10 research outputs found
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The occurrence of different intrusive errors in patients with Alzheimer's disease, multiple cerebral infarctions, and major depression
Recent evidence suggests that specific types of intrusive errors may occur more often in the protocols of Alzheimer's disease (AD) patients than in those of patients diagnosed with other types of dementia.
Using the FULD Object Memory Evaluation, we documented the occurrence of five qualitatively different types of intrusive errors for mildly and moderately impaired patients with AD and multiple cerebral infarctions (MCI). Depressed and normal elderly controls were also studied. Despite an equivalent degree of impairment on a broad array of neuropsychological measures, mildly impaired AD patients evidenced greater deficits on a measure tapping retrieval from semantic memory and demonstrated a higher occurrence of specific types of intrusive errors relative to their mildly impaired MCI counterparts. Further, both of these measures were highly correlated, suggesting that these indices may be particularly sensitive to semantic dysfunction associated with early AD
Fatigue rating scales critique and recommendations by the Movement Disorders Society task force on rating scales for Parkinson's disease
© 2010 Movement Disorder Society
[The definitive version is available at www3.interscience.wiley.com] [A versĂŁo definitiva estĂĄ disponĂvel em www3.interscience.wiley.com]Fatigue has been shown to be a consistent and common problem in Parkinson's disease (PD) in multiple countries and cultures. It is one of the most disabling of all symptoms, including motor dysfunction, and appears early, often predating the onset of motor symptoms. Several studies of the epidemiology of fatigue have been published, often using different scales, but few on treatment. The Movement Disorder Society (MDS) commissioned a task force to assess available clinical rating scales, critique their psychometric properties, summarize their clinical properties, and evaluate the evidence in support of their use in clinical studies in PD. Six clinical researchers reviewed all studies published in peer reviewed journals of fatigue in PD, evaluated the scales' previous use, performance parameters, and quality of validation data, if available. Scales were rated according to criteria provided by the MDS. A scale was ârecommendedâ if it has been used in clinical studies beyond the group that developed it, has been used in PD and psychometric studies have established that it is a valid, reliable and sensitive to change in people with PD. Requiring a scale to have demonstrated sensitivity to change in PD specifically rather than in other areas in order to attain a rating of ârecommendedâ differs from the use of this term in previous MDS task force scale reviews. âSuggestedâ scales failed to meet all the criteria of a ârecommendedâ scale, usually the criterion of sensitivity to change in a study of PD. Scales were âlistedâ if they had been used in PD studies but had little or no psychometric data to assess. Some scales could be used both to screen for fatigue as well as to assess fatigue severity, but some were only used to assess severity. The Fatigue Severity Scale was ârecommendedâ for both screening and severity rating. The Fatigue Assessment Inventory, an expanded version of the Fatigue severity Scale, is âsuggestedâ for both screening and severity. The Functional Assessment of Chronic Illness Therapy-Fatigue was ârecommendedâ for screening and âsuggestedâ for severity. The Multidimensional Fatigue Inventory was âsuggestedâ for screening and ârecommendedâ for severity. The Parkinson Fatigue Scale was ârecommendedâ for screening and âsuggestedâ for severity rating. The Fatigue Severity Inventory was âlistedâ for both screening and severity. The Fatigue Impact Scale for Daily Use, an adaptation of the Fatigue Impact Scale was âlistedâ for screening and âsuggestedâ for severity. Visual Analogue and Global Impression Scales are both âlistedâ for screening and severity. The committee concluded that current scales are adequate for fatigue studies in PD but that studies on sensitivity and specificity of the scales are still needed