218 research outputs found
A variational Bayesian method for inverse problems with impulsive noise
We propose a novel numerical method for solving inverse problems subject to
impulsive noises which possibly contain a large number of outliers. The
approach is of Bayesian type, and it exploits a heavy-tailed t distribution for
data noise to achieve robustness with respect to outliers. A hierarchical model
with all hyper-parameters automatically determined from the given data is
described. An algorithm of variational type by minimizing the Kullback-Leibler
divergence between the true posteriori distribution and a separable
approximation is developed. The numerical method is illustrated on several one-
and two-dimensional linear and nonlinear inverse problems arising from heat
conduction, including estimating boundary temperature, heat flux and heat
transfer coefficient. The results show its robustness to outliers and the fast
and steady convergence of the algorithm.Comment: 20 pages, to appear in J. Comput. Phy
Parameter Identification in a Probabilistic Setting
Parameter identification problems are formulated in a probabilistic language,
where the randomness reflects the uncertainty about the knowledge of the true
values. This setting allows conceptually easily to incorporate new information,
e.g. through a measurement, by connecting it to Bayes's theorem. The unknown
quantity is modelled as a (may be high-dimensional) random variable. Such a
description has two constituents, the measurable function and the measure. One
group of methods is identified as updating the measure, the other group changes
the measurable function. We connect both groups with the relatively recent
methods of functional approximation of stochastic problems, and introduce
especially in combination with the second group of methods a new procedure
which does not need any sampling, hence works completely deterministically. It
also seems to be the fastest and more reliable when compared with other
methods. We show by example that it also works for highly nonlinear non-smooth
problems with non-Gaussian measures.Comment: 29 pages, 16 figure
Computed tomography evaluation of rotary systems on the root canal transportation and centering ability
Aging of dissolved copper and copper-based nanoparticles in five different soils: short-term kinetics vs long-term fate
With the growing availability and use of copper based nanomaterials (Cu-NMs), there is increasing concern regarding their release and potential impact on the environment. In this study, the short term (≤ 5 days) ageing profile and the long term (4 months) speciation of dissolved Cu, copper oxide (CuO-) and copper sulfide nanoparticles (CuS-NPs) were investigated in five different soils using X-ray absorption spectroscopy (XAS). Soil pH was found to strongly influence the short term chemistry of the Cu-NMs added at 100 mg/kg above background. Low pH soils promoted rapid dissolution of CuO-NPs that effectively aligned their behaviour to that of dissolved Cu within 3 days. In higher pH soils, CuO-NPs persisted longer due to slower dissolution in the soil and resulted in contrasting short term speciation compared to dissolved Cu, which formed copper hydroxides and carbonates that were reflective of the soil chemistry. Organic matter appeared to slow the dissolution process but in the long term, the speciation of Cu added as dissolved Cu, CuO-NPs and CuS-NPs were found to be same for each soil. The results imply that in the short term Cu-NMs may exhibit unique behaviour in alkaline soils compared to their conventional forms (e.g. in the event of an adverse leaching event), but in the long term (≥ 4 months), their fates are dictated by the soil properties and are independent of the initial Cu form, and are likely to present minimal risk of nano-specific Cu-NM impact in the soil environment for the concentration studied here
Antioxidant and cytotoxic activity of Tecoma stans against lung cancer cell line (A549)
Injection Drug Use Is a Risk Factor for HCV Infection in Urban Egypt
OBJECTIVE: To identify current risk factors for hepatitis C virus (HCV) transmission in Greater Cairo. DESIGN AND SETTING: A 1:1 matched case-control study was conducted comparing incident acute symptomatic hepatitis C patients in two "fever" hospitals of Greater Cairo with two control groups: household members of the cases and acute hepatitis A patients diagnosed at the same hospitals. Controls were matched on the same age and sex to cases and were all anti-HCV antibody negative. Iatrogenic, community and household exposures to HCV in the one to six months before symptoms onset for cases, and date of interview for controls, were exhaustively assessed. RESULTS: From 2002 to 2007, 94 definite acute symptomatic HCV cases and 188 controls were enrolled in the study. In multivariate analysis, intravenous injections (OR = 5.0; 95% CI = 1.2-20.2), medical stitches (OR = 4.2; 95% CI = 1.6-11.3), injection drug use (IDU) (OR = 7.9; 95% CI = 1.4-43.5), recent marriage (OR = 3.3; 95% CI = 1.1-9.9) and illiteracy (OR = 3.9; 95% CI = 1.8-8.5) were independently associated with an increased HCV risk. CONCLUSION: In urban Cairo, invasive health care procedures remain a source of HCV transmission and IDU is an emerging risk factor. Strict application of standard precautions during health care is a priority. Implementation of comprehensive infection prevention programs for IDU should be considered
Cooperativity Dominates the Genomic Organization of p53-Response Elements: A Mechanistic View
p53-response elements (p53-REs) are organized as two repeats of a palindromic DNA segment spaced by 0 to 20 base pairs (bp). Several experiments indicate that in the vast majority of the human p53-REs there are no spacers between the two repeats; those with spacers, particularly with sizes beyond two nucleotides, are rare. This raises the question of what it indicates about the factors determining the p53-RE genomic organization. Clearly, given the double helical DNA conformation, the orientation of two p53 core domain dimers with respect to each other will vary depending on the spacer size: a small spacer of 0 to 2 bps will lead to the closest p53 dimer-dimer orientation; a 10-bp spacer will locate the p53 dimers on the same DNA face but necessitate DNA looping; while a 5-bp spacer will position the p53 dimers on opposite DNA faces. Here, via conformational analysis we show that when there are 0–2 bp spacers, p53-DNA binding is cooperative; however, cooperativity is greatly diminished when there are spacers with sizes beyond 2 bp. Cooperative binding is broadly recognized to be crucial for biological processes, including transcriptional regulation. Our results clearly indicate that cooperativity of the p53-DNA association dominates the genomic organization of the p53-REs, raising questions of the structural organization and functional roles of p53-REs with larger spacers. We further propose that a dynamic landscape scenario of p53 and p53-REs can better explain the selectivity of the degenerate p53-REs. Our conclusions bear on the evolutionary preference of the p53-RE organization and as such, are expected to have broad implications to other multimeric transcription factor response element organization
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