359 research outputs found
Statistical analysis plan for the Dual mTorc Inhibition in advanCed/recurrent Epithelial ovarian, fallopian tube or primary peritoneal cancer (of clear cell, endometrioid and high-grade serous type, and carcinosarcoma) trial (DICE)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/09/2021
- Field of study
Background Treatment for ovarian cancer includes platinum-based chemotherapy, but many women become resistant to chemotherapy, becoming platinum-resistant. Standard of care for these women is weekly paclitaxel chemotherapy, but cancers can often become paclitaxel resistant. TAK228, an investigational dual TORC1/2 inhibitor, is an oral therapy that can be added to standard treatment. The DICE trial is a phase II international multicentre, parallel-group, superiority clinical trial with 1:1, open label randomisation which has the aim of investigating the effectiveness of TAK228 plus weekly paclitaxel. The planned sample size is 124 women (62 per treatment arm) with platinum-resistant ovarian cancer. Objective To outline the planned analyses for DICE in a statistical analysis plan (SAP) before database hard lock and the start of analysis. This ensures that bias is minimised during the analysis phase. Results This SAP provides detailed descriptions of the analysis principles and statistical procedures for analysing primary and secondary outcomes of the trial. The primary outcome is overall progression-free survival (PFS). Secondary outcomes include progression-free survival (PFS) at 24 weeks, overall response rate (ORR), duration of response (DoR), time to progression (TTP), clinical benefit rate (CBR) at 4 months, Cancer Antigen 125 (CA125) response according to Gynaecological Cancer Intergroup (GCIG) criteria, overall survival (OS), safety and tolerability as assessed by adverse events and the quality-of-life questionnaires (EORTC QLQ-C30 and EORTC QLQ-OV28). This detailed description includes significance levels, sensitivity analyses and compliance analysis. Discussion The DICE trial will determine whether the addition of TAK228 to weekly paclitaxel chemotherapy shows a statistically significant improvement to participant’s progression free and overall survival and that the adverse events (AEs) and quality of life (QoL) are not significantly worse than the standard treatment. The study commenced recruitment in September 2018. An interim analysis was performed in early 2021, the results of which advised continuation of the trial. The study recruitment is ongoing and is due to complete by the end of 2021. Trial registration ClinicalTrials.govNCT03648489. Registered on 27 August 201
Neuromuscular Electrical Stimulation for Intermittent Claudication (NESIC): multicentre, randomized controlled trial
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 09/11/2023
- Field of study
\ua9 The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd. METHODS: This was an open, multicentre, randomized controlled trial. Patients with intermittent claudication attending vascular surgery outpatient clinics were randomized (1:1) to receive either neuromuscular electrical stimulation (NMES) or not in addition to local standard care available at study centres (best medical therapy alone or plus supervised exercise therapy (SET)). The objective of this trial was to investigate the clinical efficacy of an NMES device in addition to local standard care in improving walking distances in patients with claudication. The primary outcome was change in absolute walking distance, measured by a standardized treadmill test at 3 months. Secondary outcomes included intermittent claudication (IC) distance, adherence, quality of life, and haemodynamic changes. RESULTS: Of 200 participants randomized, 160 were included in the primary analysis (intention to treat, Tobit regression model). The square root of absolute walking distance was analysed (due to a right-skewed distribution) and, although adjunctive NMES improved it at 3 months, no statistically significant effect was observed. SET as local standard care seemed to improve distance compared to best medical therapy at 3 months (3.29 units; 95 per cent c.i., 1.77 to 4.82; P < 0.001). Adjunctive NMES improved distance in mild claudication (2.88 units; 95 per cent c.i., 0.51 to 5.25; P = 0.02) compared to local standard care at 3 months. No serious adverse events relating to the device were reported. CONCLUSION: Supervised exercise therapy is effective and NMES may provide further benefit in mild IC.This trial was supported by a grant from the Efficacy and Mechanism Evaluation Program, a Medical Research Council and National Institute for Health and Care Research partnership. Trial registration: ISRCTN18242823.Patients with intermittent claudication experience pain in their legs during walking or exercise which ends with rest. This severely impairs physical activity and quality of life. Treatment for such patients typically involves best medical therapy, which includes exercise advice. This study aimed to determine whether a neuromuscular electrical stimulation device improved the walking distance of patients with intermittent claudication compared to local standard care available (which may include supervised exercise therapy) in a trial. Supervised exercise improved walking distances but there was no difference in those that received a device in this patient group
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
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- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
- Author
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- Compostella G
- Conde Muino P
- Coniavitis E
- Conidi MC
- Connelly IA
- Consonni SM
- Consorti V
- Constantinescu S
- Conta C
- Conti G
- Conventi F
- Cooke M
- Cooper BD
- Cooper-Sarkar AM
- Cooper-Smith NJ
- Copic K
- Cornelissen T
- Corradi M
- Correia AMH
- Corriveau F
- Corso-Radu A
- Cortes-Gonzalez A
- Cortiana G
- Costa G
- Costa MJ
- Costanzo D
- Cote D
- Cottin G
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- Czyczula Z
- D'Auria S
- D'Onofrio M
- Da Costa JBG
- Da Costa JGPF
- Da Costa JGPF
- Da Cunha Sargedas De Sousa MJ
- Da Via C
- Dabrowski W
- Dafinca A
- Dai T
- Dale O
- Dallaire F
- Dallapiccola C
- Dam M
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- Daniells AC
- Dao V
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- de Asmundis R
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- De Castro S
- De Cecco S
- de Graat J
- De Groot N
- de Jong P
- De la Taille C
- De la Torre H
- de Lima DEF
- de Lima DEF
- De Lorenzi F
- De Mendizabal JB
- De Nooij L
- De Pedis D
- De Regie JBDV
- de Renstrom PAB
- De Salvo A
- De Sanctis U
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- Degenhardt J
- Deigaard I
- Del Peso J
- Del Prete T
- Delemontex T
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- Deliyergiyev M
- Dell'Acqua A
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- Della Pietra M
- della Porta GZ
- della Volpe D
- Delmastro M
- Delsart PA
- Deluca C
- Demers S
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- Demilly A
- Demirkoz B
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
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- Deviveiros PO
- Dewhurst A
- Dhaliwal S
- Di Ciaccio A
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- Di Domenico A
- Di Donato C
- Di Girolamo A
- Di Girolamo B
- Di Mattia A
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- Di Nardo R
- Di Simone A
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- Diglio S
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- Djama F
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- do Vale MAB
- Doan TKO
- Dobos D
- Dobson E
- Doglioni C
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- Dohmae T
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- Dolezal Z
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- Dueren M
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- Dwuznik M
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- Edson W
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- Ehrenfeld W
- Eifert T
- Eigen G
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- Ekelof T
- El Kacimi M
- El Moursli A
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- Enari Y
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- Endo M
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- Errede D
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- Errede S
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- Escalier M
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- Esch H
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- Escobar C
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- Espinal Curull X
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- Esposito B
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- Etienne F
- Etienne F
- Etienvre AI
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- Etzion E
- Etzion E
- Evans H
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- Fabbri L
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- Facini G
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- Fakhrutdinov RM
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- Falciano S
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- Faltova J
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- Fang Y
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- Farilla A
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- Farooque T
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- Farrell S
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- Farrington SM
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- Farthouat P
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- Fassi F
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- Fassnacht P
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- Fassouliotis D
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- Favareto A
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- Fayard L
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- Federic P
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- Fedin OL
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- Fedorko W
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- Fehling-Kaschek M
- Fehling-Kaschek M
- Feigl S
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- Feligioni L
- Feligioni L
- Feng C
- Feng C
- Feng EJ
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- Feng H
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- Fenyuk AB
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- Fernando W
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- Ferrag S
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- Ferrando BMS
- Ferrando J
- Ferrando J
- Ferrara V
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- Ferrari A
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- Ferrari P
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- Fiedler F
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- Filipcic A
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- Filipuzzi M
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- Filthaut F
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- Fincke-Keeler M
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- Fleischmann S
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- Floderus A
- Floderus A
- Florez Bustos AC
- Flowerdew MJ
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- Formica A
- Formica A
- Forti A
- Forti A
- Fortin D
- Fortin D
- Fournier D
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- Francavilla P
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- Franklin M
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- Franz S
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- Fraternali M
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- French ST
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- Gadomski S
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- Galea C
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- Gallas EJ
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- Gallo V
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- Garrido MDMC
- Gatti C
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- Gaudio G
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- Gaur B
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- Gecse Z
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- Gee CNP
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- Geich-Gimbel C
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- Giordani MP
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- Giordano R
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- Zeitnitz C
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- Zerwas D
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- Zhang J
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- Zhao Z
- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
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- Zhemchugov A
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- Zieminska D
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- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
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- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
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- Atoian G
- Aubert B
- Auge E
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- Avolio G
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- Axen D
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- Azuelos G
- Azuma Y
- Baak MA
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- Bacci C
- Bach AM
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- Bachy G
- Backes M
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- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
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- Baines JT
- Baker MD
- Baker OK
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- Banfi D
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- Bardin DY
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- Barnett BM
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- Baroncelli A
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- Barrera CO
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- Bartoldus R
- Barton AE
- Bartsch D
- Bartsch V
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Battistoni G
- Bauer F
- Bawa HS
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- Beauchemin PH
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- Beddall A
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- Blair RE
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
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- Thomas JP
- Thomas-Wilsker J
- Thompson AS
- Thompson EN
- Thompson PD
- Thompson PD
- Thomsen LA
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- Thong WM
- Thun RP
- Tian F
- Tibbetts MJ
- Tikhomirov VO
- Tikhonov YA
- Timoshenko S
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- Trigger IM
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- Tsiareshka PV
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- Tsipolitis G
- Tsirintanis N
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tudorache A
- Tudorache V
- Tuna AN
- Tupputi SA
- Turchikhin S
- Turecek D
- Turra R
- Tuts PM
- Tykhonov A
- Tylmad M
- Tyndel M
- Uchida K
- Ueda I
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- Uhlenbrock M
- Ukegawa F
- Unal G
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- Ungaro FC
- Unno Y
- Urbaniec D
- Urquijo P
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- Vacek V
- Vachon B
- Valencic N
- Valentinetti S
- Valero A
- Valery L
- Valkar S
- Valladolid Gallego E
- Vallecorsa S
- Valls Ferrer JA
- Van Den Wollenberg W
- Van Der Deijl PC
- van der Geer R
- van der Graaf H
- Van Der Leeuw R
- van der Ster D
- van Eldik N
- van Gemmeren P
- van Huysduynen LH
- Van Nieuwkoop J
- van Vulpen I
- van Woerden MC
- Vanadia M
- Vandelli W
- Vanguri R
- Vaniachine A
- Vankov P
- Vannucci F
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- Vichou I
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- Vilucchi E
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- Vivarelli I
- Vlachos S
- Vladoiu D
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- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorobev K
- Vos M
- Voss R
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Vykydal Z
- Wagner P
- Wagner W
- Wahlberg H
- Wahrmund S
- Wakabayashi J
- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Walls FMG
- Walsh B
- Wang C
- Wang C
- Wang F
- Wang H
- Wang H
- Wang J
- Wang J
- Wang K
- Wang R
- Wang SM
- Wang T
- Wang X
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
- Watkins PM
- Watson AT
- Watson IJ
- Watson MF
- Watts G
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- Webster JS
- Weidberg AR
- Weigell P
- Weinert B
- Weingarten J
- Weiser C
- Weits H
- Wells PS
- Wenaus T
- Wendland D
- Weng Z
- Wengler T
- Wenig S
- Wermes N
- Werner M
- Werner P
- Wessels M
- Wetter J
- Whalen K
- White A
- White MJ
- White R
- White S
- Whiteson D
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilkens HG
- Will JZ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wilson A
- Wilson JA
- Wingerter-Seez I
- Winklmeier F
- Winter BT
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wright M
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yao W-M
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Tubulin isoform composition tunes microtubule dynamics
- Author
- Abrishami V
- Al-Bassam J
- Alushin GM
- Annapurna Vemu
- Antonina Roll-Mecak
- Atherton J
- Banerjee A
- Bieling P
- Brouhard GJ
- Brown A
- Carlier M-F
- Carolyn A. Moores
- Castoldi M
- Chen S
- Chrétien D
- de la Rosa-Trevin JM
- Denoulet P
- Emsley P
- Garnham CP
- Gell C
- Grishchuk EL
- Hiser L
- Horio TH
- Hoyle HD
- Jeffrey O. Spector
- Joseph Atherton
- Kavallaris M
- Kremer JR
- Kumar P
- Laurent Blanchoin
- Leandro-García LJ
- Lopata MA
- Mandelkow EM
- Maurer SP
- Mindell JA
- Minoura I
- Mitchison TK
- Murphy DB
- Murphy DB
- Newton CN
- Nicholls RA
- Pamula MC
- Panda D
- Pecqueur L
- Podolski M
- Rao S
- Ray S
- Redeker V
- Rice LM
- Roostalu J
- Saillour Y
- Schindelin J
- Sindelar CV
- Szyk A
- VanBuren V
- Vemu A
- Vemu A
- Villasante A
- Walczak CE
- Wang D
- Wang HW
- Weisenberg RC
- Yu I
- Zambito AM
- Zhang R
- Publication venue
- 'American Society for Cell Biology (ASCB)'
- Publication date
- 01/12/2017
- Field of study
Microtubules polymerize and depolymerize stochastically, a behavior essential for cell division, motility and differentiation. While many studies advanced our understanding of how microtubule-associated proteins tune microtubule dynamics in trans, we have yet to understand how tubulin genetic diversity regulates microtubule functions. The majority of in vitro dynamics studies are performed with tubulin purified from brain tissue. This preparation is not representative of tubulin found in many cell types. Here we report the 4.2Å cryo-EM structure and in vitro dynamics parameters of α1B/βI+βIVb microtubules assembled from tubulin purified from a human embryonic kidney cell line with isoform composition characteristic of fibroblasts and many immortalized cell lines. We find that these microtubules grow faster and transition to depolymerization less frequently compared to brain microtubules. Cryo-EM reveals that the dynamic ends of α1B/βI+βIVb microtubules are less tapered and that these tubulin heterodimers display lower curvatures. Interestingly, analysis of EB1 distributions at dynamic ends suggests no differences in GTP cap sizes. Lastly, we show that the addition of recombinant α1A/βIII tubulin, a neuronal isotype overexpressed in many tumors, proportionally tunes the dynamics of α1B/βI+βIVb microtubules. Our study is an important step towards understanding how tubulin isoform composition tunes microtubule dynamics
Bee-flower association in the Neotropics: implications to bee conservation and plant pollination
- Author
- A Cavalcante
- A Müller
- AJS Pacheco Filho
- Alípio José de Souza PACHECO FILHO
- AMP Kleinert
- AT Carvalho
- AT Oliveira-Filho
- AT Oliveira-Filho
- BM Freitas
- BM Freitas
- Breno Magalhães FREITAS
- C Pinheiro-Machado
- C Robertson
- C Schlindwein
- C Schlindwein
- C Westerkamp
- CB Fenster
- CB Magalhães
- Christiano Franco VEROLA
- CML Aguiar
- CN Junqueira
- CT Rizzini
- D Goulson
- DC Michener
- DE Prado
- DM Hansen
- DM Olson
- DP Vázquez
- EL Neves
- ER Heithaus
- FG Alcorado-Filho
- GW Frankie
- I Alves-dos-Santos
- J Bascompte
- J Memmott
- J Xia
- JF Rosa
- K Faegri
- LA Garibaldi
- Luiz Wilson LIMA VERDE
- LW Lima-Verde
- M Cortopassi-Laurino
- M Osorio-Beristain
- M Ramalho
- M Spivak
- M Stang
- MLT Buschini
- MS Sazan
- N Waser
- P Milet-Pinheiro
- PA Luca De
- RA Pick
- S Cardinal
- S Patiny
- SF Sakagami
- SR Andena
- Y Antonini
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Biodiversity of the Mediterranean Sea: Estimates, Patterns, and Threats
- Author
- A Aguilar
- A Aguilar
- A Amato
- A Borrell
- A Bozzano
- A Bullock
- A Cañadas
- A Cuttelod
- A Davis
- A Frantzis
- A Garrido
- A Giangrande
- A Gruvel
- A Koukouras
- A Koukouras
- A Lascaratos
- A Logan
- A López-López
- A Maldonado
- A Meinesz
- A Milne-Edwards
- A Morales
- A Occhipinti-Ambrogi
- A Panou
- A Peirano
- A Pusceddu
- A Risso
- A Sabatés
- A Sanz-Aguilar
- A Schneider
- A Simpsom
- A Theocharis
- A Tselepides
- A Tsikliras
- A Zenetos
- A Zenetos
- A Zenetos
- A Zenetos
- AC Gucu
- AJ Gooday
- AR Robinson
- Athanasios Koukouras
- B Grbec
- B Groombridge
- B Groombridge
- B Kimor
- B Yokes
- Bella S. Galil
- BR MacKenzie
- BS Galil
- BS Galil
- BS Galil
- BS Galil
- BS Galil
- BS Galil
- BS Galil
- BS Galil
- BS Galil
- C Alfaro Giner
- C Antoniadou
- C Arvanitidis
- C Barberá Cebrián
- C Bas
- C Bas
- C Bas
- C Bernard
- C Carpine
- C Cerrano
- C Cerrano
- C Emig
- C Emig
- C Fontanier
- C Gambi
- C Gambi
- C Heller
- C Lejeusne
- C Lejeusne
- C Millot
- C Mora
- C Morri
- C Morri
- C Papaconstantinou
- C Pedrós-Alió
- C Pedrós-Alió
- C Pedrós-Alió
- C Pipitone
- C Pujol
- C Ravier
- C Rodriguez-Prieto
- C San Vicente
- C San Vicente
- C Sanpera
- C Stringer
- C Winter
- Carles San Vicente
- Carlo Froglia
- Carlo Nike Bianchi
- Carlos M. López-Fé de la Cuadra
- CC Emig
- Cd Udekem d'Acoz
- CF Boudouresque
- CF Boudouresque
- CF Boudouresque
- Chiara Piroddi
- CIESM
- CIESM
- CM Turley
- CN Bianchi
- CN Bianchi
- CN Bianchi
- CN Bianchi
- CN Bianchi
- CN Bianchi
- CN Bianchi
- CN Bianchi
- CN Bianchi
- D Bellan-Santini
- D Bellan-Santini
- D Bellan-Santini
- D Bellan-Santini
- D Bellan-Santini
- D Garcia-Castellanos
- D Golani
- D Margaritoulis
- D Mylona
- D Oro
- D Oro
- D Oro
- D Oro
- D Potter
- D Raffaelli
- D Vaqué
- Daniel Martin
- Daniel Oro
- David Mouillot
- Dimitris Vafidis
- DM Barmawidjaja
- E Azzurro
- E Ballesteros
- E Ballesteros
- E Ballesteros
- E Ballesteros
- E Bosc
- E Macpherson
- E Mínguez
- E Ramírez-Llodra
- E Sala
- E Tortonese
- E Voultsiadou
- E Voultsiadou
- E Voultsiadou
- E Voultsiadou
- E Özsoy
- EH Giglioli
- Eleni Voultsiadou
- Elijah Laxamana
- Enric Ballesteros
- EP Green
- F Abdel Razek
- F Ben Rais Lasram
- F Ben Rais Lasram
- F Ben Rais Lasram
- F Ben Rais Lasram
- F Boero
- F Boero
- F Boero
- F Boero
- F Burki
- F Cerino
- F Ferretti
- F Garibaldi
- F Gómez
- F Mineur
- F Not
- F Por
- F Sangiorgi
- F Sardà
- F Sardà
- F Sardà
- F Sardà
- F Serena
- FD Por
- FD Por
- FD Por
- FJ Avella
- François Guilhaumon
- Frida Ben Rais Lasram
- G Alongi
- G Bearzi
- G Bearzi
- G Bearzi
- G Bearzi
- G Bello
- G Bombace
- G Bombace
- G Bucciarelli
- G Fredj
- G Fredj
- G Fredj
- G Fredj
- G Mo
- G Notarbartolo di Sciara
- G Notarbartolo di Sciara
- G Notarbartolo di Sciara
- G Olivi
- G Tavecchia
- G Trégouboff
- G Tsounis
- GD Nardo
- GM Daskalov
- H Arndt
- H Bresc
- H Bresc
- H Güçlüsoy
- H Güçlüsoy
- H Zibrowius
- H Zibrowius
- Heike K. Lotze
- HK Lotze
- I Boyd
- I Faccia
- I Grubelić
- I Zohar
- IB Kuffner
- IM Ovchinnikov
- J Aguzzi
- J Alcover
- J Blondel
- J Bouillon
- J De la Rosa
- J Desse
- J Dulčić
- J Garrabou
- J Harwood
- J Haywood
- J Klein
- J Klein
- J Lleonart
- J Moranta
- J Salat
- J Templado
- J Templado
- J Templado
- J Tomas
- J Tomás
- JA Alcover
- JA Camiñas
- JA Fuhrman
- Jacopo Aguzzi
- JBC Jackson
- JC Briggs
- JC Gaertner
- JC Molinero
- JC Orr
- JC Shackleton
- JC Venter
- JD Gage
- JD Hughes
- JE Cartes
- Jeroen Steenbeek
- JF Ghiglione
- JK Pinnegar
- JL Alegret
- JL Rueda
- JM Arcos
- JM Gili
- JM Hall-Spencer
- JM Igual
- JM Pérès
- JM Pérès
- JM Rouchy
- Jordi Corbera
- Jose Ignacio Saiz-Salinas
- Josep M. Gasol
- Josephine Rius-Barile
- José Templado
- João Gil
- JP Bethoux
- JP Féral
- JP Quignard
- JP Quignard
- JP Quignard
- JP Thorpe
- JS Aguilar
- JS Gray
- K Bourgeois
- K Frangoudes
- K Kaschner
- K Kaschner
- K Soetaert
- Kathleen Kesner-Reyes
- KJ Wittmann
- KJ Wittmann
- Kristin Kaschner
- L Airoldi
- L Alonso-Sáez
- L Cros
- L Cros
- L Cros
- L De Nicolò
- L Fishelson
- L Fishelson
- L Garczarek
- L Laubier
- L Levin
- L Ruffino
- L Venizelos
- LA Levin
- LA Trakadas
- LA Trakadas
- LJV Compagno
- LM Gonzalez
- M Astraldi
- M Bally
- M Blumel
- M Coll
- M Coll
- M Coll
- M Delaugerre
- M Estrada
- M Goren
- M Goren
- M Goren
- M Hassan
- M Heads
- M Louzao
- M Louzao
- M Massutí
- M Mavidis
- M Modigh
- M Montefalcone
- M Relini
- M Rex
- M Sarà
- M Schauer
- M Stefani
- M Taviani
- M Travers
- M Verlaque
- M Zabala
- M Zabala
- M Zaballos
- M Zavatarelli
- MA Pancucci-Papadopoulou
- MA Rex
- MA Ribera
- Marta Coll
- Marta Estrada
- MC Gambi
- Miltiadis-Spyridon Kitsos
- MJ Chrétiennot-Dinet
- MJ Costello
- MK Costello
- ML Sogin
- MM Moeseneder
- MM Yakimov
- N Bahamon
- N Lampadariou
- N Myers
- N Pinardi
- N Streftaris
- N Streftaris
- Nikolaos Lampadariou
- NS Webster
- O Craig
- O Park
- O Pesta
- OG Costa
- P Abelló
- P Abelló
- P Bouchet
- P Bouchet
- P Chevaldonné
- P Dendrinos
- P Francour
- P Galand
- P Guidetti
- P Guidetti
- P Guidetti
- P Guidetti
- P Reijnders
- P Whitehead
- P Yésou
- PF Donald
- PJD Lambshead
- PJD Lambshead
- R Danovaro
- R Danovaro
- R Danovaro
- R Danovaro
- R Danovaro
- R Danovaro
- R Danovaro
- R Danovaro
- R Feingersch
- R Gertwagen
- R Gertwagen
- R Margalef
- R Margalef
- R Margalef
- R Massana
- R Massana
- R Massana
- R Pronzato
- R Reeves
- R Reeves
- R Riedl
- R Rodolfo-Metalpa
- R Zotier
- RA Jahnke
- Rc Hofrichter
- Rc Hofrichter
- RD Cavanagh
- RH Whittaker
- RJ Diaz
- RJ Etter
- Roberto Danovaro
- Roger Villanueva
- RP Higgins
- Ruthy Gertwagen
- S Açik
- S Garthe
- S Jukić-Peladić
- S Libralato
- S Panigada
- S Raicevich
- S Somot
- S Tudela
- S Tudela
- Samuel Somot
- Saša Raicevich
- SG Acinas
- SG Acinas
- SL Baldauf
- Steven J. Bograd
- SW Fowler
- T Adensamer
- T Bekker-Nielsen
- T Fortibuoni
- T Gallardo
- T Munilla
- T Ozcan
- T Perez
- T Thibaut
- Thanos Dailianis
- TS Hopkins
- U Dorigo
- U Safriel
- V Fabry
- W Fischer
- W Grant
- W Krijgsman
- WD Hummon
- WM Johnson
- WM Johnson
- Xavier Turon
- ZR Velasquez
- ZR Velasquez
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
The Mediterranean Sea is a marine biodiversity hot spot. Here we combined an extensive literature analysis with expert opinions to update publicly available estimates of major taxa in this marine ecosystem and to revise and update several species lists. We also assessed overall spatial and temporal patterns of species diversity and identified major changes and threats. Our results listed approximately 17,000 marine species occurring in the Mediterranean Sea. However, our estimates of marine diversity are still incomplete as yet—undescribed species will be added in the future. Diversity for microbes is substantially underestimated, and the deep-sea areas and portions of the southern and eastern region are still poorly known. In addition, the invasion of alien species is a crucial factor that will continue to change the biodiversity of the Mediterranean, mainly in its eastern basin that can spread rapidly northwards and westwards due to the warming of the Mediterranean Sea. Spatial patterns showed a general decrease in biodiversity from northwestern to southeastern regions following a gradient of production, with some exceptions and caution due to gaps in our knowledge of the biota along the southern and eastern rims. Biodiversity was also generally higher in coastal areas and continental shelves, and decreases with depth. Temporal trends indicated that overexploitation and habitat loss have been the main human drivers of historical changes in biodiversity. At present, habitat loss and degradation, followed by fishing impacts, pollution, climate change, eutrophication, and the establishment of alien species are the most important threats and affect the greatest number of taxonomic groups. All these impacts are expected to grow in importance in the future, especially climate change and habitat degradation. The spatial identification of hot spots highlighted the ecological importance of most of the western Mediterranean shelves (and in particular, the Strait of Gibraltar and the adjacent Alboran Sea), western African coast, the Adriatic, and the Aegean Sea, which show high concentrations of endangered, threatened, or vulnerable species. The Levantine Basin, severely impacted by the invasion of species, is endangered as well
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