A Review Of The Literature On Eco-Design In Manufacturing Industry: Are The Institutions Focusing On The Key Aspects?

[EN] The aim of this paper is to review the most important literature in relation to the special characteristics of the eco design as part of the innovation portfolio of companies. Eco design is a methodology that takes into account the environmental condition of products from conception. More than a half of the impacts can be prevented from the design process so that throughout their life circle are less harmful to the environment. As a methodology that integrates environmental criteria in the design of products and services, managing the environmental innovation through eco-design has to be considered as part of the strategic definition of both, companies and Public Agencies. We pretend to analyze literature related to eco-design in companies and the way policy makers are pretending to reinforce sustainable attitude at the industrial sector. The main objective of this paper is to uncover if there is any relation between what literature indicates companies are doing and what public administration are pretending with its industrial policies, to see if institutions are focusing on their industrial policies and check if they are covering the key.The authors acknowledge the financial aid received from the Spanish Ministry of Science and Innovation through project reference no. EC02008-05895-C02-01/ECON and from the PAID-06-2011 of the Universidad Politécnica the Valencia, that also funded a sabbatical research 2011-2012 course of M. Segarra.Segarra Oña, MDV.; De-Miguel-Molina, M.; Paya Martinez, A. (2011). A Review Of The Literature On Eco-Design In Manufacturing Industry: Are The Institutions Focusing On The Key Aspects?. Review of Business Information Systems. 15(5):61-68. doi:10.19030/rbis.v15i5.6028S616815

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that RPAP1 is essential for the expression of cell identity genes and for cell viability. Depletion of RPAP1 triggers cell de-differentiation, facilitates reprogramming toward pluripotency, and impairs differentiation. Mechanistically, we show that RPAP1 is essential for the interaction between RNA polymerase II (RNA Pol II) and Mediator, as well as for the recruitment of important regulators, such as the Mediator-specific RNA Pol II factor Gdown1 and the C-terminal domain (CTD) phosphatase RPAP2. In agreement, depletion of RPAP1 diminishes the loading of total and Ser5-phosphorylated RNA Pol II on many genes, with super-enhancer-driven genes among the most significantly downregulated. We conclude that Mediator/RPAP1/RNA Pol II is an ancient module, conserved from plants to mammals, critical for establishing and maintaining cell identity.We are grateful to Elisa Varela for assistance with morula and blastocyst fixa- tion. Work in the laboratory of M.S. is funded by the CNIO and the IRB and by grants from the Spanish Ministry of Economy co-funded by the European Regional Development Fund (ERDF) (SAF2013-48256-R), the European Research Co uncil (ERC-2014-AdG/66 9622), the Region al Government of Ma- drid co-funded by the Euro pean Social Fund (ReCaRe project), the Euro pean Union (RISK-IR project), the Botin Foundation and Banco Santander (Santander Universities Glo bal Division), the Ramon Areces Found ation, and the AXA Foundation. S.R. was funded by a contract from the Ramon y Cajal Program(RYC-2011-09242) and by the Spanish Ministry of Economy co- funded by the ERDF (SAF2013-49147- P and SAF2016-80874-PS

ZAK beta is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle

Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction-induced p38 and JNK signaling ensure adaptation to exercise, muscle repair, and hypertrophy. However, the mechanisms by which muscle fibers sense mechanical load to activate this signaling have remained elusive. Here, we show that the upstream MAP3K ZAK beta is activated by cellular compression induced by osmotic shock and cyclic compression in vitro, and muscle contraction in vivo. This function relies on ZAKO's ability to recognize stress fibers in cells and Z-discs in muscle fibers when mechanically perturbed. Consequently, ZAK-deficient mice present with skeletal muscle defects characterized by fibers with centralized nuclei and progressive adaptation towards a slower myosin profile. Our results highlight how cells in general respond to mechanical compressive load and how mechanical forces generated during muscle contraction are translated into MAP kinase signaling.Peer reviewe

Jornadas de Colaboración de Iniciativas Estratégicas (PTIs y Conexiones)

Datos técnicos: 315 minutos, color, español. Ficha técnica: Gabinete de Presidencia CSIC y Departamento de Comunicación. Emitido en directo el 14 feb 2023El próximo martes 14 de febrero, de 9:30 a 14:15 la Vicepresidencia de Investigación Científica y Técnica, organiza una Jornada en la que se buscará potenciar las colaboraciones científicas del CSIC mediante iniciativas estratégicas: las Plataformas Temáticas Interdisciplinares (PTIs) y las Conexiones.CSIC, así como poner en valor el trabajo realizado por todos los investigadores que forman parte de estas estructuras. Contará con la participación de la Presidenta del CSIC, Eloísa del Pino, representantes de las Vicepresidencias, los coordinadores científicos de las iniciativas y otros socios y colaboradores externos. Como parte de la Jornada se celebrarán tres mesas redondas en las que empresas, administraciones públicas y fundaciones compartirán sus historias de éxito alcanzadas mediante la colaboración con PTIs y Conexiones.Peer reviewe

Herramientas de comunicación y divulgación musical orientadas a la transferencia: entornos digitales 2.0

Este proyecto tiene como objeto la formación sobre recursos y herramientas de comunicación y divulgación musical en espacios 2.0, con el fin de utilizarlas en el aula y fomentar la transferencia y el emprendimiento en el ámbito de la musicología

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements