19 research outputs found

    Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials.

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    Background Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The effi cacy and safety of the phosphodiesterase-4 inhibitor rofl umilast have been investigated in studies of patients with moderate-to-severe COPD, but not in those concomitantly treated with longacting inhaled bronchodilators. The eff ect of rofl umilast on lung function in patients with COPD that is moderate to severe who are already being treated with salmeterol or tiotropium was investigated. Methods In two double-blind, multicentre studies done in an outpatient setting, after a 4-week run-in, patients older than 40 years with moderate-to-severe COPD were randomly assigned to oral rofl umilast 500 μg or placebo once a day for 24 weeks, in addition to salmeterol (M2-127 study) or tiotropium (M2-128 study). The primary endpoint was change in prebronchodilator forced expiratory volume in 1 s (FEV1). Analysis was by intention to treat. The studies are registered with ClinicalTrials.gov, number NCT00313209 for M2-127, and NCT00424268 for M2-128. Findings In the salmeterol plus rofl umilast trial, 466 patients were assigned to and treated with rofl umilast and 467 with placebo; in the tiotropium plus rofl umilast trial, 371 patients were assigned to and treated with rofl umilast and 372 with placebo. Compared with placebo, rofl umilast consistently improved mean prebronchodilator FEV1 by 49 mL (p<0·0001) in patients treated with salmeterol, and 80 mL (p<0·0001) in those treated with tiotropium. Similar improvement in postbronchodilator FEV1 was noted in both groups. Furthermore, rofl umilast had benefi cial eff ects on other lung function measurements and on selected patient-reported outcomes in both groups. Nausea, diarrhoea, weight loss, and, to a lesser extent, headache were more frequent in patients in the rofl umilast groups. These adverse events were associated with increased patient withdrawal. Interpretation Rofl umilast improves lung function in patients with COPD treated with salmeterol or tiotropium, and could become an important treatment for these patients

    Measurement of charm production at central rapidity in proton-proton collisions at ps = 7 TeV

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    The p t-differential inclusive production cross sections of the prompt charmed mesons D0, D+, and D*+ in the rapidity range |y| < 0.5 were measured in proton-proton collisions at Ös = 7 TeVs=7TeV at the LHC using the ALICE detector. Reconstructing the decays D0 → K−π+, D+ → K−π+π+, D*+ → D0π+, and their charge conjugates, about 8,400 D0, 2,900 D+, and 2,600 D*+ mesons with 1 < p t < 24 GeV/c were counted, after selection cuts, in a data sample of 3.14 × 108 events collected with a minimum-bias trigger (integrated luminosity L int = 5 nb−1). The results are described within uncertainties by predictions based on perturbative QCD

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    A measurement of inclusive ZZ production cross section and constraints on anomalous triple gauge couplings in proton-proton collisions at s\sqrt{s} = 8 TeV are presented. A data sample, corresponding to an integrated luminosity of 19.6 inverse-femtobarns was collected with the CMS experiment at the LHC. The measurements are performed in the leptonic decay modes ZZllllZZ \to lll'l', where l=e,μl = e, \mu and l=e,μ,τl' = e, \mu, \tau. The measured total cross section, σ(ppZZ)=7.7±0.5(stat.)0.4+0.5(syst.)±0.4(theo.)±0.2(lum.)pb\sigma (pp \to ZZ) = 7.7 \pm 0.5 (stat.)^{+0.5}_{-0.4} (syst.) \pm 0.4 (theo.) \pm 0.2 (lum.) pb for both Z bosons produced in the mass range mZm_Z within 60 and 120 GeV, is consistent with standard model predictions. Differential cross sections are measured and well described by the theoretical predictions. The invariant mass distribution of the four-lepton system is used to set limits on anomalous ZZZ and ZZγ\gamma couplings at the 95% confidence level: f4Zf_4^Z in (-0.004,+0.004), f5Zf_5^Z in (-0.005,+0.005), f4γf_4^\gamma in (-0.004,+0.004), and f5γf_5^\gamma in (-0.005,+0.005)

    Search for supersymmetry in pp collisions at in events with a single lepton, large jet multiplicity, and multiple b jets

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    Results are reported from a search for supersymmetry in pp collisions at a center-of-mass energy of 8 TeV, based on events with a single isolated lepton (electron or muon) and multiple jets, at least two of which are identified as b jets. The data sample corresponds to an integrated luminosity of 19.3 fb(-1) recorded by the CMS experiment at the LHC in 2012. The search is motivated by supersymmetric models that involve strong-production processes and cascade decays of new particles. The resulting final states contain multiple jets as well as missing transverse momentum from weakly interacting particles. The event yields, observed across several kinematic regions, are consistent with the expectations from standard model processes. The results are interpreted in the context of simplified supersymmetric scenarios with pair production of gluinos, where each gluino decays to a top quark-antiquark pair and the lightest neutralino. For the case of decays via virtual top squarks, gluinos with a mass smaller than 1.26 TeV are excluded for low neutralino masses

    Measurement of the production cross section for a W boson and two b jets in pp collisions at root s=7 TeV

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    The production cross section for a Wboson and two b jets is measured using proton-proton collisions at v root s = 7 TeV in a data sample collected with the CMS experiment at the LHC corresponding to an integrated luminosity of 5.0 fb(-1). The W + bbevents are selected in the W..decay mode by requiring a muon with transverse momentum pT> 25GeVand pseudorapidity |eta| 25GeVand |eta| < 2.4. The measured W + bbproduction cross section in the fiducial region, calculated at the level of final-state particles, is s(pp. W + bb) xB(W..) = 0.53 +/- 0.05 (stat.) +/- 0.09 (syst.) +/- 0.06 (theo.) 0.01 (lum.) pb, in agreement with the standard model prediction. In addition, kinematic distributions of the W + bbsystem are in agreement with the predictions of a simulation usingMadGraphandpythia

    Measurement of the ratio B(t -> Wb)/B(t -> Wq) in pp collisions at root s=8 TeV

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    The ratio of the top-quark branching fractions R = B(t --> Wb)/B(t --> Wq), where the denominator includes the sum over all down-type quarks (q = b, s, d), is measured in the t (t) over bar dilepton final state with proton-proton collision data at root s = 8 TeV from an integrated luminosity of 19.7 fb(-1), collected with the CMS detector. In order to quantify the purity of the signal sample, the cross section is measured by fitting the observed jet multiplicity, thereby constraining the signal and background contributions. By counting the number of b jets per event, an unconstrained value of R = 1.014 +/- 0.003 (stat.) +/- 0.032 (syst.) is measured, in a good agreement with current precision measurements in electroweak and flavour sectors. A lower limit R > 0.955 at the 95% confidence level is obtained after requiring R 0.975 is set at 95% confidence level. The result is combined with a previous CMS measurement of the t-channel single-top-quark cross section to determine the top-quark total decay width, Gamma(t) = 1.36 +/- 0.02 (stat.)(-0.11)(+0.14) (syst.) GeV

    Alignment of the CMS tracker with LHC and cosmic ray data

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    The central component of the CMS detector is the largest silicon tracker ever built. The precise alignment of this complex device is a formidable challenge, and only achievable with a significant extension of the technologies routinely used for tracking detectors in the past. This article describes the full-scale alignment procedure as it is used during LHC operations. Among the specific features of the method are the simultaneous determination of up to 200 000 alignment parameters with tracks, the measurement of individual sensor curvature parameters, the control of systematic misalignment effects, and the implementation of the whole procedure in a multiprocessor environment for high execution speed. Overall, the achieved statistical accuracy on the module alignment is found to be significantly better than 10 mu m

    Measurement of the t(t)over-bar production cross section in pp collisions at root s=8 TeV in dilepton final states containing one tau lepton

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    The top-quark pair production cross section is measured in final states with one electron or muon and one hadronically decaying tau lepton from the process t (t) over bar -> (l nu(l))(tau nu(tau))b (b) over bar, where l = e, mu. The data sample corresponds to an integrated luminosity of 19.6 fb(-1) collected with the CMS detector in proton-proton collisions at root s = 8 TeV. The measured cross section sigma(t (t) over bar) = 257 +/- 3 (stat) +/- 24 (syst) +/- 7 (lumi) pb, assuming a top-quark mass of 172.5 GeV, is consistent with the standard model prediction

    Search for a standard model-like Higgs boson in the mu(+)mu(-) and e(+)e(-) decay channels at the LHC

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    A search is presented for a standard model-like Higgs boson decaying to the mu(+)mu(-) or e(+)e(-) final states based on proton-proton collisions recorded by the CMS experiment at the CERN LHC. The data correspond to integrated luminosities of 5.0 fb(-1) at a centre-of-mass energy of 7 TeV and 19.7 fb(-1) at 8 TeV for the mu(+)mu(-) search, and of 19.7 fb(-1) at 8 TeV for the e(+)e(-) search. Upper limits on the production cross section times branching fraction at the 95% confidence level are reported for Higgs boson masses in the range from 120 to 150 GeV. For a Higgs boson with a mass of 125 GeV decaying to mu(+)mu(-), the observed (expected) upper limit on the production rate is found to be 7.4 (6.5(-1.9)(+2.8)) times the standard model value. This corresponds to an upper limit on the branching fraction of 0.0016. Similarly, for e(+)e(-), an upper limit of 0.0019 is placed on the branching fraction, which is approximate to 3.7 x 10(5) times the standard model value. These results, together with recent evidence of the 125 GeV boson coupling to tau-leptons with a larger branching fraction consistent with the standard model, confirm that the leptonic couplings of the new boson are not flavour-universal
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