Biomimetic soft matter

Biomaterials are often soft materials. There is now growing interest in designing, synthesizing and characterising soft materials that mimic the properties of biological materials such as tissue, proteins, DNA or cells. Research on biomimetic soft matter is therefore a developing theme with important emerging applications in biomedicine including tissue engineering, diagnostics, gene therapy, drug delivery and many others. There are also important basic science questions concerning the use of concepts from colloid and polymer science to understand the self-assembly of biomimetic soft materials. This issue of Soft Matter presents a selection of extremely topical articles on a diversity of biomimetic soft matter systems. I thank the contributors for this quite remarkable collection of papers, which report many fascinating discoveries and insights

Arcjet load characteristics

Experiments were conducted to define the interface characteristics and constraints of 1 kW class arcjets run on simulated decomposition products of hydrazine and power processors. The impacts of power supply output current ripple on arcjet performance were assessed by variation of the ripple frequency from 100 Hz to 100 kHz with 10 percent peak-to-peak ripple amplitude at 1.2 kW. Ripple had no significant effects on thrust, specific impulse or efficiency. The impact of output ripple on thruster lifetime was not assessed. The static and dynamic impedances of the arcjet were quantified with two thrusters of nearly identical configuration. Superposition of an AC component on the DC arc current was used to characterize the dynamic impedance as a function of flow rate and DC current level. A mathematical model was formulated from these data. Both the static and dynamic impedance magnitude were found to be dependent on mass flow rate. The amplitude of the AC component was found to have little effect on the dynamic impedance. Reducing the DC level from 10 to 8 amps led to a large change in the magnitude of the dynamic impedance with no observable phase change. The impedance data compared favorably between the two thrusters

Ceramic wiring board increases packaging density of electronic modules

Ceramic multilayer wiring board interconnects large scale integration /LSI/ modules which dissipate nearly 2W/cc. Extremely high packaging density is possible by application of alumina cover hermetically sealed to board. Signal interconnections are completely dependent on transfer heat between layers

Fibrillisation of hydrophobically modified amyloid peptide fragments in an organic solvent

The self-assembly of a hydrophobically modified fragment of the amyloid beta(A beta) peptide has been studied in methanol. The peptide FFKLVFF is based on A beta(16-20) extended at the N terminus by two phenylalanine residues. The formation of amyloid-type fibrils is confirmed by Congo Red staining, thioflavin T fluorescence and circular dichroism experiments. FTIR points to the formation of beta-sheet structures in solution and in dried films and suggests that aggregation occurs at low concentration and is not strongly affected by further increase in concentration, i.e. the peptide is a strong fibril-former in methanol. UV fluorescence experiments on unstained peptide and CD point to the importance of aromatic interactions between phenylalanine groups in driving aggregation into beta-sheets. The CD spectrum differs from that usually observed for beta-sheet assemblies formed by larger peptides or proteins and this is discussed for solutions in methanol and also trifluoroethanol. The fibril structure is imaged by transmission electron microscopy and scanning electron microscopy on dried samples and is confirmed by small-angle X-ray scattering experiments in solution

Lifshitz points in blends of AB and BC diblock copolymers

We consider micro- and macro-phase separation in blends of AB and BC flexible diblock copolymers. We show that, depending on architecture, a number of phase diagram topologies are possible. Microphase separation or macrophase separation can occur, and there are a variety of possible Lifshitz points. Because of the rich parameter space, Lifshitz points of multiple order are possible. We demonstrate Lifshitz points of first and second order, and argue that, in principle, up to 5th-order Lifshitz points are possible

PepMat 2016: The second conference on peptide-based materials for biomedicine and nanotechnology

Postprint (published version

Power electronics for low power arcjets

In anticipation of the needs of future light-weight, low-power spacecraft, arcjet power electronics in the 100 to 400 W operating range were developed. Limited spacecraft power and thermal control capacity of these small spacecraft emphasized the need for high efficiency. Power topologies similar to those in the higher 2 kW and 5 to 30 kW power range were implemented, including a four transistor bridge switching circuit, current mode pulse-width modulated control, and an output current averaging inductor with an integral pulse generation winding. Reduction of switching transients was accomplished using a low inductance power distribution network, and no passive snubber circuits were necessary for power switch protection. Phase shift control of the power bridge was accomplished using an improved pulse width modulation to phase shift converter circuit. These features, along with conservative magnetics designs allowed power conversion efficiencies of greater than 92.5 percent to be achieved into resistive loads over the entire operating range of the converter. Electromagnetic compatibility requirements were not considered in this work, and control power for the converter was derived from AC mains. Addition of input filters and control power converters would result in an efficiency of on the order of 90 percent for a flight unit. Due to the developmental nature of arcjet systems at this power level, the exact nature of the thruster/power processor interface was not quantified. Output regulation and current ripple requirements of 1 and 20 percent respectively, as well as starting techniques, were derived from the characteristics of the 2 kW system but an open circuit voltage in excess of 175 V was specified. Arcjet integration tests were performed, resulting in successful starts and stable arcjet operation at power levels as low as 240 W with simulated hydrazine propellants

Surface structure of thin asymmetric PS-b-PMMA diblock copolymers investigated by atomic force microscopy

Asymmetric poly(styrene-b-methyl methacrylate) (PS-b-PMMA) diblock copolymers of molecular weight M-n = 29,700g mol(-1) (M-PS = 9300 g mol(-1) M-PMMA = 20,100 g mol(-1), PD = 1.15, chi(PS) = 0.323, chi(PMMA) = 0.677) and M-n = 63,900 g mol(-1) (M-PS = 50,500 g mol(-1), M-PMMA = 13,400 g mol(-1), PD = 1.18, chi(PS) = 0.790, chi(PMMA) = 0.210) were prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization. Atomic force microscopy (AFM) was used to investigate the surface structure of thin films, prepared by spin-coating the diblock copolymers on a silicon substrate. We show that the nanostructure of the diblock copolymer depends on the molecular weight and volume fraction of the diblock copolymers. We observed a perpendicular lamellar structure for the high molar mass sample and a hexagonal-packed cylindrical patterning for the lower molar mass one. Small-angle X-ray scattering investigation of these samples without annealing did not reveal any ordered structure. Annealing of PS-b-PMMA samples at 160 degrees C for 24 h led to a change in surface structure

Beyond teenage motherhood: navigating life stages and issues of identity into adulthood

Jemma Hamley explored the retrospective reflections of former teenage mothers. Results of her study indicate that understanding former teenage mothers' lived experiences across their lifespan entails an appreciation of disadvantage, stigma, oppression, and resilience. Unique areas of life stage phenomena were explored, and implications for social work practice identified

The effect of changing spectral composition on the photosynthetic efficiency and survival rate of Goniastrea sp. Ex Situ

Corals exposed to high light intensity may be susceptible to bleaching, therefore understanding the effect of light on coral photophysiology is vital to their protection. Goniastrea corals collected from Hall Bank Reef were placed under four different light filter treatments: blue, clear, red and UV opaque under outdoor conditions at Perth, Western Australia and photosynthetic activities were measured using a Diving-PAM. The main aim of this study was determining light composition (exposed λ) effect on the corals’ photosynthetic efficiency and survival rate. The photosynthetic efficiency was quantified as Fv/Fm (the effective quantum yield of Photosystem II), the electron transport rate (ETR and ETRmax), non-photochemical quenching (NPQ), and alpha (α). Coral survival was monitored until all corals had died, and it was found that corals subjected to shorter wavelengths (the blue light treatment) survived longer than other light treatments. The corals were initially collected from 12 m depth, where they are naturally adapted to an environment that is exposed to mainly blue light (450-495 nm); therefore they would be adapted to these conditions. The Fv/Fm dropped significantly over the course of the experiment, with higher Fv/Fm reduction in clear and UV light filter treatments when compared to corals kept at blue and red spectra. Fv/Fm reduction over time may be due to chronic photoinhibition damaging PSII and lowering the overall photosynthetic yield of the algal symbiont. The Fv/Fm of the corals subjected to the blue light treatment was consistently higher, most likely due to lower PAR (Photosynthetically Active Radiation) level transmitting this filter. The diurnal trials indicated there was a peak in Fv/Fm at 9am, before decreasing at midday under all light treatments. This was attributed to the high irradiance at this time of day causing dynamic photoinhibition and thus a temporary lowering of the photosynthetic yield of the symbionts. ETRmax, α and NPQ did not change significantly over time, however α and ETRmax showed a general trend of increasing until midday (when irradiance is highest) and then decreasing. Overall this showed that corals exposed to broader bands of the electromagnetic spectrum are more likely to experience damage to PSII and subsequent decrease in photosynthetic yield, as well as lowered survival rate. The results of this study indicate that altering the transmission of light in the ocean may have detrimental effects on coral reefs