Формування системного підходу до оптимізування маркетинг-менеджменту підприємства

The problem of forming a system approach to the application of marketing management to the activities of machine–building enterprises is theoretically substantiated and solved. A system of marketing management of the activities of industrial enterprises was designed. A model of the system of marketing management of an enterprise was constructed. The model contains elements of marketing research, it is based on strategic, tactical and operational management of marketing activities, implies formation of an algorithm of optimization of organizational structures of marketing, and the result of its implementation is the design of a scenario-based approach to substantiating decisions regarding increase in efficiency of marketing management at machine-building enterprises.The process of making management decisions about the organization of marketing activities is based on economic-mathematical modeling and provides the alternativity of choice among creation, reengineering, improvement of organizational structure of marketing, a form of fulfilling marketing activities without creating rigid organizational systems and/or delegating part of marketing functions to the outsourcing by specialized consulting company. The model of optimizing a system of marketing management of an enterprise was proposed, which takes into account clusterization of enterprises by the characteristic of fulfilling marketing functions; the process of management decision making was improved regarding the choice of an optimal structure of organization of marketing management at an enterprise.Теоретически обосновывается и решается проблема формирования системного подхода к применению маркетингового управления. Разработана система маркетингового управления деятельностью промышленных предприятий. Сформирована модель оптимизации системы маркетинг-менеджмента предприятия, которая основывается на кластеризации предприятий по признаку выполнения маркетинговых функций; усовершенствован процесс принятия управленческих решений по выбору оптимальной структуры организации маркетинг-менеджмента.Теоретично обґрунтовується і вирішується проблема формування системного підходу до застосування маркетинг–менеджменту в діяльності машинобудівних підприємств. Розроблено систему маркетинг-менеджменту діяльності промислових підприємств. Запропоновано модель оптимізування системи маркетинг–менеджменту підприємства, яка враховує кластеризацію підприємств за ознакою виконання маркетингових функцій; удосконалено процес прийняття управлінських рішень стосовно вибору оптимальної структури організування маркетинг–менеджменту на підприємстві

VISCERAL MIGRATING LARVA. CLINICAL CASES. UKRAINIAN BURDEN

Introduction. The work highlights the problematic issues of diagnosis and treatment of toxocariasis infection in people in Ukraine, which become even more acute and urgent due to the migration of the population and animals, and the destruction of the country's infrastructure as a result of the war unleashed by Russia. The aim of the study. Improvement of aspects of clinical, laboratory and instrumental diagnostics, as well as treatment of VML in humans Materials and methods. A literature research of the state of the problem of primary and differential diagnosis of the migrating larva in Ukraine and the world has been conducted. 2 clinical cases of diagnosis and treatment of migrating larva in are described. Results. The article describes two clinical cases of visceral migrating larva. The differences of these cases, in addition to the migrating formations in the lungs, were the asymptomatic course, the absence of eosinophilia, and the simultaneous determination of blood class G antibodies by ELISA to Toxocar and human roundworm (A. lumbricoide), which persisted even after treatment. Patients at the stage of diagnosis were examined in an oncology hospital, were consulted by thoracic surgeons and oncologists to exclude lung cancer. Both women were immunocompetent, one patient had a history of cervical cancer. From the epidemiological anamnesis, both women kept cats, and one of them, during chemotherapy for the treatment of a tumor, had a propensity for carnivorous raw-eating. Before prescribing systemic antiparasitic chemotherapy, the patients were examined by an ophthalmologist to exclude parasitic chorioretinitis. The patients were prescribed a 20-day course of albendazal 800 mg/day in two doses. Support therapy consisted of a 5-day course of prednisolone at a dose of 30 mg/day orally in two doses, which started one day before the appointment of albendazole. A control CT scan of the lungs after therapy did not reveal any formations, fibrosis, or calcifications. Discussion. This case proves that tocoscarosis in humans is a multidisciplinary medical and social problem. Conclusions were made on the need to restore the national registration of the disease, adopt national consensuses on treatment and diagnosis, and implement into clinical practice modern methods of verification of specific antibodies to nematodes based on immunoblotting. Conclusions. The registration of cases of VML and T. in the system of control and prevention of infectious diseases in Ukraine should be resumed. It is expedient to introduce specific studies on nematodes in clinical laboratory practice

Immunobiological reactivity of calf body during the compatible application of nanotechnological citrates of trace elements in the ration

Background. Nanotechnology in animal husbandry is an important area of research and development, which includes environmental sustainability, human health and food security. Nanotechnology has the potential to solve many questions related to animal health, production, reproduction, good hygienic practices during rearing and maintaining of animals. Therefore, the research aimed to find out the biological effect of separate and combined feeding of nanotechnological citrates that show high physiological activity in doses much lower than their mineral salts. Materials and Methods. The research was conducted on 15 heifers and bulls divided into three groups five days after birth: control (I) and experimental (II, III) ones, five animals in each. Calves of group I received 240 kg of natural milk with the addition of a mineral-concentrate supplement (MCS) and grass hay for 60 days. Calves of group II were fed similar feed to that of group I with the replacement of MCS with a nutritionally equivalent quantity of cereal grains and soybeans and the introduction of nanotechnological citrates of microelements (NTC ME) I, Se, Cr, Cu, Co, Mn, Zn, Fe into milk in the proportion of 10 %. Calves of group III were fed with a complex of feeds of group I, adding 10 % of NTC ME. Physiological and biochemical indicators of blood and wool of calves were studied on the 10th, 40th and 70th days of growing period. Results. Statistically significant changes in the immunobiological indicators of the blood of calves of group II were found with an increase in the concentration of circulating immune complexes, haptoglobin, and sialic acids in the blood on the 40th day and ceruloplasmin, sialic acids, hexoses bound to proteins and chromium on the 70th day. An increase in the detoxification function of the calves’ liver was recorded, with an increase in the blood level of phenol sulfates by 11.2 % and phenol glucuronides by 18.8% during this period. The combined use of 10 % NTC microelements and MCS in feeding calves of group III led to a statistically significant increase in the blood content of circulating immune complexes, phenol sulfates, phenol glucuronides, and zinc on the 40th and 70th days compared to their level in animals of the control group. Body weight gain in calves of group II was higher by 7.7 %, and in group III – by 4.3 % compared to the control. Conclusion. The addition of NTC ME in the amount of 10 % of the rationed food for these elements to the milk for calves of group II, with the exclusion of the mineral-concentrate supplement from the feeding scheme, led to the activation of the immunobio­logical reactivity of the organism. The combined use of 10 % of NTC ME and mineral-concentrate supplement in the diet of calves of group III resulted in a lesser immunobiological reactivity of the organism, and strengthened the detoxification ability of the body

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Measurement of the top quark mass using charged particles in pp collisions at root s=8 TeV

Peer reviewe

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

Peer reviewe