457 research outputs found
The Harris-Luck criterion for random lattices
The Harris-Luck criterion judges the relevance of (potentially) spatially
correlated, quenched disorder induced by, e.g., random bonds, randomly diluted
sites or a quasi-periodicity of the lattice, for altering the critical behavior
of a coupled matter system. We investigate the applicability of this type of
criterion to the case of spin variables coupled to random lattices. Their
aptitude to alter critical behavior depends on the degree of spatial
correlations present, which is quantified by a wandering exponent. We consider
the cases of Poissonian random graphs resulting from the Voronoi-Delaunay
construction and of planar, ``fat'' Feynman diagrams and precisely
determine their wandering exponents. The resulting predictions are compared to
various exact and numerical results for the Potts model coupled to these
quenched ensembles of random graphs.Comment: 13 pages, 9 figures, 2 tables, REVTeX 4. Version as published, one
figure added for clarification, minor re-wordings and typo cleanu
Effect of the intermediate velocity emissions on the quasi-projectile properties for the Ar+Ni system at 95 A.MeV
The quasi-projectile (QP) properties are investigated in the Ar+Ni collisions
at 95 A.MeV taking into account the intermediate velocity emission. Indeed, in
this reaction, between 52 and 95 A.MeV bombarding energies, the number of
particles emitted in the intermediate velocity region is related to the overlap
volume between projectile and target. Mean transverse energies of these
particles are found particularly high. In this context, the mass of the QP
decreases linearly with the impact parameter from peripheral to central
collisions whereas its excitation energy increases up to 8 A.MeV. These results
are compared to previous analyses assuming a pure binary scenario
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
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In situ, satellite measurement and model evidence on the dominant regional contribution to fine particulate matter levels in the Paris megacity
A detailed characterization of air quality in the megacity of Paris (France) during two 1-month intensive campaigns and from additional 1-year observations revealed that about 70 % of the urban background fine particulate matter (PM) is transported on average into the megacity from upwind regions. This dominant influence of regional sources was confirmed by in situ measurements during short intensive and longer-term campaigns, aerosol optical depth (AOD) measurements from ENVISAT, and modeling results from PMCAMx and CHIMERE chemistry transport models. While advection of sulfate is well documented for other megacities, there was surprisingly high contribution from long-range transport for both nitrate and organic aerosol. The origin of organic PM was investigated by comprehensive analysis of aerosol mass spectrometer (AMS), radiocarbon and tracer measurements during two intensive campaigns. Primary fossil fuel combustion emissions constituted less than 20 % in winter and 40 % in summer of carbonaceous fine PM, unexpectedly small for a megacity. Cooking activities and, during winter, residential wood burning are the major primary organic PM sources. This analysis suggests that the major part of secondary organic aerosol is of modern origin, i.e., from biogenic precursors and from wood burning. Black carbon concentrations are on the lower end of values encountered in megacities worldwide, but still represent an issue for air quality. These comparatively low air pollution levels are due to a combination of low emissions per inhabitant, flat terrain, and a meteorology that is in general not conducive to local pollution build-up. This revised picture of a megacity only being partially responsible for its own average and peak PM levels has important implications for air pollution regulation policies
Consenso Mexicano de Hepatitis AlcohĂłlica
La hepatitis alcohĂłlica es una condiciĂłn frecuente en la poblaciĂłn mexicana, se
caracteriza por insuficiencia hepĂĄtica aguda sobre crĂłnica, importante reacciĂłn inflamatoria
sistémica y fallo multiorgånico, que en la variante grave de la enfermedad implica una elevada
mortalidad. Por lo anterior, la AsociaciĂłn Mexicana de GastroenterologĂa y la AsociaciĂłn Mexicana
de HepatologĂa conjuntaron un equipo multidisciplinario de profesionales de la salud para
elaborar el primer consenso mexicano de hepatitis alcohĂłlica. El consenso fue elaborado con la
metodologĂa Delphi, emitiendo 37 recomendaciones. La enfermedad hepĂĄtica relacionada con
el consumo de alcohol comprende un amplio espectro, que incluye esteatosis, esteatohepatitis,
fibrosis en diferentes grados, cirrosis y sus complicaciones. La hepatitis alcohĂłlica grave se
define por una funciĂłn modificada de Maddrey
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32 o por un puntaje de MELD (Model for End-
Stage Liver Disease) igual o mayor a 21. Actualmente no existe un biomarcador especĂfico para el diagnĂłstico. La presencia de leucocitosis con neutrofilia, hiperbilirrubinemia (> 3 mg/dL),AST > 50 U/L ( 1.5-2 pueden orientar al diagnĂłstico. La piedraangular del tratamiento es la abstiencia junto con el soporte nutricional. Los esteroides estanindicados en la forma grave, en donde han resultado efectivos para reducir la mortalidad a28 dĂas. El trasplante hepĂĄtico es en la actualidad la Ășnica opciĂłn con que se cuenta parasalvar la vida de pacientes que no responden a los esteroides. Ciertos fĂĄrmacos, como la N-acetilcisteĂna, el factor estimulante de colonias de granulocitos y la metadoxina, pueden seruna terapia adyuvante que puede mejorar la supervivencia de los pacientes
The Mexican consensus on alcoholic hepatitis
Alcoholic hepatitis is a frequent condition in the Mexican population. It is characterized
by acute-on-chronic liver failure, important systemic inflammatory response, and
multiple organ failure. The severe variant of the disease implies elevated mortality. Therefore,
the AsociaciĂłn Mexicana de GastroenterologĂa and the AsociaciĂłn Mexicana de HepatologĂa
brought together a multidisciplinary team of health professionals to formulate the first Mexican consensus on alcoholic hepatitis, carried out utilizing the Delphi method and resultingin 37 recommendations. Alcohol-related liver disease covers a broad spectrum of patholo-gies that includes steatosis, steatohepatitis, different grades of fibrosis, and cirrhosis and itscomplications. Severe alcoholic hepatitis is defined by a modified Maddreyâs discriminant func-tion score â„ 32 or by a Model for End-Stage Liver Disease (MELD) score equal to or above 21.There is currently no specific biomarker for its diagnosis. Leukocytosis with neutrophilia, hyper-bilirubinemia (>3 mg/dl), AST > 50 U/l ( 1.5-2 can guide thediagnosis. Abstinence from alcohol, together with nutritional support, is the cornerstone oftreatment. Steroids are indicated for severe disease and have been effective in reducing the28-day mortality rate. At present, liver transplantation is the only life-saving option for patientsthat are nonresponders to steroids. Certain drugs, such as N-acetylcysteine, granulocyte-colonystimulating factor, and metadoxine, can be adjuvant therapies with a positive impact on patientsurvival
Measurement of the cross section for isolated-photon plus jet production in pp collisions at âs=13 TeV using the ATLAS detector
The dynamics of isolated-photon production in association with a jet in protonâproton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fbâ1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photonâjet invariant mass and the scattering angle in the photonâjet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements
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