199 research outputs found
Using reduced rank regression methods to identify dietary patterns associated with obesity: a cross-country study among European and Australian adolescents
- Author
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/01/2017
- Field of study
This study aims to examine repeatability of reduced rank regression (RRR) methods in calculating dietary patterns (DP) and cross-sectional associations with overweight (OW)/obesity across European and Australian samples of adolescents. Data from two cross-sectional surveys in Europe (2006/2007 Healthy Lifestyle in Europe by Nutrition in Adolescence study, including 1954 adolescents, 12-17 years) and Australia (2007 National Children's Nutrition and Physical Activity Survey, including 1498 adolescents, 12-16 years) were used. Dietary intake was measured using two non-consecutive, 24-h recalls. RRR was used to identify DP using dietary energy density, fibre density and percentage of energy intake from fat as the intermediate variables. Associations between DP scores and body mass/fat were examined using multivariable linear and logistic regression as appropriate, stratified by sex. The first DP extracted (labelled energy dense, high fat, low fibre') explained 47 and 31 % of the response variation in Australian and European adolescents, respectively. It was similar for European and Australian adolescents and characterised by higher consumption of biscuits/cakes, chocolate/confectionery, crisps/savoury snacks, sugar-sweetened beverages, and lower consumption of yogurt, high-fibre bread, vegetables and fresh fruit. DP scores were inversely associated with BMI z-scores in Australian adolescent boys and borderline inverse in European adolescent boys (so as with %BF). Similarly, a lower likelihood for OW in boys was observed with higher DP scores in both surveys. No such relationships were observed in adolescent girls. In conclusion, the DP identified in this cross-country study was comparable for European and Australian adolescents, demonstrating robustness of the RRR method in calculating DP among populations. However, longitudinal designs are more relevant when studying diet-obesity associations, to prevent reverse causality
Heat Shock Response in Yeast Involves Changes in Both Transcription Rates and mRNA Stabilities
- Author
- A Rowley
- A Trott
- A Yamamoto
- AP Gasch
- AP Gerber
- B Hayles
- C Cheadle
- C Molin
- C Ruiz-Roig
- DB Berry
- DJ Hogan
- E Garí
- EA Abbondanzieri
- Enrique Herrero
- F Estruch
- F Sherman
- FA Gonzales
- G Bellí
- G Bellí
- Gemma Bellí
- H Riezman
- HC Causton
- J García-Martínez
- J García-Martínez
- J Warringer
- JD Keene
- JE Pérez-Ortin
- JE Pérez-Ortín
- Joaquín Moreno
- José E. Pérez-Ortín
- José García-Martínez
- JR Warner
- JS Hahn
- JS Hahn
- Jürg Bähler
- KJ Travers
- L Romero-Santacreu
- Laia Castells-Roca
- MM Molina-Navarro
- N Yamamoto
- O Elemento
- O Shalem
- R Duttagupta
- R Elkon
- SA Etchells
- TS Kim
- Y Liu
- YX Mejia
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
We have analyzed the heat stress response in the yeast Saccharomyces cerevisiae by determining mRNA levels and transcription rates for the whole transcriptome after a shift from 25°C to 37°C. Using an established mathematical algorithm, theoretical mRNA decay rates have also been calculated from the experimental data. We have verified the mathematical predictions for selected genes by determining their mRNA decay rates at different times during heat stress response using the regulatable tetO promoter. This study indicates that the yeast response to heat shock is not only due to changes in transcription rates, but also to changes in the mRNA stabilities. mRNA stability is affected in 62% of the yeast genes and it is particularly important in shaping the mRNA profile of the genes belonging to the environmental stress response. In most cases, changes in transcription rates and mRNA stabilities are homodirectional for both parameters, although some interesting cases of antagonist behavior are found. The statistical analysis of gene targets and sequence motifs within the clusters of genes with similar behaviors shows that both transcriptional and post-transcriptional regulons apparently contribute to the general heat stress response by means of transcriptional factors and RNA binding proteins
Light Localization Effect on the Optical Properties of Opals Doped with Gold Nanoparticles
- Author
- Amendola V.
- Amendola V.
- Amendola V.
- Amendola V.
- Bulu I.
- Centini M.
- Davide Comoretto
- Dowling J. P.
- Eradat N.
- Franco Marabelli
- Freymann G.
- Galisteo-Lopez J. F.
- Galisteo-Lopez J. F.
- Galisteo-Lopez J. F.
- Huang J.
- Huang J. D.
- Huang K. C.
- Huang K. C.
- Huang K. C.
- John S.
- Kamaev V.
- Kulinowski K. M.
- Lopez C.
- Miclea P. T.
- Morandi V.
- Moreno Meneghetti
- Moroz A.
- Moroz A.
- Moroz A.
- Pokrovsky A. L.
- Popov O.
- Rodriguez-Gonzales B.
- Romanov S. G.
- Romanov S. G.
- Scalora M.
- Sivachenko A. Y.
- Sumioka K.
- Tan Y.
- Tessier P. M.
- The
- The
- Valentina Morandi
- Vincenzo Amendola
- Vlasov Y. A.
- Vlasov Y. A.
- Vlasov Y. A.
- Vlasov Y. A.
- Vos W. L.
- Wang D.
- Wang D.
- Wang W.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A.
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R.
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
- Adella Fidelis Jacklyn
- Adelshone Abdelrahman
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O.
- Ademuyiwa Adesoji O.
- Adenekan Babajide
- Adeniran James
- Adeniyi Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adeyeye Ademola
- Adeyeye Ademola
- Adhitama Novia
- Adil Muhammad
- Adisa Adewale O.
- Adiyaman Can
- Adu-Aryee Niiarmah
- Afana Samah
- Agalianos Christos
- Agarwal Arnav
- Agarwal Arnav
- Agbedinu Kwabena
- Aglan Amro
- Aguado Suarez Nuria
- Aguilera Maria Lorena
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlonsou Germain
- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
- Ahmed Ataa
- Ahmed Hayam
- Ahmed Hussien
- Ahmed Lopna Ahmed Mohamed
- Ahmed Sara
- Ahmed Saraibrahim
- Ahounou Ernest Yemalin Stephane
- Ajah Jonathan
- Ajai Olalekan
- Ajao Akinlabi
- Ajiboye Anthony
- Akoto Elliot
- Akpenyi Onyinye
- Al Amin Shadid
- Al Attar Samaa Mahmoud
- Al Barraw Fayez Elian
- Al Bastawis Fatema
- Al Meligy Amgad
- Al Rafati Ahmad Abdel Razaq
- Al Raouf Eman Abd
- Al Saied Ghiath
- Al Subaie Norah
- Al-Bahrani Ahmed
- Al-Buhaisi Alaa
- Al-Dakka Emad
- Al-faqawi Maha
- Al-farram Hadeel
- Al-khatib Ahmed
- Al-Marakby Dina
- Al-saqqa Sara
- Al-Saqqa Sara W.
- Al-Slaibi Ibrahim
- Al-taher Taher
- AlaaelDein Shahinaz
- Alada Muslimat
- Alakaloko Felix
- Alaloul Enas
- Alamin Shadid
- Alamoudi Mohammed
- Albiety Adel
- Alcca Ticona Willy
- Alejos Bermudez Ysabel Esthefany
- Alexander Philip
- Alexander Philip
- Alexandre Challine
- Alghamdi Ahmed
- Alghamdi Mohammed Saleh A.
- Alhady Khaled
- Alhammali Tariq
- Alhassan Basmah
- Alhazmi Wedyan
- Alherz Mohammad
- Ali Ahmed
- Ali Citra Dewi Mohd
- Ali Elsayed
- Ali Safia
- Ali Syed Abdul Wahhab Eusoffee Wan
- Ali Tebian Hassanein Ahmed
- Ali Wadah
- Alihonou Thierry
- Alis Halil
- Aliyu Halima
- Aliyu Mohammad
- Aliyu Shamsudeen
- Aljboor Khaled
- Aljiffry Murad
- Alkaaki Aroub
- Alkelani Muhammad
- Allam Meran
- Allam Yomna
- Alnaby Mohamed Hassab
- Alnusairat Aseel
- Alqahtani Saleh
- Alsaggaf Mohammed Ubaid
- Alser Osaid H.
- Alshareef Reham
- Altaf Abdulmalik
- Altamimi Abdullah
- Altamimi Afnan
- Altamini Afnan
- Altarayra Marwa
- Altibi Ahmed
- Altinel Yuksel
- Altinel Yuksel
- Altwijri Abdulaziz
- Alvi Abdul Rehman
- Aly Mohammed Yahia Mohamed
- Alyacoubi Said
- Alyahya Reem
- Alzahrani Ahmed
- Aman Nowrin F.
- Amandito Radhian
- Amandito Radhian
- Ambrona-Zafra David
- Amin Hager Abdul Aziz
- Amjad Mohammadasim
- Amoah Michael
- Amoako Joachim
- Amoako Philip Taah
- Amoako-Boateng Mabel
- Amole Isaac
- Amreia Mahmoud
- Anderson Frank
- Andika Ferry Fitriya Ayu
- Andreotti Dario
- Andress Cedar
- Andriola Valeria
- Ang Yun Lin
- Angelieri Daniele
- Anis Echaieb
- Ansaloni Luca
- Ansaloni Luca
- Ansaloni Luca
- Antezana Diego
- Anthoulakis Christos
- Antoniozzi Angelo
- Anwar Nourhan
- Anyanwu Lofty-John
- Aonzo Paolo
- Appeadu-Mensah William
- Appiah Eric Kofi
- Aquilino Fabrizio
- Arafa Omar
- Arafa Sara
- Arango Maria Clara Mendoza
- Arcudi Claudio
- Armellini Andrea
- Arnaud Alexis
- Arnaud Alexis Pierre
- Arshad Mohammad Mohsin
- Arslan Ekin
- Arsyad Hasbi Maulana
- Arthur Tom
- Aruldas Neerav
- Asar Yomna Hosny
- Asare-Bediako Kwasi
- Ashour Ahmad
- Ashour Ahmad
- Ashour Khlood
- Ashtari Morvarid
- Asi Fatema
- Asilah Siti Mohd Desa
- Assal Abdelrahman
- Asturias Sabrina
- Asumah Hamza
- Ata Ahmed
- Ata Aya Yehia
- Atiyeh Anwar
- Atkins Ebenezer Takyi
- Attia Attia
- Augestad Knut Magne
- Aviles Susan
- Avoka Anthony
- Awad Israa
- Awad Sawsan Adel
- Awadallah Salwa
- Ayandipo Omobolaji
- Aydin Mehmet Can
- Aziz Dayang Nita Abdul
- Aziz Mohamed Rezal Abdul
- Aziz Nora Abdul
- Azizeldine Mohammed G.
- Azzie Georges
- Azzis Olivier
- Baba Suleiman
- Bachri Houda
- Badawy Mahmoud
- Badenjki Mohamed Adel
- Badicel Maria
- Badr Mohamed Fawzy Mahrous
- Badwi Nermin Mohamed
- Bahar Suraya
- Baillie Katie
- Baki Bahadir Emre
- Bakr Ahmad
- Bakry Hesham Mohammed
- Bala Miklosh
- Balalis Dimitrios
- Balducci Genoveffa
- Ballouhey Quentin
- Balmaceda Ruben
- Balmaceda Ruben
- Balogun Fatai
- Baltrunas Robertas
- Baluch Fatima
- Bamford Rebecca
- Bamicha Athanasia
- Banaitis Vincas Jonas
- Bandi Ashwath
- Bandoh Dickson
- Bani-Sadar Ahmad
- Banipal Gurpreet Singh
- Baquero Suarez Alibeth Andres
- Baraka Heba
- Barendegere Venerand
- Barkolias Christos
- Barmayehvar Behrad
- Barnabas Gandau Naa
- Barrios Emmanuel
- Basilico Silvia
- Basir Elissa Rifhan Mohd
- Bassem Monica
- Bassit Khalil Abdul
- Basso Stefano M. M.
- Bayram Sefa
- Beamon Mieshia
- Bedada Alemayehu Ginbo
- BediakoBowan Antoinette
- Bekhet Amira Hassan
- Bekhet Nada Mohamed
- Beleno Alvaro Enrique Mendoza
- Belkouchi Abdelkader
- Belli Andrea
- Bello Bashir
- Benammi Sarah
- Benevento Angelo
- Bennai Redouane Mammar
- Bentounsi Zineb
- Benyaiche Chaymae
- Berti Stefano
- Bertuello Isaac
- Beuran Mircea
- Bhangu Aneel
- Bhangu Aneel
- Bhangu Anna
- Bhatnagar Ankur
- Bhopal Kamran Faisal
- Bianco Federica
- Bigaran Annamaria
- Billy Matthew
- Bin Adnan Ahmad
- Bin Hasnan Muhammad
- Bin Ismail Mohamad Jeffrey
- Birindelli Arianna
- Bisset Carly
- Bjorklund Ida
- Blacker Sarah
- Blackwell James
- Blanco Ruth
- Blanco-Colino Ruth
- Blencowe Natalie
- Bliksoen Marte
- Bluelle Rafael
- Bocchetti Tommaso
- Bode Chris
- Bodur Selim
- Boggon Adam
- Bonavia Karl
- Bonavina Luigi
- Bond-Smith Giles
- Bondin John
- Bondurri Andrea
- Boni Silvia
- Bonney William
- Borda-Luque Giuliano
- Borg Elaine
- Borg Elaine
- Bortolasi Luca
- Bottini Corrado
- Bougard Heather
- Boukhal Khaoula
- Bowabsak Alaa
- Bowling Kirk
- Bradulskis Saulius
- Bratu Matei
- Bratu Matei Razvan
- Breaud Jean
- Breistrand Michaela
- Breslin Ryan
- Brincat Svetlana Doris
- Broch Aline
- Brunoni Beatrice
- Bsisu Isam
- Bucci Luigi
- Buisson Philippe
- Bunting David
- Burger Sule
- Burmistrovas Andrius
- Bustangi Nasir
- Bustangi Nasir
- Butt Muhammad Talha
- Cakaloglu Haluk Cem
- Caliman Celeste
- Callan Rory
- Camilleri Georgette Marie
- Camilleri-Brennan Julian
- Campagnaro Tommaso
- Canta Calua Alexander
- Capito Carmen
- Carabott Kurt
- Carmela Lapitan Marie
- Carmona Juan Manuel
- Carpio Juan
- Carrasco Nahilia
- Cassar Kristina
- Catani Marco
- Cautiero Roberto
- Caydiid Hanaan
- Cecilia Tolg
- Celik Saban
- Cengiz Turgut Bora
- Cengiz Yucel
- Cengiz Yucel
- Cevik Muazzez
- Chabok Abbas
- Chai Chu-Ann
- Chai Feng Yih
- Chan Luke
- Chan Tsz-Yan Katie
- Chan Xue Wei
- Charles Angeline
- Cheah Alvin Ee Zhiun
- Chen Kar Yan
- Chen Tzu-Ling
- Cheong Yih Jeng
- Chetta Nicola
- Cheung Yuk Hong Eric
- Chibuye Chali
- Chiesa Deborah
- Chilton Gareth
- Chin Pui Xin
- Chin Ye Ru
- Chiu Seehui
- Choi Philip
- Chong Choon Seng
- Chong Hoong-Yin
- Choudhry Asad
- Chow Crystal Yern Nee
- Chowdhury Debkumar
- Chu Kathryn
- Chung Kuet Jun
- Chungui Bravo Jorge Armando
- Ciccioli Eleonora
- Ciubotaru Cezar
- Claire Raquillet
- Clarissa Audrey
- Clegg-Lampety Joe-Nat
- Clegg-Lamptey Joe-Nat
- Clerico Giuseppe
- Coccolini Federico
- Coccolini Federico
- Cocorullo Gianfranco
- Cohen Fraser
- Cole Simon
- Coletta Diego
- Coletti Massimo
- Collaborative GlobalSurg
- Cona Camilla
- Conci Simone
- Confalonieri Gianmaria
- Conlon Kevin C.
- Connor Katie
- Contreras Elisa
- Coompson Christian Lari
- Corbellini Carlo
- Corbellino Mario
- Cornick Jen
- Coronel Jazmin
- Corral Moreno Sara
- Correa Juan Camilo
- Corro-Diaz Samantha
- Costa Cecilia
- Costa-Maia Jose
- Costas-Chavarri Ainhoa
- Courboin Etienne
- Cox Daniel
- Cox Michael
- Coyoy-Gaitan Otto
- Craus-Miguel Andrea
- Cullen Fraser
- Curletti Gianluca
- Currow Chelise
- D'Amours Scott
- D'Souza Michelle S.
- Dabboor Majd
- Dabbour Kareem
- Dagoe Enoch
- Dahy Ahmed
- Dainius Edvinas
- Dakubo Jonathan
- Dalli Jeffrey
- Dally Charles
- Dambrauskas Zilvinas
- Daniyan Muhammad
- Danys Donatas
- Dao Weihei
- Dar Wasim
- Dardenne Sabrina
- Darwish Abdelrhman K. Z.
- Dasari Mohini
- Dashnyam Enkhbat
- Dassah Victor
- Datta Uttaran
- Davies Rachel
- Davor Anthony
- Dawood Khaled
- Dayie Makafui
- De Boni Davide
- De Franciscis Silvia
- De Luca Emilia
- De Marco Paolino
- Deal Rebecca
- Deane Chelsea
- Debrah Sam
- Dedekind Britta
- Dedey Florence
- Del Basso Celeste
- del Pilar Paucar Arazzelly
- Delforge Xavier
- Dell Angela
- Denakpo Max
- Denewar Adel
- Depalma Norma
- Der Yishan
- Deutschmann Peter
- Dhillon Dharminder
- Di Martino Natale
- Di Saverio Salomone
- Diaconescu Bogdan
- Diaz Vico Tamara
- Diaz Zorrilla Carmina
- Diaz-Jover Paula
- Dick Lachlan
- Dijan Emilio
- Dimech Thea
- Din Farhat
- Dindyal Shiva
- Dione Parreno-Sacdalan Marie
- Dissanayake Tharindra
- Djivoh Fernande
- Domini Edgar
- Donnelly Philippa
- Dorani Radin Mohd Nurrahman Radin
- Dorisme Asnel
- Dossou Francis
- Dousset Bertrand
- Dragatas Deividas
- Drake Thomas M.
- Drake Thomas M.
- Drungilas Mantas
- du Plooy Flip
- Du Toit Frederick
- Duane Therese
- Duinhouwer Lucia
- Dulskas Audrius
- Ebidy Mai
- Ebidy Mai Mohamed
- Eid Mostafa Mahmoud
- El Dahab Ali Abo
- El Gendy Noran Halim
- El Halawany Mohamed
- El Jamassi Alaa
- El Kashash Ahmed
- El Sayed Islam Magdy
- El-Dien Khalid Salah
- El-Din Reham Alaa
- El-Din Shahinaz Alaa
- El-Gizawy Esraa
- El-Sagheer Nada
- El-Sawy Aya
- El-Sehily Ahmed
- El-Taher Esraa
- Elashry Rehab
- Elazab Alaa
- Elbanby Esraa Samir
- Elbe Peter
- Elbisomy Khaled Hesham
- Eldafrawy Mahmoud
- Eldeeb Ahmed Zaki
- Eldeen Esraa Alm
- Eldin Mostafa Ahmed Bahaa
- Elebute Olumide
- Elfarargy Arwa
- Elfeki Hossam
- Elfiky Mahmoud
- Elfouly Nesma
- Elfouly Yasmin
- Elgendy Alyaa Halim
- Elgheriany Mohammed
- Elhadad Alaa
- Elhadary Nourhan Medhat
- Elhadry Shady
- Elhalawany Esraa
- Elhamouly Sara
- Elhelbawy Mohamed Salah
- Elhendawy Abdelaziz
- Elhoseny Ghada
- Elhusseiny Ahmed Abd Elmoen
- Elkholy Shimaa Said
- Ellison Quinn
- Elmashala Amjad
- Elmasry Maha
- Elmihy Sohaila
- Elnagar Ahmedglal
- Elnajjar Mahmoud A.
- Elrazek Aly Abd
- Elsabbagh Nourhan
- Elsameea Ahmed Abd
- Elsawy Amira
- Elsayed Nada Ahmed Reda
- Elsemelawy Rofida
- Elshaar Mohammed
- Elshaer Mohamed
- Elshami Mohamedraed
- Elsharkawy Aya Adel
- Elsherbiney Saged
- Elsherif Fawzia Abdellatif
- Elwy Eman
- Elzahed Nada
- Emadeldin Hossam
- Emara Eman
- Emile Sameh
- Eng Calvin
- English William
- Esam Abeer
- Escalante Salas Marilia Del Carmen
- Espin-Basany Eloy
- Espinoza Fernando
- Essam A. A.
- Essam Ahmed
- Essam Mahitab
- Essoun Samuel
- Esteban Enrique
- Estee Mahnuma Mahfuz
- Etchill Eric
- Etienne Sara
- Etwire Victor
- Evajelista Cicilia Viany
- Evans David
- Evans Elizabeth
- Ezzat Eslam
- Ezzat Tarek
- Faboya Omolara
- Fahim Marwan
- Fairfield Cameron
- Falaschi Federica
- Falco Nicolo
- Falzon Malcolm
- Farag Ahmed
- Farag Sameh
- Farahat Mahitab Morsy
- Fares Mohamed
- Farhan-Alanie Muhamed M. H.
- Farhangmehr Neda
- Farouk Sara Amr Mohamed
- Farrugia Alexia
- Farrugia Alexia
- Faruq Amreen
- Fathy Aya Mohamed
- Fatuga Adedeji
- Faturoti Olubukola
- Favero Alessandro
- Feidantsis Thomas
- Fergany Alaa
- Fergusson Stuart J.
- Fergusson Stuart J.
- Fermani Claudio Gabriel
- Fernandes Cristina
- Fernandez Carmen
- Fernandez-Vega Laura
- Ferousis Christoforos
- Ferrero Esther
- Filatau Aliaksandr
- Firdouse Mohammed
- Firdouse Mohammed
- Firwana Aya
- Fitsum Agazi
- Fitzgerald J. Edward
- Fitzgerald J. Edward
- Florez Farfan Erick Samuel
- Foco Maurizio
- Fok Chi Ying Jacquelyn
- Fontana Tommaso
- Foo Chi Chung
- Forlin Louise
- Fouad Dina
- Fourcade Laurent
- Francisco Roxas Manuel
- Franco Helena
- Francois Poddevin
- Francone Elisa
- Frey Daniel
- Fuentes-Rivera Lorena
- Gaafar Shireen
- Gaarder Tina
- Gad Ahmed
- Gad Mariam O.
- Gadelkarim Mohamed
- Gado Ammar
- Gaizauskas Vytautas
- Gala Tanzeela
- Gala Tanzeela
- Galiqi Gezim
- Galleano Raffaele
- Gallo Gaetano
- Gamal Dina
- Gamal Esraa
- Gamal Heba
- Gamal Shimaa
- Gamil Doaa
- Gan Cheewei
- Gan Yiing Yee
- Gani Mohammed Akil
- Garcia Bernardo Carmen
- Garcia Septiem Javier
- Garcia-Florez Luis
- Gash Katherine
- Gash Katherine
- Gastaldi Pauline
- Gaujoux Sebastien
- Gavagna Laura
- Gbessi Dansou Gaspard
- Gemenetzis Georgios
- Germanos Stylianos
- Gerosa Alexandra
- Geuoshy Abdelrahman
- Ghaben Ahed
- Ghanem Ahmed
- Ghanem Sara
- Ghannam Mohammad
- Ghoneim Omar
- Giardino Francesco Ruben
- Giavarini Luisa
- Giglio Mariano Cesare
- Giraldo Ruben Santiago Restrepo
- Giuliani Stefano
- Gkiokas Georgios
- Glasbey James
- Glasbey James
- Glover-Addy Hope
- Glynn Martha
- Goh Wennweoi
- Goldin Elena
- Gonzales Montejo Maria Soledad
- Gonzalez Mariana
- Gonzalez Mariana
- Gouws Juan
- Gran Mads
- Gravante Gianpiero
- Gray Demi
- Grech Nicole
- Grella Maria Giovanna
- Gribauskaite Jolanta
- Griffiths Ewen
- Grima Tara
- Grisin Edvard
- Grizhja Besmir
- Grobler D. C.
- Grosos Celine
- Gubeli Alissa
- Gudal Ahmad
- Gudal Ahmad
- Guevara Torres Shalon
- Guglielmo Vania
- Gui Daniele
- Gul Enisburak
- Gulbinas Antanas
- Gulcicek Osman Bilgin
- Gulielmi Alfredo
- Gultom Phebe Anggita
- Gunaseelan Kuhaendran
- Gunawan Rudy
- Guner Ali
- Gupta Ashish
- Guzman Duenas Carolina
- Gyamfi Frank Enoch
- Gyedu Adam
- Habeeb Olufemi
- Haddad Nadeem
- Hafez Mohamed
- Hafez Sarah
- Haffreingue Aurore
- Hagan Richmond
- Haines Morgan
- Hajeh Haidar
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- Timothy Oyediran Kehinde
- Ting Jesse Ron Swire
- To Kathleen
- Tolonen Matti
- Tolotra Todisoa Emmanuella Christina
- Tomas Kadir
- Tori Sayeeda Aktar
- Toribio Orbegozo Pedro Angel
- Torrance Hew D.
- Torres Cardozo Jorge
- Torres Rodriguez Servio Tulio
- Toto Omer Faruk
- Townsend Dominic
- Trompetto Mario
- Tselos Angelos
- Tshisola Serge Kapenda
- Tugnoli Gregorio
- Tun Myint
- Turati Luca
- Turkustani Sondos
- Turpo Espinoza Kenny
- Turpo Espinoza Kevin
- Tutino Roberta
- Tverskis Zygimantas
- Tyler Robert
- Tze R. Goh Ern
- Tzikos Georgios
- Ubiali Paolo
- Ukwenya Yahaya
- ul Razi Syed Asaat
- Ulusahin Mehmet
- Upadhyaya Vijaid
- Urbonas Tomas
- Urniezius Zigmantas
- Uscinas Laimonas
- Uzabumwana Norbert
- Vaicius Arturas
- Valcarcel-Saldana Maria
- Valioulis Ioannis
- Van Der Naald Niels
- Van Niekerk Michael
- Van Straten Stephanie
- Vargas Marvin
- Vartanoglu Talar
- Vartic Mihaela
- Vasquez Giorgio
- Vasquez Idelso
- Veen Torhild
- Velasquez Ricardo
- Venclauskas Linas
- Vendramin Elena
- Venskutonis Donatas
- Venskutonis Donatas
- Verbeek Anna
- Vergara Mejia Angelica Genoveva
- Verjee Azmina
- Vermaas Maarten
- Vicario Erika
- Vicenta Collado Maria
- Vida Lucian Corneliu
- Vilcinskas Mantas
- Villalobos Santiago
- Violi Paola
- Visinskas Petras
- Voulgaris Evangelos
- Wael Noha
- Wakefield Rebecca
- Waledziak Maciej
- Walker Michael
- Walker Nathan
- Walls Luke
- Walsh Michael
- Waqar Muhammad
- Warren Oliver
- Waterman Ade
- Werder Gabriela
- Whitaker John
- White Rebecca
- Whitehurst Katharine
- Wiborg Joachim
- Widiastini T. Ariani
- Widmer Lukas Werner
- Wijayarathna L. S.
- Williams Omolara
- Wilson Ling
- Wilson Michael
- Wilson Michael
- Wimalge P. M. S. N.
- Wogensen Fredrik
- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- Elsevier
- Publication date
- 01/06/2003
- Field of study
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Competition and habitat quality influence age and sex distribution in wintering rusty blackbirds.
- Author
- A Kaiser
- AL Ornat
- AM Strong
- Anne Pellegrini
- AR Campos
- BJ Hoye
- C Both
- CA Nicolai
- CE Studds
- CH Flather
- CH Sekercioglu
- CJ Schweitzer
- CJW McClure
- Claudia Mettke-Hofmann
- CME Keller
- D Delnicki
- DJ Twedt
- DJ Twedt
- DJ Twedt
- DK Niven
- DR Ardia
- DR Brown
- ES Morton
- FA Servello
- Gerhard Hofmann
- GR Hepp
- Gregorio Moreno-Rueda
- HE Kennedy Jr
- J Brzezinska
- J Gonzales-Solis
- J Perez-Tris
- JA Allen
- JA Stanturf
- JC Kilgo
- JD Wolfe
- Jennifer Malpass
- JJ Buler
- JM Townsend
- LH Fredrickson
- LM Tronstad
- M Gochfeld
- MD Johnson
- MD Johnson
- ME Heitmeyer
- Megan Garfinkel
- MF Hodges
- ML Avery
- Nathan Schiff
- NS Zeller
- P Pyle
- Paul B. Hamel
- PB Hamel
- PP Marra
- PP Marra
- PP Marra
- R Greenberg
- R Greenberg
- R Sallabanks
- RD Stevenson
- RM Corcoran
- Russell Greenberg
- S Bearhop
- SC Latta
- SL King
- SM Flaxman
- SW Raudenbush
- Theodore J. Zenzal Jr.
- TW Sherry
- U Bauchinger
- V Krivtsov
- Y Wan
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 06/05/2015
- Field of study
Bird habitat quality is often inferred from species abundance measures during the breeding and non-breeding season and used for conservation management decisions. However, during the non-breeding season age and sex classes often occupy different habitats which suggest a need for more habitat-specific data. Rusty Blackbird (Euphagus carolinus) is a forested wetland specialist wintering in bottomland hardwood forests in the south-eastern U. S. and belongs to the most steeply declining songbirds in the U.S. Little information is available to support priority birds such as the Rusty Blackbird wintering in this threatened habitat. We assessed age and sex distribution and body condition of Rusty Blackbirds among the three major habitats used by this species in the Lower Mississippi Alluvial Valley and also measured food availability. Overall, pecan groves had the highest biomass mainly driven by the amount of nuts. Invertebrate biomass was highest in forests but contributed only a small percentage to overall biomass. Age and sex classes were unevenly distributed among habitats with adult males primarily occupying pecan groves containing the highest nut biomass, females being found in forests which had the lowest nut biomass and young males primarily staying in forest fragments along creeks which had intermediate nut biomass. Males were in better body condition than females and were in slightly better condition in pecan groves. The results suggest that adult males occupy the highest quality habitat and may competitively exclude the other age and sex classes
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
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- A Yacoub M.
- A. Adam M.
- A. Nassar M.
- A. Nemer A.
- Aahlin E. K.
- Ab Rahim M. F.
- Abad Gurumeta A.
- Abad-Motos A.
- Abang Jamari D. Z. H.
- Abantanga F.
- Abarca S.
- Abazid E.
- Abbas A.
- Abbas K.
- Abbas M. M.
- Abbasy J.
- Abbosh A.
- Abd B.
- Abd Karim M. F. S.
- Abd Wahab H. H.
- Abdalei A.
- Abdalla Ahmed Elkamel A.
- Abdallah A.
- AbdAllah M. S. M.
- Abdel Malik A. B.
- Abdelhady Mousa H.
- Abdelhady S.
- Abdelhakim A.
- Abdelkader M.
- Abdelkawy S.
- Abdelkhalek M.
- Abdellatif E.
- Abdelmaksoud Tawakel N.
- Abdelmohsen N.
- Abdelmotaleb I.
- Abdelrazek A.
- Abdelsalam I.
- Abdelshakour M.
- Abdelwahed A. M.
- Abdou A.
- Abdou A. O.
- Abdou H.
- Abdul Aziz M. R.
- Abdul Aziz N.
- Abdulgawad Almogy M.
- Abdulla M. A.
- Abdullah M. T.
- Abdullahi L.
- Abdullayev S.
- Abed S.
- Abello D.
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- Abo mahadi A.
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- Wong L. F.
- Wong M. P. -K.
- Wong S. -W.
- Wong T. L. E.
- Wood L.
- Woon-Shoo-Tong X. -M. S.
- Wren S.
- Wuraola F.
- Xanthopoulou G.
- Yabut K.
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- Yaghi N.
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- Yahia Mohamed Ali M.
- Yakushkina A.
- Yalcinkaya A.
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- Yoong A.
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- Yotsov T.
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- Younes E.
- Younes M.
- Yousry B.
- Yozgatli T. K.
- Yu K.
- Yue S. Y. P.
- Yuksel O.
- Yunes A.
- Yusuf B.
- Zabiyaka M.
- Zachariah S. K.
- Zafar S. N.
- Zaffaroni G.
- Zahra B.
- Zahran D.
- Zakaria A. D.
- Zakaria M.
- Zakaria O.
- Zakaria Z.
- Zambrana Campos V.
- Zammit M.
- Zanini N.
- Zara V. J.
- Zarti H.
- Zarzycki P.
- Zatecky J.
- Zattoni D.
- Zavala G.
- Zawahrah H.
- Zeiton A.
- Zeko A.
- Zeng Z.
- Zeromskas P.
- Zhang G.
- Zhivkov E.
- Zid E.
- Zidan A. M.
- Zielasek C.
- Zilinskas J.
- Zimmermann B.
- Ziprin P.
- Zizzo M.
- Zografos G.
- Zoikas A.
- Zorrilla Matilla L. P.
- Zoulamoglou M.
- Zreeg D.
- Zub-Pokrowiecka A.
- Zubiaurre V.
- Zuhdy M.
- Zuikyte D.
- Zuloaga Fernandez del Valle C. J.
- Zulu S.
- Zumbakys
- Zupan D.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
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- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
- Farhad M
- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald JE
- Fitzgerald JE
- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
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- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
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- Garland A
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- Gaujoux S
- Gavagna L
- Gbessi DG
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
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- Ghanem S
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- Ghannam M
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- Ghazy AA
- Gheith A
- Ghetia M
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- Giardino FR
- Giavarini L
- Giglio MC
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- Glynn M
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- Goldin E
- Golding D
- Gomaa A
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- Grobler DC
- Grosos C
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- Guevara Torres S
- Guevara R
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- Gul E
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- Gulcicek OB
- Gulielmi A
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- Gunawan R
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- Hache-Marliere M
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- Hafiz S
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- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
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- Hamarshi A
- Hamasaki Hamaguchi JL
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- Hashim A
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- Hassaan A
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- Ibrahim A
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- Iqbal FM
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- Mochet S
- Modolo MM
- Modolo MM
- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok YT
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- Monrad-Hansen PW
- Monteleone M
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- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora JJV
- Morales C
- Morandi E
- Moreira G
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- Morton R
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- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
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- Mshelbwala P
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- Munipalle PC
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- Musowoya J
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- Musyoka CK
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- Mutlu V
- Muzio E
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- Nanthakumaran S
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- Naranjo Aristizaibal FA
- Narayanan R
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- Nashidengo P
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- Nataraja R
- Natili A
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- Nazir M
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- Ndegwa W
- Ndlovu SR
- Ndwambi P
- Negida A
- Negoi I
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- Neo YN
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- Nepogodiev D
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- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
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- Ngwa TE
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana VJP
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- Ntirenganya F
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- Nurqistan HD
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
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- Palomino Castillo VD
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- Pesenti G
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- Rahantasoa FCFP
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- Samalavicius NE
- Samaraweera DI
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- Tansoker I
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- Tedeschi U
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- Telfah MM
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- Ukwenya Y
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- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
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- Uscinas L
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- Vergara Mejia AG
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- Yavuz MA
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- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
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- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
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- Zil-E-Ali A
- Zilinskas J
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- Zilinskiene R
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- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
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- Zateyshchikova A.
- Zauzig H-D
- Zauzig H.
- Zecca C.
- Zemlianskaia O.
- Zhai H.
- Zhan Q.
- Zhang G. S.
- Zhang H. Q.
- Zhang Q.
- Zhang R.
- Zhang Y.
- Zhao R. P.
- Zhao Y. S.
- Zheng W. Y.
- Zhirov I
- Zhou B.
- Zhou Z. H.
- Zhu X. Y.
- Zhuravleva E.
- Zhurba S.
- Zidek M.
- Zidkova E.
- Ziefle S.
- Zika J.
- Zillo M.
- Zimmett L.
- Zimny H-H
- Zincke S.
- Zinka E.
- Zotova I
- Zrazhevskiy K.
- Zubeeva G.
- Zuber M.
- Zurbrigk F. J.
- Zutz S.
- Zyczynska-Szmon M.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- Abantanga FA
- Abatli SJ
- Abbas W
- Abbo O
- Abd Elmenam M
- Abd Razak RB
- Abdelbaqi R
- Abdelhady DS
- Abdelhafez MOM
- Abdelhamid SS
- Abdelmaksoud S
- Abdelmoumen R
- Abdelmutalib F
- Abdul-Mumin A
- Abduljawad FM
- Abdullah F
- Abdulraheem N
- Abdulrahman A
- Abdulsalam MA
- Abdunomonovich DA
- Abib SDCV
- Aboelela A
- Abouheba M
- Abrahamsson K
- Abu Ajwa AE
- Abu Al-saleem HSH
- Abu Alamrain AA
- Abu Bakar AH
- Abu Farha MS
- Abu Jamie N
- Abu Jamie YMK
- Abu Jayyab M
- Abu Mayaleh A
- Abu Shiha E
- Abu Za'nouneh FJ
- Abu-Nejmah F
- Abuajaila A
- Abuattaya AA
- Abubakar AM
- Abueideh A
- Abuhayyeh HA
- Abuhlega MA
- Abukhalaf S
- Abumunshar AA
- Acuna G
- Adams S
- Adamu S
- Adanan MFSBM
- Adawi I
- Adawi S
- Adawy A
- Ade-Ajayi N
- Adegboyega R
- Ademuyiwa A
- Adesanya O
- Adhiwidjaja CF
- Adofo-Ansong N
- Agboola TH
- Agelebe E
- Aguiar AA
- Aguilar FA
- Aguirre-Lopez P
- Agulham MA
- Ahmad H
- Ahmad ZAH
- Ahmed H
- Ahmed MA
- Ajai OT
- Ajao EA
- Ajiboye OS
- Ajrami Y
- Akan ME
- Akhbari M
- Akhter N
- Akova F
- Al Dammagh NM
- Al Hussein S
- Al Massry NA
- Al Quran TM
- Al-Attar HM
- Al-Halbouni L
- Al-Mamun A
- Al-Mayoof AF
- Al-Momani HM
- Al-Mouakeh A
- Al-Rayyes M
- Al-Salhi AA
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- Al-Slaibi I
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- Algabri HNO
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- Blain OE
- Blanc T
- Blanchet EB
- Blazquez-Gomez E
- Blom MD
- Bode C
- Bonnard A
- Boonthai A
- Borbonet D
- Borges CG
- Bouhadiba N
- Bowder A
- Bradshaw K
- Bragagnini P
- Brahmamdam P
- Bravo MN
- Bravo MRDT
- Brenner NK
- Bright BP
- Broch A
- Brunero M
- Bruxel CL
- Bsisu I
- Bucaram E
- Burgos CM
- Burks SS
- Burns K
- Butler M
- Bvulani B
- Caamal LJ
- Cai D
- Calancea C
- Calderon LO
- Calistus N
- Calle CS
- Cama J
- Camacho FRC
- Camamra K
- Cameron F
- Camp L
- Canozer A
- Caouette-Laberge L
- Carbajal LF
- Carloni ICS
- Carrasco AL
- Carrasco-Ortega C
- Carrillo I
- Casado FT
- Caseb P
- Casquero V
- Castaneda FDMD
- Castillo MN
- Cavaiuolo S
- Cekic B
- Celik M
- Centen SV
- Cepeda R
- Cesur IB
- Chan J
- Chang J
- Charras MD
- Chaudary AR
- Chaudhry MA
- Chauhan N
- Chen J
- Chen L
- Chen R
- Cheung M
- Chipalavela RF
- Chipana CLA
- Chiriboga E
- Chiroque CM
- Chitiavi SW
- Chitnis M
- Cho SH
- Choo CSC
- Chukwu I
- Chukwuemeka AL-J
- Chung JH
- Cino EL
- Cletus C
- Coghill G
- Collins N
- Comert HSY
- Contreras CS
- Coon J
- Cordonnier A
- Cordova KH
- Cornelli F
- Cornwall H
- Corona MQ
- Correa A
- Correa C
- Cortez LFG
- Cosoreanu V
- Costa EC
- Costas-Chavarri A
- Cripovich A
- Cruzado GJS
- Cunningham A
- Cury EK
- Czauderna P
- da Cunha AG
- da Silva EAD
- da Silva JAN
- da Silva KI
- Dagilyte R
- Daher AP
- Dahman NBH
- Dalek NFRA
- Dallegre MB
- Dalloul H
- Damiani A
- Dania B
- Darras OM
- Darwish A
- Darwish AS
- Dass A
- Dassonville M
- Davenport K
- David K
- Davies J
- Davis JK
- de Almeida TL
- de Andrade SO
- de Fernandez y Alcazar FR
- de Fraga JCS
- de Guzman J
- de Holanda FC
- De La Cruz RR
- de Oliveira DF
- de Oliveira DP
- de Souza RF
- de Vos C
- Dedeke F
- Defago VH
- Defert C
- Delefortrie T
- Delforge X
- Dendusic N
- Derbew M
- Derks T
- Deya C
- Deyab A
- Deyl RT
- Di Siervi O
- Dias AIBDS
- Dieudonne L
- Dimatatac DM
- Djordjevic I
- do Nascimento SD
- Dogar S
- Doheim MF
- Dominguez D
- Dominguez MA
- dos Santos CS
- dos Santos MSF
- Dosselman LJ
- Douiri A
- Drah W
- Dube AM
- Duchesne C
- Duggan E
- Dure C
- Ebeido A
- Echegaray MD
- Egbuchulem IK
- Ejinkeonye EC
- Ekenze SO
- Ekwunife OH
- El Tallaa MA
- El-Ghazaly M
- Elassall GMH
- Elayeb A
- Elebute OA
- Elewaily M
- Elfiky M
- Elgammudi M
- Elghazaly SM
- Elhadi A
- Elhadi M
- Elhajjaji YA
- Elhattab A
- Elias RA
- Elisante J
- Elkaloush AA
- Elkhazmi EOA
- Elmzyyen AM
- Elrais SA
- Elsadek MA
- Elsaied A
- Elshaer OA
- Elsherbiny M
- Elsiraffy OO
- Elstad M
- Elzohiri M
- Elzowawi F
- Emam OS
- Emil S
- Ensar N
- Ercin S
- Erdem M
- Eren E
- Ergenekon E
- Eroglu E
- Erturk N
- Eshkabilov S
- Espineda B
- Espinosa SC
- Espinoza PP
- Essa TM
- Essamilghi KAM
- Ezidiegwu US
- Ezomike UO
- Faboya OM
- Fachin C
- Fadhle MJ
- Fajardo GYP
- Faks V
- Falah EH
- Farag EM
- Fares J
- Farion-Aguiar L
- Fawzy OM
- Fayez M
- Fazli MR
- Feldens L
- Felix M
- Feliz E
- Ferdinando DLT
- Ferdousi T
- Fernandez JY
- Ferreira JL
- Ferreira MDSS
- Ferrer MF
- Flores IMR
- Ford K
- Fory GO
- Fouda MF
- Fouly MAN
- Fouquet-Languillat V
- Fourcade L
- Fowler KL
- Fox S
- Franco H
- Frutos FJL
- Furtado M
- Gabriel C
- Gad D
- Gadelha AAB
- Gadepalli S
- Gai A
- Galdeano M
- Gallego EA
- Gallindo RM
- Galvez PC
- Gamage T
- Gao Z
- Gao ZC
- Garcia I
- Garcia M
- Garcia V
- Garcia-Aparicio L
- Gargum SA
- Gargurevich PPA
- Garnier H
- Garrett-Cox R
- Gasana G
- Gashugi IS
- Gatzinsky V
- Gavrila B
- Gavrilovska-Brzanov A
- Gee O
- Gerus S
- Geze S
- Ghabayen ATS
- Ghallab A
- Ghaly KAE
- Ghanem WH
- Ghayth S
- Ghazzawi I
- Ghorab IA
- Ghosh D
- Gilardi J
- Giovanoni LS
- Goddard L
- Goebel P
- Gohil H
- Gomes AL
- Gomez J
- Gomez JMD
- Gomez O
- Goncalves PCB
- Goncalves V
- Gondal MF
- Gonzales B
- Gonzalez CCP
- Gonzalez DE
- Gonzalez J
- Gosain A
- Grabowski A
- Graneli C
- Greenberg J
- Grella MG
- Grosos C
- Grottling E
- Grynberg L
- Guadagno E
- Guayelema M
- Guazzotti M
- Guerin F
- Guimaraes P
- Guinsburg R
- Guisse C
- Guo X
- Gurgel do Amaral AC
- Gurskas P
- Gutierrez EA
- Gutierrez NT
- Guzman NJT
- Habiba A
- Hagander L
- Hagander L
- Haidari SA
- Haider N
- Hajajreh MS
- Hakan N
- Halabi YA
- Hall N
- Hall T
- Hameed S
- Hamidi N
- Hamidovic A
- Hamill J
- Hamilton A
- Hammato AY
- Hammond P
- Hammouri AG
- Hamzah SNABH
- Han Y
- Hanifah NABM
- Haraux E
- Harilal S
- Harper L
- Hasan S
- Hasan S
- Hasanain DK
- Hashim HHB
- Hashim I
- Hashim S
- Hassan MA
- Hassan MYM
- Hassan ZBM
- Herdan MO
- Herrera C
- Herrera L
- Hery G
- Hinojosa AS
- Hinostroza D
- Hisham I
- Hodgman E
- Honhar M
- Horacio B
- Horozic D
- Hospital SI
- Hossini SL
- Hu D
- Huang L
- Huang S
- Huang T
- Huespe E
- Hukic L
- Huq U
- Hussain SR
- Hussein OG
- Hussien M
- Hwang IJ
- Hyeon CS
- Hyman G
- Ibarra D
- Ibrahim EAA
- Ibrahim F
- Ibrahim MA
- Ibukunolu O
- Igoche M
- Ihediwa G
- Imamoglu M
- Ionescu S
- Iracelay S
- Iriondo M
- Ishak S
- Ismail EM
- Ismavel VA
- Isolan PMBS
- Itangishaka I
- Ivanov M
- Jabaiti MS
- Jabang JN
- Jaber D
- Jacobson J
- Jain S
- Jaiteh M
- Jallow CS
- Jalo I
- Jamal MU
- Jaramillo M
- Jauregui L
- Jauri C
- Jayaratnam S
- Jeremie N
- Jester I
- Joda AE
- Joharifard S
- Johnson S
- Jones B
- Jones C
- Jones M
- Jonuzi A
- Jooma U
- Joubeh S
- Jovcheski L
- Juhasz L
- Julio L
- Junes MDC
- Juricic M
- Jusabani M
- Jyun KWY
- Kader S
- Kalicinsk P
- Kamel TM
- Kamilovski M
- Kannessan H
- Kano Y
- Kapihya C
- Karabulut R
- Karakus SC
- Karamustafic A
- Karavdic K
- Karim S
- Karim S
- Kaya H
- Kayed YIO
- Kayibanda E
- Kchiche N
- Kcomt SG
- Kelay A
- Keles E
- Keshtgar A
- Khaled A
- Khalel WIA
- Khalid HM
- Khamag O
- Khatatba LZA
- Khattak MAK
- Khlevner J
- Khorana J
- Kihiko D
- Kim H-Y
- King S
- Kist IN
- Kluppel EN
- Knorr C
- Knurowska A
- Kohaut J
- Koipapi S
- Korlacki W
- Koshy RM
- Kostic A
- Koszutski T
- Kowalewsk G
- Krause H
- Krayem Y
- Krisanova D
- Krishnaswami S
- Kufeji D
- Kukkady A
- Kumar V
- Kumolalo FO
- Kunfah SMP
- Kurian M
- Kurt G
- Kwasau H
- Laberge J-M
- Labonia C
- Ladino AMF
- Ladipo-Ajayi O
- Lahlooh RA
- Lakhoo K
- Lander T
- Langer M
- Langley J
- Lapouble F
- Lara S
- Latiff ZA
- Lawal T
- Lawalbarau A
- Layas T
- Laymouna MA
- Le Gall C
- Leal PO
- Leather AJM
- Lechmiannandan A
- Lee JY
- Lee S
- Leech M
- Leite MTC
- Leles KDDP
- Leon CD
- Leon JLA
- Leon NRM
- Lerma S
- Letic E
- Levard G
- Levitt M
- Leyba MF
- Li H
- Li S
- Li Z
- Liang L
- Liljesthrom K
- Lim F
- Lin N
- Lindert J
- Liu Y
- Liubsys A
- Liukitithara S
- Liyenzero PO
- Ljuhar D
- Lobos P
- Lodhia J
- Lofberg K
- Losa GN
- Losty P
- Lotfollahzadeh S
- Lu J
- Lubbad W
- Lucio P
- Lui Y
- Lukac M
- Lule J
- Luo W
- Lv J
- Lv Z
- Lyttle BD
- Mac C
- Macdonald A
- Machado ABS
- Machemedze S
- Madieh J
- Madziba S
- Magro NMH
- Mahmoud AM
- Mahmud K
- Mahmud R
- Mairami AB
- Maistry N
- Makepeace LM
- Makhmud A
- Malaga FPD
- Malcius D
- Maldonado JEG
- Malik J
- Malik S
- Mancera J
- Mangray H
- Manirambona E
- Manjira E
- Manni F
- Mansfield S
- Mansour I
- Mansour MA
- Manteola ER
- Marcos D
- Marianella D
- Marin AM
- Marmol M
- Marques GMN
- Marta O
- Martin AD
- Martin B
- Martinez HG
- Martinez-Leo B
- Martins BMR
- Matias MA
- Matos JPV
- Matour BM
- Mazzuca RB
- Mbonicura JC
- Mbonisweni A
- Mccluney S
- Medard P
- Meftah A
- Mellado DH
- Meloche-Dumas L
- Mena A
- Mendizabal DB
- Menin FA
- Mercado P
- Mert MK
- Mesic A
- Meyer KF
- Michael V
- Middlesworth W
- Middleton T
- Mieres C
- Mikneviciute A
- Milisic E
- Millan C
- Miranda CT
- Miriam A
- Mironescu A
- Mirza MB
- Misk RA
- Mitul A
- Mitul AR
- Modekwe V
- Modi V
- Mohammad MA
- Mohammed A
- Mohammed AA
- Mohammed HM
- Mohammed KA
- Mohammed MM
- Mohammed OAA
- Moitt N
- Molina M
- Molinelli M
- Monawar AB
- Montoya D
- Moore AC
- Mora M
- Moraes M
- Morales A
- Morales LB
- Morales O
- Morejon VJ
- Moreno ME
- Mori FT
- Moriya E
- Morjan M
- Mose M
- Motee J
- Motter SB
- Motter SB
- Mounira BNEI
- Mouti MB
- Mouttalib S
- Mshelbwala PM
- Msuya D
- Mugambi S
- Mugo R
- Muhic A
- Mulu J
- Mumtaz U
- Munoz G
- Muntean L
- Murad AMI
- Muradi T
- Muragijimana JDD
- Muraveji Q
- Murillo IVE
- Murshidi RM
- Murtadi HM
- Murzaie MY
- Muslimovich AM
- Mussein HM
- Mustufa H
- Mutlu M
- Mvukiyehe JP
- Mwai T
- Nageh M
- Nah SA
- Naidoo R
- Naim NABM
- Naim SRR
- Naranjo K
- Nassar I
- Nataraja RM
- Naumeri F
- Naunova VC
- Ndata A
- Ndayishimiye I
- Ndungu J
- Negash S
- Negida A
- Negrete A
- Nemer AA
- Nemer R
- Neyra MSL
- Nezerwa YC
- Ngerncham M
- Ngwenya S
- Nisar MU
- Niyukuri A
- Nkuliza D
- Nkunzimana E
- Nofal AH
- Noor WR
- Nor MTM
- Nour I
- Nour IR
- Nour IR
- Novotny N
- Nuntasunti W
- Nwangwu EI
- Nwankwo EP
- Nwosu DC
- O'Connor J
- O'Connor Z
- Obeso AS
- Obianyo NE
- Ochieng K
- Ochieng R
- Odi AA-NB
- Ogundoyin O
- Ojeda AG
- Olabisi OO
- Olanrewaju M
- Olayade K
- Olori S
- Olulana DI
- Omari RY
- Omling E
- Ortiz RS
- Osagie O
- Osazuwa M
- Oshiba AM
- Osman M
- Osowicka M
- Osuigwe AN
- Osuoji RI
- Otuneye AT
- Outani O
- Oviedo JJM
- Owiwi Y
- Owusu S
- Owusu-Sekyere F
- Oyebanji L
- Oyinloye A
- Ozcelik Z
- Ozen MA
- Pachl M
- Padilla CP
- Pajouhandeh F
- Palacios N
- Palomino AG
- Pandit GS
- Papa A
- Pardo L
- Pardo LM
- Pardy C
- Paredes ER
- Paredes VS
- Parigi GB
- Parker S
- Parmentier B
- Pasaoglu M
- Pasierbek M
- Pasqua N
- Patel A
- Patkowski D
- Patzer L
- Pauzi SFM
- Peraza JL
- Perez JO
- Perez MO
- Perez RD
- Pernik MN
- Pesara LMH
- Petel MR
- Peycelon M
- Phannua R
- Philipo GS
- Piche N
- Picon CMDJT
- Pigeolet M
- Pilkington M
- Pinar B
- Piotrowska A
- Planka L
- Poenaru D
- Poocharoen W
- Popovic N
- Porras JD
- Portilla EF
- Pos L
- Prabhu PS
- Prat J
- Puentes MC
- Puglia P
- Puig MG
- Puligandla P
- Putruele D
- Qabaja MM
- Qadomi AB
- Qawwash A
- Qi TTH
- Qudah HA
- Quevedo LMB
- Quinteros EFD
- Quiroz NH
- Qunaibi MAF
- Qureshi T
- Qutishat H
- Qwaider YZ
- Raboe E
- Rackova T
- Radwan AS
- Raffaele A
- Raicevic M
- Raj A
- Ramli NB
- Ramos Y
- Rani Z
- Raposo JW
- Rasaki A
- Rashid S
- Rashwan H
- Ravetta P
- Ravi K
- Raymond KJ
- Raza R
- Reda A
- Rehman WU
- Rengura C
- Reuter C
- Rex D
- Reyes GY
- Rhodes H
- Ribas B
- Riboni C
- Rieth A
- Rincon LC
- Rissmann A
- Risteski T
- Rite S
- Rivarola NI
- Rivera AC
- Rivera JRCC
- Roberts CA
- Roberts K
- Roberts R
- Rojas N
- Rolle U
- Romano PG
- Rosa BR
- Rosas FA
- Roszkiewicz A
- Ruan W
- Rudolfson N
- Ruzgar N
- Rygl M
- Saad AM
- Saad MM
- Sabbatini S
- Sabic A
- Sabti S
- Sadagurschi M
- Sadek K
- Sadek M
- Safa N
- Safus A
- Sahnoun L
- Sahuanay VRC
- Salah M
- Salawu MM
- Salazar K
- Saldana L
- Saleem A
- Saleem M
- Saleh A
- Saleh M
- Salem HK
- Salha AAS
- Salim JM
- Salinas V
- Salo M
- Samad L
- Samadi AZ
- Samarah YA
- Samarakkody U
- Sambo YT
- Samy D
- San Miguel DO
- Sanchez A
- Sanchez B
- Sanchez CIA
- Sanchez J
- Sanchez JS
- Sanchez N
- Saousen B
- Sara N
- Saracevic A
- Sarhan OAK
- Sarihan H
- Sarkaz TL
- Sayeed F
- Sbaih MF
- Scalabre A
- Scherl H
- Schmedding A
- Schopf LF
- Sehic A
- Sehwiel AS
- Sekyere O
- Selak N
- Sempertegui D
- Serban AM
- Seref K
- Serezo B
- Sevdalis N
- Seyi-Olajide J
- Sferco CA
- Shabana OS
- Shahbal S
- Shaheen AA
- Shaheen N
- Shajin T
- Shaklawoon A
- Shalaby A
- Shalaby H
- Shalluf HA
- Shan CH
- Sharabati F
- Sharabati M
- Sharif M
- Sharif RAM
- Shaw K
- Shehada M
- Shehu I
- Sheir H
- Sherer K
- Sherzad A
- Shikha A
- Shinondo P
- Shnishah AE
- Shokri HA
- Shonubi A
- Shoubaki A
- Shu Q
- Siddiqui SM
- Sidler D
- Sigalet D
- Sihem B
- Sikwete G
- Silva E
- Silva J
- Silva MDA
- Silva RV
- Silva XG
- Silva Y
- Sim M
- Simeon T
- Simon S
- Sindi O
- Singer G
- Singh M
- Sivaraj J
- Sivasubramaniam M
- Siyotula T
- Skvaril J
- Slavkovi A
- Slavkovic M
- Smith ER
- Sobrero H
- Soccorso G
- Sokolovic E
- Sola J
- Solanki M
- Soldan CP
- Soliman NA
- Son J
- Song ES
- Sonmez K
- Soomro A
- Sotelo LO
- Souhem T
- Soula E
- Sowe B
- Sriniworn A
- St-Louis E
- St-Vil D
- Stark D
- Stichhauer R
- Stojanovic M
- Stringer M
- Strumila A
- Sueiras I
- Suleiman F
- Sultana S
- Sundeep PT
- Suradi HH
- Sutcliffe J
- Suzen A
- Svensson E
- Svirsky A
- Swessi H
- Syed S
- Syovata F
- Szklarz MT
- Tababa O
- Tabari AK
- Tabiri S
- Tadesse A
- Tahyneh AAA
- Takrouney MH
- Talat N
- Tamada H
- Tamaddun HFB
- Tang W
- Tanimola AG
- Tanming P
- Tanny ST
- Tantush SA
- Tarabishi AS
- Tarek A
- Tarmohamed M
- Tarniba SA
- Tarrado X
- Tasker D
- Tauffer MG
- Teague W
- Telles L
- Temilade BB
- Teo R
- Teran A
- Terzic S
- Testoni D
- Thaiwatcharamas K
- Thiessen J
- Thomas AH
- Thomas G
- Thomas MC
- Thompson H
- Till H
- Tillig B
- Tobor S
- Toczewski K
- Tom A
- Toplicic D
- Toral E
- Torres-Canchala L
- Toselli L
- Touabti S
- Toufik IA
- Trainba S
- Trein CS
- Trojanova B
- Trypens A
- Tumi M
- Turkyilmaz C
- Turkyilmaz Z
- Tuyishime E
- Ubhi H
- Ugwu JO
- Ugwunne CA
- Ulasi I
- Ullrich S
- Unchon GL
- Urquizo MML
- Vacek J
- Vaitkiene A
- Valencia S
- Valeria P
- Valerio-Vazquez R
- Valladares PS
- Vanis N
- Vaquila J
- Varela MF
- Vargas OP
- Vatta F
- Vazquez MEM
- vd Merwe E
- Velana J
- Velasco JJCR
- Vellusamy VMM
- Venant N
- Venkatraman SS
- Verdeata R
- Verduga L
- Vergara C
- Verkauskas G
- Veronica S
- Vervoort D
- Vianney BJM
- Vida L
- Vidal CRZ
- Vierboom L
- Villalba AV
- Vinskaite A
- von Bismarck S
- von Delft D
- Vosoughi A
- Wafa T
- Walker G
- Wang D
- Wang J
- Wang J
- Wang P
- Waseem B
- Weeratunga N
- Weiszewsk A
- Wen G
- Wester T
- Wijekoon N
- Wilke A
- Williams I
- Williams O
- Williams R
- Wilson MDF
- Win WSP
- Wishah BDM
- Wishah N
- Wissanji H
- Wolak P
- Wolny A
- Wong J
- Wong M
- Wright NJ
- Wu G
- Wyrzykowski D
- Xie H
- Yacoub MA
- Yaghi B
- Yaghi DH
- Yalcinkaya A
- Yang H-B
- Yanis AH
- Yao Y
- Yapo B
- Yeniay AO
- Yola MM
- Yong F
- Youn JK
- Yousuf H
- Yu M
- Yu R
- Yuen QS
- Yuldashev RZ
- Yunus A
- Zaghlol LY
- Zain M
- Zaman ASK
- Zanellato JB
- Zea-Salazar LE
- Zeinelabdeen A
- Zelada JA
- Zhao X
- Zhu J
- Zhu L
- Zidan M
- Zivanovic D
- Zreeg DAS
- Zurikat RO
- Zvizdic N
- Zvizdic Z
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
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