21 research outputs found
Usefulness of PCR-based assays to assess drug efficacy in Chagas disease chemotherapy: value and limitations
- Author
- Andrade AL
- Andrade AL
- Andrade SG
- Andrade SG
- Andrade SG
- Andrade SG
- Andrade SG
- Andrade SG
- Andrade ZA
- Apt W
- Apt W
- Avila HA
- Avila HA
- Bellotti G
- Berger A
- Bittencourt AL
- Blanco SB
- Blanco SB
- Bocchi EA
- Bosseno MF
- Brandariz S
- Brener Z
- Brener Z
- Brenière SF
- Britto C
- Britto C
- Britto C
- Burgos JM
- Cançado JR
- Cançado JR
- Cançado JR
- Cançado JR
- Cançado JR
- Castro AM
- Chiari E
- Constança Carvalho Britto
- Coronado X
- Coura JR
- Coura JR
- Coura JR
- Cummings KL
- Cunha-Neto E
- Cunha-Neto E
- da Silveira Pinto A
- da Silveira Pinto A
- de Castro AM
- Deane MP
- Duffy T
- Fabbro De Suasnábar D
- Fernandes O
- Filardi LS
- Fragata Filho AA
- Freilij H
- Freilij H
- Freitas JM
- Galleano RH
- Galvão LMC
- Galvão LMC
- Girones N
- Gomes ML
- Gomes ML
- Guedes PMM
- Guzmán-Brancho C
- Higuchi ML
- Iwai LK
- Jones EM
- Junqueira ACV
- Kalil J
- Kierszenbaum F
- Krettli AU
- Krettli AU
- Krettli AU
- Lages-Silva E
- Lane JE
- Lauria-Pires L
- Lauria-Pires L
- Levin MJ
- Luquetti A
- Machado CR
- Maldonado C
- Manzullo EC
- Marin-Neto JA
- Marin-Neto JA
- Martins HR
- Martins HR
- Medrano NM
- Mora MC
- Moser DR
- Moya PR
- Murta SM
- Olivares-Villagómez D
- Piatak M Jr
- Piron M
- Pontes-de-Carvalho L
- Rassi A
- Rassi A
- Rassi Jr A
- Rassi Jr A
- Revollo S
- Russomando G
- Schijman AG
- Schijman AG
- Schofield CJ
- Silva JS
- Solari A
- Sosa-Estani S
- Sosa-Estani S
- Sosa-Estani S
- Sturm NR
- Sánchez G
- Tarleton RL
- Tarleton RL
- Tarleton RL
- Tibayrenc M
- Toledo MJ
- Toledo MJ
- Urbina JA
- Urbina JA
- Vago AR
- Villa L
- Viotti R
- Viotti R
- Virreira M
- Virreira M
- Virreira M
- Wendel S
- Winker P
- Winker P
- Winker P
- Zingales B
- Zulantay I
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2009
- Field of study
One major goal of research on Chagas disease is the development of effective chemotherapy to eliminate the infection from individuals who have not yet developed cardiac and/or digestive disease manifestations. Cure evaluation is the more complex aspect of its treatment, often leading to diverse and controversial results. The absence of reliable methods or a diagnostic gold standard to assess etiologic treatment efficacy still constitutes a major challenge. In an effort to develop more sensitive tools, polymerase chain reaction (PCR)-based assays were introduced to detect low amounts of Trypanosoma cruzi DNA in blood samples from chagasic patients, thus improving the diagnosis and follow-up evaluation after chemotherapy. In this article, I review the main problems concerning drug efficacy and criteria used for cure estimation in treated chagasic patients, and the work conducted by different groups on developing PCR methodologies to monitor treatment outcome of congenital infections as well as recent and late chronic T. cruzi infections
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agaliotis EL
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
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- Apolinario L
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- Appleby RB
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- Aslanides E
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- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/06/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
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- Aguilera-Verdugo JJ
- Ahnen JV
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
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- Aleksa M
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- Alexahin Y
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- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yildiz HD
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
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- Zaborowska A
- Zadeh SG
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
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- Zick G
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- Zurita J
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/06/2019
- Field of study
We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
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- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
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- Appeloe D
- Appleby RB
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- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
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- Arsenyev SA
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- Asai S
- Aslanides E
- Assmann RW
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- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
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- Eskola KJ
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- Yao W-M
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- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
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- Zaborowska A
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
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- Zhang Z
- Zhao Z
- Zhong Y-M
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- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
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- Zupan J
- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
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- Antusch S
- Anulli F
- Apolinario L
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- Apollonio A
- Appeloe D
- Appleby RB
- Apyan A
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- Aslanides E
- Assmann RW
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- Atieh S
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- Auchmann B
- Audurier A
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- Avino F
- Avrillaud G
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- Bachacou H
- Baek YW
- Baglin V
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- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
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- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
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- Bellafont I
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- Bellegarde N
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- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
- Benedikt M
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- Bernet C
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- Bernini C
- Berriaud C
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- Biagini ME
- Biarrotte J-L
- Bibet Chevalier A
- Bielert ER
- Biglietti M
- Bilei GM
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- Bishara F
- Blanco-Garcia OR
- Blanquez FR
- Blekman F
- Blondel A
- Bluemlein J
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- Bogacz SA
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- Boland MJ
- Bologna S
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- Bondarenko S
- Bonvini M
- Boos E
- Bordini B
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- Bortoletto D
- Boscherini D
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- Boselli S
- Bosley RR
- Bossu F
- Botta C
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- Buffat X
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- Collamati F
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- Costa Pinto P
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- da Silveira GG
- Dachauer C
- Daibo M
- Dainese A
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- Dallapiazza W
- Dam M
- Das SP
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- David A
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- De Curtis S
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- de Florian D
- de Jong SJ
- De Lucia E
- De Renstrom P Brueckman
- de Rijk G
- De Roeck A
- de Vivie de Regie JB
- Deandrea A
- Debono CJ
- Deghaye S
- Del Bo C
- Del Duca V
- Delikaris D
- Deliot F
- Dell'Acqua A
- Delle Rose L
- Delmastro M
- Demarteau M
- Denegri D
- Deniau L
- Denisov D
- Denizli H
- Denner A
- Derue F
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- Dev PSB
- Dewanjee RK
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- Di Cicco A
- Di Micco B
- Di Nezza P
- Di Vita S
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- Doblhammer A
- Dominjon A
- Dordei F
- Drago A
- Draper P
- Drasal Z
- Drewes M
- du Pree T
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- Dubovyk I
- Duda P
- Dudarev A
- Dudko L
- Duellmann D
- Duenser M
- Duran Yildiz H
- Durante M
- Dutta S
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
HE-LHC: The High-Energy Large Hadron Collider
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
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- Barnes MJ
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- Barranco Garcia J
- Barreiro Guimaraes da Costa J
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- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
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- Bellomo G
- Belomestnykh S
- Bencivenni G
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- Bernet C
- Bernhardt JM
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- Salgado CA
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- Salzburger A
- Sampayo OA
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- Sarasola X
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- Sharkov BY
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- Steerenberg R
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- Turri M
- Tydecks T
- Usovitsch J
- Uythoven J
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- Valdivia Garcia MA
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- Valente RU
- Valente-Feliciano A-M
- Valentino G
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- van Leeuwen M
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- Verwilligen O
- Viazlo O
- Vicini A
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- Vorotnikov G
- Voutsinas GG
- Vysotsky V
- Wagner U
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- Weiland C
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- Welsch CP
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- Widorski M
- Wiedemann UA
- Wienands H-U
- Wilkinson G
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- Wohlfahrt A
- Wojton T
- Wollmann D
- Womersley J
- Woog D
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- Yanehsari MK
- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
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- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
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- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
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- Appleby RB
- Apyan A
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- Arbuzov A
- Arduini G
- Ari V
- Arias S
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- Arsenyev SA
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- Aslanides E
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- Auchmann B
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- Azzolini O
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- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
- Barnafoeldi GG
- Barnes MJ
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- Snoeys W
- Soffi L
- Sollander P
- Solovyanov O
- Soltveit HK
- Song H
- Sopicki P
- Sorbi M
- Spallino L
- Spannowsky M
- Spataro B
- Sphicas P
- Spiesberger H
- Spiller P
- Spira M
- Srivastava T
- Stachel J
- Stakia A
- Stanyard JL
- Starchenko E
- Starikov AY
- Stasto AM
- Statera M
- Steerenberg R
- Steggemann J
- Stenvall A
- Stivanello F
- Stoeckinger D
- Stoeger-Pollach M
- Stoel LS
- Strauss B
- Stuart M
- Stupakov G
- Su S
- Sublet A
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- Sulak L
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- Sumida T
- Suzuki K
- Sylva G
- Syphers MJ
- Sznajder A
- Taborelli M
- Tahir NA
- Takeuchi M
- Tal Hod E
- Tambasco C
- Tanaka J
- Tang K
- Tapan I
- Taroni S
- Tartarelli GF
- Tassielli G
- Tavian L
- Taylor GN
- Taylor TM
- Teixeira AM
- Tejeda-Munoz G
- Telnov VI
- ten Kate HHJ
- Tenchini R
- Terashi K
- Tesi A
- Testa M
- Tetrel C
- Teytelman D
- Thaler J
- Thamm A
- The FCC Collaboration
- Thomas S
- Tiirakari MT
- Tikhomirov V
- Tikhonov D
- Timko H
- Tisserand V
- Tkachenko LM
- Tkaczuk J
- Tock JP
- Todd B
- Todesco E
- Tomas Garcia R
- Tommasini D
- Tonelli G
- Toral F
- Torims T
- Torre R
- Townsend Z
- Trant R
- Treille D
- Trentadue L
- Tricoli A
- Tricomi A
- Trischuk W
- Tropin IS
- Tuchming B
- Tudora AA
- Turbiarz B
- Turk Cakir I
- Turri M
- Tydecks T
- Usovitsch J
- Uythoven J
- Vaglio R
- Valassi A
- Valchkova F
- Valdivia Garcia MA
- Vale Silva L
- Valente P
- Valente RU
- Valente-Feliciano A-M
- Valentino G
- Valet JM
- Valizadeh R
- Valle JWF
- Vallecorsa S
- Vallone G
- van Leeuwen M
- van Rienen UH
- van Riesen-Haupt L
- Varasteh M
- Vecchi L
- Vedrine P
- Velev G
- Veness R
- Ventura A
- Venturini Delsolaro W
- Verducci M
- Verhaaren CB
- Vernieri C
- Verweij AP
- Verwilligen O
- Viazlo O
- Vicini A
- Viehhauser G
- Vignaroli N
- Vignolo M
- Vitrano A
- Vivarelli I
- Vlachos S
- Voelkl V
- Vogel M
- Vogt DM
- Volkov P
- Volpini G
- von Ahnen J
- Vorotnikov G
- Voutsinas GG
- Vysotsky V
- Wagner U
- Wallny R
- Wang K
- Wang L-T
- Wang R
- Ward BFL
- Watson NK
- Watson TP
- Weiland C
- Weinzierl S
- Welsch CP
- Wenninger J
- Widorski M
- Wiedemann UA
- Wienands H-U
- Wilkinson G
- Williams PH
- Winter A
- Wohlfahrt A
- Wojton T
- Wollmann D
- Womersley J
- Woog D
- Ws Z
- Wu X
- Wulzer A
- Yanehsari MK
- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
Comprehensive molecular characterization of the hippo signaling pathway in cancer
- Author
- Abdel-Rahman MH
- Abeshouse A
- Adebamowo C
- Adebamowo SN
- Agnew K
- Ahn K
- Ajani JA
- Akbani R
- Akeredolu T
- Al-Ahmadie H
- Albert M
- Alexopoulou I
- Ally A
- Alvaro D
- Anderson ML
- Andry C
- Antenucci A
- Anur P
- Appelbaum EL
- Aredes ND
- Armenia J
- Arnaout A
- Asa SL
- Auman JT
- Aymerich M
- Aziz D
- Bailey M
- Balasundaram M
- Balu S
- Barnett G
- Barnholtz-Sloan JS
- Barrett W
- Bartlett J
- Bathe O
- Baudin E
- Baylin S
- Becker K-F
- Beer D
- Behera M
- Behrens C
- Bell D
- Bell S
- Bellair M
- Bennett J
- Benz C
- Berchuck A
- Berger AC
- Bergeron A
- Berkowitz R
- Bernard B
- Beroukhim R
- Beuschlein F
- Bhavana VH
- Bifulco C
- Bigner D
- Birrer M
- Birsoy K
- Bocklage T
- Bodenheimer T
- Bondaruk J
- Bootwalla MS
- Borad M
- Borgia JA
- Bossler A
- Botnariuc N
- Boussioutas A
- Bowen J
- Bowlby R
- Bowman R
- Bradford C
- Bragazzi MC
- Brat DJ
- Breggia A
- Brewer C
- Brimo F
- Broaddus R
- Brooks D
- Broom BM
- Broudy T
- Bryce AH
- Bubley G
- Bueno R
- Burnette A
- Caesar-Johnson SJ
- Calatozzolo C
- Camargo F
- Campo E
- Campos B
- Caraman I
- Cardinale V
- Carey F
- Carey T
- Carlotti CG
- Carlsen R
- Carney M
- Carpino G
- Carroll PR
- Carter C
- Carvalho AL
- Castle E
- Castro PD
- Catto J
- Cebulla CM
- Cernat M
- Chabot J
- Chakravarty D
- Chambwe N
- Chan JM
- Chan TA
- Chandan V
- Chang K
- Chatila WK
- Chemencedji I
- Chen A
- Chen C
- Chen H
- Chen Z
- Cheng F
- Cherniack AD
- Chesla D
- Chevalier S
- Cheville J
- Cho J
- Chuah E
- Chudamani S
- Chung K
- Cibulskis C
- Clipca A
- Colman H
- Cope L
- Copland JA
- Corcoran N
- Cordes MG
- Costello T
- Cottingham S
- Couce M
- Covington K
- Crain D
- Cramer D
- Creaney J
- Creighton CJ
- Creighton CJ
- Cuppini L
- Curley E
- Cuzzubbo S
- Czerniak B
- Danilova L
- Davis A
- de Bruijn I
- de Carvalho AC
- de Krijger R
- De Rienzo A
- De Rose A
- DeFreitas T
- Delman K
- Demchok JA
- Desjardins L
- Devine K
- Deyarmin B
- Dhalla N
- Dhanasekaran R
- Dhankani V
- Dhir R
- Dill MT
- DiMeco F
- Ding L
- Dinh H
- Dinkin M
- DiPersio J
- Disaia P
- Doddapaneni H
- Donehower LA
- Doruc S
- Dos Santos JS
- Dottino PR
- Drake B
- Drummond J
- Drwiega P
- Du D
- Dubina M
- Duell R
- Duffy ER
- Eckman J
- Edenfield WJ
- Eijckenboom W
- Elder JB
- Engel J
- Eschbacher J
- Esmaeli B
- Evason K
- Facciolo F
- Fan C
- Fan H
- Fantacone-Campbell JL
- Farnell M
- Farver C
- Fassnacht M
- Fehrenbach A
- Felau I
- Feldman M
- Feltmate C
- Ferguson ML
- Finocchiaro G
- Flotte T
- Fong KM
- Force S
- Forgie I
- Frazer S
- Fregnani JH
- Fronick CC
- Fujimoto J
- Fulop J
- Fulton LA
- Fulton RS
- Gabra H
- Gabriel SB
- Galbraith J
- Gao GF
- Gao J
- Gardner J
- Gastier-Foster JM
- Gaudio E
- Ge Z
- Gehlenborg N
- Gerken M
- Gershenwald J
- Getz G
- Ghossein R
- Giama N
- Gibbs RA
- Gilbert S
- Gillis A
- Gimenez-Roqueplo A-P
- Giné E
- Giordano T
- Girard N
- Giuliante F
- Glenn P
- Glenn R
- Godwin AK
- Godwin EM
- Gonzalez AMA
- Goodman M
- Gopalan A
- Goparaju C
- Gorincioi G
- Govindan R
- Graefen M
- Grazi G
- Grizzle WE
- Gross BE
- Guillermo AL
- Guo C
- Ha G
- Haddad A
- Hagedorn CH
- Hale W
- Han L
- Han Y
- Hanh PT
- Hansen P
- Harr J
- Hartmann A
- Haydu L
- Hayes DN
- Hayward N
- Heath S
- Hegde AM
- Heiman DI
- Heins ZJ
- Henderson J
- Hermes B
- Hernandez B
- Herold-Mende C
- Hersey P
- Hess J
- Hibshoosh H
- Hilty J
- Hinoue T
- Ho T
- Hoadley KA
- Holt R
- Hooke JA
- Hoon D
- Horowitz N
- Houck J
- Hovens C
- Hoyle AP
- Hu H
- Hu J
- Huland H
- Hung NP
- Huntsman D
- Hutter CM
- Iacocca M
- Ittmann M
- Jacobus L
- Jakrot V
- Janssen K-P
- Jefferys SR
- Jeong KJ
- Jimeno A
- Jones CD
- Jones SJM
- Ju Z
- Juhl H
- Jungk C
- Junker K
- Kakavand H
- Kalkanis S
- Kanchi RS
- Kandoth C
- Kang KJ
- Karlan BY
- Kasaian K
- Kasapi M
- Kastl A
- Kebebew E
- Kefford R
- Kelley RK
- Kemp R
- Kendall S
- Kendler A
- Kendrick M
- Khuri F
- Kibel A
- Kim J
- Knijnenburg T
- Knudson M
- Knutson T
- Kocher J-P
- Kohl B
- Kopp K
- Korchina V
- Korkut A
- Korpershoek E
- Korst R
- Kovatich AJ
- Kramer R
- Kucherlapati MH
- Kucherlapati RS
- Kumar B
- Kundra R
- Kvecher L
- Kycler W
- La K
- Lacombe L
- Ladanyi M
- Lai PH
- Laird PW
- Landen CN
- Landrum L
- Lang J
- Larson C
- Latour M
- Lau K
- Lawrence MS
- Lazar AJ
- Le X
- Lechan R
- Lee D
- Lee JI
- Lee K
- Lee S
- Lehman NL
- Leinonen K
- Leraas KM
- Levine DA
- Lewis L
- Ley T
- Li J
- Li J
- Li W
- Liang H
- Liang H
- Lichtenberg TM
- Lin P
- Linehan WM
- Ling S
- Lipp E
- Liptay MJ
- Liu J
- Liu W
- Liu X
- Liu Y
- Logothetis C
- Lohavanichbutr P
- Lolla L
- Long G
- Longatto-Filho A
- Looijenga L
- Lu Y
- Luketich J
- Luna A
- Lyadov V
- Ma D
- Ma Y
- Madan R
- Maglic D
- Maglinte DT
- Magliocca K
- Maithel S
- Mallery D
- Malykh A
- Mandt R
- Manikhas G
- Mann G
- Mannel R
- Mannelli M
- Mardis ER
- Mariamidze A
- Mariani O
- Marino M
- Marks J
- Marra MA
- Martignetti JA
- Martin J
- Mattei L
- Mayo M
- McCall S
- McGraw M
- McKercher G
- McLellan MD
- McLendon R
- McPherson C
- Meier S
- Melamed J
- Meng S
- Meric-Bernstam F
- Merola R
- Mes-Masson A-M
- Metwalli AR
- Meyerson M
- Mieczkowski PA
- Mikkelsen T
- Milhem M
- Miller CA
- Miller J
- Miller M
- Mills GB
- Mills GB
- Mirsaidi C
- Moiseenko F
- Mojumdar K
- Moncrieff M
- Moore K
- Moore RA
- Moran C
- Moreno D
- Morgan M
- Morris S
- Morrison C
- Morton D
- Mose LE
- Moser C
- Moxley K
- Moyer J
- Mungall AJ
- Mungall K
- Mura S
- Mural RJ
- Murawa D
- Muto M
- Muzny D
- Myers J
- Nagorney D
- Nair P
- Naresh R
- Naska T
- Nelson M
- Ng K-S
- Ng PK-S
- Nguyen P
- Nissan MG
- Noble MS
- Noss A
- Noushmehr H
- Ochoa A
- Olabode O
- Olson JJ
- Omberg L
- Oosterhuis W
- Ostrom QT
- Owonikoko T
- O’Brien D
- O’Neill BP
- Pacak K
- Paklina O
- Parfitt J
- Park J-W
- Parker JS
- Pass H
- Patel T
- Paulauskis J
- Peng X
- Pennell NA
- Penny R
- Perin A
- Perou AH
- Perou CM
- Petersen G
- Peterson L
- Peto M
- Phillips J
- Phillips SM
- Phu BD
- Piché A
- Pickens A
- Pihl T
- Pilarski R
- Pinero EMM
- Pinto PA
- Pirtac M
- Pollo B
- Pool M
- Porten S
- Postier R
- Potapova O
- Powers J
- Prados M
- Prince M
- Que F
- Quinn M
- Quintero-Aguilo M
- Rabeno B
- Rai K
- Ramalingam S
- Ramirez NC
- Ramondetta L
- Rao A
- Rassl DM
- Rathmell WK
- Raut CP
- Raymond D
- Reis RM
- Reuter V
- Reynolds S
- Reznik E
- Rice D
- Richards WG
- Rintoul RC
- Rivera M
- Roach J
- Roberts L
- Robertson AG
- Robinson B
- Roggin K
- Roman-Roman S
- Rosenthal HG
- Rozek L
- Rubin MA
- Ryan M
- Saad F
- Sadeghi S
- Saksena G
- Sanchez-Vega F
- Sander C
- Sankarankuty A
- Santibanez J
- Sastre X
- Sauter G
- Saw R
- Scapulatempo-Neto C
- Scarpace L
- Schadendorf D
- Schein JE
- Schiffman M
- Schilero C
- Schlomm T
- Schmidt HK
- Schmidt LS
- Schoenfield L
- Schultz N
- Schumacher SE
- Scolyer R
- Secord A
- Seder CW
- Sekhon H
- Senecal K
- Sepulveda A
- Setdikova G
- Sexton KC
- Shabunin A
- Shannon K
- Sharp A
- Shelley CS
- Shelton C
- Shelton T
- Shen H
- Sheridan R
- Sherman M
- Sheth M
- Shi Y
- Shih J
- Shimmel K
- Shin DM
- Shinbrot E
- Shipman C
- Shmulevich I
- Shriver CD
- Sica G
- Sifri S
- Sigmund R
- Signoretti S
- Silveira HCS
- Simko J
- Simon R
- Simons JV
- Singer S
- Singh B
- Singh R
- Sipahimalani P
- Skelly T
- Sloan AE
- Slotta-Huspenina J
- Smallridge R
- Smith J
- Smith-McCune K
- Smolenski K
- Smyrk T
- Sofia HJ
- Soloway MG
- Somiari S
- Sood A
- Spellman P
- Spillane A
- Stancul I
- Stanton M
- Staugaitis SM
- Steele R
- Stepa S
- Stern M-H
- Stoehr C
- Stoehr R
- Stoop H
- Stretch J
- Stuart JM
- Su T
- Sumer SO
- Sun Q
- Sun Y
- Swanson P
- Swisher E
- Synott M
- Tam A
- Tamakawa R
- Tamboli P
- Tan D
- Tang Y
- Tarnuzzer R
- Taubert H
- Tavobilov M
- Taylor BS
- Tcaciuc D
- Tennstedt P
- Thiessen N
- Thomas G
- Thompson E
- Thompson J
- Thompson RH
- Thompson T
- Thorp R
- Thorsson V
- Tien NV
- Timmers H
- Tirapelli D
- Tischler A
- Torbenson M
- Troncoso P
- Tsang YH
- Tsao A
- Tse K
- Tucker K
- Têtu B
- Unterberg A
- Urba W
- Valdivieso F
- Van Bang N
- Van Den Berg DJ
- van Kessel KE
- Van Meir EG
- Van Tine B
- VandenBerg S
- Veluvolu U
- Vicha A
- Vidal DO
- Vocke CD
- Voet D
- von Deimling A
- Voronina O
- Wach S
- Wakely P
- Waldmann J
- Walker J
- Wan Y
- Wang J
- Wang J
- Wang L
- Wang M
- Wang T
- Wang Y
- Wang Z
- Warnick R
- Weinstein JN
- Weisenberger DJ
- Wentzensen N
- Westervelt P
- Wheeler DA
- Wilkerson MD
- Williams F
- Wilmott J
- Wilson RK
- Wise L
- Wistuba I
- Wiznerowicz M
- Wolf G
- Wolinsky Y
- Wong CK
- Wong T
- Worrell R
- Wu Y
- Wullich B
- Xi L
- Xu X
- Yang H
- Yang I
- Yang JD
- Yang L
- Yau C
- Yena P
- Zach LA
- Zaren H
- Zelinka T
- Zenklusen JC
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang JJ
- Zhang L
- Zhang W
- Zhao F
- Zhou W
- Zmuda E
- Zuna R
- Zwarthoff EC
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional “omic” data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the related microRNA (miRNA) regulators, and using functional genomic approaches, we experimentally characterize YAP and TAZ mutation effects and miR-590 and miR-200a regulation for TAZ. Hippo pathway activity is best characterized by a YAP/TAZ transcriptional target signature of 22 genes, which shows robust prognostic power across cancer types. Our elastic-net integrated modeling further reveals cancer-type-specific pathway regulators and associated cancer drivers. Our results highlight the importance of Hippo signaling in squamous cell cancers, characterized by frequent amplification of YAP/TAZ, high expression heterogeneity, and significant prognostic patterns. This study represents a systems-biology approach to characterizing key cancer signaling pathways in the post-genomic era
Areas of endemism in the Atlantic Forest: quantitative biogeography insights from orchid bees (Apidae: Euglossini)
- Author
- A Ferrari
- A Michel-Salzat
- A Nemésio
- A Nemésio
- A Nemésio
- A Nemésio
- A Nemésio
- A Nemésio
- ALM Lepeletier
- André R.S. GARRAFFONI
- Anete P. LOURENÇO
- BR Rosen
- BR Rosen
- CA Szumik
- CA Szumik
- CD Michener
- CW Dick
- D Casagranda
- FA Silveira
- Filipe R. MOURA
- GC Silveira
- HA Tyler
- J Cracraft
- JC Hoffmannsegg
- JJ Morrone
- JJ Morrone
- JJ Morrone
- JJ Morrone
- JMC Silva da
- LP Costa
- LRR Faria-Jr
- LS Kimsey
- LS Kimsey
- M Kuhlmann
- MA Viotti
- MB DaSilva
- MD Casagranda
- ML Oliveira
- MM López-Uribe
- NV Sydney
- P Müller
- PA Goloboff
- PC Morellato
- R Contreras-Medina
- R Ferrari
- R Pinto-Da-Rocha
- SR Ramírez
- SS Nihei
- SS Nihei
- T Escalante
- TDA Cockerell
- U Oliveira
- Y Antonini
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Supervision of Community Health Agents in the Family Health Strategy: the perspective of nurses
- Author
- Araújo MBS
- Ayres JA
- Campos GWS
- Campos GWS
- Carvalho JFS
- Cinira Magal Fortuna
- Coelho MMF
- Costa SM
- Fabiana Ribeiro Santana
- Foucault M
- Franciele Maia Marciano
- Gonçalves RBM
- Gorry C
- Jael Bernardes Silva
- Juliana Sterci da Silva
- Kawata LS
- Lanzoni GMM
- Maria José Bistafa Pereira
- Marianna Ferreira
- Marin MJS
- Matumoto S
- Medeiros CRG
- Merhy EE
- Minayo MCS
- Nogueira RP
- Oliveira VC
- Pinto RM
- Rocha SMM
- Sant’Anna CF
- Silvana Martins Mishima
- Silveira DS
- Silvia Matumoto
- Souza MG
- Triviños ANS
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study