Sonografski prikaz dimenzija bubrega u bolesnika s esencijalnom hipertenzijom u sveučilišnoj bolnici Abubakar Tafawa Balewa u gradu Bauchi u Nigeriji

Introduction: Hypertension is one of the commonest non-communicable diseases worldwide; it is the second most common cause of end-stage renal disease. Objective: To evaluate the renal dimensions and volume of essential hypertension patients in Abubakar Tafawa Balewa University Teaching Hospital, Bauchi and to compare the dimensions with that of apparently healthy volunteers. Materials and Methods: A total of two hundred and eleven individuals (comprising 121 females and 90 males) with essential hypertension attending an outpatient clinic in Abubakar Tafawa Balewa University Teaching Hospital Bauchi, and an equal number of healthy volunteers (comprising of 172 females and 49 males) were studied as controls. Both the healthy volunteers and the Hypertensive patients’ renal length, renal width, antero-posterior diameter, and parenchymal thickness were assessed. Statistical Package for Social Sciences (SPSS version 20.0) was used for data analysis. Results: Study show the mean renal length for hypertensive patients to be 9.1 ± 0.79 cm and 9.1 ± 0.73 cm, the mean renal width of 3.5 ± 0.48 cm and 3.8 ± 0.68 cm, and mean renal volume of 87.22 ± 19.58 cm3 and 95.08 ± 22.93 cm3 for the right and left kidneys respectively. Results equally show statistically significant difference in anteroposterior diameter (p<0.05), parenchymal thickness (p<0.05) and renal volume (p<0.05) between the hypertensive group and the volunteer group for both right and left kidneys. Conclusion: This study has established baseline renal dimensions for hypertensive in our population (Bauchi Metropolis). The hypertensive subjects showed a decrease in renal anteroposterior diameter, parenchymal thickness and volume compared to control group.Uvod: Hipertenzija je jedna od najčešćih nezaraznih bolesti u svijetu; drugi je najčešći uzrok završnog stadija bubrežne bolesti. Cilj: Procijeniti dimenzije bubrega i bubrežni volumen kod hipertenzivnih bolesnika u Sveučilišnoj bolnici Abubakar Tafawa Balewa u gradu Bauchi i usporediti ih s dimenzijama kod naizgled zdravih ispitanika koji su se dobrovoljno javili za sudjelovanje u istraživanju. Materijali i metode: Uzorak se sastojao od dvjesto jedanaest ispitanika (121 žena i 90 muškaraca) koji boluju od esencijalne hipertenzije i na ambulantnom su liječenju u Sveučilišnoj bolnici Abubakar Tafawa Balewa u gradu Bauchi i jednakog broja zdravih ispitanika (172 žene i 49 muškaraca), koji su bili kontrolna skupina. Proučavana je duljina i širina bubrega, anteroposteriorni promjer i debljina parenhima kod ispitanika s hipertenzijom i kod zdravih ispitanika. Za analizu podataka primijenjen je statistički paket za društvene znanosti (SPSS verzija 20.0). Rezultati: Studija pokazuje da je prosječna dužina bubrega kod hipertenzivnih bolesnika 9,1 ± 0,79 cm i 9,1 ± 0,73 cm, prosječna bubrežna širina 3,5 ± 0,48 cm i 3,8 ± 0,68 cm, a prosječni bubrežni volumen 87,22 ± 19,58 cm3 i 95,08 ± 22,93 cm3 za desni i lijevi bubreg pojedinačno. Rezultati također pokazuju statistički značajnu razliku u anteroposteriornom promjeru (p < 0,05), debljini parenhima (p < 0,05) i bubrežnom volumenu (p < 0,05) između hipertenzivne skupine i kontrolne skupine za desni i lijevi bubreg. Zaključak: Ovom su studijom utvrđene osnovne bubrežne dimenzije kod hipertenzivnih bolesnika u populaciji grada Bauchi, glavnog grada Savezne države Bauchi u Nigeriji. Kod ispitanika koji boluju od hipertenzije ustanovljeno je smanjenje anteroposteriornog promjera bubrega, debljine parenhima i bubrežnog volumena u usporedbi s kontrolnom skupinom

Wholesale pricing in a small open economy

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Designing a broad-spectrum integrative approach for cancer prevention and treatment

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notablesuccesses in some cancers; however, significant problems remain with this approach. Many targetedtherapies are highly toxic, costs are extremely high, and most patients experience relapse after a fewdisease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistantimmortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are notreliant upon the same mechanisms as those which have been targeted). To address these limitations, aninternational task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspectsof relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a widerange of high-priority targets (74 in total) that could be modified to improve patient outcomes. For thesetargets, corresponding low-toxicity therapeutic approaches were then suggested, many of which werephytochemicals. Proposed actions on each target and all of the approaches were further reviewed forknown effects on other hallmark areas and the tumor microenvironment. Potential contrary or procar-cinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixedevidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of therelationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. Thisnovel approach has potential to be relatively inexpensive, it should help us address stages and types ofcancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for futureresearch is offered

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Measurement of the cross section for isolated-photon plus jet production in pp collisions at √s=13 TeV using the ATLAS detector

The dynamics of isolated-photon production in association with a jet in proton–proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb−1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photon–jet invariant mass and the scattering angle in the photon–jet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements

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