41 research outputs found
An X-ray Spectral Survey of Radio-Loud AGN With ASCA
We present a uniform and systematic analysis of the 0.6-10 keV X-ray spectra
of radio-loud active galactic nuclei (AGN) observed by ASCA. The sample 10
BLRGs, 5 QSRs, 9 NLRGs, and 10 RGs. At soft X-rays, about half of the NLRGs and
all of the RGs exhibit a thermal plasma component, with a bimodal distribution
of temperatures and luminosities, suggesting an origin either in a surrounding
cluster or loose group or in a hot corona. At energies above 2 keV, a hard
power-law component is detected in 90% of cases. The power-law photon indices
and luminosities in BLRGs, QSRs, and NLRGs are similar, consistent with
orientation-based unification schemes. Significant excess cold absorption is
detected in most NLRGs, but also in some BLRGS and QSRs, which was somewhat
unexpected. In contrast to Seyfert galaxies, only one object showss the
signature of a warm absorber. The nuclear X-ray luminosity is correlated with
the luminosity of the [O III] emission line, the FIR emission at 12 microns,
and the lobe radio power at 5 GHz. The Fe K line is detected in 50% of BLRGs,
one QSR, and a handful of NLRGs. This sample also includes 6 Weak Line Radio
Galaxies (WLRGs). Their spectra WLRGs can be generally decomposed into a soft
thermal component with hard absrorbed power-law component, which is
significantly flatter than any other radio-loud AGNs. Their intrinsic
luminosities are two orders of magnitude lower than in other sources of the
sample. An interesting possibility is that WLRGs represent an extreme
population of radio galaxies in which the central black hole is accreting at a
rate well below the Eddington rate.Comment: To appear in the Astrophysical Journal. 72 pages, including many
tables and figures. Fig 1 is separate, in TIFF format. Postscript version of
fig 1 and postscript version of entire preprint can be obtained from
http://www.astro.psu.edu/users/mce/preprint_index.htm
Uncovering the Genetic Landscape for Multiple Sleep-Wake Traits
Despite decades of research in defining sleep-wake properties in mammals, little is known about the nature or identity of genes that regulate sleep, a fundamental behaviour that in humans occupies about one-third of the entire lifespan. While genome-wide association studies in humans and quantitative trait loci (QTL) analyses in mice have identified candidate genes for an increasing number of complex traits and genetic diseases, the resources and time-consuming process necessary for obtaining detailed quantitative data have made sleep seemingly intractable to similar large-scale genomic approaches. Here we describe analysis of 20 sleep-wake traits from 269 mice from a genetically segregating population that reveals 52 significant QTL representing a minimum of 20 genomic loci. While many (28) QTL affected a particular sleep-wake trait (e.g., amount of wake) across the full 24-hr day, other loci only affected a trait in the light or dark period while some loci had opposite effects on the trait during the light vs. dark. Analysis of a dataset for multiple sleep-wake traits led to previously undetected interactions (including the differential genetic control of number and duration of REM bouts), as well as possible shared genetic regulatory mechanisms for seemingly different unrelated sleep-wake traits (e.g., number of arousals and REM latency). Construction of a Bayesian network for sleep-wake traits and loci led to the identification of sub-networks of linkage not detectable in smaller data sets or limited single-trait analyses. For example, the network analyses revealed a novel chain of causal relationships between the chromosome 17@29cM QTL, total amount of wake, and duration of wake bouts in both light and dark periods that implies a mechanism whereby overall sleep need, mediated by this locus, in turn determines the length of each wake bout. Taken together, the present results reveal a complex genetic landscape underlying multiple sleep-wake traits and emphasize the need for a systems biology approach for elucidating the full extent of the genetic regulatory mechanisms of this complex and universal behavior
Broad Line Radio Galaxies Observed with Fermi-LAT: The Origin of the GeV Gamma-Ray Emission
We report on a detailed investigation of the gamma-ray emission from 18 broad
line radio galaxies (BLRGs) based on two years of Fermi Large Area Telescope
(LAT) data. We confirm the previously reported detections of 3C 120 and 3C 111
in the GeV photon energy range; a detailed look at the temporal characteristics
of the observed gamma-ray emission reveals in addition possible flux
variability in both sources. No statistically significant gamma-ray detection
of the other BLRGs was however found in the considered dataset. Though the
sample size studied is small, what appears to differentiate 3C 111 and 3C 120
from the BLRGs not yet detected in gamma-rays is the particularly strong
nuclear radio flux. This finding, together with the indications of the
gamma-ray flux variability and a number of other arguments presented, indicate
that the GeV emission of BLRGs is most likely dominated by the beamed radiation
of relativistic jets observed at intermediate viewing angles. In this paper we
also analyzed a comparison sample of high accretion-rate Seyfert 1 galaxies,
which can be considered radio-quiet counterparts of BLRGs, and found none were
detected in gamma-rays. A simple phenomenological hybrid model applied for the
broad-band emission of the discussed radio-loud and radio-quiet type 1 active
galaxies suggests that the relative contribution of the nuclear jets to the
accreting matter is > 1 percent on average for BLRGs, whilst <0.1 percent for
Seyfert 1 galaxies.Comment: 18 pages, 9 figures, accepted for publication in the Ap
Recent advances in hydrothermal carbonisation:from tailored carbon materials and biochemicals to applications and bioenergy
Introduced in the literature in 1913 by Bergius, who at the time was studying biomass coalification, hydrothermal carbonisation, as many other technologies based on renewables, was forgotten during the "industrial revolution". It was rediscovered back in 2005, on the one hand, to follow the trend set by Bergius of biomass to coal conversion for decentralised energy generation, and on the other hand as a novel green method to prepare advanced carbon materials and chemicals from biomass in water, at mild temperature, for energy storage and conversion and environmental protection. In this review, we will present an overview on the latest trends in hydrothermal carbonisation including biomass to bioenergy conversion, upgrading of hydrothermal carbons to fuels over heterogeneous catalysts, advanced carbon materials and their applications in batteries, electrocatalysis and heterogeneous catalysis and finally an analysis of the chemicals in the liquid phase as well as a new family of fluorescent nanomaterials formed at the interface between the liquid and solid phases, known as hydrothermal carbon nanodots
A large-scale genome-wide association study meta-analysis of cannabis use disorder
Summary Background Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50â70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder. Methods To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20â916 case samples, 363â116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations. Findings We identified two genome-wide significant loci: a novel chromosome 7 locus (FOXP2, lead single-nucleotide polymorphism [SNP] rs7783012; odds ratio [OR] 1·11, 95% CI 1·07â1·15, p=1·84âĂâ10â9) and the previously identified chromosome 8 locus (near CHRNA2 and EPHX2, lead SNP rs4732724; OR 0·89, 95% CI 0·86â0·93, p=6·46âĂâ10â9). Cannabis use disorder and cannabis use were genetically correlated (rg 0·50, p=1·50âĂâ10â21), but they showed significantly different genetic correlations with 12 of the 22 traits we tested, suggesting at least partially different genetic underpinnings of cannabis use and cannabis use disorder. Cannabis use disorder was positively genetically correlated with other psychopathology, including ADHD, major depression, and schizophrenia. Interpretation These findings support the theory that cannabis use disorder has shared genetic liability with other psychopathology, and there is a distinction between genetic liability to cannabis use and cannabis use disorder. Funding National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; Center for Genomics and Personalized Medicine and the Centre for Integrative Sequencing; The European Commission, Horizon 2020; National Institute of Child Health and Human Development; Health Research Council of New Zealand; National Institute on Aging; Wellcome Trust Case Control Consortium; UK Research and Innovation Medical Research Council (UKRI MRC); The Brain & Behavior Research Foundation; National Institute on Deafness and Other Communication Disorders; Substance Abuse and Mental Health Services Administration (SAMHSA); National Institute of Biomedical Imaging and Bioengineering; National Health and Medical Research Council (NHMRC) Australia; Tobacco-Related Disease Research Program of the University of California; Families for Borderline Personality Disorder Research (Beth and Rob Elliott) 2018 NARSAD Young Investigator Grant; The National Child Health Research Foundation (Cure Kids); The Canterbury Medical Research Foundation; The New Zealand Lottery Grants Board; The University of Otago; The Carney Centre for Pharmacogenomics; The James Hume Bequest Fund; National Institutes of Health: Genes, Environment and Health Initiative; National Institutes of Health; National Cancer Institute; The William T Grant Foundation; Australian Research Council; The Virginia Tobacco Settlement Foundation; The VISN 1 and VISN 4 Mental Illness Research, Education, and Clinical Centers of the US Department of Veterans Affairs; The 5th Framework Programme (FP-5) GenomEUtwin Project; The Lundbeck Foundation; NIH-funded Shared Instrumentation Grant S10RR025141; Clinical Translational Sciences Award grants; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences.Peer reviewe
Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies
First published: 16 February 202
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 x 10(-13)) and African ancestries (rs2066702; P = 2.2 x 10(-9)). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, attention deficit-hyperactivity disorder, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.Peer reviewe
Multi-User Virtual Reality Therapy for Post-Stroke Hand Rehabilitation at Home
Our paper describes the development of a novel multi-user virtual reality (VR) system for post-stroke rehabilitation that can be used independently in the home to improve upper extremity motor function. This is the pre-clinical phase of an ongoing collaborative, interdisciplinary research project at the Rehabilitation Institute of Chicago involving a team of engineers, researchers, occupational therapists and artists. This system was designed for creative collaboration within a virtual environment to increase patients' motivation, further engagement and to alleviate the impact of social isolation following stroke. This is a low-cost system adapted to everyday environments and designed to run on a personal computer that combines three VR environments with audio integration, wireless Kinect tracking and hand motion tracking sensors. Three different game exercises for this system were developed to encourage repetitive task practice, collaboration and competitive interaction. The system is currently being tested with 15 subjects in three settings: a multi-user VR, a single-user VR and at a tabletop with standard exercises to examine the level of engagement and to compare resulting functional performance across methods. We hypothesize that stroke survivors will become more engaged in therapy when training with a multi-user VR system and this will translate into greater gains