Fully Printed Flexible Ultrasound Transducer for Medical Applications

The fabrication of a fully printed, lead-free, polymer piezoelectric transducer is presented and the characterization of its structural, dielectric, and ferroelectric properties at different processing stages is demonstrated. The performance of poly(vinylidene fluoride-trifluoroethylene) transducers with resonance frequency analyses, acoustic power measurements, and pulse-echo experiments is evaluated. Notably, for the first time for a fully printed transducer, an optimal performance in the medical ultrasound range (<15 MHz) is demonstrated with acoustic power >1 W cm(-2), which is promising for applications in epidermal and wearable electronics. Overall, the findings provide a strong foundation for future research in the area of flexible ultrasound transducers

Towards a Novel Ultrasound System Based on Low-Frequency Feature Extraction From a Fully-Printed Flexible Transducer

Ultrasound is a key technology in healthcare, and it is being explored for non-invasive, wearable, continuous monitoring of vital signs. However, its widespread adoption in this scenario is still hindered by the size, complexity, and power consumption of current devices. Moreover, such an application demands adaptability to human anatomy, which is hard to achieve with current transducer technology. This paper presents a novel ultrasound system prototype based on a fully printed, lead-free, and flexible polymer ultrasound transducer, whose bending radius promises good adaptability to the human anatomy. Our application scenario focuses on continuous blood flow monitoring. We implemented a hardware envelope filter to efficiently transpose high-frequency ultrasound signals to a lower-frequency spectrum. This reduces computational and power demands with little to no degradation in the task proposed for this work. We validated our method on a setup that mimics human blood flow by using a flow phantom and a peristaltic pump simulating 3 different heartbeat rhythms: 60, 90 and 120 beats per minute. Our ultrasound setup reconstructs peristaltic pump frequencies with errors of less than 0.05 Hz (3 bpm) from the set pump frequency, both for the raw echo and the enveloped echo. The analog pre-processing showed a promising reduction of signal bandwidth of more than 6x: pulse-echo signals of transducers excited at 12.5 MHz were reduced to about 2 MHz. Thus, allowing consumer MCUs to acquire and elaborate signals within mW-power range in an inexpensive fashion.Comment: 5 pages, 2 tables, 3 figures, Accepted at IEEE BioCAS 202

Temporary tattoo as unconventional substrate for conformable and transferable electronics on skin and beyond

International audienceIn the growing field of conformable electronics, tattoo technology has emerged from among the various approaches so farHere, temporary tattoo paper is adopted as unconventional substrate to build up transferable body compliant devices, which establishes a stable and long-lasting interface with the skin. Tattoo-based devices have shown their capabilities in multiple fields, with the main application in human health biomonitoring. Such an approach is advancing to become state-of-the-art, overcoming some limits of existing technologies, as in the case of skin-contact electrodes and sweat analysis. Temporary tattoo has also been adopted in other fields, such asorganic electronics, the development of organic solar cells, and transferable edible transistors. Multiple and complementary fabrication approaches on temporary tattoos have been demonstrated, spanning from traditional vacuum-based deposition methods to various printing technologies. In this review, together with reporting and discussing the main fabrication methods and applications of tattoo technology, we describe the main features of the tattoo substrate. New insights into its material composition and properties are given, discussing the pros and cons in comparison to other approaches adopted in conformable electronics. Together with providing a comprehensive and up to date review of advancements in tattoo technology, this review aims to contribute in a better understanding of the capabilities offered by such a low cost and versatile substrate. This can help in opening up new research for emerging applications, like in the relevant field of sustainable electronics

Doppler spectra of airborne sound backscattered by the free surface of a shallow turbulent water flow

Measurements of the Doppler spectra of airborne ultrasound backscattered by the rough dynamic surface of a shallow turbulent flow are presented in this paper. The interpretation of the observed acoustic signal behavior is provided by means of a Monte Carlo simulation based on the Kirchhoff approximation and on a linear random-phase model of the water surface elevation. Results suggest that the main scattering mechanism is from capillary waves with small amplitude. Waves that travel at the same velocity of the flow, as well as dispersive waves that travel at a range of velocities, are detected, studied and used in the acoustic Doppler analysis. The dispersive surface waves are not observed when the flow velocity is slow compared to their characteristic velocity. Relatively wide peaks in the experimental spectra also suggest the existence of nonlinear modulations of the short capillary waves, or their propagation in a wide range of directions. The variability of the Doppler spectra with the conditions of the flow can affect the accuracy of the flow velocity estimations based on backscattering Doppler. A set of different methods to estimate this velocity accurately and remotely at different ranges of flow conditions is suggested

Perturbative Heavy Quark Fragmentation Function through O(alpha_s^2)

We derive the initial condition for the perturbative fragmentation function of a heavy quark through order O(alpha_s^2) in the MS-bar scheme. This initial condition is useful for computing heavy quark (or lepton, in case of QED) energy distributions from calculations with massless partons. In addition, the initial condition at O(alpha_s^2) can be used to resum collinear logarithms ln(Q^2/m^2) in heavy quark energy spectrum with next-to-next-to-leading logarithmic accuracy by solving the DGLAP equation.Comment: 14 pages, uses axodraw.sty; minor clarifications in the text; Fig(1,2) corrected; references adde

Contrasting patterns of evolutionary constraint and novelty revealed by comparative sperm proteomic analysis in Lepidoptera

Background: Rapid evolution is a hallmark of reproductive genetic systems and arises through the combined processes of sequence divergence, gene gain and loss, and changes in gene and protein expression. While studies aiming to disentangle the molecular ramifications of these processes are progressing, we still know little about the genetic basis of evolutionary transitions in reproductive systems. Here we conduct the first comparative analysis of sperm proteomes in Lepidoptera, a group that exhibits dichotomous spermatogenesis, in which males produce a functional fertilization-competent sperm (eupyrene) and an incompetent sperm morph lacking nuclear DNA (apyrene). Through the integrated application of evolutionary proteomics and genomics, we characterize the genomic patterns potentially associated with the origination and evolution of this unique spermatogenic process and assess the importance of genetic novelty in Lepidopteran sperm biology. Results: Comparison of the newly characterized Monarch butterfly (Danaus plexippus) sperm proteome to those of the Carolina sphinx moth (Manduca sexta) and the fruit fly (Drosophila melanogaster) demonstrated conservation at the level of protein abundance and post-translational modification within Lepidoptera. In contrast, comparative genomic analyses across insects reveals significant divergence at two levels that differentiate the genetic architecture of sperm in Lepidoptera from other insects. First, a significant reduction in orthology among Monarch sperm genes relative to the remainder of the genome in non-Lepidopteran insect species was observed. Second, a substantial number of sperm proteins were found to be specific to Lepidoptera, in that they lack detectable homology to the genomes of more distantly related insects. Lastly, the functional importance of Lepidoptera specific sperm proteins is broadly supported by their increased abundance relative to proteins conserved across insects. Conclusions: Our results identify a burst of genetic novelty amongst sperm proteins that may be associated with the origin of heteromorphic spermatogenesis in ancestral Lepidoptera and/or the subsequent evolution of this system. This pattern of genomic diversification is distinct from the remainder of the genome and thus suggests that this transition has had a marked impact on lepidopteran genome evolution. The identification of abundant sperm proteins unique to Lepidoptera, including proteins distinct between specific lineages, will accelerate future functional studies aiming to understand the developmental origin of dichotomous spermatogenesis and the functional diversification of the fertilization incompetent apyrene sperm morph

The origins and spread of domestic horses from the Western Eurasian steppes

This is the final version. Available on open access from Nature Research via the DOI in this recordData availability: All collapsed and paired-end sequence data for samples sequenced in this study are available in compressed fastq format through the European Nucleotide Archive under accession number PRJEB44430, together with rescaled and trimmed bam sequence alignments against both the nuclear and mitochondrial horse reference genomes. Previously published ancient data used in this study are available under accession numbers PRJEB7537, PRJEB10098, PRJEB10854, PRJEB22390 and PRJEB31613, and detailed in Supplementary Table 1. The genomes of ten modern horses, publicly available, were also accessed as indicated in their corresponding original publications57,61,85-87.NOTE: see the published version available via the DOI in this record for the full list of authorsDomestication of horses fundamentally transformed long-range mobility and warfare. However, modern domesticated breeds do not descend from the earliest domestic horse lineage associated with archaeological evidence of bridling, milking and corralling at Botai, Central Asia around 3500 BC. Other longstanding candidate regions for horse domestication, such as Iberia and Anatolia, have also recently been challenged. Thus, the genetic, geographic and temporal origins of modern domestic horses have remained unknown. Here we pinpoint the Western Eurasian steppes, especially the lower Volga-Don region, as the homeland of modern domestic horses. Furthermore, we map the population changes accompanying domestication from 273 ancient horse genomes. This reveals that modern domestic horses ultimately replaced almost all other local populations as they expanded rapidly across Eurasia from about 2000 BC, synchronously with equestrian material culture, including Sintashta spoke-wheeled chariots. We find that equestrianism involved strong selection for critical locomotor and behavioural adaptations at the GSDMC and ZFPM1 genes. Our results reject the commonly held association between horseback riding and the massive expansion of Yamnaya steppe pastoralists into Europe around 3000 BC driving the spread of Indo-European languages. This contrasts with the scenario in Asia where Indo-Iranian languages, chariots and horses spread together, following the early second millennium BC Sintashta culture

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements