257 research outputs found
The genomes of two key bumblebee species with primitive eusocial organization
- Author
- A Buttstedt
- A Conesa
- A Fauser-Misslin
- A Garcia-Bellido
- A Marchler-Bauer
- A Sewer
- A Stamatakis
- AA Lazareva
- Aarti Venkat
- AD Chipman
- AF Bourke
- AJ Vanbergen
- Ajay Nair
- AK Hassani El
- AK Jones
- Alvaro G Hernandez
- Amy Osborne
- Andrew FG Bourke
- Andrew G Cridge
- Andrew K Jones
- Anna K Bennett
- AP Lourenco
- Arian Köhler
- Ariel D Chipman
- AV Lobanov
- B Boerjan
- B Dauwalder
- B Langmead
- Bart Devreese
- Ben M Sadd
- Bertrand Fouks
- Björn D Schmitt
- BM Sadd
- BR Herb
- BY Kim
- C Claudianos
- C Elsik
- C Elsik
- C Fontaine
- C Grüter
- Carolina G Santos
- CD Smith
- CD Smith
- CE Chapple
- Christie Kovar
- Christina Schulte
- Christine G Elsik
- Christopher Pham
- Claire Asher
- Claire E Johnson
- Cornelis JP Grimmelikhuijzen
- CR Smith
- CW Whitfield
- D Goulson
- Daniel G Pinheiro
- Daniela Puiu
- David F Clarke
- David H Collins
- David S Marco Antonio
- DB Weaver
- DeNard Simmons
- DF Simola
- Didac Santesmasses
- Dirk C de Graaf
- Donna M Muzny
- DR Kelley
- DR Nassel
- E Clare
- E Duncan
- E Geuverink
- E Keibler
- E Privman
- E Stolle
- E Stolle
- E Stolle
- Eamonn B Mallon
- EB Rubin
- Eckart Stolle
- EJ Duncan
- EJ Duncan
- Elizabeth Duncan
- EM Zdobnov
- Erich Bornberg-Bauer
- Eva C Winnebeck
- Evgeny M Zdobnov
- F Bernhard Kraus
- F Graeve De
- F Hauser
- F Hauser
- F Liu
- F Lyko
- Fernanda C Humann
- Florian Wolschin
- Flávia CP Freitas
- FM Nunes
- Francis MF Nunes
- Francisco Câmara
- Frank Hauser
- Frano Irvine
- G Bloch
- G Bloch
- G Parra
- G Parra
- G Suen
- GA Lockett
- Gabrielle A Lockett
- GE Robinson
- Gene E Robinson
- Geoffrey Okwuonu
- Griet Debyser
- Gro V Amdam
- GS Slater
- Guy Bloch
- Guy Smagghe
- H Li
- H Matsuura
- H Michael G Lattorff
- H Ono
- H Shpigler
- HE Amarasinghe
- HHW Velthuis
- HM Hines
- HM Robertson
- HM Robertson
- HM Robertson
- HM Robertson
- Hugh M Robertson
- Inga Nissen
- Irene F Newsham
- Ivan Meeus
- J Debski
- J Jurka
- J Lu
- J Maynard Smith
- J Schultz
- J-H Xiao
- JA Campos-Ortega
- JA Lynch
- JA Vizcaino
- James C Carolan
- Jay Evans
- JD Evans
- JD Lozier
- JD Lozier
- JD Thompson
- Jeffrey D Lozier
- JG Oakeshott
- JH Werren
- JH Willis
- Jiaxin Qu
- Jinzhi Niu
- Jireh Santibanez
- Jisheng Liu
- JK Colbourne
- JK Greenberg
- JL Kelley
- JM Jandt
- John G Oakeshott
- Jonathan H Kidner
- Joy Jayaseelan
- JR Martins
- Julie Blommaert
- JY Kwon
- Jürgen Gadau
- K Chen
- K Sorefan
- K Touhara
- K Venkatachalam
- Kaat Cappelle
- Kate L Ciborowski
- Katharina Hoff
- Kathrin Näpflin
- KB Flores
- Kerstin P Blankenburg
- Kevin Flores
- Kim C Worley
- Kimberly KO Walden
- KJ Emerson
- KK Ingram
- Klaus Hartfelder
- KS Delaplane
- KW Wanner
- L Wilfert
- L Wilfert
- LA Garibaldi
- LA Weiss
- LaRonda Jackson
- Lars Chittka
- Lars S Jermiin
- LB Kent
- LB Vosshall
- Liezl Francisco
- Ling-Ling Pu
- Louis du Plessis
- LRS Zanette
- Luc Swevers
- M Beye
- M Hasselmann
- M Jinek
- M Maibeche-Coisne
- M Mariotti
- M Mariotti
- M Punta
- M Stanke
- M Stauber
- MA Furst
- MA Larkin
- Marco Mariotti
- Marcus Coyle
- Marianne Otte
- Mark JF Brown
- Mark L Blaxter
- Martin Beye
- Martin Hasselmann
- Matthew Beckers
- Matthew E Hudson
- Matthias Biewer
- Matthias Van Vaerenbergh
- MC Munoz-Torres
- MC Otterstatter
- Meaghan P O’Neill
- Megan Leask
- Michael Holder
- Michelle PM Soares
- Monica Munoz-Torres
- Monika Marxer
- Márcia MG Bitondi
- N Kapan
- NA Baird
- Na Yu
- Nehad Saada
- Nina Rossié
- NT Dittmer
- O Kohany
- Olav Rueppell
- Olivier Christiaens
- P Danecek
- P Schmid-Hempel
- P Schmid-Hempel
- P Skorupski
- PA Hohenlohe
- Paul Schmid-Hempel
- PD Etter
- Peshtewani K Aqrawi
- Peter Dearden
- PH Williams
- PH Williams
- PK Dearden
- QWT Chan
- R Bommarco
- R Bonasio
- R Crozier
- R Feyereisen
- R Kucharski
- R Nielsen
- R Schlatter
- R Schmid-Hempel
- R Winfree
- RC Edgar
- RD Finn
- Rebecca Thornton
- Reed M Johnson
- Regula Schmid-Hempel
- RG Côté
- RG Hatfield
- Richard A Gibbs
- RJ Gegear
- RJ Gill
- RM Waterhouse
- Robert M Waterhouse
- Robert Mata
- Robin FA Moritz
- Robin Ngo
- Roderic Guigó
- Rossanah Cameron
- S Brown
- S Cameron
- S Capella-Gutierrez
- S Cardinal
- S Foret
- S Gotz
- S Griffiths-Jones
- S Hunter
- S Kocher
- S Moxon
- S Nygaard
- S Richards
- S Schmieder
- S Yerushalmi
- S Zou
- SA Cameron
- SA Cameron
- SA West
- Sandra L Lee
- Seirian Sumner
- Seth M Barribeau
- Severine D Buechel
- SH Woodard
- SI Ashraf
- Silvio Erler
- SJ Marygold
- SK Behura
- Sophie Helbing
- Steffen Klasberg
- Stephanie Dreier
- Stephen Richards
- Steven E Scherer
- Steven L Salzberg
- T Conrad
- T Doerks
- T Flutre
- T Hagai
- T Ings
- T Louis
- T Miyamoto
- T Wicker
- Tamas Dalmay
- Tanja Gempe
- Taro Fuchikawa
- Tatsuhiko Kadowaki
- TD Tayler
- Terence Murphy
- The Honeybee Genome Sequencing Consortium
- Thomas J Colgan
- Tiago Falcon
- Tittu Mathew
- TJ Colgan
- TS Korneliussen
- UP Consortium
- V Croset
- V Koch
- V Mommaerts
- V Raymond-Delpech
- V Solovyev
- Vandita Joshi
- Vasco Koch
- VV Kapitonov
- VV Kapitonov
- W Mao
- W Mao
- WD Hamilton
- WJ Kent
- WO Hughes
- X Zhou
- Y Qiu
- Y Wurm
- Y Xiong
- YL Dupont
- Yuan-Qing Wu
- YW Yuan
- Zilá LP Simões
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. Conclusions: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alda Junior WL
- Alexander J
- Aliev T
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
- Assran Y
- Ata M
- Atac M
- Atramentov O
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachtis M
- Baden A
- Baeni L
- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Ball AH
- Ball G
- Ban Y
- Banerjee S
- Banerjee S
- Bansal S
- Banzuzi K
- Barbagli G
- Barberis E
- Barbone L
- Bardak C
- Barfuss AF
- Bargassa P
- Barge D
- Baringer P
- Barker A
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Barrett M
- Bartalini P
- Barth C
- Basegmez S
- Basso L
- Battilana C
- Baty C
- Bauer G
- Bauerdick LAT
- Baumgartel D
- Baur U
- Bayshev I
- Bazterra VE
- Bean A
- Beauceron S
- Beaudette F
- Beaupere N
- Bedjidian M
- Beernaert K
- Behrenhoff W
- Behrens U
- Belforte S
- Beliy N
- Belknap D
- Bell AJ
- Bell KW
- Bellan P
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- Bellinger JN
- Belotelov I
- Belyaev A
- Belyaev A
- Benaglia A
- Bencze G
- Bendavid J
- Benedetti D
- Benelli G
- Benhabib L
- Beni N
- Benucci L
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- Benvenuti AC
- Beranek S
- Beretvas A
- Bergauer T
- Berger J
- Bergholz M
- Beri SB
- Bernardes CA
- Bernardini J
- Bernet C
- Berry D
- Berry E
- Berryhill J
- Bertl W
- Berzano U
- Besancon M
- Betchart B
- Bethani A
- Betts RR
- Beuselinck R
- Bhat PC
- Bhatnagar V
- Bhattacharya S
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- Bhatti A
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- Bialkowska H
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- Bilin B
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- Boccali T
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- Chatterjee A
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- Clarida W
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- Clerbaux B
- Cline D
- CMS Collaboration
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
- Cole JE
- Colino N
- Collard C
- Colling D
- Conetti S
- Contardo D
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- Daubie E
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- Yilmaz Y
- Yohay R
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
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- Zeuner WD
- Zeyrek M
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- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Acosta MV
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- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
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- Yu I
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
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- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
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- Acosta JG
- Acosta MV
- Adair A
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- Adiguzel A
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- Afanasiev S
- Agostino L
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- Winer BL
- Winn D
- Winstrom L
- Wissing C
- Wittich P
- Wittmer B
- Woehri HK
- Wolf M
- Wolf R
- Womersley WJ
- Won S
- Wood D
- Wood J
- Wood JS
- Worm SD
- Wright D
- Wrochna G
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- Wuerthwein F
- Wulz C-E
- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam N
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
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- Yilmaz Y
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- Yun JC
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- Zielinski M
- Zito G
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
A search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Compressed representation of a partially defined integer function over multiple arguments
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta MV
- Adair A
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- Adams MR
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- Agram J-L
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahuja S
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- Akgun B
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- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alderweireldt S
- Alexander J
- Aliev T
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- Anastassov A
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Measurement of jet fragmentation into charged particles in pp and PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Zielinski M
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- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Jet fragmentation in pp and PbPb collisions at a centre-of-mass energy of
2.76 TeV per nucleon pair was studied using data collected with the CMS
detector at the LHC. Fragmentation functions are constructed using
charged-particle tracks with transverse momenta pt > 4 GeV for dijet events
with a leading jet of pt > 100 GeV. The fragmentation functions in PbPb events
are compared to those in pp data as a function of collision centrality, as well
as dijet-pt imbalance. Special emphasis is placed on the most central PbPb
events including dijets with unbalanced momentum, indicative of energy loss of
the hard scattered parent partons. The fragmentation patterns for both the
leading and subleading jets in PbPb collisions agree with those seen in pp data
at 2.76 TeV. The results provide evidence that, despite the large parton energy
loss observed in PbPb collisions, the partition of the remaining momentum
within the jet cone into high-pt particles is not strongly modified in
comparison to that observed for jets in vacuum.Comment: Submitted to the Journal of High Energy Physic
A phase IV, multi-centre, randomized clinical trial comparing two pertussis-containing vaccines in pregnant women in England and vaccine responses in their infants.
- Author
- A Malek
- AB Berenson
- AJ Hardy-Fairbanks
- C Vizzotti
- CM Healy
- D Barug
- EO Kharbanda
- FM Munoz
- FR Mooi
- G Amirthalingam
- G Amirthalingam
- G Dabrera
- H Petousis-Harris
- HTT Hoang
- J Bellido-Blasco
- J Storsaeter
- J Taranger
- JB Griffin
- JB Layton
- JD Cherry
- JL Morgan
- K Donegan
- K Maertens
- K Maertens
- K Maertens
- K Winter
- K Winter
- L Sukumaran
- N Saul
- PL Moro
- Public Health England
- R Baxter
- SA Halperin
- SN Ladhani
- SN Ladhani
- TF Rice
- TH Skoff
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2021
- Field of study
BACKGROUND: Pertussis vaccines containing three or five pertussis antigens are recommended in pregnancy in many countries, but no studies have compared the effect on infants' antigen-specific immunoglobulin G (IgG) concentrations. The aim of this study was to compare anti-pertussis IgG responses following primary immunization in infants of mothers vaccinated with TdaP5-IPV (low dose diphtheria toxoid, tetanus toxoid, acellular pertussis [five antigens] and inactivated polio) or TdaP3-IPV in pregnancy (three pertussis antigens). METHODS: This multi-centre phase IV randomized clinical trial was conducted in a tertiary referral centre and primary care sites in England. Women were randomized to receive TdaP5-IPV (n = 77) or TdaP3-IPV (n = 77) at 28-32 gestational weeks. A non-randomized control group of 44 women who had not received a pertussis-containing vaccine in pregnancy and their 47 infants were enrolled post-partum. RESULTS: Following infant primary immunization, there was no difference in the geometric mean concentrations (GMCs) of anti-pertussis toxin, filamentous haemagglutinin or pertactin IgG between infants born to women vaccinated with TdaP5-IPV (n = 67) or TdaP3-IPV (n = 63). However, the GMC of anti-pertussis toxin IgG was lower in infants born to TdaP5-IPV- and TdaP3-IPV-vaccinated mothers compared to infants born to unvaccinated mothers (n = 45) (geometric mean ratio 0.71 [0.56-0.90] and 0.78 [0.61-0.98], respectively); by 13 months of age, this difference was no longer observed. CONCLUSION: Blunting of anti-pertussis toxin IgG response following primary immunization occurs in infants born to women vaccinated with TdaP5-IPV and TdaP3-IPV, with no difference between maternal vaccines. The blunting effect had resolved by 13 months of age. These results may be helpful for countries considering which pertussis-containing vaccine to recommend for use in pregnancy. TRIAL REGISTRATION: ClinicalTrials.gov , NCT02145624 , registered 23 May 2014
The Early Data Release of the Dark Energy Spectroscopic Instrument
- Author
- Adame AG
- Aguilar J
- Ahlen S
- Alam S
- Aldering G
- Alexander DM
- Alfarsy R
- Allende Prieto C
- Alvarez M
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- Anand A
- Andrade-Oliveira F
- Armengaud E
- Asorey J
- Avila S
- Aviles A
- Bailey S
- Balaguera-Antolinez A
- Ballester O
- Baltay C
- Bault A
- Bautista J
- Behera J
- Beltran SF
- BenZvi S
- Beraldo e Silva L
- Bermejo-Climent JR
- Berti A
- Besuner R
- Beutler F
- Bianchi D
- Blake C
- Blum R
- Bolton AS
- Brieden S
- Brodzeller A
- Brooks D
- Brown Z
- Buckley-Geer E
- Burtin E
- Cabayol-Garcia L
- Cai Z
- Canning R
- Cardiel-Sas L
- Carnero Rosell A
- Castander FJ
- Cervantes-Cota JL
- Chabanier S
- Chaussidon E
- Chaves-Montero J
- Chen S
- Chen X
- Chuang C
- Claybaugh T
- Cole S
- Cooper AP
- Cuceu A
- Davis TM
- Dawson K
- de Belsunce R
- de la Cruz R
- de la Macorra A
- de Mattia A
- Della Costa J
- Demina R
- Demirbozan U
- DeRose J
- Dey A
- Dey B
- Dhungana G
- Ding J
- Ding Z
- Doel P
- Doshi R
- Douglass K
- Edge A
- Eftekharzadeh S
- Eisenstein DJ
- Elliott A
- Ereza J
- Escoffier S
- Fagrelius P
- Fan X
- Fanning K
- Fawcett VA
- Ferraro S
- Flaugher B
- Font-Ribera A
- Forero-Romero JE
- Forero-Sanchez D
- Frenk CS
- Gansicke BT
- Garcia LA
- Garcia-Bellido J
- Garcia-Quintero C
- Garrison LH
- Gil-Marin H
- Golden-Marx J
- Gontcho Gontcho SA
- Gonzalez-Morales AX
- Gonzalez-Perez V
- Gordon C
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- Green D
- Gruen D
- Guy J
- Hadzhiyska B
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- Hanif MMS
- Herrera-Alcantar HK
- Honscheid K
- Hou J
- Howlett C
- Huterer D
- Irsic V
- Ishak M
- Jacques A
- Jana A
- Jiang L
- Jimenez J
- Jing YP
- Joudaki S
- Joyce R
- Jullo E
- Juneau S
- Karacayli NG
- Karim T
- Kehoe R
- Kent S
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- Kim S
- Kirkby D
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- Kitaura F
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- Koposov SE
- Kovacs A
- Kremin A
- Krolewski A
- L'Huillier B
- Lahav O
- Lambert A
- Lamman C
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- Landriau M
- Lang D
- Lange JU
- Lasker J
- Le Guillou L
- Leauthaud A
- Levi ME
- Li TS
- Linder E
- Lyons A
- Magneville C
- Manera M
- Manser CJ
- Margala D
- Martini P
- McDonald P
- Medina GE
- Medina-Varela L
- Meisner A
- Mena-Fernandez J
- Meneses-Rizo J
- Mezcua M
- Miquel R
- Montero-Camacho P
- Moon J
- Moore S
- Moustakas J
- Mueller E
- Mundet J
- Munoz-Gutierrez A
- Myers AD
- Nadathur S
- Napolitano L
- Neveux R
- Newman JA
- Nie J
- Nikutta R
- Niz G
- Norberg P
- Noriega HE
- Paillas E
- Palanque-Delabrouille N
- Palmese A
- Pan Z
- Parkinson D
- Penmetsa S
- Percival WJ
- Perez-Fernandez A
- Perez-Rafols I
- Pieri M
- Poppett C
- Porredon A
- Pothier S
- Prada F
- Pucha R
- Raichoor A
- Ramirez-Perez C
- Ramirez-Solano S
- Rashkovetskyi M
- Ravoux C
- Rocher A
- Rockosi C
- Ross AJ
- Rossi G
- Ruggeri R
- Ruhlmann-Kleider V
- Sabiu CG
- Said K
- Saintonge A
- Samushia L
- Sanchez E
- Saulder C
- Schaan E
- Schlafly EF
- Schlegel D
- Scholte D
- Schubnell M
- Seo H
- Shafieloo A
- Sharples R
- Sheu W
- Silber J
- Sinigaglia F
- Siudek M
- Slepian Z
- Smith A
- Soumagnac MT
- Sprayberry D
- Stephey L
- Suarez-Perez J
- Sun Z
- Tan T
- Tarle G
- Tojeiro R
- Urena-Lopez LA
- Vaisakh R
- Valcin D
- Valdes F
- Valluri M
- Vargas-Magana M
- Variu A
- Verde L
- Walther M
- Wang B
- Wang MS
- Weaver BA
- Weaverdyck N
- Wechsler RH
- White M
- Xie Y
- Yang J
- Yeche C
- Yu J
- Yuan S
- Zhang H
- Zhang Z
- Zhao C
- Zheng Z
- Zhou R
- Zhou Z
- Zou H
- Zou S
- Zu Y
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/08/2024
- Field of study
\ua9 2024. The Author(s). Published by the American Astronomical Society. The Dark Energy Spectroscopic Instrument (DESI) completed its 5 month Survey Validation in 2021 May. Spectra of stellar and extragalactic targets from Survey Validation constitute the first major data sample from the DESI survey. This paper describes the public release of those spectra, the catalogs of derived properties, and the intermediate data products. In total, the public release includes good-quality spectral information from 466,447 objects targeted as part of the Milky Way Survey, 428,758 as part of the Bright Galaxy Survey, 227,318 as part of the Luminous Red Galaxy sample, 437,664 as part of the Emission Line Galaxy sample, and 76,079 as part of the Quasar sample. In addition, the release includes spectral information from 137,148 objects that expand the scope beyond the primary samples as part of a series of secondary programs. Here, we describe the spectral data, data quality, data products, Large-Scale Structure science catalogs, access to the data, and references that provide relevant background to using these spectra
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry
- Author
- Adoue D
- Agard C
- Ahmadi K
- Airo P
- Aizpuru EM
- Akanay-Diesel S
- Albertsson K
- Almeida I
- Alsheimer B
- Alves J
- Andersen M
- Anderson M
- Andresen J
- Angeles Aquirre M
- Antivalle M
- Aries P
- Aslanidis S
- Aslkaksen HK
- Assmann G
- Assous N
- Athanassiou P
- Athiveer P.
- Baguley E
- Bajoochi G
- Bakkeheim V
- Bakland G
- Balquiere S
- Barbado J
- Barca BA
- Barnd A
- Barth S
- Battaglia E
- Baudaoin P
- Baumann C
- Becerra ND
- Becker M
- Becvar R
- Bekou V
- Belin E
- Bellido D
- Bellisai F
- Bellissimo S
- Belloli L
- Belloni B
- Bendvold A
- Beneton N
- Berezne A
- Berthier S
- Bessis D
- Beyer C
- Bezanahary H
- Bijl M
- Bitter H
- Blaise S
- Blanco JJ
- Blanco JS
- Blank N
- Bloching HH
- Blum L
- Blume J
- Boesenberg I
- Bohmova J
- Bootsma H
- Boro D
- Bortoluzzi A
- Boulon C
- Boussely N
- Bracin T
- Brand H
- Bravetti V
- Brodmann M
- Broll H
- Brouwer L
- Brown S
- Bruckner L
- Bruyn G
- Bucci R
- Caamano M
- Cabane J
- Callejas JL
- Calvo J
- Camara I
- Camps MT
- Cantatore F
- Carpentier P
- Cartry O
- Castellvi I
- Castellvi I
- Cazalets-lacoste C
- Chakravarty K
- Charlanne H
- Chatelus E
- Chiffot H
- Choong LM
- Chromik S
- Cipriani P
- Coelho P
- Cohen JD
- Colaci M
- Cole S
- Coleman JV
- collet E
- Colonna L
- Constans J
- Coppere B
- Cordeiro A
- Corteguera M
- Costa J
- Couraud A
- Couret B
- Cozzi F
- Crespo M
- Cruz A
- Cruz J
- Cuomo G
- D'Cruz D
- Dadban A
- De Angeli R
- de Bois M
- De la Puente C
- de la Torre RG
- de Long AJ
- de Ramon E
- de Vicuna RG
- De Vita S
- Deboves O
- Decaux O
- Deininger F
- del Carmen Ortega de la O M
- del Carmen Torres Martin M
- del la Pena Lefebvre PG
- del Mar Ripoll Macias M
- Del Papa N
- del Rio AH
- Delgado EG
- den Hengst C
- Denton C
- Denton CP
- Deppermann N
- Desmurs-Clavel H
- Deuschle K
- Diaz JJ
- Dietl S
- Dimitroulas T
- Diot E
- Distler J
- Distler O
- Dobson J
- Doeffel-hantz V
- Dohse A
- Dolhain R
- Dolnicar AS
- Doutre MS
- Doveri M
- Droitcourt C
- Dumonteil S
- DUO Registry investigators. Collaborators: Stetter M
- Durant C
- Duval-modeste AB
- Dyballa J
- Ebel J
- Eiden E
- Eilbacher P
- Elezoglou A
- Enderlein M
- Erfurt-berge C
- Espinosa G
- Espinposa G
- Ewals J
- Faggioli P
- Faizal A
- Farcas C
- Farge D
- Fauchais AL
- Faustini F
- Federow I
- Feldmann R
- Fell I
- Fernandez AS
- Fernandez C
- Fernandez NC
- Fernandez S
- Ferraccioli G
- Ferrandiz D
- Ferri C
- Fiene M
- Fierlbeck G
- Filloy JA
- Flaig W
- Fojtik Z
- Foti R
- Frambach Y
- Frances C
- Fretter P
- Freundlieb C
- Frey P
- Funkert A
- Fusaro E
- Fuzibet JG
- Gabrielli A
- Gaches F
- Galanopoulo V
- Galanopoulos N
- Galeazzi M
- Galluccio F
- Garcia A
- Garcia PV
- Garyfallos A
- Gatti S
- Gaubitz M
- Gause A
- Gawlik A
- Gerards AH
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- Vacca A
- Valentijn R
- van Hagen M
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- van der Veen MJ
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- van Zeben D
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- Vengemyr K
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- Verner D
- Victoria Egurbide M
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- Xu Y
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- Zeni S
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- Zimba S
- Zuily S
- Zultak M
- Zuper R
- Zwenger S
- Publication venue
- BMJ Group
- Publication date
- 01/01/2012
- Field of study
OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc).
METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers.
RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group.
CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies
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