Scanning Electron Microscopy - Electron Beam Induced Current and Deep Level Transient Spectroscopy Studies of GaAs(In) Layers grown by Molecular Beam Epitaxy

Electrically active defects in indium-doped (0.6%) GaAs layers grown by Molecular Beam Epitaxy (MBE) on Si-doped (≈1x1018 cm-3) GaAs substrates have been studied by the combination of two techniques: Scanning Electron Microscope - Electron Beam Induced Current (SEM-EBIC) technique, and Deep Level Transient Spectroscopy (DLTS). The epilayers studied were three microns thick. No electrically active defects were revealed by the EBIC micrographs in the top one micron of the epilayers, whereas a large number of non-propagating misfit dislocations were observed at the epilayer/substrate interface. DLTS measurements made in the dislocation free top region of the epilayer showed the presence of three well known traps, which had previously been observed to also exist near the interface. It is concluded that these traps are not related to misfit dislocations

Emission reduction via supply chain coordination

This paper examines the environmental impact of potential coordination on supply chains. A decentralized two-node supply chain is studied, in which one node is a buyer ordering from a second node, who is a supplier operating under the lot-for-lot policy. The supplier is allowed to use a quantity discount to manipulate the buyer's decision reducing both his individual cost and system's operational costs. This results in decreasing the frequency of deliveries. We demonstrate that environmentally friendly policies could be also cost saving. The crucial factor about the environmental benefits is the total distance travelled rather than the vehicle loads. We establish the magnitude of the environmental benefits using numerical examples under specific operational parameters. Complete and incomplete information cases are investigated, where the buyer and the supplier make their decisions to optimize their own business operations

Coordinating Lot Sizing Decisions Under Bilateral Information Asymmetry

We consider inventory management decisions when manufacturing and warehousing are controlled by independent entities. The latter possess private information that affects their choices and are allowed to communicate via a mediator who attempts to streamline their decisions without restricting their freedom. The mediator designs a mechanism based on quantity discounts to minimize the overall system costs, attempting to reach a win‐win situation for both entities. Using the Revelation Principle we show that it is in the entities’ self‐interest to reveal their information and we prove that coordination is attainable even under bilateral information asymmetry. The acceptable cost allocation is not unique, providing adequate flexibility to the mediator during mechanism design; the flexibility may reflect the relative power of the entities and is quantified in our work by a series of computational experiments. Our approach is motivated by inventory management practices in a manufacturing group and, thus, it is directly applicable to real‐life cases

An adaptive memory programming framework for the resource-constrained project scheduling problem

The Resource-Constrained Project Scheduling Problem (RCPSP) is one of the most intractable combinatorial optimisation problems that combines a set of constraints and objectives met in a vast variety of applications and industries. Its solution raises major theoretical challenges due to its complexity, yet presenting numerous practical dimensions. Adaptive memory programming (AMP) is one of the most successful frameworks for solving hard combinatorial optimisation problems (e.g. vehicle routing and scheduling). Its success stems from the use of learning mechanisms that capture favourable solution elements found in high-quality solutions. This paper challenges the efficiency of AMP for solving the RCPSP, to our knowledge, for the first time in the literature. Computational experiments on well-known benchmark RCPSP instances show that the proposed AMP consistently produces high-quality solutions in reasonable computational times

Utilizing Co-Creative Principles to Develop an E-Learning Platform for Interprofessional Training on Tinnitus: The Erasmus+ Project Tin-TRAC

Tinnitus treatment, diagnosis and management across Europe varies significantly. The lack of national clinical guidelines for tinnitus management in most European countries and the absence of a common language across all disciplines involved is reflected in the diversification of healthcare practices. Interprofessional Training for Tinnitus Researchers and Clinicians (Tin-TRAC) is an Erasmus+ project that aims to develop common educational ground in the form of an e-Learning platform, co-created by patients, researchers and clinicians, which is able to unify tinnitus diagnosis and treatment strategies across Europe. A pan-European thematic educational platform integrating the best practices and latest research achievements with regard to tinnitus diagnosis and management has the potential to act as a facilitator of the reduction of interdisciplinary and interregional practice diversification. A detailed analysis of the educational needs of clinicians and researchers across disciplines will be followed by the co-creative development of the curriculum. Reusable learning objects will incorporate the training contents and will be integrated in an open e-Learning platform. Tin-TRAC envisions that its output will answer the need to create a common language across the clinicians and researchers of different disciplines that are involved in tinnitus management, and reduce patients’ prolonged suffering, non-adherence and endless referral trajectories

Supported Gold Nanoparticle-Catalyzed Selective Reduction of Multifunctional, Aromatic Nitro Precursors into Amines and Synthesis of 3,4-Dihydroquinoxalin-2-Ones

The synthesis of 3,4-dihydroquinoxalin-2-ones via the selective reduction of aromatic, multifunctional nitro precursors catalyzed by supported gold nanoparticles is reported. The reaction proceeds through the in situ formation of the corresponding amines under heterogeneous transfer hydrogenation of the initial nitro compounds catalyzed by the commercially available Au/TiO2-Et3SiH catalytic system, followed by an intramolecular C-N transamidation upon treatment with silica acting as a mild acid. Under the present conditions, the Au/TiO2-TMDS system was also found to catalyze efficiently the present selective reduction process. Both transfer hydrogenation processes showed very good functional-group tolerance and were successfully applied to access more structurally demanding products bearing other reducible moieties such as chloro, aldehyde or methyl ketone. An easily scalable (up to 1 mmol), low catalyst loading (0.6 mol%) synthetic protocol was realized, providing access to this important scaffold. Under these mild catalytic conditions, the desired products were isolated in good to high yields and with a TON of 130. A library analysis was also performed to demonstrate the usefulness of our synthetic strategy and the physicochemical profile of the derivatives

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

Genetic, biochemical, and animal model studies strongly suggest a central role for α-synuclein in the pathogenesis of Parkinson's disease. α-synuclein lacks a signal peptide sequence and has thus been considered a cytosolic protein. Recent data has suggested that the protein may be released from cells via a non-classical secretory pathway and may therefore exert paracrine effects in the extracellular environment. However, proof that α-synuclein is actually secreted into the brain extracellular space in vivo has not been obtained. We developed a novel highly sensitive ELISA in conjugation with an in vivo microdialysis technique to measure α-synuclein in brain interstitial fluid. We show for the first time that α-synuclein is readily detected in the interstitial fluid of both α-synuclein transgenic mice and human patients with traumatic brain injury. Our data suggest that α-synuclein is physiologically secreted by neurons in vivo. This interstitial fluid pool of the protein may have a role in the propagation of synuclein pathology and progression of Parkinson's disease

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements