly Mechanism of AMPA Receptors
- Author
- A Bertolotti
- A Clayton
- A Inanobe
- A Kuusinen
- A Miyazawa
- A Nishimune
- A Pasternack
- A Priel
- A Robert
- AC Penn
- AD Milstein
- AI Sobolevsky
- AR Aricescu
- AR Aricescu
- AS Kato
- AS Leonard
- AV Kenny
- AY Hsia
- B Sommer
- B Sommer
- C Korber
- C Rosenmund
- C Toyoshima
- CD Blackstone
- CG Tate
- CM Low
- CR Midgett
- CS Walker
- D Cheng
- D Ng
- D Soto
- DA Doyle
- DM Talos
- DM Talos
- DR Madden
- DS Koh
- E Karakas
- E Kubalek
- EB Ziff
- ES Lein
- F Kamenetz
- F Perin-Dureau
- G Ayalon
- G Ayalon
- G Lynch
- GL Collingridge
- GM Sia
- GT Swanson
- H Dong
- H Furukawa
- H Furukawa
- H Hsieh
- H Lomeli
- H Meguro
- H Monyer
- HK Lee
- HK Lee
- HP Harding
- I Song
- IH Greger
- IH Greger
- IH Greger
- IH Greger
- IH Greger
- J Boulter
- J Engelhardt von
- J Frank
- J Kumar
- J Powers
- J Schwenk
- J Shen
- J Xia
- J Zuo
- JD Shepherd
- K Keinanen
- K Keinanen
- K Krampfl
- K Moriyoshi
- K Plant
- K Sakimura
- K Williams
- KA Stauffer
- L Chen
- L Ellgaard
- L Saglietti
- L Shen
- L Valluru
- M Farrant
- M Fischer
- M Gielen
- M Heine
- M Hennegriff
- M Higuchi
- M Higuchi
- M Hollmann
- M Hollmann
- M Koike
- M Lai
- M Morimoto-Tomita
- M Nuriya
- M Ohi
- M Park
- M Roelandse
- M Safferling
- M Sheng
- MD Ehlers
- MH Nanao
- ML Mayer
- ML Mayer
- MM Soundarapandian
- MS Gorbatyuk
- MS Horning
- MW Fleck
- N Armstrong
- N Armstrong
- N Armstrong
- N Armstrong
- N Kunishima
- N Matsuo
- N Nakanishi
- N Unwin
- NF Shanks
- OM Schluter
- P Naur
- P Osten
- P Paoletti
- PH Andersen
- PH Seeburg
- QX Jiang
- R Dingledine
- R Grisshammer
- R Jin
- R Jin
- R Jin
- R Jin
- R Malinow
- RA Nicoll
- RH Scannevin
- RJ O’Brien
- RJ O’Brien
- RJ Wenthold
- S Cull-Candy
- S Hestrin
- S Kawamoto
- S Matsuda
- S Nakanishi
- S Roth
- S Shi
- S Springer
- S Tomita
- S Tomita
- SB Long
- SF Traynelis
- SH Lee
- SH Shi
- SI Bannykh
- SJ Mah
- SK Coleman
- SK Coleman
- SW Rogers
- SY Bednarek
- T Gonen
- T Li
- T Nakagawa
- T Nakagawa
- T Nakagawa
- T Walz
- TA Schroer
- TA Verdoorn
- Terunaga Nakagawa
- TG Banke
- TP Dryja
- TP Dryja
- TP Roosild
- TW Schulz
- UE Petaja-Repo
- W Ju
- W Tichelaar
- W Vandenberghe
- W Vandenberghe
- W Zhang
- WD Leuschner
- Y Cheng
- Y Hayashi
- Y Kawahara
- Y Shi
- Y Stern-Bach
- Y Sun
- Y Wu
- Y Zheng
- YB Choi
- Z Songyang
- ZG Wo
- Publication venue
- Humana Press Inc
- Publication date
- 01/01/2010
- Field of study
The AMPA-type ionotropic glutamate receptors (AMPA-Rs) are tetrameric ligand-gated ion channels that play crucial roles in synaptic transmission and plasticity. Our knowledge about the ultrastructure and subunit assembly mechanisms of intact AMPA-Rs was very limited. However, the new studies using single particle EM and X-ray crystallography are revealing important insights. For example, the tetrameric crystal structure of the GluA2cryst construct provided the atomic view of the intact receptor. In addition, the single particle EM structures of the subunit assembly intermediates revealed the conformational requirement for the dimer-to-tetramer transition during the maturation of AMPA-Rs. These new data in the field provide new models and interpretations. In the brain, the native AMPA-R complexes contain auxiliary subunits that influence subunit assembly, gating, and trafficking of the AMPA-Rs. Understanding the mechanisms of the auxiliary subunits will become increasingly important to precisely describe the function of AMPA-Rs in the brain. The AMPA-R proteomics studies continuously reveal a previously unexpected degree of molecular heterogeneity of the complex. Because the AMPA-Rs are important drug targets for treating various neurological and psychiatric diseases, it is likely that these new native complexes will require detailed mechanistic analysis in the future. The current ultrastructural data on the receptors and the receptor-expressing stable cell lines that were developed during the course of these studies are useful resources for high throughput drug screening and further drug designing. Moreover, we are getting closer to understanding the precise mechanisms of AMPA-R-mediated synaptic plasticity
Purinergic signalling and immune cells
- Author
- A Ben Addi
- A Ben Addi
- A Buenestado
- A Cuschieri
- A Filippini
- A Fortin
- A Grenz
- A Harish
- A Kaufmann
- A Kawano
- A Kawano
- A Leoutsakos
- A McRae
- A McRae
- A Ohta
- A Piccini
- A Rey del
- A Sala la
- A Sala la
- A Schmidt
- A Serafeim
- A Shin
- A Tokunaga
- A Vergani
- A Vergani
- A Yang
- AA Chimote
- AA Link
- AA Santos Jr
- AC Newby
- AG Orr
- AJ Sharp
- AL Horenstein
- AL Schwartz
- AM Forsyth
- AN Shemon
- AW Ford-Hutchinson
- AY Warren
- B Brône
- B Csóka
- B Csóka
- B Csóka
- B Diamant
- B Gu
- B Newson
- B Sperlágh
- BA Walker
- BA Walker
- BB Fredholm
- BB Fredholm
- BC Chen
- BC Chen
- BC Suh
- BD Freedman
- BD Humphreys
- BD Humphreys
- BG Campos
- BH Lee
- BJ Gu
- BJ Gu
- BJ Gu
- BM Saunders
- BN Cronstein
- BN Cronstein
- BN Cronstein
- BN Cronstein
- BP Ramakers
- BP Ramakers
- C Cappelli
- C Cekic
- C el-Moatassim
- C el-Moatassim
- C Feng
- C Furlan-Freguia
- C Lecut
- C Lecut
- C Mutini
- C Pizzirani
- C Ponti De
- C Seror
- CB Grahames
- CD McWhinney
- CE Gargett
- CI Ezeamuzie
- CI Ezeamuzie
- CK Ayata
- CM Cruz
- CM Lappas
- CM Lappas
- CM Wang
- CP Nielson
- CP Sevigny
- CS Soledade
- D Bald
- D Barbieri
- D Biswas
- D Brough
- D Brough
- D Eschke
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Hoeven van der
- D Hoeven van der
- D Knight
- D Lappin
- D Lappin
- D Myrtek
- D Myrtek
- D Perregaux
- DA Lammas
- DB Kuhns
- DC Altieri
- DJ Kusner
- DJ Kusner
- DJ Schrier
- DK Blanchard
- DL Marquardt
- DL Marquardt
- DL Marquardt
- DS Burt
- DW Riches
- E Adinolfi
- E Asgari
- E Bulanova
- E Bulanova
- E Bulanova
- E Chelmicka-Schorr
- E Crivellato
- E Krump
- E Panther
- E Panther
- E Panther
- E Velot
- ER Lazarowski
- F Aeffner
- F Alkayed
- F Anselmi
- F Aswad
- F Aswad
- F Ben Yebdri
- F Bretschneider
- F Ghaemi Oskouie
- F Grassi
- F Haag
- F Jacob
- F Jeffe
- F Laghi Pasini
- F Laghi Pasini
- F Markwardt
- F Marteau
- F Marteau
- F Rassendren
- F Scheuplein
- F Tuluc
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Wilkin
- F Wilkin
- FB Chekeni
- FC Weber
- FE Parkinson
- FM Konrad
- FR Rose
- G Beldi
- G Borsellino
- G Burnstock
- G Burnstock
- G Burnstock
- G Burnstock
- G Burnstock
- G Burnstock
- G Corrêa
- G Elson
- G Giannattasio
- G Gomez
- G Haskó
- G Haskó
- G Haskó
- G Haskó
- G Krüger
- G Lin
- G Marone
- G Marone
- G Marone
- G Marone
- G Marone
- G Martel-Gallegos
- G Petrovski
- G Vanderstocken
- G Vanderstocken
- G Wolberg
- G Wolberg
- GA Weisman
- GE Hardart
- Geoffrey Burnstock
- GJ Hallak
- GK Akbar
- GL Silva da
- GP Jamieson
- GP Smith
- GP Smith
- GR Dubyak
- GR Somers
- GW Sullivan
- H Asako
- H Bessler
- H Chen
- H Kawamura
- H Kawamura
- H Kettenmann
- H Moon
- H Saito
- H Sakaki
- H Zhong
- HK Eltzschig
- HK Eltzschig
- HK Eltzschig
- HK Takahashi
- HK Takahashi
- HM Costa-Junior
- HM Costa-Junior
- HP Buisman
- HP Langston
- HW Young
- I Bar
- I Drygiannakis
- I Ernens
- I Feoktistov
- I Garcia-Castro
- I Jalilian
- I Kaufmann
- I Lemaire
- I Lemaire
- I Marriott
- I Nagaoka
- I Pechán
- ID Mascanfroni
- IJ Elenkov
- IP Fairbairn
- J Barankiewicz
- J Barankiewicz
- J Bienenstock
- J Bienenstock
- J Challier
- J Dornand
- J Lin
- J Linden
- J Pfeilschifter
- J Reutershan
- J Xaus
- JA Auchampach
- JA Burgers
- JA Kiernan
- JA Kiernan
- JA Sommer
- JD Levine
- JE Hazleton
- JE Kim
- JE Salmon
- JE Salmon
- Jean-Marie Boeynaems
- JG Foster
- JG Kilian
- JG Mohanty
- JG Zhang
- JH Wilkinson
- JI Elliott
- JI Sesma
- JJ Field
- JJ Kobie
- JK Murphy
- JM Armstrong
- JM Langosch
- JM Sanz
- JM Wilson
- JM Wilson
- JR Fozard
- JS Cadieux
- JS Wiley
- JS Wiley
- JS Wiley
- JT Keller
- JT Merrill
- JW DePierre
- JW Goding
- K Atarashi
- K Barczyk
- K Christenson
- K Delmich
- K Färber
- K Heiss
- K Inoue
- K Inoue
- K McCallion
- K Niemi
- K Ohsawa
- K Ohsawa
- K Sugiyama
- K Varani
- K Varani
- K Varani
- K Varani
- K Wareham
- K Wilhelm
- K Yasui
- KE Barletta
- KL Han
- KL Wallace
- KM Dwyer
- KM Dwyer
- KR Vaughan
- KS Madden
- L Antonioli
- L Antonioli
- L Antonioli
- L Bazzichi
- L Chen
- L Genton
- L Himer
- L Homolya
- L Mircevová
- L Skelton
- L Stokes
- L Vitiello
- L Wang
- L Yip
- LA Schultz
- LC Denlinger
- LJ Murphree
- LM Hill
- LM Kreckler
- LM Zheng
- LY Lenertz
- M Aga
- M Baroni
- M Butler
- M Frascoli
- M Horckmans
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Koshiba
- M Koshiba
- M Koshiba
- M Kronlage
- M Kuroki
- M Lucattelli
- M Mandapathil
- M Manohar
- M Mirabet
- M Murgia
- M Murgia
- M Nakanishi
- M Nakanishi
- M Nakano
- M Nikolova
- M Nikolova
- M Nowak
- M Nowak-Machen
- M Perez-Aso
- M Pospísil
- M Sakowicz-Burkiewicz
- M Salmi
- M Schnurr
- M Schnurr
- M Schnurr
- M Scrivens
- M Scrivens
- M Seman
- M Sitkovsky
- M Subramanian
- M Takedachi
- M Thiel
- M Tonetti
- M Tonetti
- M Tsuda
- M Tsukimoto
- M Tsukimoto
- M Warny
- MA Ventura
- MD Desrosiers
- MD Wewers
- MG Bouma
- MJ Lohse
- MK Church
- MK Church
- MK Church
- MM Chaves
- MO Barrett
- MP Lees
- MR Elliott
- MS Alam
- MV Sitkovsky
- MV Sitkovsky
- N Arizono
- N Bles
- N Bles
- N Grosman
- N Li
- N McNamara
- N Mizumoto
- N Thibault
- O Leavy
- OK Nihei
- OR Baricordi
- OR Baricordi
- P Chiozzi
- P Pelegrin
- P Schubert
- P Schubert
- PA Beavis
- PA Beavis
- PA Lang
- PA Ward
- PA Ward
- PB Ernst
- PE Ross
- PE Tatham
- PE Zarek
- PJ Hanley
- PJ Hughes
- PJ Hughes
- PT Peachell
- PT Smith
- PV Nagy
- QH Liu
- R Corriden
- R Corriden
- R Coutinho-Silva
- R Coutinho-Silva
- R Coutinho-Silva
- R Coutinho-Silva
- R Coutinho-Silva
- R Dahlquist
- R Hamano
- R Keller
- R Krishnaraj
- R Krishnaraj
- R Mandler
- R Placido
- R Rizzo
- R Seifert
- R Sluyter
- R Sluyter
- R Suzuki
- R Zeiser
- RA Axtell
- RB Banati
- RD Salter
- RF Fishman
- RF Kefford
- RF Zanin
- RH Straub
- RI Ludowyke
- RJ Griffiths
- RM Williams
- RR Aksamit
- S Adriouch
- S Arandjelovic
- S Armstrong
- S Berchtold
- S Cicko
- S Cockcroft
- S Cockcroft
- S Cockcroft
- S Colli
- S Deaglio
- S Deaglio
- S Dichmann
- S Falzoni
- S Franco-Martínez
- S Gardella
- S Gessi
- S Gessi
- S Gessi
- S Gorini
- S Greenberg
- S Huang
- S Hubert
- S Ikehara
- S Koizumi
- S Koizumi
- S Lépine
- S Padeh
- S Ring
- S Ryzhov
- S Sengstake
- S Trabanelli
- S Tsuruta
- S Tsutsui
- SD Skaper
- SD Skaper
- SE Haynes
- SE Hickman
- SF Häusler
- SF Moore
- SG Apasov
- SG Apasov
- SH Gregory
- SJ Leibovich
- SL Fernando
- SL Tilley
- SL Tilley
- SM O'Grady
- SP Chaves
- SQ Yao
- SR McColl
- SS Sung
- SV Novitskiy
- SY Eun
- T Henriksson
- T Johansen
- T Kobayashi
- T Kusu
- T Müller
- T Priebe
- T Raskovalova
- T Watanabe
- T Woehrle
- T Woehrle
- T Yamada
- T Yu
- TH Steinberg
- TH Steinberg
- TL Whiteside
- TM Chused
- TP Gottwald
- U Schenk
- U Schenk
- V Dimitriadou
- V Dimitriadou
- V Kumar
- V Ramkumar
- V Vraux Le
- VB Mehta
- VS Muniz
- W Nörenberg
- W Walz
- W Wei
- WC Sun
- WG Junger
- WG Junger
- WH Loomis
- WM Hon
- X Duhant
- X Hua
- X Hua
- X Zhong
- Y Bao
- Y Chen
- Y Chen
- Y Hu
- Y Inoue
- Y Inoue
- Y Kohno
- Y Kurashima
- Y Qu
- Y Qu
- Y Qu
- Y Zhang
- YG Chen
- YJ Chen
- YX Qian
- Z Saze
- Z Yang
- Z Yang
- Z Zhang
- Z Zídek
- ZA Pfeiffer
- ZG Gao
- ZG Gao
- ZH Németh
- ZH Németh
- ZH Németh
- ZQ Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
This review article provides a historical perspective on the role of purinergic signalling in the regulation of various subsets of immune cells from early discoveries to current understanding. It is now recognised that adenosine 5'-triphosphate (ATP) and other nucleotides are released from cells following stress or injury. They can act on virtually all subsets of immune cells through a spectrum of P2X ligand-gated ion channels and G protein-coupled P2Y receptors. Furthermore, ATP is rapidly degraded into adenosine by ectonucleotidases such as CD39 and CD73, and adenosine exerts additional regulatory effects through its own receptors. The resulting effect ranges from stimulation to tolerance depending on the amount and time courses of nucleotides released, and the balance between ATP and adenosine. This review identifies the various receptors involved in the different subsets of immune cells and their effects on the function of these cells
Measurement of the W±Z boson pair-production cross section in pp collisions at √s=13TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Aben R
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agricola J
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- AlconadaVerzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alstaty M
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amako K
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amundsen G
- Anastopoulos C
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- Andari N
- Andeen T
- Anders CF
- Anders G
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov AV
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- Annovi A
- Antel C
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- Antonov A
- Anulli F
- Aoki M
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- Arai Y
- Araque JP
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans RC
- Armbruster AJ
- Armitage LJ
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- Ashkenazi A
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- Baker OK
- Baldin EM
- Balek P
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- Bannoura AAE
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- Beemster LJ
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- Begel M
- Behr JK
- Belanger-Champagne C
- Bell AS
- Bella G
- Bella LA
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Bendtz K
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
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- Berlendis S
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- Bernius C
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- Bindi M
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- Blair RE
- Blanchard J-B
- Blanco JE
- Blazek T
- Bloch I
- Blocker C
- Blum W
- Blumenschein U
- Blunier S
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
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- Boehler M
- Boeriu OEV
- Boerner D
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- Bogavac D
- Bogdanchikov AG
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- Boldyrev AS
- Bomben M
- Bona M
- Boonekamp M
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
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- Boscherini D
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- Boudreau J
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- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Boutle SK
- Boveia A
- Boyd J
- Boyko IR
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- Brandt A
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- Braun HM
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- Zhemchugov A
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- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zu Theenhausen HM
- zur Nedden M
- Zwalinski L
- Publication venue
- Netherlands
- Publication date
- 01/01/2016
- Field of study
published_or_final_versio
Anatomy of the sign-problem in heavy-dense QCD
- Author
- Adam E Romero
- Aranda C Padilla
- Arjanovic MM
- Armadans R Caminal
- Astigarraga ME Pozo
- Barajas CA Chavez
- Bechtle P
- Beck HP
- Becker K
- Becker M
- Beckingham M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behr JK
- Belanger-Champagne C
- Bell AS
- Bella G
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Bendtz K
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Berghaus F
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertolucci F
- Bertram IA
- Bertsche C
- Bertsche D
- Besjes GJ
- Bessner M
- Besson N
- Betancourt C
- Bethke S
- Bevan AJ
- Bhimji W
- Bianchi RM
- Bianchini L
- Bianco M
- Biebel O
- Biedermann D
- Bielski R
- Biesuz NV
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biondi S
- Bjergaard DM
- Black CW
- Black JE
- Black KM
- Blackburn D
- Blair RE
- Blanchard J-B
- Blanco JE
- Blazek T
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- Walkowiak W
- Wallangen V
- Walls FM Garay
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- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Washbrook A
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- Watts G
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- Waugh BM
- Webb S
- Weber MS
- Weber SW
- Webster JS
- Weidberg AR
- Weinert B
- Weingarten J
- Weiser C
- Weits H
- Wells PS
- Wenaus T
- Wengler T
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- Wermes N
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- Wetter J
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- Whallon NL
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- Wiedenmann W
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- Wong KH Yau
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wu M
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- Wu SL
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- Wyatt TR
- Wynne BM
- Xella S
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yakabe R
- Yamaguchi D
- Yamaguchi Y
- Yamamoto A
- Yamamoto S
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
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- Yang Y
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- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yen AL
- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yuen SPY
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang G
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- Zhang J
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- Zhang R
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- Zhang X
- Zhang Z
- Zhao X
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- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
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- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
QCD at finite densities of heavy quarks is investigated
using the density-of-states method. The phase factor
expectation value of the quark determinant is calculated to
unprecedented precision as a function of the chemical potential.
Results are validated using those from a reweighting
approach where the latter can produce a significant signalto-noise
ratio. We confirm the particle–hole symmetry at low
temperatures, find a strong sign problem at intermediate values
of the chemical potential, and an inverse Silver Blaze
feature for chemical potentials close to the onset value: here,
the phase-quenched theory underestimates the density of the
full theory
- …