66 research outputs found
Why Who Does What Matters: Governmental Design, Agency Performance, the CFPB and PPACA
- Author
- &
- . The George Washington Law Id
- A David
- Cutler Memo
- D Michael
- David A. Hyman
- David Nather
- E G See
- E Spencer
- George Washington Law The
- Going Public
- Harv L Rev
- Id
- Id
- Id
- Id
- Id
- Id
- Id
- J R Deshazo
- Jackie Calmes
- Jody Freeman
- Keith Bradley
- Lewis See
- Mario J Rizzo &
- Michael B Mierzewski
- Nikki Sutton
- Peter Coy
- Rachel E Barkow
- Richard H Cf
- Richard Pollock
- Sandhya Somashekhar
- See Stephanie Kirchgaessner
- See Zywicki
- Stephanie Kirchgaessner
- Timothy B Clark
- U S C
- U S C
- William E Kovacic
- William E. Kovacic
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Guías de práctica clínica para el tratamiento de la hipertensión arterial 2007
- Author
- Abuissa
- Adler
- Agabiti-Rosei
- Agodoa
- Aksnes
- Alderman
- Alderman
- Al’Absi
- Al’Absi
- Amar
- Amarenco
- Ambrosioni
- Ambrosioni
- Amery
- Andersen
- Antonios
- Appel
- Appel
- Arima
- Arnlov
- Asmar
- Asmar
- Asselbergs
- Assmann
- Atallah
- Atkins
- Aurell
- Aurigemma
- Baguet
- Bakris
- Balkau
- Bang
- Bangalore
- Bao
- Barnett
- Bathl
- Bella
- Benetos
- Benetos
- Benetos
- Benetos
- Bigazzi
- Bigger
- Birns
- Bjorklund
- Blacher
- Black
- Bobrie
- Bonet
- Borghi
- Borhani
- Bosch
- Bosch
- Bots
- Boutitie
- Boutouyrie
- Bradley
- Bravo
- Bravo
- Bravo
- Brenner
- Brewster
- Brown
- Brown
- Bruce
- Bulpitt
- Burek
- Bursi
- Burt
- Cadman
- Calhoun
- Campos
- Carroll
- Casas
- Casiglia
- Chasan-Taber
- Chen
- Chiasson
- Chobanian
- Christensen
- Churchill
- Ciulla
- Ciulla
- Ciulla
- Ciulla
- Clearfield
- Clement
- Coats
- Cockroft
- Colhoun
- Collins
- Collins
- Conn
- Conroy
- Coope
- Coppage
- Cornelissen
- Cornelissen
- Criqui
- Cruickshank
- Culleton
- Curtis
- Cushman
- Cuspidi
- Cuspidi
- Cuspidi
- Cuspidi
- Cuspidi
- Cuspidi
- Cuspidi
- Cuspidi
- Cuspidi
- Cutler
- Dahlof
- Dahlof
- Dahlof
- Dahlof
- Dahlof
- Dalla Vestra
- Daniels
- Darne
- Davis
- De Backer
- De Leeuw
- De Leeuw
- De Leeuw
- De Luca
- De Luca
- De Simone
- De Simone
- De Swiet
- De Zeeuw
- De Zeeuw
- Deedwania
- Dekker
- Despres
- Devereux
- Devereux
- Devereux
- Devereux
- Dhakam
- Dhakam
- Dickerson
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- Dickstein
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- Dimmitt
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- Doll
- Domanski
- Domanski
- Dong
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- D’Agostino
- Eberly
- Eide
- El-Tamimi
- Elliott
- Elliott
- Elliott
- Estacio
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- Evans
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- Fagard
- Fagard
- Fagard
- Fagard
- Fagard
- Fagard
- Fagard
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- Grobbee
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- Gueyffier
- Haffner
- Halcox
- Hallan
- Han W-
- Hankey
- Hansen
- Hansen
- Hansson
- Hansson
- Hansson
- Hansson
- Havranek
- Hayden
- Haynes
- He
- He
- He
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- Kannel
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- Karalliedde
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- Kearney
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- Khattar
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- Kincaid-Smith
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- Kjeldsen
- Kjeldsen
- Klag
- Kleiger
- Klingbeil
- Knight
- Knowler
- Knowler
- Kokkinos
- Koler
- Koren
- Koren
- Korsgaard
- Kosoglou
- Kostis
- Krauss
- Krum
- Krumme
- Kurtz
- La Rovere
- Lakatta
- Lakka
- Lane
- Lang
- Langford
- Lauer
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- Laurent
- Laurent
- Laurent
- Lavie
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- Law
- Law
- Lawes
- Lee
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- Leonetti
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- Levine
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- Levy
- Levy
- Levy
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- Lewis
- Liao
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- Lindholm
- Lindholm
- Lindqvist
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- Lip
- Lip
- Lip
- Lithell
- Liu
- Liu
- Logan
- Longstreth
- Lonn
- Lubsen
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- Lurbe
- Lydakis
- MacKinnon
- MacMahon
- MacMahon
- Madrid
- Magee
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- Malacco
- Malmqvist
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mancia
- Mann
- Mann
- Mann
- Mann
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- Messerli
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- Mogensen
- Mogensen
- Morgan
- Morgan
- Morris
- Moser
- Moutquin J-
- Muiesan
- Muiesan
- Mule
- Muller
- Muller-Brunotte
- Munakata
- Mundal
- Nakao
- Narkiewicz
- Narkiewicz
- Nathan
- Neal
- Nesto
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- Nguyen
- Nides
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- Noon
- Nordmann
- Norris
- Oakley
- Ogunyankin
- Ohkubo
- Ohkubo
- Ohkubo
- Ohkubo
- Okin
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- Olsen
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- Omvik
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- Otten
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- O’Brien
- O’Brien
- O’Brien
- O’Brien
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- Palatini
- Palatini
- Palatini
- Palatini
- Paliotti
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- Parati
- Parati
- Parati
- Parati
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- Parving
- Parving
- Parving
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- Pescatello
- Pfeffer
- Pfeffer
- Phillips
- Pi-Sunyer
- Pickering
- Pickering
- Pickering
- Pilz
- Pimenta
- Pischon
- Pitt
- Pitt
- Pitt
- Plouin
- Pohl
- Poole-Wilson
- Poole-Wilson
- Port
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- Pourdjabbar
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- Prince
- Prins
- Puddey
- Puddey
- Qiu
- Rahman
- Rahman
- Rajzer
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- Redon
- Redon
- Redon
- Redon
- Reichek
- Reisch
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- Ridker
- Ridker
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- Rizzoni
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- Ruggenenti
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- Ruilope
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- Staessen
- Staessen
- Staessen
- Staessen
- Staessen
- Staessen
- Staessen
- Staessen
- Staessen
- Staessen
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- Undar
- Van de Laar
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- Van Zwieten
- Vasan
- Vasan
- Vasan
- Vasbinder
- Verdecchia
- Verdecchia
- Verdecchia
- Verdecchia
- Verdecchia
- Verdecchia
- Verdecchia
- Verdecchia
- Verdecchia
- Verdecchia
- Verma
- Vermeer
- Vermeer
- Vermeer
- Vermeer
- Vermes
- Vessey
- Viberti
- Villamil
- Visvanathan
- Vogt
- Vogt
- Vogt
- Volpe
- Von Dadelszen
- Voyaki
- Wachtell
- Wachtell
- Waeber
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- Wang
- Wang
- Wannamethee
- Weber
- Weber
- Webster
- Wei
- Werner
- Whelton
- White
- Williams
- Willich
- Willum-Hansen
- Wilson
- Wilson
- Wilson
- Wing
- Wing
- Wing
- Wolf-Maier
- Wong
- Wong
- Wood
- Woods
- Wright
- Wright
- Yap
- Yui
- Yusuf
- Yusuf
- Yusuf
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zanchetti
- Zannad
- Zarnke
- Zillich
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2007
- Field of study
The Science Performance of JWST as Characterized in Commissioning
- Author
- Abell Jim
- Abney Faith
- Abul-Huda Yasin
- Acton D. Scott
- Adams Evan
- Adler David
- Aguilar Jonathan
- Ahmed Nasif
- Alarcon Rafael Ramos
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Marsha
- Altenburg Martin
- Alvarez Jose Lorenzo
- Andersen Greg
- Anderson Harry
- Anderson Sara
- Argyriou Ioannis
- Armstrong Amber
- Arribas Santiago
- Artigau Etienne
- Arvai Amanda
- Atkinson Charles
- Bacon Gregory
- Bair Thomas
- Banks Kimberly
- Barrientes Jaclyn
- Barringer Bruce
- Bartosik Peter
- Bast William
- Baudoz Pierre
- Beatty Thomas
- Bechtold Katie
- Beck Tracy
- Bergeron Eddie
- Bergkoetter Matthew
- Bhatawdekar Rachana
- Birkmann Stephan
- Blazek Ronald
- Blome Claire
- Boccaletti Anthony
- Boeker Torsten
- Boia John
- Bonaventura Nina
- Bond Nicholas
- Bosley Kari
- Boucarut Ray
- Bourque Matthew
- Bouwman Jeroen
- Bower Gary
- Bowers Charles
- Boyer Martha
- Bradley Larry
- Brady Greg
- Braun Hannah
- Breda David
- Bresnahan Pamela
- Bright Stacey
- Britt Christopher
- Bromenschenkel Asa
- Brooks Brian
- Brooks Keira
- Brown Bob
- Brown Matthew
- Brown Patricia
- Bunker Andy
- Burger Matthew
- Bushouse Howard
- Cale Steven
- Cameron Alex
- Cameron Peter
- Canipe Alicia
- Caplinger James
- Caputo Francis
- Cara Mihai
- Carey Larkin
- Carniani Stefano
- Carrasquilla Maria
- Carruthers Margaret
- Case Michael
- Catherine Riggs
- Chance Don
- Chapman George
- Charlot Stéphane
- Charlow Brian
- Chayer Pierre
- Chen Bin
- Cherinka Brian
- Chichester Sarah
- Chilton Zack
- Chonis Taylor
- Clampin Mark
- Clark Charles
- Clark Kerry
- Coe Dan
- Coleman Benee
- Colon Knicole
- Comber Brian
- Comeau Tom
- Connolly Dennis
- Cooper James
- Cooper Rachel
- Coppock Eric
- Correnti Matteo
- Cossou Christophe
- Coulais Alain
- Coyle Laura
- Cracraft Misty
- Curti Mirko
- Cuturic Steven
- Davis Katherine
- Davis Michael
- de Oliveira Catarina Alves
- Dean Bruce
- Del Pino Bruno Rodriguez
- DeLisa Amy
- deMeester Wim
- Dencheva Nadezhda
- Dencheva Nadia
- DePasquale Joseph
- Deschenes Jeremy
- Detre Örs Hunor
- Diaz Rosa
- Dicken Dan
- DiFelice Audrey
- Dillman Matthew
- Dixon William
- Doggett Jesse
- Donaldson Tom
- Douglas Rob
- Doyon René
- DuPrie Kimberly
- Dupuis Jean
- Durning John
- Easmin Nilufar
- Eck Weston
- Edeani Chinwe
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan
- Eisenhower Michael
- Elie Michelle
- Elliott James
- Elliott Kyle
- Ellis Tracy
- Engesser Michael
- Espinoza Nestor
- Etienne Odessa
- Etxaluze Mireya
- Falini Patrick
- Feeney Matthew
- Feinberg Lee
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph
- Fincham Brian
- Fix Mees
- Flagey Nicolas
- Florian Michael
- Flynn Jim
- Fontanella Erin
- Ford Terrance
- Forshay Peter
- Fox Ori
- Franz David
- Friedman Scott
- Fu Henry
- Fullerton Alexander
- Galkin Sergey
- Galyer Anthony
- Gardner Jonathan
- Gardner Lisa
- Garland Dennis
- Garrett Bruce
- Gasman Danny
- Gaspar Andras
- Gaudreau Daniel
- Gauthier Peter
- Geers Vincent
- Geithner Paul
- Gennaro Mario
- Giardino Giovanna
- Girard Julien
- Giuliano Mark
- Glasse Alistair
- Glassmire Kirk
- Glauser Adrian
- Glazer Stuart
- Godfrey John
- Golimowski David
- Gollnitz David
- Gong Fan
- Gonzaga Shireen
- Gordon Karl
- Gordon Michael
- Goudfrooij Paul
- Greene Thomas
- Greenhouse Matthew
- Grimaldi Stefano
- Groebner Andrew
- Grundy Timothy
- Guillard Pierre
- Gutman Irvin
- Ha Kong Q.
- Haderlein Peter
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hami Maryam
- Hamilton Forrest
- Hammel Heidi
- Hansen Carl
- Harkins Tom
- Harr Michael
- Hart Jessica
- Hart Quyen
- Hartig George
- Hashimoto Ryan
- Haskins Sujee
- Hathaway William
- Havey Keith
- Hayden Brian
- Hecht Karen
- Heller-Boyer Chris
- Henriques Caroline
- Henry Alaina
- Hermann Karl
- Hernandez Scarlin
- Hesman Brigette
- Hicks Brian
- Hilbert Bryan
- Hines Dean
- Hoffman Melissa
- Holfeltz Sherie
- Holler Bryan J.
- Hoppa Jennifer
- Hott Kyle
- Howard Joseph
- Howard Rick
- Hunter Alexander
- Hunter David
- Hurst Brendan
- Husemann Bernd
- Hustak Leah
- Ignat Luminita Ilinca
- Illingworth Garth
- Irish Sandra
- Jackson Wallace
- Jahromi Amir
- Jakobsen Peter
- James Bryan
- James LeAndrea
- Januszewski William
- Jenkins Ann
- Jirdeh Hussein
- Johnson Phillip
- Johnson Timothy
- Jones Danny
- Jones Olivia
- Jones Ron
- Jones Vicki
- Jordan Ian
- Jordan Margaret
- Jurczyk Sarah
- Jurling Alden
- Kaleida Catherine
- Kalmanson Phillip
- Kammerer Jens
- Kang Huijo
- Kao Shaw-Hong
- Karakla Diane
- Kavanagh Patrick
- Kelly Doug
- Kendrew Sarah
- Kennedy Herbert
- Kenny Deborah
- Keski-kuha Ritva
- Keyes Charles
- Kidwell Richard
- Kimble Randy
- Kinzel Wayne
- Kirk Jeff
- Kirkpatrick Mark
- Kirshenblat Danielle
- Klaassen Pamela
- Knapp Bryan
- Knight J. Scott
- Knollenberg Perry
- Koehler Robert
- Koekemoer Anton
- Kovacs Aiden
- Kulp Trey
- Kumari Nimisha
- Kyprianou Mark
- La Massa Stephanie
- Labador Aurora
- Lagage Pierre-Olivier
- Lajoie Charles-Phillipe
- Lallo Matt
- Lallo Matthew
- Lam May
- Lamb Tracy
- Lambros Scott
- Lampenfield Richard
- Langston James
- Larson Kirsten
- Law David
- Lawrence Jon
- Lee David
- Leisenring Jarron
- Lepo Kelly
- Leveille Michael
- Levenson Nancy
- Levine Marie
- Levy Zena
- Lewis Dan
- Lewis Hannah
- Libralato Mattia
- Lightsey Paul
- Link Miranda
- Liu Lily
- Lo Amy
- Lockwood Alexandra
- Logue Ryan
- Long Chris
- Long Douglas
- Loomis Charles
- Lopez-Caniego Marcos
- Love-Pruitt Jennifer
- Lucy Adrian
- Luetzgendorf Nora
- Maghami Peiman
- Maiolino Roberto
- Major Melissa
- Malla Sunita
- Malumuth Eliot
- Manjavacas Elena
- Mannfolk Crystal
- Marin Macarena Garcia
- Marquez Javier Alvarez
- Marrione Amanda
- Marston Anthony
- Martel André
- Maschmann Marc
- Masci Gregory
- Masciarelli Michaela
- Maszkiewicz Michael
- Mather John
- McElwain Michael
- McKenzie Kenny
- McLean Brian
- McMaster Matthew
- Melbourne Katie
- Meléndez Marcio
- Menzel Michael
- Merz Kaiya
- Meyett Michele
- Meza Luis
- Milam Stefanie
- Miskey Cherie
- Misselt Karl
- Moller Christopher
- Morrison Jane
- Morse Ernie
- Moseley Harvey
- Mosier Gary
- Mountain Matt
- Mueckay Julio
- Mueller Michael
- Mullally Susan
- Murphy Jess
- Murray Claire
- Murray Katherine
- Mustelier David
- Muzerolle James
- Mycroft Matthew
- Myers Richard
- Myrick Kaila
- Nanavati Shashvat
- Nance Elizabeth
- Nayak Omnarayani
- Naylor Bret
- Neff Susan
- Neira Irma Quispe
- Nelan Edmund
- Nickson Bryony
- Nielson Alethea
- Nieto-Santisteban Maria
- Nikolov Nikolay
- Noriega-Crespo Alberto
- O'Shaughnessy Brian
- O'Sullivan Brian
- Ochs William
- Ogle Patrick
- Oleszczuk Brenda
- Olmsted Joseph
- Ortega Alvaro Labiano
- Osborne Shannon
- Ottens Richard
- Owens Beverly
- Pacifici Camilla
- Pagan Alyssa
- Page James
- Park Sang
- Parrish Keith
- Patapis Polychronis
- Paul Lee
- Pauly Tyler
- Pavlovsky Cheryl
- Pedder Andrew
- Peek Matthew
- Pena-Guerrero Maria
- Pennanen Konstantin
- Perez Yesenia
- Perna Michele
- Perriello Beth
- Perrin Marshall
- Phillips Kevin
- Pietraszkiewicz Martin
- Pinaud Jean-Paul
- Pirzkal Norbert
- Pitman Joseph
- Piwowar Aidan
- Platais Vera
- Plate Maurice Te
- Player Danielle
- Plesha Rachel
- Pollizi Joe
- Polster Ethan
- Pontoppidan Klaus
- Porterfield Blair
- Proffitt Charles
- Pueyo Laurent
- Pulliam Christine
- Quirt Brian
- Ramsay Leah
- Rapp Greg
- Rapp Robert
- Rauscher Bernard
- Ravindranath Swara
- Rawle Timothy
- Regan Michael
- Reichard Timothy A.
- Reis Carl
- Ressler Michael E.
- Rest Armin
- Reynolds Paul
- Rhue Timothy
- Richon Karen
- Rickman Emily
- Ridgaway Michael
- Rieke George
- Rieke Marcia
- Rigby Jane
- Ritchie Christine
- Rix Hans-Walter
- Robberto Massimo
- Robinson Gregory
- Robinson Michael
- Robinson Orion
- Rock Frank
- Rodriguez David
- Roellig Thomas
- Rohrbach Scott
- Roman Anthony
- Romelfanger Fred
- Rose Perry
- Roteliuk Anthony
- Roth Marc
- Rothwell Braden
- Rowlands Neil
- Roy Arpita
- Royer Pierre
- Royle Patricia
- Rui Chunlei
- Rumler Peter
- Runnels Joel
- Russ Melissa
- Rustamkulov Zafar
- Ryden Grant
- Ryer Holly
- Sabata Modhumita
- Sabatke Derek
- Sabbi Elena
- Samuelson Bridget
- Sapp Benjamin
- Sappington Bradley
- Sargent B.
- Sauer Arne
- Scheithauer Silvia
- Schlawin Everett
- Schlitz Joseph
- Schmitz Tyler
- Schneider Analyn
- Schreiber Jürgen
- Schulze Vonessa
- Schwab Ryan
- Scott John
- Sembach Kenneth
- Shanahan Clare
- Shaughnessy Bryan
- Shaw Richard
- Shawger Nanci
- Shay Christopher
- Sheehan Evan
- Shen Sharon
- Sherman Allan
- Shiao Bernard
- Shih Hsin-Yi
- Shivaei Irene
- Sienkiewicz Matthew
- Sing David
- Sirianni Marco
- Sivaramakrishnan Anand
- Skipper Joy
- Sloan Gregory
- Slocum Christine
- Slowinski Steven
- Smith Corbett
- Smith Denise
- Smith Eric
- Smith Erin
- Snyder Gregory
- Soh Warren
- Sohn Tony
- Soto Christian
- Spencer Richard
- Stallcup Scott
- Stansberry John
- Stark Christopher
- Starr Carl
- Starr Elysia
- Stewart Alphonso
- Stiavelli Massimo
- Straughn Amber
- Strickland David
- Stys Jeff
- Summers Francis
- Sun Fengwu
- Sunnquist Ben
- Swade Daryl
- Swam Michael
- Swaters Robert
- Swoish Robby
- Taylor Joanna M.
- Taylor Rolanda
- Tea Mason
- Teague Kelly
- Telfer Randal
- Temim Tea
- Thatte Deepashri
- Thompson Christopher
- Thompson Linda
- Thomson Shaun
- Tikkanen Tuomo
- Tippet William
- Todd Connor
- Toolan Sharon
- Tran Hien
- Trejo Edwin
- Truong Justin
- Tsukamoto Chris
- Tustain Samuel
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- Uzzo Michael
- Valenti Jeff
- Van Campen Julie
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- Waldman Mark
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- Watkins Mitchell
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- Weilert Mark
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- Weiss Ben
- Weissman Sarah
- Welty Alan
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- Wheate Lauren
- Wheatley Elizabeth
- Wheeler Thomas
- White Rick
- Whiteaker Kevin
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- Williams Christina
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- Willott Chris
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- Wirth Gregory
- Wislowski Emily
- Wolf Erin
- Wolfe David
- Wolff Schuyler
- Workman Bill
- Wright Gillian
- Wright Ray
- Wu Carl
- Wu Rai
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- Yates Kayla
- Yeager Christopher
- Yeates Jared
- Yerger Ethan
- Yoon Jinmi
- Young Alice
- Yu Susan
- Zak Dean
- Zeidler Peter
- Zhou Julia
- Zielinski Thomas
- Zincke Cristian
- Zonak Stephanie
- Publication venue
- 'IOP Publishing'
- Publication date
- 10/04/2023
- Field of study
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy
- Author
- A. R. Dennison
- Abbas Kadhim
- Abdalla Eisawi
- Abdulzahra A. Hussain
- Abheesh R. Prasad
- Abhilasha Patel
- Abi Mawhinney
- Abraham Joel
- Adam Chambers
- Adam Janeczko
- Adam Kimble
- Adeshina S. Fawole
- Adnan Hussain
- Adrian W. O’Sullivan
- Ahmad H. Nassar
- Ahmed Al-Muhktar
- Ahmed K. Mirza
- Ahmed M. Khalil
- Ahmed Z. Al-Bahrani
- Ajit Dhillon
- Alan J. Grant
- Alan T. Boyd
- Alex Hrycaiczuk
- Alexa Templeton
- Alexander Boddy
- Alexander E. J. Trevatt
- Alexandros Charalabopoulos
- Alfred Choy
- Alhafidz Hamdan
- Ali Alison Luther
- Ali Majeed
- Alice Bryant
- Alice Chambers
- Alice Chambers
- Alicja Psica
- Alison Kinghorn
- Alistair Reid
- Alok Chhabra
- Altaf Awan
- Amanda J. Kirkham
- Amanda Roebuck
- Amarah Khan
- Ambareen Kausar
- Amir Forouzanfar
- Amir Khawaja
- Ana C. Pinho-Gomes
- Andrea R. G. Sheel
- Andreas Luhmann
- Andrew Harris
- Andrew J. Cockbain
- Andrew Jackson
- Andrew L. Baker
- Andrew Macdonald
- Andrew McClarey
- Andrew McGuigan
- Andrew Tsang
- Andrzej Goscimski
- Angus G. K. McNair
- Angus J. M. Watson
- Aniket Sonsale
- Anisha Sukha
- Anita Hargreaves
- Ansar Farooq
- Anthony J. Rate
- Antonio Manzelli
- Anwar Ahmad
- Anwar Hussain
- April Nilsen-Nunn
- Arikoge Ogedegbe
- Arnold D. K. Hill
- Arnold D. K. Hill
- Arslan Pannu
- Ashish Kiran Shrestha
- Ashvina Segaran
- Babu Karavadra
- Barry McAree
- Beatrix Weber
- Beatrix Weber
- Belinda Pearce
- Benjamin Drake
- Benjamin Hopwood
- Benjamin Knight
- Benjamin Z. Starmer
- Benoy I. Babu
- Bhavani Sidhartha Mothe
- Bilal Al-Sarireh
- Brendan L. Skelly
- Brian Dobbins
- Bryony Lovett
- C. Ross Carter
- Carla Rengifo
- Caroline Hindley
- Caroline Yao
- Catherine Bunnell
- Catherine Zhang
- Cathy Malcolm
- Chamindri Weerasinghe
- Chanpreet Arhi
- Charlotte Kallaway
- Cherith M. L. R. Sutton
- Cheuk-Bong Tang
- Chris Kendal
- Christina A. W. Macano
- Christina Lo
- Christine Blane
- Christopher P. J. Wood
- Christopher R. Nicolay
- Christopher Taylor
- Ciny P. Parappally
- Claire Hall
- Claire Jackson
- Claire Jones
- Claire L. Rutherford
- Clare Jelley
- Colin H. Richards
- Colin McIlmunn
- Colin Peirce
- Colman K. Byrnes
- Conor J. Magee
- Conor Warren
- Conrad D’Costa
- Constantine Halkias
- Corinna Slawinski
- Craig R. Forrest
- Dalvir S. Bajwa
- Damian McKay
- Damien Durkin
- Dan Rodriguez
- Danail Aleksandrov
- Daniel Brett
- Daniel J. Puntis
- Daniel Urriza Rodriguez
- Darius Mirza
- David A. Longbotham
- David Finch
- David G. Vass
- David Hou
- David I. Hunter
- David J. Holroyd
- David Kennedy
- David Larkin
- David Lindsay
- David Lloyd
- David M. Bunting
- David M. Rae
- David Monk
- David Naumann
- David R. Andrew
- David Shier
- David W. Borowski
- Deep Malde
- Deepak Singh-Ranger
- Deepak Vijayan
- Deirdre M. Nally
- Denise Mason
- Denise Wainwright
- Derek A. O’Reilly
- Derek Alderson
- Des C. Winter
- Dhakshinamoorthy Vijayanand
- Dhivya Subramanium
- Diana Duke
- Dimitrios Kyriakidis
- Dipankar Mukherjee
- Donal Bradley
- Donal Maguire
- Donald Menzies
- Dorothy Johnston
- Duncan J. Simpson
- Duncan J. Stewart
- E. Stirland
- Edrin Iskandar
- Eduardo Villatoro
- Edward Read
- Eleanor Brooke
- Elinor Jones
- Elizabeth M. Vaughan
- Elmoataz Khogali
- Elzanati Hisham
- Emir Hoti
- Emma A. Upchurch
- Emma Hamilton
- Emma M. Lyons
- Emma Nofal
- Emma R. McGlone
- Emmet Dorrian
- Essam Ghareeb
- Evangelos Photi
- Ewen A. Griffiths
- Ewen Griffiths
- Ewen Harrison
- Eyad Issa
- Faith Dalgaty
- Farooq Dar
- Farrukh M. Bajwa
- Fergus Noble
- Fiachra Cooke
- Fotini M. Asprou
- Francesco Giovinazzo
- Francis Bartlett
- Frank McDermott
- Frida Nilsson
- Gareth Bashir
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- Gareth Hooks
- Gary A. Nicholson
- Gary Spence
- Geoffrey P. Roberts
- Geoffrey Yeldham
- George Thomas
- George Tsavellas
- Gerry P. McEntee
- Geta Maharaj
- Ghulam Murtaza
- Gianpiero Gravante
- Giles Bond-Smith
- Giorgios Galanopoulos
- Giuseppe Garcea
- Giuseppe Preziosi
- Gourab Sen
- Graeme Ferguson
- Graeme J. K. Guthrie
- Greg W. Taylor
- Guiseppe Fusai
- Guy M. Shingler
- Haitham Qandeel
- Hamdi Ebdewi
- Haney Youssef
- Hannah Lennon
- Hannah Welbourn
- Hannah Winter
- Harald Bausbacher
- Haythem Ali
- Helen Hawkins
- Helen M. Mohan
- Helen Watkin
- Hema Sekhar
- Henry C. C. Lim
- Hrishikesh Shenoy
- Husam Ebied
- Iain J. D. McCallum
- Ian Finlay
- Ilayaraja Rajendran
- Ileana Geogloma
- Imeshi Wijetunga
- Imogen J. Fordham
- Imran A. Chishti
- Imran Alam
- Irfan Ahmed
- Ivan Ivanovski
- J. G. Finch
- J. Guy Finch
- J. Parmar
- Jack Broadhurst
- Jack Martin
- Jake Sloane
- James A. Gossage
- James A. Nicholson
- James Barnes
- James C. Hewes
- James Davies
- James Francombe
- James Gardner-Thorpe
- James Hewes
- James Hodson
- James Kynaston
- James Mbuvi
- James Milburn
- James Nicholson
- James O. Murphy
- James P. Byrne
- Jamil Ahmed
- Janahan Sarveswaran
- Jane Hornsby
- Jane M. Blazeby
- Javed Ahmed
- Jean Deguara
- Jenifer Barrie
- Jennifer Law
- Jennifer R. Hoban
- Jeremy Batt
- Jessica Chang
- Jessica R. Packer
- Joanna Buchan
- Joanna Reed
- Joel Lambert
- John P. Slavin
- John Spearman
- John T. Cassidy
- John Terrace
- John Wayman
- Jonathan B. Cowley
- Jonathan de Siqueira
- Jonathan Heath
- Jonathan Porter
- Jonathan R. L. Wild
- Joseph Varghase
- Joshil Lodhia
- Joshua A. De Marchi
- Joshua M. Clements
- Judith Ritchie
- Justin Alberts
- Justin G. Geoghegan
- Justine Downing
- Justine Downing Katherine A. Mockford
- Kabita Gurung
- Kam Wa Jessica Mok
- Kamal Aryal
- Karoly Szentpali
- Kas Sarvananthan
- Kate Carney
- Kate Carney
- Kate Hancorn
- Katherine L. Pearson
- Kathryn A. Hodgkins
- Kathryn Lee
- Kathryn M. Boyce
- Kathryn M. O’shea
- Katie Fleming
- Katrina Knight
- Katy Newton
- Keerthika Sampat
- Keith S. Cross
- Keith Seymour
- Ken Keogh
- Ken McCune
- Ken Mealy
- Kenneth B. Hosie
- Kenneth B. Hosie
- Kevin Wheatley
- Khalid Al Amari
- Khalid Amin
- Khaliel Madbak
- Kirsty L. Mozolowski
- Krashna Patel
- Krzysztos Cieplucha
- Kushik Lalla
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- Laura Gould
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- Laurence Devoto
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- M. Angharad Jones
- Madhusoodhana Hebbar
- Maeve A. O’Neill
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- Manraj Phull
- Mansoor Akhtar
- Manzarul Haque
- Marc D. Wilkinson
- Marcus Reddy
- Maria Coats
- Maria Irene Bellini
- Marianne Johnstone
- Marianne Johnstone
- Mark A. Tomlinson
- Mark B. Peter
- Mark Peterson
- Marta Madurska
- Martin Connelly
- Martin Gough
- Martin R. Hossack
- Martin Trotter
- Martin Wadley
- Marwan Farouk
- Mathew Giles
- Matthew Boal
- Matthew Doe
- Matthew G. Tutton
- Matthew Lee
- Matthew MacArtney
- Matthew Popplewell
- Mavis N. Orizu
- Mazin Sayegh
- Mehek Asad
- Mekhlola Mallik
- Melanie Cheung
- Melvinder Basra
- Michael Abayomi
- Michael Boland
- Michael E. Kelly
- Michael Hughes
- Michael I. Booth
- Michael I. Ramage
- Michael J. Courtney
- Michael J. Jones
- Michael Lewis
- Michael P. Tilston
- Michael S. J. Wilson
- Michael Saunders
- Michael Silva
- Michail Kourkulos
- Michelle A. Johnpulle
- Midhat N. Siddiqui
- Mike Pellen
- Mohamed Elmasry
- Mohamed Elshaer
- Mohamed Heshaishi
- Mohamed Rabie
- Mohammad A. Khan
- Mohammed Basheer
- Mohammed Elsayed
- Mohammed F. Hamdan
- Mohammed M. Sadat
- Mohan Harilingam
- Moh’d Rami Obeidallah
- Mudassar A. Ghazanfar
- Muhammad A. S. Khan
- Muhammad Fahad Ullah
- Muhammad Hanif Shiwani
- Musallam Al-Akash
- Nabeela S. Malik
- Naga V. G. Jayanthi
- Najaf Siddiqi
- Najam Hussain
- Naomi Bullen
- Naomi Sakai
- Naresh Pore
- Natalie A. Hirst
- Natalie Elkheir
- Natasha Henley
- Nayab Shah
- Neal Chauhan
- Nehemiah Samuel
- Neil A. Jennings
- Neil Bradley
- Nicholas C. Carter
- Nicholas F. Watson
- Nicholas Mowbray
- Nick Carty
- Nick Heywood
- Nicola Tanner
- Nigel Noor
- Nikita Joji
- Nisheeth Kansal
- null Aymon
- null null
- Nusrat Iqbal
- Obuobi Reece-Bolton
- Oliver J. Old
- Omer Al-Taan
- Parminder Kaur
- Patrick O’Dwyer
- Paul Ainley
- Paul Balfe
- Paul Burke
- Paul Carroll
- Paul Ferris
- Paul J. Needham
- Paul Leeder
- Paul Marriott
- Paul Morcous
- Paul N. Rogers
- Paul Turner
- Paul V. Gallagher
- Paul Ziprin
- Paula Loughlin
- Pawan Mathur
- Pedro Cunha
- Pei J. Lim
- Periyathambi Jambulingam
- Peter D. Willson
- Peter J. Driscoll
- Peter O. Coe
- Peter Wood
- Phil Davey
- Philip Spreadborough
- Philip Spreadborough
- Philippa Orchard
- Piyush B. Sarmah
- Pradeep Basynat
- Pradeep Kumar
- Pradeep Pati
- Pratik A. Sufi
- Priyadarssini Karunakaran
- Prizzi Zarsadias
- Quentin M. Nunes
- Rabiya Aseem
- Rachel C. Rolph
- Raj Prasad
- Raja Basit Khan
- Rajasundaram Rajaganeshan
- Rajiv V. Dave
- Rajwinder S. Nijjar
- Rami Radwan
- Ravi Marudanayagam
- Ravinder S. Vohra
- Ravindra Date
- Rebecca L. Teasdale
- Reena Shah
- Reshma Bharamgoudar
- Richard C. Newton
- Richard Dickson-Lowe
- Richard J. Frame
- Richard Krysztopik
- Risha Lane
- Robert P. Jones
- Robert Padwick
- Robert Sutcliffe
- Roberto Pezzuto
- Roger Lawther
- Rohan T. Gunasekera
- Rohan Thakkar
- Roland C. Aldridge
- Ronald L. E. Thompson
- Ross Kenny
- Rowena Belding
- Ruairi Digney
- Sadaf F. Jafferbhoy
- Sadaf Gull
- Sadiq Bawa
- Saj Wajed
- Salama Yahya
- Salim Tayeh
- Sam Kanavati
- Sameh F. Farag
- Samer Ul Haque
- Sami Mansour
- Sandro Pasquali
- Sanjoy Basu
- Santosh Bhandari
- Saquib Rahman
- Saquib Zeeshan
- Sara Jamel
- Sara Napetti
- Sara Zafar
- Sarah Mohamed
- Sarah Pollock
- Sarah Prince
- Sarah Robinson
- Sarantos Kaptanis
- Saurabh Jamdar
- Sean T. Martin
- Serena Martin
- Shabuddin Khan
- Shahab Khan
- Shahda Ali
- Shailendra Singh
- Shakira Patel
- Shameen Jaunoo
- Shamsi S. El-Hasani
- Shaun Appleton
- Shaun R. Preston
- Shazia Hafiz
- Shiva Dindyal
- Sidhartha Sinha
- Simon Gibson
- Simon J. Dwerryhouse
- Simon K. C. Toh
- Simon Lammy
- Simon M. Higgs
- Simon Weaver
- Simon Wood
- Sivakumar Gopalswamy
- Smeer Kumar Aggarwal
- Sofoklis Panteleimonitis
- Somaiah Aroori
- Sonia Puig
- Soofiyah Ayaani
- Sophie Emesih
- Sophie Tate
- Sophie V. Williams
- Sotonye Tolofari
- Soulat Raza
- Sritharan Kadirkamanathan
- Stacy Wardle
- Stella R. Smith
- Stella R. Smith
- Stephen Brennan
- Stephen Fenwick
- Stephen McCain
- Stephen McKenzie
- Stephen O’Neill
- Stephen P. Bennett
- Steve Satheesan
- Steve T. Hornby
- Steven J. Robinson
- Steven M. Jones
- Stratos Gerakopoulos
- Stuart J. Mercer
- Stuart Robinson
- Stuart Suttie
- Sudhindra T. V. Rao
- Sudipta Roy
- Suroosh Madanipour
- Suvi Virupaksha
- Suzanne Dawson
- Swethan Alagaratnam
- Syed Yusuf Iftikhar
- Taha Lazim
- Talat Ahmed
- Tamsin E. M. Morrison
- Tamzin Cuming
- Tani Fasih
- Tanvir Hossain
- Ted Fletcher
- Theo G. Delisle
- Thomas E. J. Stevenson
- Thomas J. Hardy
- Thomas Rhys
- Thomas Woodman
- Thusidaran Yoganathan
- Timothy H. Brown
- Timothy J. White
- Timothy R. Wilson
- Tom Diamond
- Tom Nieto
- Tom Wallace
- Tomas Urbonas
- Toritseju O. Sillo
- Tracey K. Williamson
- Triantafyllos Doulias
- Vardhini Vijay
- Venkatesh Kanakala
- Victor Miu
- Victoria Banwell
- Vikas Acharya
- Vinutha Shetty
- Vish Bhattacharya
- Vivek Chitre
- Wael Shabo
- Waleed Al-Khyatt
- Wee Sing Ngu
- Wei Ming Chan
- Wei-Min Ho
- William Campbell
- William D. Beasley
- William R. Ball
- William Robb
- Yahya A. Al-Abed
- Yan Li Goh
- Yesar El-Dhuwaib
- Yogesh Puri
- Yousef Shahin
- Yousif Aawsaj
- Yuwaraja Nedujchelyn
- Zakhi Zafrani
- Zayed Hamady
- Zechan Khawaja
- Zohaib Siddiqui
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations.
Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves.
Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p 90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score.
Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
- Boyce Leslye A.
- Boyer Christine T.
- Boyer Martha L.
- Boyer Michael
- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
- Brandl Bernhard R.
- Brannen Judith L.
- Breda David
- Bremmer Harold G.
- Brennan David
- Bresnahan Pamela A.
- Bright Stacey N.
- Broiles Brian J.
- Bromenschenkel Asa
- Brooks Brian H.
- Brooks Keira J.
- Brown Bob
- Brown Bruce
- Brown Thomas M.
- Bruce Barry W.
- Bryson Jonathan G.
- Bujanda Edwin D.
- Bullock Blake M.
- Bunker A. J.
- Bureo Rafael
- Burt Irving J.
- Bush James Aaron
- Bushouse Howard A.
- Bussman Marie C.
- Böker Torsten
- Cabaud Olivier
- Cale Steven
- Calhoon Charles D.
- Calvani Humberto
- Canipe Alicia M.
- Caputo Francis M.
- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
- Cheezum Jeffrey I.
- Chen Bin
- Chen Christine H.
- Cherinka Brian
- Chichester Sarah C.
- Chilton Zachary S.
- Chittiraibalan Dharini
- Clampin Mark
- Clark Charles R.
- Clark Kerry W.
- Clark Stephanie M.
- Claybrooks Edward E.
- Cleveland Keith A.
- Cohen Andrew L.
- Cohen Lester M.
- Coleman Benee L.
- Colina Luis
- Colón Knicole D.
- Comber Brian J.
- Comeau Thomas M.
- Comer Thomas
- Connolly Dennis C.
- Conroy Kyle E.
- Contos Adam R.
- Contreras James
- Cook Neil J.
- Cooper James L.
- Cooper Rachel Aviva
- Correia Michael F.
- Correnti Matteo
- Cossou Christophe
- Costanza Brian F.
- Costas Maria Begoña Vila
- Coulais Alain
- Cox Colin R.
- Coyle Ray T.
- Cracraft Misty M.
- Crew Keith A.
- Curtis Gary J.
- Cusveller Bianca
- Dailey Christopher T.
- Darveau-Bernier Antoine
- Daugeron Frédéric
- Davidson Greg S.
- Davies James E.
- Davis Katherine Anne
- Davis Michael S.
- Day Ratna
- de Chambure Daniel
- de Jong Pauline
- De Marchi Guido
- De Meester Wim
- de Oliveira Catarina Alves
- Dean Bruce H.
- Decker John E.
- del Pino Bruno Rodríguez
- Delisa Amy S.
- Dell Lawrence C.
- Dellagatta Gail
- Dembinska Franciszka
- Demosthenes Sandor
- Dencheva Nadezhda M.
- Deneu Philippe
- DePriest William W.
- Deschenes Jeremy
- Dethienne Nathalie
- Detre Örs Hunor
- Diaz Rosa Izela
- Dicken Daniel
- DiFelice Audrey S.
- Dillman Matthew
- Disharoon Maureen O.
- Dixon William V.
- Doggett Jesse B.
- Dominguez Keisha L.
- Donaldson Thomas S.
- Doria-Warner Cristina M.
- Doty Heather
- Douglas Jr. Robert E.
- Doyon René
- Dressler Alan
- Driggers Jennifer
- Driggers Phillip A.
- Dunn Jamie L.
- DuPrie Kimberly C.
- Dupuis Jean
- Durning John
- Dutta Sanghamitra B.
- Earl Nicholas M.
- Eccleston Paul
- Ecobichon Pascal
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan D.
- Eisenhower Michael
- Eisenstein Daniel J.
- Elie Michelle L.
- Elliott James
- Elliott Kyle Wesley
- Engesser Michael
- Espinoza Néstor
- Etienne Odessa
- Etxaluze Mireya
- Evans Leah
- Fabreguettes Luce
- Falcolini Massimo
- Falini Patrick R.
- Fatig Curtis
- Feeney Matthew
- Feinberg Lee D.
- Fels Raymond
- Ferdous Nazma
- Ferguson Henry C.
- Ferrarese Laura
- Ferreira Marie-Héléne
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph Charles
- Firre Daniel
- Fix Mees
- Flagey Nicolas
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- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
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- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
- A. Bowes
- A. Brady
- A. Brayne
- A. Brown
- A. Brown
- A. Butler
- A. Carter
- A. Collins
- A. Cowley
- A. Cowton
- A. Cowton
- A. Cox
- A. Crew
- A. Dance
- A. Daniel
- A. Daniels
- A. Dela Rosa
- A. Drummond
- A. Durie
- A. E. Heron
- A. Easthope
- A. Easthorpe
- A. Evans.
- A. Fofano
- A. Gales
- A. Ganesan
- A. Gardner
- A. Garg
- A. Gherman
- A. Gordon
- A. Gratrix
- A. Gulati
- A. Gupta
- A. Haigh
- A. Haldeos
- A. Harrison
- A. Harvey
- A. Hayes
- A. Higham
- A. Higham
- A. Hilldrith
- A. Holden
- A. Hormis
- A. Hutcheon
- A. Javaid
- A. Joseph
- A. Kaliappan
- A. Katary
- A. Kay
- A. Kayani
- A. Kent
- A. Kirkby
- A. Knight
- A. Kubisz-Pudelko
- A. Kuravi
- A. Lewis
- A. Loveridge
- A. Lyle
- A. Mayer
- A. McAlpine
- A. McCarthy
- A. McGregor
- A. McGregor
- A. Meikle
- A. Mitchell
- A. Mitra
- A. Morris
- A. Morrison
- A. Naranjo
- A. Nicholson
- A. Nicholson
- A. Noakes
- A. Patel
- A. Pickard
- A. Price
- A. Puxty
- A. Quinn
- A. Quinn
- A. Raithatha
- A. Rattray
- A. Reddy
- A. Reed
- A. Reyes
- A. Rose
- A. Rose
- A. Rostron
- A. Roy
- A. Roynon-Reed
- A. S. Raj
- A. Salberg
- A. Sanderson
- A. Serrano-Ruiz
- A. Solesbury
- A. Sukha
- A. Swain
- A. Tariq
- A. Thomas
- A. Thomas
- A. Todd
- A. Tomas
- A. Tridente
- A. Tucci
- A. Turnbull
- A. Uriel
- A. Ustianowski
- A. Vochin
- A. Vuylsteke
- A. Waite
- A. Walden
- A. Whileman
- A. Wilkinson
- A. Williams
- A. Williams
- A. Wilson
- A. Zak
- A. Zaki
- Achille Iolascon
- Adam Brown
- Adam Krętowski
- Adriana Roży
- Agnese Verzuri
- Agnieszka Adamek
- Agnieszka Bielska
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Albert Tenesa
- Aleksandra Berkan-Kawinska
- Aleksandra Jezela-Stanek
- Aleksandra Starosz
- Alessandra Guarnaccia
- Alessandra Renieri &
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alice Donati
- Alison Meynert
- Alistair Nichol
- Anders Larsson
- Andrea Antinori
- Andrea Cossarizza
- Andrea Gabbuti
- Andrea Tommasi
- Andrew D. Bretherick
- Andrew Law
- Andrew Stenhouse
- Andrzej Eljaszewicz
- Andrzej Horban
- Andy Law
- Angelica Pagliazzi
- Angie Fawkes
- Anke Hinney
- Anna Canaccini
- Anna Kruk
- Anna Maria Pinto
- Anna Moniuszko-Malinowska
- Anna Parfieniuk-Kowerda
- Anna Piekarska
- Anna Szałkowska
- Annarita Giliberti
- Anne Richmond
- Antonella D. ’Arminio Monforte
- Antonella Vincenti
- Antonia Ho
- Antonio Di Biagio
- Antonio Perrella
- Arianna Emiliozzi
- Arianna Gabrieli
- Arsalin Azzadin
- Asma Al Thani &
- Athanasios Kousathanas
- Audrey Coutts
- Axel Schmidt
- Axel Schmidt
- B. Anwar
- B. Attwood
- B. Baines
- B. Blackledge
- B. Borislavova
- B. Chandler
- B. Charles
- B. Creagh-Brown
- B. David
- B. Deacon
- B. Deacon
- B. Digby
- B. Faulkner
- B. Fuller
- B. Gumbrill
- B. Gurung
- B. Hadebe
- B. Hairsine
- B. Hopkins
- B. Johnson
- B. Lenagh
- B. Masunda
- B. Ogg
- B. Patel
- B. Player
- B. Purewal
- B. Scholefield
- B. Shelley
- B. Sloan
- B. Thomas
- B. Wadams
- B. Welsh
- B. Wilkinson
- B. Winter-Goodwin
- B. Yates
- Barbara Rossetti
- Barbara Shih
- Barbara Sobala-Szczygiel
- Beata Puzanowska
- Benedetta Romanin
- Björn Jensen
- Bo Wang
- Brent Richards
- Bruno Frediani
- C. Adams
- C. Ahmed
- C. Almaden-Boyle
- C. Ashbrook-Raby
- C. Basikolo
- C. Battle
- C. Beazley
- C. Beith
- C. Borra
- C. Brandwood
- C. Brantwood
- C. Burnett
- C. Castro Delgado
- C. Clark
- C. Clulow
- C. Collins
- C. Cruz
- C. Davis
- C. Demetriou
- C. Dennis
- C. Dexter
- C. Downes
- C. Eastgate
- C. Finch
- C. Gibson
- C. Gorman
- C. Hays
- C. Hewitt
- C. Holl
- C. Howcroft
- C. Humphrey
- C. Jackson
- C. Jardine
- C. Jennings
- C. Jones
- C. Kaye
- C. Lynch
- C. Lyons
- C. McCulloch
- C. McParland
- C. McParland
- C. Murphy
- C. Parmar
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- S. Mohamed Ally
- S. Monnery
- S. Moore
- S. Morrison
- S. Moultrie
- S. Mtuwa
- S. Mulla
- S. Munt
- S. Murdoch
- S. O’Sullivan
- S. Packham
- S. Patch
- S. Pearson
- S. Pitts
- S. Preston
- S. Purvis
- S. Quaid
- S. Ray
- S. Roche
- S. Rose
- S. Rundell
- S. Salmi
- S. Sathe
- S. Selvanayagam
- S. Shelton
- S. Shepardson
- S. Siddiqui
- S. Sousa Arias
- S. Spencer
- S. Srikaran
- S. Stone
- S. Swann
- S. Tilbey
- S. Turki
- S. Turney
- S. Twiss
- S. Wadd
- S. Whiteley
- S. Williams
- S. Wood
- S. Yussuf
- Sabino Scolletta
- Sabrina Ravaglia
- Said I. Ismail
- Salam Massadeh
- Sandra Uszok
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara Bulow Anderberg
- Sara Clohisey
- Sara Clohisey
- Sara Clohisey Peter Horby
- Sara Modica
- Sarah Galien
- Sarah Iacopini
- Sarah Law
- Sarah McCafferty
- Sauro Luchi
- Saverio Giuseppe Parisi
- Selina Rolker
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Silvia Baroni
- Silvia Cappelli
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slawomir Czaban
- SMelling
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Sten Rubertsson
- Stephan Ossowski
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Sławomir Pancewicz
- T. Anderson
- T. Arden
- T. Baird
- T. Behan
- T. Bemand
- T. Cosier
- T. Coventry
- T. Duncan
- T. Felton
- T. Geary
- T. Hazleton
- T. Joefield
- T. Kannan
- T. Marsden
- T. Martin
- T. McHugh
- T. Newman
- T. Nortcliffe
- T. O. Jones
- T. Pogreban
- T. Rees
- T. Samakomva
- T. Smith
- T. Smith
- T. Szakmany
- T. Varghes
- T. Williams
- T. Wood
- Tammy Gilchrist
- Thorsten Brenner
- Tim Walsh
- Tiziana Bachetti
- Tomas Luther
- Tommaso Matucci
- Tony Wackett
- Torsten Feldt
- Trevor Paterson
- Tullio Trotta
- U. Poultney
- Ulrike Protzer
- Umberto Zuccon
- Urszula Korotko
- Urszula Lechowicz
- Urszula Polowianiuk
- V. Amin
- V. Anumakonda
- V. Bastion
- V. Cannons
- V. Crickmore
- V. Gopal
- V. Irvine
- V. Kasipandian
- V. Krishnamurthy
- V. Lake
- V. Linnett
- V. Martinson
- V. Nagarajan
- V. Page
- V. Parris
- V. Parris
- V. Pristopan
- V. Ratnam
- V. Rivers’
- V. Sarathy
- V. Thomas
- V. Thwaites
- V. Tuckey
- V. Turner
- V. Wagstaff
- V. Waugh
- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
- W. Khaliq
- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
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- Carmen Marciano
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- Carrol Gamble
- Caterina Lo Rizzo
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- Caulfield Mark
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- Chloe Donohue
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- Cristina Mussini
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- E Abaleke
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- E Massey
- E McKenna
- E Meadows
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- E Peasgood
- E Perkins
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- E Smith
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- E Treus Gude
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- Elisabetta Schiaroli
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- Enrico Martinelli
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- F Anderson
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- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
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- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
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- Floriana Valentino
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- Furniss James
- G Andrew
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- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
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- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
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- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
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- Grimes Graeme
- H Bancroft
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- H Brooke
- H Button
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- H Curgenven
- H Filipe
- H Fox
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- H Houlden
- H Jeffrey
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- H Turner
- H Whittle
- H Willis
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- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
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- I Edmond
- I Frost
- I Hass
- I Hussain
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- I Leadbitter
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- Immacolata Andolfo
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- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
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- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
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- Thushan de Silva
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- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
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- V Crickmore
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- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
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- Afilalo J.
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- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
What Performance Analysts Need to Know About Research Trends in Association Football (2012–2016): A Systematic Review
- Author
- A Dellal
- A Soroka
- A Williams
- Allistair McRobert
- António Figueiredo
- B Noel
- B Travassos
- BV Gonçalves
- C Carling
- C Cavalera
- C Collet
- C Cotta
- C Lago-Penas
- C Pulling
- C Pulling
- C Winter
- CA Casal
- CA Casal
- CH Almeida
- CH Almeida
- CL Penas
- D Araújo
- D Link
- D Memmert
- Duarte Araújo
- E Rey
- FA Moura
- FA Moura
- FA Moura
- FA Moura
- Filipe Manuel Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- FM Clemente
- G David
- GP Nassis
- GP Nassis
- H Sarmento
- H Sarmento
- H Sarmento
- Hugo Sarmento
- HY Liu
- HY Liu
- HY Liu
- IR Faber
- IT Costa
- J Castellano
- J Castellano
- J Castellano
- J Castellano
- J Fernandez-Navarro
- J Gama
- J Garcia-Rubio
- J Gonzalez-Rodenas
- J Lago-Ballesteros
- J Padulo
- JL Wallace
- JR Silva
- K Harrop
- Keith Davids
- L Fradua
- M Aguiar
- M Andrzejewski
- M Andrzejewski
- M Lames
- M Law
- M Russell
- M Russell
- M Siegle
- M Siegle
- M Sparks
- MA Gomez
- MA Gomez
- MC Varley
- MS Couceiro
- MW Hoppe
- O Camerino
- P Bradley
- P Paixao
- P Passos
- PS Baranda De
- PS Bradley
- R Bartlett
- R Duarte
- R Duarte
- R Rein
- RA Farina
- S McLean
- S Wierike
- T Favero
- TU Grund
- V Salvo Di
- V Salvo Di
- V Zurloni
- W Frencken
- W Frencken
- W Frencken
- Z Yue
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 14/12/2017
- Field of study
Evolving patterns of match analysis research need to be systematically reviewed regularly since this area of work is burgeoning rapidly and studies can offer new insights to performance analysts if theoretically and coherently organized
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N.S.
- Acquilini D.
- Adams C.
- Adams E.L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Agüero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich A.
- Al Harthi F.
- Al Mutairi A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A.E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
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- Ali A.
- Ali I.A.M.
- Ali S.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Z.
- Allen L.
- Allen M.
- Allen S.
- Allibone S.
- Allison K.S.
- Allos R.
- Almaden-Boyle C.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
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- Alvaro A.
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- Amin V.
- Amirsavadkouhi A.
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- Anastasescu E.
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- Åsvold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
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