Sobre la poesía de Camilo Pessanha

Camilo Pessanha nació en 1867, en Coimbra (Portugal), y murió en Macao (1926). Licenciado en derecho (1891), fue profesor de filosofía del liceo de Macao, a donde llegó en 1894, y también registrador de propiedad y magistrado. Se interesó por la estética y la literatura oriental, y reunió una significativa colección de arte chino. Desde 1885 publicó en periódicos y revistas su poesía, que en parte sería recogida en el volumen Clepsydra (Lisboa, 1920)

El poder curativo de las plantas medicinales : investigación local, Bagadó, Chocó

Se describe el trabajo desarrollado en el convenio SENA-Tropenbos que hace parte de la serie “formación en Gestión Ambiental y Cadenas Productivas Sostenibles” en la que se recopila un listado de plantas medicinales en Bagadó, Chocó así como sus usos y preparación, calendarios de cosecha y testimoniosThe work developed in the SENA-Tropenbos agreement is described, which is part of the series "Training in Environmental Management and Sustainable Productive Chains" in which a list of medicinal plants is collected in Bagadó, Chocó as well as their uses and preparation, calendars of harvest and testimoniesPresentación -- Nuestro propósito -- Quiénes somos y donde estamos -- Usos de algunas plantas medicinales que debemos tener en nuestras casas -- Nuestra huerta casera -- Nuestro patio -- Testimoniosna23 página

Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points

Clinical manifestations of intermediate allele carriers in Huntington disease

Objective: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. Methods: We assessed a cohort of participants at risk with <36 CAG repeats of the huntingtin (HTT) gene. Outcome measures were the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive, and behavior domains, Total Functional Capacity (TFC), and quality of life (Short Form-36 [SF-36]). This cohort was subdivided into IA carriers (27-35 CAG) and controls (<27 CAG) and younger vs older participants. IA carriers and controls were compared for sociodemographic, environmental, and outcome measures. We used regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12,190 participants, 657 (5.38%) with <36 CAG repeats were identified: 76 IA carriers (11.56%) and 581 controls (88.44%). After correcting for multiple comparisons, at baseline, we found no significant differences between IA carriers and controls for total UHDRS motor, SF-36, behavioral, cognitive, or TFC scores. However, older participants with IAs had higher chorea scores compared to controls (p 0.001). Linear regression analysis showed that aging was the most contributing factor to increased UHDRS motor scores (p 0.002). On the other hand, 1-year follow-up data analysis showed IA carriers had greater cognitive decline compared to controls (p 0.002). Conclusions: Although aging worsened the UHDRS scores independently of the genetic status, IAs might confer a late-onset abnormal motor and cognitive phenotype. These results might have important implications for genetic counseling. ClinicalTrials.gov identifier: NCT01590589