347 research outputs found
A comparison of the effects of physical and chemical mutagens in sesame (Sesamum indicum L.)
- Author
- Publication venue
- Sociedade Brasileira de Genética
- Publication date
- 01/01/2009
- Field of study
Three sesame genotypes (Rama, SI 1666 and IC 21706) were treated with physical (γ-rays: 200 Gy, 400 Gy or 600 Gy) or chemical (ethyl methane sulphonate, EMS: 0.5%, 1.0%, 1.5% or 2.0%) mutagens and their mutagenic effectiveness and efficiency were estimated in the M 2 generation. The M 3 generation was used to identify the most effective mutagen and dose for induction of mutations. The average effectiveness of EMS was much higher than γ-rays. The lowest dose of γ-rays (200 Gy) and the lowest concentration of EMS (0.5%) showed the highest mutagenic efficiency in all genotypes. Analysis of the M 3 generation data based on parameters such as the variance ratio and the difference in residual variances derived from the model of Montalván and Ando indicated that 0.5% concentration of EMS was the most effective treatment for inducing mutations
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
- Aasvang GM
- Abajobir AA
- Abate KH
- Abbafati C
- Abbas KM
- Abd-Allah F
- Abdulle AM
- Abera SF
- Abraham B
- Abu-Raddad LJ
- Abyu GY
- Adebiyi AO
- Adedeji IA
- Ademi Z
- Adou AK
- Adsuar JC
- Afshin A
- Agardh EE
- Agarwal A
- Agrawal A
- Ajala ON
- Akinyemiju TF
- Al-Aly Z
- Alam K
- Alam NKM
- Aldhahri SF
- Aldridge RW
- Alemu ZA
- Alexander LT
- Ali R
- Alkerwi A
- Alla F
- Allebeck P
- Alsharif U
- Altirkawi KA
- Alvarez Martin E
- Alves Silveira DG
- Alvis-Guzman N
- Amare AT
- Amberbir A
- Amegah AK
- Amini H
- Ammar W
- Amrock SM
- Andersen HH
- Anderson BO
- Anderson HR
- Antonio CAT
- Anwar P
- Aquino Faraon EJ
- Arnlov J
- Artaman A
- Asayesh H
- Asghar RJ
- Assadi R
- Atique S
- Avokpaho EFGA
- Awasthi A
- Azzopardi P
- Bacha U
- Badawi A
- Baernighausen T
- Bahit MC
- Balakrishnan K
- Bans C
- Barac A
- Barber RM
- Barker-Collo SL
- Barquera S
- Barregard L
- Barrero LH
- Basu S
- Bazargan-Hejazi S
- Beardsley J
- Beatriz Heredia-Pi I
- Beatriz Lawrynowicz AE
- Bedi N
- Beghi E
- Bell ML
- Bello AK
- Bennett DA
- Bensenor IM
- Berhane A
- Bernabe E
- Betsu BD
- Beyene AS
- Bhala N
- Bhansali A
- Bhatt S
- Bhutta ZA
- Biadgilign S
- Bicer BK
- Bikbov B
- Biryukov S
- Bisanzio D
- Bjertness E
- Blore JD
- Borschmann R
- Boufous S
- Bourne RRA
- Brainin M
- Brauer M
- Brazinova A
- Breitborde NJK
- Brenner H
- Broday DM
- Brugha TS
- Brunekreef B
- Burnett R
- Butt ZA
- Cahill LE
- Caicedo AJP
- Calabria B
- Cardenas R
- Carmen Gomez-Cabrera M
- Carpenter D
- Casey DC
- Castaneda-Oquela CA
- Castillo Rivas J
- Catala-Lopez F
- Cercy K
- Chang J-C
- Charlson FJ
- Chiang PP-C
- Chibalabala M
- Chimed-Ochir O
- Chisumpa VH
- Chitheer AA
- Choi J-YJ
- Christensen H
- Christopher DJ
- Ciobanu LG
- Coates MM
- Cohen AJ
- Colquhoun SM
- Cooper LT
- Cooperrider K
- Cornaby L
- Cortinovis M
- Crump JA
- Cuevas-Nasu L
- Damasceno A
- Dandona L
- Dandona R
- Darby SC
- Dargan PI
- das Neves J
- Davis AC
- Davletov K
- De la Cruz-Gongora V
- De Leo D
- Defo BK
- Degenhardt L
- Del Gobbo LC
- del Pozo-Cruz B
- Dellavalle RP
- Deribew A
- Des Jarlais DC
- Dharmaratne SD
- Dhillon PK
- Diaz-Tome C
- Dicker D
- Dimbuene ZT
- Ding EL
- Dolores Sanchez-Nino M
- Dorsey ER
- Doyle KE
- Driscoll TR
- Duan L
- Dubey M
- Duncan BB
- Elyazar I
- Endries AY
- Ermakov SP
- Erskine HE
- Eshrati B
- Estanislao Castro R
- Esteghamati A
- Estep K
- Factors GBDR
- Fahimi S
- Farid TA
- Faro A
- Farvid MS
- Farzadfar F
- Feigin VL
- Fereshtehnejad S-M
- Fernandes JG
- Ferrari AJ
- Filipa de Castro E
- Fischer F
- Fitchett JRA
- Fleming T
- Foigt N
- Foreman K
- Forouzanfar MH
- Fowkes FGR
- Francisco Hernandez-Llanes N
- Franklin RC
- Frostad JJ
- Fuerst T
- Fullman N
- Futran ND
- Gakidou E
- Garcia-Basteiro AL
- Gebrehiwot TT
- Gebremedhin AT
- Geleijnse JM
- Gessner BD
- Gething PW
- Giref AZ
- Giroud M
- Gishu MD
- Godwin WW
- Goenka S
- Gomez-Dantes H
- Gona P
- Goodridge A
- Gopalani SV
- Gotay CC
- Goto A
- Gouda HN
- Griswold M
- Gugnani HC
- Guillemin F
- Guo Y
- Gupta R
- Gupta R
- Gutierrez RA
- Haagsma JA
- Hafezi-Nejad N
- Haile D
- Hailu GB
- Halasa YA
- Hamadeh RR
- Hamidi S
- Handal AJ
- Hankey GJ
- Hao Y
- Harb HL
- Harikrishnan S
- Hassanvand MS
- Hassen TA
- Havmoeller R
- Heydarpour P
- Hoek HW
- Hoffman HJ
- Horino M
- Horita N
- Hosgood HD
- Hoy DG
- Hsairi M
- Htet AS
- Hu G
- Huang JJ
- Husseini A
- Hutchings SJ
- Huybrechts I
- Iburg KM
- Idrisov BT
- Ileanu BV
- Inoue M
- Jacobs TA
- Jacobsen KH
- Jahanmehr N
- Jakovljevic MB
- Jansen HAFM
- Jassal SK
- Javanbakht M
- Jayatilleke AU
- Jee SH
- Jeemon P
- Jha V
- Jiang Y
- Jibat T
- Jin Y
- Johnson CO
- Jonas JB
- Kabir Z
- Kalkonde Y
- Kamal R
- Kan H
- Karch A
- Karema CK
- Karimkhani C
- Kasaeian A
- Kaul A
- Kawakami N
- Kazi DS
- Keiyoro PN
- Kemp AH
- Kengne AP
- Keren A
- Kesavachandran CN
- Khader YS
- Khan AR
- Khan EA
- Khan G
- Khang Y-H
- Khatibzadeh S
- Khera S
- Khoja TAM
- Khubchandani J
- Kiadaliri AA
- Kieling C
- Kim C-I
- Kim D
- Kimokoti RW
- Kinfu Y
- Kissoon N
- Kivipelto M
- Knibbs LD
- Kokubo Y
- Kopec JA
- Koul PA
- Koyanagi A
- Kravchenko M
- Kromhout H
- Krueger H
- Ku T
- Kuchenbecker RS
- Kuipers EJ
- Kumar GA
- Kwan GF
- Kyu HH
- Lal DK
- Lalloo R
- Lallukka T
- Lan Q
- Landon N
- Larson HJ
- Larsson A
- Latif AA
- Leasher JL
- Leigh J
- Leung J
- Levi M
- Levy TS
- Li X
- Li Y
- Liang J
- Liang X
- Lim SS
- Liu PY
- Liu S
- Lloyd BK
- Logroscino G
- Lopez AD
- Lotufo PA
- Lozano R
- Lunevicius R
- Maclntyre M
- Mahdavi M
- Mahesh PA
- Majdan M
- Majeed A
- Malekzadeh R
- Malta DC
- Manamo WAA
- Mapoma CC
- Marcenes W
- Marczak L
- Maria Haro J
- Martin RV
- Martinez-Raga J
- Masiye F
- Matsushita K
- Matzopoulos R
- Mayosi BM
- McGrath JJ
- McKee M
- Meaney PA
- Medina C
- Mehari A
- Mekonnen AB
- Melaku YA
- Memish ZA
- Mena-Rodriguez F
- Mendoza W
- Mensah GA
- Mensink GBM
- Meretoja A
- Meretoja TJ
- Mesfin YM
- Mhimbira FA
- Miller TR
- Mills EJ
- Mirarefin M
- Misganaw A
- Mock CN
- Mohammadi A
- Mohammed S
- Mokdad AH
- Mola GLD
- Monasta L
- Montanez Hernandez JC
- Montico M
- Moradi-Lakeh M
- Morawska L
- Mori R
- Mozaffarian D
- Mueller UO
- Mullany E
- Mumford JE
- Murray CJL
- Murthy GVS
- Nachega JB
- Naghavi M
- Naheed A
- Nangia V
- Nassiri N
- Neal B
- Newton JN
- Ng M
- Nguyen QL
- Nisar MI
- Norheim OF
- Norman RE
- Norrving B
- Nyakarahuka L
- Obermeyer CM
- Ogbo FA
- Oh I-H
- Oladimeji O
- Olivares PR
- Olsen H
- Olusanya BO
- Olusanya JO
- Opio JN
- Oren E
- Orozco R
- Ortiz A
- Ota E
- Pana A
- Park E-K
- Parry CD
- Parsaeian M
- Patel T
- Patil ST
- Patten SB
- Patton GC
- Pearce N
- Pereira DM
- Perico N
- Pesudovs K
- Pete PMN
- Petzold M
- Phillips MR
- Piel FB
- Pillay JD
- Plass D
- Polinder S
- Pond CD
- Pope CA
- Pope D
- Popova S
- Poulton RG
- Pourmalek F
- Prasad NM
- Qorbani M
- Quintanilla BPA
- Rabiee RHS
- Radfar A
- Rafay A
- Rahimi-Movaghar V
- Rahman M
- Rahman MHU
- Rahman SU
- Rai RK
- Rajsic S
- Raju M
- Ram U
- Rana SM
- Ranganathan K
- Rao P
- Razo Garcia CA
- Refaat AH
- Rehm CD
- Rehm J
- Reinig N
- Reitsma MB
- Remuzzi G
- Resnikoff S
- Ribeiro AL
- Ricardo Campos-Nonato I
- Rivera JA
- Rodriguez A
- Rodriguez-Ramirez S
- Rojas-Rueda D
- Rolm HS
- Roman Y
- Ronfani L
- Roshandel G
- Roth GA
- Rothenbacher D
- Roy A
- Saleh MM
- Salomon JA
- Sanabria JR
- Sanchez-Pimienta TG
- Sandar L
- Santomauro DF
- Santos IS
- Sarmiento-Suarez R
- Sartorius B
- Satpathy M
- Savic M
- Sawhney M
- Schmidhuber J
- Schmidt MI
- Schneider IJC
- Schoettker B
- Schutte AE
- Schwebel DC
- Scott JG
- Seedat S
- Sepanlou SG
- Servan-Mori EE
- Shaheen A
- Shahraz S
- Shaikh MA
- Sharma R
- She J
- Sheikhbahaei S
- Shen J
- Sheth KN
- Shi P
- Shibuya K
- Shigematsu M
- Shin M-J
- Shiri R
- Shishani K
- Shiue I
- Shrime MG
- Sigfusdottir ID
- Silva DAS
- Silverberg JI
- Simard EP
- Sindi S
- Singh A
- Singh JA
- Singh PK
- Slepak EL
- Sofia E Sa Farinha C
- Soljak M
- Soneji S
- Sorensen RJD
- Sposato LA
- Sreeramareddy CT
- Stathopoulou V
- Steckling N
- Steel N
- Stein DJ
- Stein MB
- Stockl H
- Stranges S
- Stroumpoulis K
- Sunguya BF
- Sur PJ
- Swaminathan S
- Sykes BL
- Szoeke CEI
- Tabares-Seisdedos R
- Takahashi K
- Talongwa RT
- Tanne D
- Tavakkoli M
- Taye BW
- Taylor HR
- Tedla BA
- Tefera WM
- Tegegne TK
- Tekle DY
- Terkawi AS
- Thakur JS
- Thomas BA
- Thomas ML
- Thomson AJ
- Thorne-Lyman AL
- Thrift AG
- Thurston GD
- Tillmann T
- Tobe-Gai R
- Tobollik M
- Topor-Madry R
- Topouzis F
- Towbin JA
- Tran BX
- Tsilimparis N
- Tura AK
- Tuzcu EM
- Tyrovolas S
- Ukwaja KN
- Undurraga EA
- Uneke CJ
- Uthman OA
- van Donkelaar A
- van Os J
- Varakin YY
- Vasankari T
- Veerman JL
- Venketasubramanian N
- Violante FS
- Vollset SE
- Vos T
- Wagner GR
- Wagner JA
- Waller SG
- Wang H
- Wang J
- Wang L
- Wang Y
- Weichenthal S
- Weiderpass E
- Weintraub RG
- Werdecker A
- Westerman R
- Whiteford HA
- Wijeratne T
- Wiysonge CS
- Wolfe CDA
- Won S
- Woolf AD
- Wubshet M
- Xavier D
- Xu G
- Yadav AK
- Yakob B
- Yalew AZ
- Yano Y
- Yaseri M
- Ye P
- Yip P
- Yonemoto N
- Yoon S-J
- Younis MZ
- Yu C
- Zaidi Z
- Zaki MES
- Zhao Y
- Zhou M
- Zhu J
- Zipkin B
- Zodpey S
- Zuhlke LJ
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation
Evidence for Involvement of Th17 Type Responses in Post Kala Azar Dermal Leishmaniasis (PKDL)
- Author
- A Awasthi
- A Ismail
- A Jayakumar
- A Kano
- AB Gottlieb
- Avninder Singh
- BL Herwaldt
- CP Thakur
- D Kumar
- D Miljkovic
- DV Jovanovic
- E Volpe
- EE Zijlstra
- F Gerosa
- FP Heinzel
- Gajendra Kumar Katara
- GK Katara
- II Ivanov
- IS Grewal
- JK Kolls
- K Roychoudhury
- L Lyakh
- L Zhang
- LC Green
- LC Zaba
- M Cabrera
- M Lohoff
- M Miyamoto
- MG Pitta
- N Martin-Orozco
- NA Ansari
- NA Ansari
- NA Ansari
- NA Ansari
- Nasim Akhtar Ansari
- ND Marin
- O Bacellar
- O Brandonisio
- P Desjeux
- Poonam Salotra
- Q Wang
- R Kumar
- R Singh
- RK Mathur
- S Ganguly
- S Gasim
- S Saha
- S Sundar
- S Verma
- SA Khader
- SC Liang
- Shaden Kamhawi
- SL Kostka
- SQ Crome
- SQ Crome
- T Korn
- V Peruhype-Magalhaes
- V. Ramesh
- VS Boaventura
- W Solbach
- X Ma
- Publication venue
- Public Library of Science
- Publication date
- 19/06/2012
- Field of study
Post kala azar dermal leishamniasis (PKDL), an unusual dermatosis, develops in 5–15% of apparently cured visceral leishmaniasis cases in India and in about 60% of cases in Sudan. PKDL cases assume importance since they constitute an important human reservoir for the parasite. Host immunological responses, considered as major factors in PKDL development, are poorly understood. Limited studies have been performed to explore the host immune responses and that too, restricted to a few immune parameters. The present study employed cDNA array technique that identified various host immuno-determinants including cytokines, chemokines, apoptotic and signaling molecules which were not reported previously in PKDL. In addition, we showed for the first time that Th17 responses are present during L. donovani infection in PKDL which possibly contributes significantly to disease pathogenesis by inducing TNF-α and nitric oxide production. Our findings lead to improved understanding of the host parasite interaction in terms of immune responses and pathology in tissue lesions of PKDL
Review on the transmission porcine reproductive and respiratory syndrome virus between pigs and farms and impact on vaccination
- Author
- A Bouma
- A Bøtner
- A Kittawornrat
- A Romagosa
- A Stegeman
- B Roic
- C Alonso
- C Charpin
- C Nathues
- C Prieto
- C Trincado
- C Trincado
- CL Loving
- CM Evans
- D Klinkenberg
- DA Benfield
- DA Benfield
- DC Horter
- DCL Linhares
- DJ Holtkamp
- E Albina
- E Albina
- E Mateu
- E Mondaca-Fernández
- E Pileri
- EA Wagstrom
- EFSA Panel on Animal Health and Welfare
- EJ Neumann
- Emanuela Pileri
- Enric Mateu
- FA Osorio
- FJ Martínez-Lobo
- G Nodelijk
- G Nodelijk
- G Nodelijk
- G Nodelijk
- G Reiner
- GG Labarque
- GP Kwong
- GW Stevenson
- H Guarino
- I Díaz
- I Díaz
- I Kang
- IFA Linden Van Der
- IFA Linden Van Der
- IJ Yoon
- IS Frydas
- IS Frydas
- IS Frydas
- J Beyer
- J Christopher-Hennings
- J Christopher-Hennings
- J Christopher-Hennings
- J Prickett
- J Shirai
- JA Baroch
- JA Schurrer
- JA Schurrer
- JE Lowe
- JG Cho
- JG Cho
- JH Sur
- JJ Zimmerman
- JP Cano
- JP Cano
- JR Hermann
- JR Hermann
- KD Rossow
- KD Rossow
- KJ Yoon
- KK Thakur
- KL Klinge
- KM Lager
- KM Lager
- KM Lager
- L Lamontagne
- M Allerson
- M Bloemraad
- M Scortti
- M Torremorell
- M Velasova
- MC Jong De
- MD Bierk
- MP Murtaugh
- MP Murtaugh
- N Nieuwenhuis
- N Rose
- O Diekmann
- OJ Lopez
- P Bonilauri
- P Martelli
- PG Halbur
- PGW Plagemann
- R Allende
- R Bilodeau
- R Larochelle
- R Magar
- R Thanawongnuwech
- RD Moon
- RRR Rowland
- RW Wills
- RW Wills
- RW Wills
- RW Wills
- RW Wills
- S Mortensen
- S Otake
- S Otake
- S Otake
- S Otake
- S Otake
- S Otake
- S Vilcek
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SH Done
- SJ Tousignant
- SL Swenson
- SR Baker
- SR Lawson
- T Rosendal
- T Stadejek
- TD Cutler
- TL Nielsen
- U Carlsson
- U Oslage
- UU Karniychuk
- UU Karniychuk
- W Hall
- WA Meier
- WG Alstine Van
- WT Christianson
- X Duan
- X Li
- Y Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update
- Author
- ACT-HBV Asia-Pacific Steering Committee Members
- AS Lok
- AS Lok
- B Canbakan
- BC Yoo
- BC Yoo
- BK Park
- C Hsu
- C Niederau
- CH Chen
- CJ Chen
- CK Hui
- CK Hui
- CL Lai
- CL Lai
- CM Chu
- CM Chu
- CM Chu
- CM Chu
- CM Chu
- CM Chu
- CM Chu
- CT Yeh
- E Gane
- E Sokal
- EB Keeffe
- Edward Gane
- EH Buster
- EJ Gane
- ER Schiff
- F Bommel van
- F Bonino
- G Lau
- George K. K. Lau
- GK Lau
- GV Papatheodoridis
- HI Yang
- HJ Flink
- HJ Flink
- HL Chan
- HL Chan
- HL Chan
- HL Chan
- HLA Janssen
- I Rapti
- IS Sheen
- J Summers
- J You
- JH Hoofnagle
- JH Kao
- JH Kao
- JH Kao
- Jia-Horng Kao
- JJ Feld
- JW Jang
- Kwang-Hyub Han
- M Lai
- M Sherman
- MF Yuen
- MF Yuen
- MM Jonas
- MW Fried
- MW Yu
- Nancy Leung
- NW Leung
- O Yokosuka
- P Angus
- P Farci
- P Lampertico
- P Lampertico
- P Marcellin
- P Vandepapeli’ere
- R Iorio
- RG Gish
- Richard Guan
- RJ Fontana
- RN Chein
- RN Chien
- RN Chien
- RN Chien
- RN Chien
- S Iino
- S Mahmood
- SC Ong
- SE Livingston
- SG Lim
- SJ Hadziyannis
- SK Fung
- SK Sarin
- SK Sarin
- SM Lin
- Stephen Locarnini
- T Piratvisuth
- Teerha Piratvisuth
- TT Chang
- UH Iloeje
- V Di Marco
- V Thakur
- WGF Cooksley
- YC Chen
- YC Chen
- YC Chou
- YF Liaw
- YF Liaw
- YF Liaw
- YF Liaw
- YF Liaw
- YF Liaw
- YF Liaw
- YF Liaw
- YF Liaw
- YF Liaw
- YF Liaw
- YH Ni
- YS Hsu
- Yun-Fan Liaw
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2008
- Field of study
Large amounts of new data on the natural history and treatment of chronic hepatitis B virus (HBV) infection have become available since 2005. These include long-term follow-up studies in large community-based cohorts or asymptomatic subjects with chronic HBV infection, further studies on the role of HBV genotype/naturally occurring HBV mutations, treatment of drug resistance and new therapies. In addition, Pegylated interferon α2a, entecavir and telbivudine have been approved globally. To update HBV management guidelines, relevant new data were reviewed and assessed by experts from the region, and the significance of the reported findings were discussed and debated. The earlier “Asian-Pacific consensus statement on the management of chronic hepatitis B” was revised accordingly. The key terms used in the statement were also defined. The new guidelines include general management, special indications for liver biopsy in patients with persistently normal alanine aminotransferase, time to start or stop drug therapy, choice of drug to initiate therapy, when and how to monitor the patients during and after stopping drug therapy. Recommendations on the therapy of patients in special circumstances, including women in childbearing age, patients with antiviral drug resistance, concurrent viral infection, hepatic decompensation, patients receiving immune-suppressive medications or chemotherapy and patients in the setting of liver transplantation, are also included
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
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- Afshin A
- Agardh EE
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- Agesa KM
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- Aghamir SMK
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- Ahmadi A
- Ahmadi K
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- Ahmadpour E
- Ahmed MB
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- Akalu TY
- Akinyemi RO
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- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
- Ullah I
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- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
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- Valdez PR
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- Venketasubramanian N
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- Wickramasinghe ND
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- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
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- Wu A-M
- Wu C
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- Wunrow HY
- Xie Y
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- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
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- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
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- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
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- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
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- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
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- Bayati M
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- Bedi N
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- Bibi S
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- Bijani A
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- Bilano V
- Bin Sayeed MS
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- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
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- Bjorge T
- Bockarie MJ
- Bohlouli S
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- Borges G
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- Breitborde NJK
- Breitner S
- Brenner H
- Breusov AV
- Briant PS
- Briggs AM
- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
- Buchbinder R
- Bumgarner BR
- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
- Cahuana-Hurtado L
- Cai T
- Callender CSKH
- Camera LA
- Campos-Nonato IR
- Cao J
- Car J
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- Carreras G
- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
- Castro E
- Castro F
- Catala-Lopez F
- Causey K
- Cederroth CR
- Cercy KM
- Cerin E
- Chalek J
- Chandan JS
- Chang AR
- Chang AY
- Chang J-C
- Chang K-L
- Charan J
- Charlson FJ
- Chattu VK
- Chaturvedi S
- Cherbuin N
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- Chin KL
- Chirinos-Caceres JL
- Cho DY
- Choi J-YJ
- Christensen H
- Chu D-T
- Chung MT
- Chung S-C
- Cicuttini FM
- Ciobanu LG
- Cirillo M
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- Classen TKD
- Cohen AJ
- Collins EL
- Comfort H
- Compton K
- Conti S
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- Cortesi PA
- Costa VM
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- Cowie BC
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- Cross DH
- Cross M
- Crowe CS
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- Cunningham M
- D'Amico E
- da Silva DD
- Dahlawi SMA
- Dai H
- Dai H
- Damasceno AAM
- Damiani G
- Dandona L
- Dandona R
- Daneshpajouhnejad P
- Dangel WJ
- Danielsson A-K
- Dargan PI
- Darshan BB
- Darwesh AM
- Daryani A
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- Das Neves J
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- Dash AP
- Davey G
- Davila-Cervantes CA
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- Davitoiu DV
- Davletov K
- De Leo D
- De Neve J-W
- Dean FE
- DeCleene NK
- Deen A
- Defo BK
- Degenhardt L
- DeLang M
- Dellavalle RP
- Demeke FM
- Demoz GT
- Demsie DG
- Denova-Gutierrez E
- Dereje ND
- Deribe K
- Dervenis N
- Desai R
- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
- Dianatinasab M
- Diaz D
- Dichgans M
- Didarloo A
- Dingels ZV
- Dippenaar IN
- Dirac MA
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
- Dolecek C
- Dolgert AJ
- Dorostkar F
- Doshi CP
- Doshi PP
- Doshmangir L
- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
- Eagan AW
- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
- Elhabashy HR
- Elsharkawy A
- Elyazar IRF
- Emamian MH
- Emmons-Bell S
- Erskine HE
- Eshrati B
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- Eskandarieh S
- Esmaeilnejad S
- Esmaeilzadeh F
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- Etisso AE
- Ezekannagha O
- Fanzo J
- Farag T
- Farahmand M
- Faraj A
- Faraon EJA
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- Faridnia R
- Farinha CSES
- Farioli A
- Faris PS
- Faro A
- Faruque M
- Farzadfar F
- Fattahi N
- Fazaeli AA
- Fazlzadeh M
- Feigin VL
- Feldman R
- Fereshtehnejad S-M
- Fernandes E
- Ferrara G
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- Ferreira ML
- Feyissa GT
- Filip I
- Fischer F
- Fisher JL
- Fitzgerald R
- Flohr C
- Flor LS
- Foigt NA
- Folayan MO
- Fomenkov AA
- Force LM
- Fornari C
- Forooshani ZSD
- Foroutan M
- Fox JT
- Francis JM
- Frank TD
- Franklin RC
- Freitas M
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- Fukumoto T
- Fukutaki K
- Fuller JE
- Fullman N
- Furtado JM
- Gad MM
- Gaidhane AM
- Gakidou E
- Galles NC
- Gallus S
- Gamkrelidze A
- Garcia-Basteiro AL
- Gardner WM
- Geberemariyam BS
- Gebrehiwot AM
- Gebremedhin KB
- Gebremeskel GG
- Gebremeskel LG
- Gebresillassie BM
- Gebreslassie AAAA
- Gela JD
- Geramo YCD
- Geremew A
- Gesesew HA
- Gething PW
- Gezae KE
- Ghadimi M
- Ghadiri K
- Ghaffarifar F
- Ghafourifard M
- Ghajar A
- Ghamari F
- Ghashghaee A
- Ghiasvand H
- Ghith N
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- Ghosh R
- Giampaoli S
- Gilani SA
- Gill PS
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- Ginawi IA
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- Gitimoghaddam M
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- Glushkova EV
- Gnedovskaya EV
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- Gopalani SV
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- Goulart BNG
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- Gugnani HC
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- Guimaraes RA
- Guled RA
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- Haile TG
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- Hanson SW
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- Ibeneme CU
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- Iqbal U
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Zeuner WD
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- Zorbilmez C
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- Özçelik Ö
- Široký J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Evidence for Top Quark Production in Nucleus-Nucleus Collisions
- Author
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- Aarup Petersen H
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- Abbiendi G
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Peer reviewe
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- Adán DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Ahuja S
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- Albrow M
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- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
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- Alonso AG
- Alvarez JDR
- Alverson G
- Alves GA
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- Alyari M
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- Amaral SMSD
- Amendola C
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- Amsler C
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- Anampa KH
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
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- Angioni GLP
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- Antunovic Z
- Anuar AAB
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- Asawatangtrakuldee C
- Asenov P
- Asghar MI
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- Askew A
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- Atakisi IO
- Atanasov I
- Ather MW
- Attikis A
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- Auzinger G
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- Awan MIM
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- Ayala G
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
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