Architecture as Place Making: a Sustainable Farmstead and Staff Housing

A growing number of architects are becoming aware of the necessity to design with respect and response to the natural ecosystem. The advent of environmental criteria in architecture is part of a burgeoning realization that industrial societies are not environmentally sustainable..

Fermionic Expressions for the Characters of c(p,1) Logarithmic Conformal Field Theories

We present fermionic quasi-particle sum representations consisting of a single fundamental fermionic form for all characters of the logarithmic conformal field theory models with central charge c(p,1), p>=2, and suggest a physical interpretation. We also show that it is possible to correctly extract dilogarithm identities.Comment: 19 pages, LaTeX; v2: typos corrected. This is the version accepted for publication in Nucl. Phys.

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.

Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-line process in which each module of enzymes in turn specifies attachment of a particular chemical unit. Although polyketide synthase encoding genes have been successfully engineered to produce novel analogues, the process can be relatively slow, inefficient, and frequently low-yielding. We now describe a method for rapidly recombining polyketide synthase gene clusters to replace, add or remove modules that, with high frequency, generates diverse and highly productive assembly lines. The method is exemplified in the rapamycin biosynthetic gene cluster where, in a single experiment, multiple strains were isolated producing new members of a rapamycin-related family of polyketides. The process mimics, but significantly accelerates, a plausible mechanism of natural evolution for modular polyketide synthases. Detailed sequence analysis of the recombinant genes provides unique insight into the design principles for constructing useful synthetic assembly-line multienzymes

African Linguistics in Central and Eastern Europe, and in the Nordic Countries

Non peer reviewe