620 research outputs found
A pretty girl is like a melody
https://digitalcommons.library.umaine.edu/mmb-vp/2398/thumbnail.jp
A Diffusion-Based Approach to Geminate Recombination of Heme Proteins with Small Ligands
A model of postphotodissociative monomolecular (geminate) recombination of
heme proteins with small ligands (NO, O2 or CO) is represented. The
non-exponential decay with time for the probability to find a heme in unbound
state is interpreted in terms of diffusion-like migration of ligabs
physics/0212040 and between protein cavities. The temporal behavior for the
probability is obtained from numerical simulation and specified by two
parameters: the time \tau_{reb} of heme-ligand rebinding for the ligand
localized inside the heme pocket and the time \tau_{esc} of ligand escape from
the pocket. The model is applied in the analysis of available experimental data
for geminate reoxygenation of human hemoglobin HbA. Our simulation is in good
agreement with the measurements. The analysis shows that the variation in pH of
the solution (6.0<pH<9.4) results in considerable changes for \tau_{reb} from
0.36 ns (at pH=8.5) up to 0.5 ns (pH=6.0) but effects slightly on the time
\tau_{esc} (\tau_{esc} ~ 0.88 ns).Comment: 8 pages with 4 figures, submitted to Chem. Phy
A bayesian meta-analysis of multiple treatment comparisons of systemic regimens for advanced pancreatic cancer
© 2014 Chan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: For advanced pancreatic cancer, many regimens have been compared with gemcitabine (G) as the standard arm in randomized controlled trials. Few regimens have been directly compared with each other in randomized controlled trials and the relative efficacy and safety among them remains unclear
New insights into the classification and nomenclature of cortical GABAergic interneurons.
A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus
Critical analysis of the reporting quality of case reports focusing on dental traumatology using the Preferred Reporting Items for Case reports in Endodontics 2020 checklist: A baseline evaluation prior to checklist publication
Background/Aims: The Preferred Reporting Items for Case Reports in Endodontics (PRICE) 2020 guidelines were published to help authors produce highâquality case reports. The aim of this study was to use the PRICE 2020 guidelines to appraise a sample of 50 case reports related to dental traumatology that were published before the guidelines were available in order to assess various parameters influencing the reporting quality. Methods: Fifty case reports published between 2015 and 2019 and related to dental traumatology were randomly selected from the PubMed database. Reports were assessed by two independent evaluators using the PRICE checklist. Each item received a score of â1â if the manuscript met all pertinent criteria, â0â if it was not reported, and â0.5â if it was reported insufficiently. âNot Applicableâ (NA) was assigned to items that were irrelevant to a specific report. The estimated total PRICE score for each case report was computed by adding all the scores, with a maximum score of 47 minus any âNAâ scores. Descriptive and Inferential statistics (Student's tâtest and ANOVA) were used for analysis. Results: The percentage of case reports that fully met each applicable criteria ranged from 0% to 100%. The percentage of case reports partially satisfying each applicable criterion varied from 0% to 88%. There was a significant difference in scores for case reports published in journals with an impact factor compared with those without (p = .042). No significant difference was observed between the mean scores that compared the period of publication. There was no significant difference between journals that followed the CARE guidelines and those that did not. Conclusion: Several items within the PRICE 2020 guidelines were either not reported or only partially reported in case reports related to dental traumatology prior to the checklist publication. It is recommended that authors follow the PRICE 2020 guidelines to improve the overall quality of their case reports
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