13 research outputs found
McCune-Albright syndrome
- Author
- A Barone
- A Corsi
- A Diaz
- A Giusti
- A Shenker
- A Theos
- AI Leet
- AI Leet
- AM Pierini
- B Chan
- BD Idowu
- C Defilippi
- Claudia E Dumitrescu
- CM Cutler
- D Liens
- D Zimmerman
- DJ McCune
- E Ippolito
- EA Eugster
- EF Scanlon
- ES Hart
- ES Silva
- F Albright
- F Galland
- FH Glorieux
- G Mastorakos
- H Plotkin
- HD Dorfman
- JM Kirk
- JS Lee
- JY Reginster
- L Terpstra
- LJH Lichtenstein
- LS Weinstein
- M Danon
- M Riminucci
- M Riminucci
- M Riminucci
- MH Kelly
- Michael T Collins
- MM Hammami
- MT Collins
- MT Collins
- MT Collins
- MT Collins
- MT Collins
- MT Collins
- P Bianco
- P Bianco
- P Blanco
- P Chanson
- P Feuillan
- P Ruggieri
- PP Feuillan
- PP Feuillan
- PP Feuillan
- R Lopez-Ben
- RA Schwartz
- RD Chapurlat
- RP Stanton
- RW Byard
- S Hashemipour
- SI Sherman
- SO Akintoye
- SO Akintoye
- TS Hannon
- U Ehrig
- V Congedo
- WD Leslie
- WF Schwindinger
- Y Tanabeu
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous dysplasia of bone (FD), café-au-lait skin spots, and precocious puberty (PP). It is a rare disease with estimated prevalence between 1/100,000 and 1/1,000,000. FD can involve a single or multiple skeletal sites and presents with a limp and/or pain, and, occasionally, a pathologic fracture. Scoliosis is common and may be progressive. In addition to PP (vaginal bleeding or spotting and development of breast tissue in girls, testicular and penile enlargement and precocious sexual behavior in boys), other hyperfunctioning endocrinopathies may be involved including hyperthyroidism, growth hormone excess, Cushing syndrome, and renal phosphate wasting. Café-au-lait spots usually appear in the neonatal period, but it is most often PP or FD that brings the child to medical attention. Renal involvement is seen in approximately 50% of the patients with MAS. The disease results from somatic mutations of the GNAS gene, specifically mutations in the cAMP regulating protein, Gs alpha. The extent of the disease is determined by the proliferation, migration and survival of the cell in which the mutation spontaneously occurs during embryonic development. Diagnosis of MAS is usually established on clinical grounds. Plain radiographs are often sufficient to make the diagnosis of FD and biopsy of FD lesions can confirm the diagnosis. The evaluation of patients with MAS should be guided by knowledge of the spectrum of tissues that may be involved, with specific testing for each. Genetic testing is possible, but is not routinely available. Genetic counseling, however, should be offered. Differential diagnoses include neurofibromatosis, osteofibrous dysplasia, non-ossifying fibromas, idiopathic central precocious puberty, and ovarian neoplasm. Treatment is dictated by the tissues affected, and the extent to which they are affected. Generally, some form of surgical intervention is recommended. Bisphosphonates are frequently used in the treatment of FD. Strengthening exercises are recommended to help maintaining the musculature around the FD bone and minimize the risk for fracture. Treatment of all endocrinopathies is required. Malignancies associated with MAS are distinctly rare occurrences. Malignant transformation of FD lesions occurs in probably less than 1% of the cases of MAS
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- AasarĂžd Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso InĂȘs
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- BlĂŒher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
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- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
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- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
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- Collins Francis S
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- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
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- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
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- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
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- Curhan Gary
- d'Adamo Pio
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- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
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- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
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- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
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- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
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- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
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- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
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- Dupuis Josee
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- Durda Peter
- Döring Angela
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- Eastell Richard
- Easton Douglas F
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- Egan Josephine
- Ehret Georg
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- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
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- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
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- Ernst Florian
- Esko Tonu
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- Glazer Nicole
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- Glenn Kim
- Glorioso Nicola
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- Goel Anuj
- Goessling Wolfram
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- Goldstein Benjamin A
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- Goodloe Robert
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- Nyberg Fredrik
- Nyholt Dale R
- Nöthlings Ute
- O'Connell Jeffrey R
- O'Donnell Chris
- O'Rahilly Stephen
- O'Reilly Paul
- O'Reilly Paul F
- O'Seaghdha Conall M
- Obermayer-Pietsch Barbara
- Oei Ling
- Oetjens Matthew
- Ogihara Toshio
- Ohkubo Takayoshi
- Ohlsson Claes
- Okamura Tomonori
- Oksa Heikki
- Olafsson Isleifur
- Oldehinkel Albertine J
- Olden Matthias
- Olmos José M
- Olsson Christian
- Ong Ken K
- Ong Rick Twee-Hee
- Ongen Halit
- Onland-Moret N Charlotte
- Oostra Ben A
- Ordovas Jose M
- Org Elin
- Ormel Johan
- Orru Marco
- Ouwehand Willem H
- Painter Jodie N
- Palmas Walter
- Palmen Jutta
- Palmer Cameron
- Palmer Colin
- Palmer Lyle J
- Palmer Nicholette D
- Palotie Aarno
- Palsson Stefan Th
- Panduru Nicolae Mircea
- Pankow James
- Papamarkou Theodore
- Parish Sarah
- Park Jeong E
- Park Lani
- Parker Alex N
- Parkkonen Maija
- Parsa Afshin
- Parts Leopold
- Parving Hans-Henrik
- Paré Guillaume
- Pasko Dorota
- Pastinen Tomi
- Patel Millan S
- Paterson Andrew D
- Patsy Bruce
- Pattaro Cristian
- Paulweber Bernhard
- Peacock Munro
- Pechlivanis Sonali
- Peden John F
- Pedersen Nancy L
- Peeters Petra H M
- Peloso Gina M
- Peltonen Leena
- Pendergrass Sarah
- Pennell Craig E
- Penninx Brenda W
- Peralta Carmen A
- Perola Markus
- Perry John R B
- Pers Tune H
- Person Sharina
- Peters Annette
- Peters Marjolein J
- Peters Ulrike
- Petersen Ann-Kristin
- Pettersson-Kymmer Ulrika
- Peyser Patricia A
- Pharoah Paul
- Pihur Vasyl
- Pirastu Mario
- Pistis Giorgio
- PitkÀniemi Janne
- Platou Carl G P
- Plump Andrew
- Plump Andrew S
- Polasek Ozren
- Pols Huibert A P
- Pomilla Cristina
- Pop Victor J M
- Porcu Eleonora
- Portas Laura
- Postma Dirkje S
- Potter Simon
- Pouta Anneli
- Power Chris
- Prabhakaran Dorairajan
- Pramstaller Peter P
- Prentice Ross
- Prezelj Janez
- Price Jackie F
- Prince Richard L
- Prior Sarah
- Probst-Hensch Nicole M
- Prokopenko Inga
- Province Michael
- Province Michael A
- Psaty Bruce
- PĂ©russe Louis
- Qi Lu
- Quertermous Thomas
- Quibrera Miguel
- Rader Daniel J
- Rafelt Suzanne
- Raffel Leslie J
- Rafnar Thorunn
- Raitakari Olli
- Ralston Stuart H
- Randall Joshua C
- Rankinen Tuomo
- Rao D C
- Rao Dabeeru C
- Rao Madhumathi
- Rasheed Asif
- Rasmussen-Torvik Laura J
- Rathmann Wolfgang
- Rauramaa Rainer
- Raychaudhuri Soumya
- Rayner N William
- Rayner Nigel W
- Redline Susan
- Reeve Jonathan
- Rehnberg Emil
- Reid David M
- Reid Ian R
- Reilly Muredach
- Reinmaa Eva
- Renstrom Frida
- Reppe Sjur
- Restrepo Nicole
- Rettig Rainer
- Riancho José A
- Ricceri Fulvio
- Rice John P
- Rice Kenneth
- Rice Kenneth M
- Rice Treva K
- Rich Stephen S
- Richards J Brent
- Richards John Brent
- Ridker Paul
- Ried Janina S
- Rigalleau Vincent
- Ring Susan M
- Ripatti Samuli
- Ritchie Marylyn
- Rivadeneira Fernando
- Robbins John
- Roberts Robert
- Robertson Neil
- Robino Antonietta
- Roman Tamara S
- Rose Lynda M
- Roseman Fenella
- Rosengren Annika
- RosengÄrd-BÀrlund Milla
- Rosinger Silke
- Rosmalen Judith G M
- Rosse Stephanie
- Rossing Peter
- Rotimi Charles
- Rotter Jerome I
- Rousseau François
- Roussel Ronan
- Rubin Diana
- Rudan Igor
- Rudock Megan E
- Ruggiero Daniela
- Rumpf Moritz P
- Ruokonen Aimo
- Rybin Denis
- RÀikkönen Katri
- Saaristo Timo E
- Sadlier Denise M
- Sala Cinzia
- Salako Tunde
- Saleheen Danish
- Salem Rany M
- Salo Perttu
- Salomaa Veikko
- Salumets Andres
- Samani Nilesh
- Sambrook Philip N
- Sandholm Niina
- Sandhu Manjinder S
- Sanghera Dharambir K
- Sanna Serena
- Saraheimo Markku
- Saramies Jouko
- Sarti Cinzia
- Sarzynski Mark A
- Sattar Naveed
- Savage David A
- Saxena Richa
- Schadt Eric
- Scharnagl Hubert
- Scherag André
- Schlessinger David
- Schmidt Ellen M
- Schmidt Helena
- Schmidt Reinhold
- Scholtens Salome
- Schork Nicholas J
- Schreiber Stefan
- Schumacher Fredrick
- Schunkert Heribert
- Schwartz Stephen M
- Schwarz Peter E H
- SchÀfer Arne
- Scollen Serena
- Scott James
- Scott Laura J
- Scott Robert A
- Scuteri Angelo
- Seeley Janet
- SegrĂš Ayellet V
- Sehmi Joban S
- Seielstad Mark
- Sekowska Magdalena
- Semple Robert
- Sengupta Sebanti
- Sennblad Bengt
- Serafinceanu Cristian
- Service Susan K
- Seshadri Sudha
- Seufferlein Thomas
- Shah Sonia
- Shah Svati H
- Sham Pak Chung
- Sharma Pankaj
- Shaw-Hawkins Sue
- Sheu Wayne H-H
- Shi Gang
- Shin So-Youn
- Shlipak Michael G
- Shohet Ralph
- Shrine Nick R G
- Shriner Daniel
- Shuldiner Alan R
- Shungin Dmitry
- Sidore Carlo
- Siegbahn Agneta
- Siggeirsdottir Kristin
- Sigurdsson Gunnar
- Sijbrands Eric J G
- Silander Kaisa
- Sim Xueling
- Singleton Andrew
- Sinisalo Juha
- Siscovick David S
- Sitlani Colleen M
- Sivananthan Mohan
- Sjögren Marketa
- Skorpen Frank
- Slaets Joris P
- Slagboom P Eline
- Small Kerrin
- Small Kerrin S
- Smit Johannes H
- Smith Albert
- Smith Erin N
- Smith George Davey
- Smith Jennifer A
- Smith Nicholas L
- Snider Harold
- Snieder Harold
- Soininen Pasi
- Song Ci
- Song Kijoung
- Soranzo Nicole
- Sorice Rossella
- Soro-Paavonen Aino
- Sovio Ulla
- Spector Tim D
- Spector Timothy D
- Speliotes Elizabeth K
- Spencer Kylee
- Srinivasan Sathanur R
- St Pourcain Beate
- Stacey Simon N
- Staessen Jan A
- StanÚåkovå Alena
- StanÄĂĄkovĂĄ Alena
- Stark Klaus
- Starr John M
- Stathopoulou Maria G
- Stavarachi Monica
- Stefansson Kari
- Steinle Nanette I
- Steinthorsdottir Valgerdur
- Stewart Alexandre F R
- Stirrups Kathleen
- Stolk Lisette
- Stolk Ronald P
- Strachan David P
- Stracke Sylvia
- Stram Daniel
- Strauch Konstantin
- Strawbridge Rona J
- Streeten Elizabeth A
- Stringham Heather M
- Struchalin Maksim
- Stumvoll Michael
- Styrkarsdottir Unnur
- Sulem Patrick
- Sun Yan V
- Sundström Johan
- Surakka Ida
- Surdulescu Gabriela
- Svensson Olle
- Swan Elizabeth J
- Swertz Morris A
- Swift Amy J
- Syreeni Anna
- SyvÀnen Ann-Christine
- SÔber Siim
- Söderlund Jenny
- Tabara Yasuharu
- Tai E Shyong
- Taliun Daniel
- Talmud Philippa J
- Tammesoo Mar-Liis
- Tan Sian-Tsung
- Tanaka Toshiko
- Tang Nelson L S
- Tarnow Lise
- Taylor Andrew
- Taylor Kira
- Tayo Bamidele
- Tenesa Albert
- Terzic Janos
- Teslovich Tanya M
- Teumer Alexander
- Thelle Dag S
- Thompson John R
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorn Lena M
- Thornton-Wells Tricia
- Thorsteinsdottir Unnur
- Thun Gian-Andri
- Tiirikainen Maarit
- Tikkanen Emmi
- Tikkanen Heikki
- Timpson Nicholas
- Timpson Nicholas J
- Tin Adrienne
- Tiret Laurence
- Tobin Martin
- Tobin Martin D
- Toenjes Anke
- Tolonen Nina
- Tomaschitz Andreas
- Tomaszewski Maciej
- Toniolo Daniela
- Townsend Raymond R
- Tracy Russell P
- Travers Mary E
- Tregouet David-Alexandre
- Treloar Susan A
- Tremblay Angelo
- Tremoli Elena
- Tripathy Vikal
- Troffa Chiara
- Trompet Stella
- Trummer Olivia
- Tryggvadottir Laufey
- Tryggvason Karl
- Trégouët David-Alexandre
- Tsaprouni Loukia
- Tsoka Sophia
- Tsui Kim
- Tukiainen Taru
- Tuomilehto Jaakko
- Turner Stephen T
- Tylavsky Frances A
- Tyrer Jonathon
- Tzoulaki Ioanna
- Tönjes Anke
- Uda Manuela
- Ueshima Hirotsugu
- Uh Hae-Won
- Uiterwaal Cuno S P M
- Uitterlinden Andre G
- Uitterlinden André G
- Ulivi Sheila
- Ulivi Shelia
- Umans Jason
- Umemura Satoshi
- Urreizti Roser
- Uusitupa Matti
- Vallejo Edgar E
- van Dam Rob M
- Van den Herik Evita G
- van der Harst Pim
- van der Klauw Melanie M
- van der Schoot C Ellen
- van der Schouw Yvonne T
- van Duijn Cornelia
- Van Duijn Cornelia
- van Gils Carla H
- van Gilst Wiek H
- van Heemst Diana
- Van Hul Wim
- van Meurs Joyce B J
- van Meurs Joyve B J
- van Nierop Peter
- van Oort Floor V A
- van Pelt L Joost
- van Schoor Natasja M
- Van Vliet-Ostaptchouk Jana V
- van Wingerden Sophie
- van Wingerden Sophie W
- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
- Visscher Peter M
- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
- Voight Benjamin F
- Volcik Kelly A
- Vollenweider Peter
- Vonk Judith M
- Voorhuis Marlies
- Völker Uwe
- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber GĂ©rard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
- Warrington Nicole M
- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
- Welch Ryan P
- Wells George A
- Wennauer Roman
- Westra Harm-Jan
- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- WĂŒrtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo LoĂŻc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia MarĂa T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ărnlöv Johan
- Ăsterholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (PÂ <Â 5Â ĂÂ 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
- Botero Rodrigo
- Botsyurko Volodymyr
- Bouarich Hanane
- Brada Michal
- Brandao Ilidio
- Brar Harjeet
- Braun Hermann
- Brezina Jiri
- Brian Susan
- Brietzke Stephen
- Brito Claudia
- Bruchfeld Annette
- Bruno Giorda Carlo
- Brusco Osvaldo
- Bu Ruifang
- Bucek Petr
- Buganova Ingrid
- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
- Caceaune Elena
- Cai Hanqing
- Calabr\uf2 Paolo
- Calero Francesca
- Canadas Rafael
- Canani Luis
- Caramori Maria
- Cardona Jose
- Cariou Bertrand
- Carlo Maggi Davide
- Carlos Palma Juan
- Carlos Prieto Juan
- Carlson Brian
- Carpio Jose
- Carvalho Rui
- Case Christopher
- Castro Cristina
- Catindig Elizabeth
- Catrinoiu Doina
- Cayli Murat
- Cereto Castro Fernando
- Cerqueira Maria
- Chahin Mariano
- Chang Chiz-Tzung
- Chantrel Fran\ue7ois
- Chen Dejun
- Chen Nan
- Chen Qinkai
- Cheng Jinluo
- Chernikova Viktoriia
- Chernin Gil
- Chernyavskaya Elena
- Chew Wong Alfredo
- Christina Nowack
- Chuang Lee-Ming
- Chung ChoonHee
- Ciechanowski Kazimierz
- Cieslik Grazyna
- Cigarr\ue1n Guldris Secundino
- Cimino Roberto
- Clavel Sylvaine
- Clodi Martin
- Cobos Jorge
- Colman Peter
- Colquhoun David
- Constantin Ciprian
- Contzen Christel
- Conway James
- Coronel Julian
- Cortes-Maisonet Gregorio
- Cortes-Maisonet Gregorio
- Cournoyer Serge
- Crawford Veronica
- Cristina Gregorini Maria
- Cruz Humberto
- Cruzado Garrit Josep
- Cure Carlos
- Curiac Dan
- Cutfield Rick
- Dandillaya Ramprasad
- Dang Cuong
- Danos Peter
- Darawsha Mahmud
- de \uc1lvaro Fernando
- de Paula Rogerio
- Deerochanawong Chaicharn
- Degenhardt Stefan
- Demko Arkadiy
- Derwahl Karl
- Dhanireddy Soni
- Din Zia
- Distiller Larry
- Dixon Bradley
- Dolores Mart\uednez Esteban M\uaa
- Donath Marc
- Donets Oleksandra
- Dong Junwu
- Dong Youping
- Doshi Ankur
- Doubel Peter
- Dreval Alexander
- Drexel Heinz
- Du Yuming
- Dumas Richard
- Dumitrescu Adriana
- Dunn Peter
- Dur\ue1n Carlos
- Duyck Francis
- Dzupina Andrej
- E Costa Fernando Teixeira
- Ebenbichler Christoph
- Ebisui Osamu
- Edelsberger Tomas
- Edin Anton
- Eduardo Figueiredo Carlos
- Eduardo Salles Joao
- Efrati Shai
- Ekinci Elif
- El Shahawy Mahfouz
- El-Shahawy Mohammed
- Elbert Alicia
- Elias Mazen
- Eliaschewitz Freddy
- Eliasson Ken
- Emdin Michele
- Engelen Wendy
- Eren Necmi
- Eriksen Erik
- Ermakova Polina
- Escalada San Mart\uedn Javier
- Escobedo de la Pe\uf1a Jorge
- Esteves Cesar
- Eugenia Canziani Maria
- Eustace Joe
- Evans John
- Faber Jens
- Fadda George
- Fang Sum Chee
- Fang Yi
- Fangh\ue4nel Salm\uf3n Guillermo
- Farah Ghassan
- Farber Evgeny
- Farooq Umar
- Fauvel Jean-Pierre
- Fernando Roland
- Fiaccadori Enrico
- Fikry Sameh
- Fink Raymond
- Finnes Trine
- Fiorina Paolo
- First Brian
- Fitz-Patrick David
- Flack John
- Fliesser-G\uf6rzer Evelyn
- Fluck Patrick
- Fogelfeld Leon
- Fonseca Vivian
- Forti Adriana
- Franek Edward
- Frank Malin
- Frias Juan
- Fujita Naruhiro
- Furuya Ryuichi
- Fushtey Ivan
- G Lieverse A
- Galcer\ue1n Josep
- Gallouj Karim
- Galphin Claude
- Galyavich Albert
- Gansevoort Ron
- Garc\ueda Hern\ue1ndez Pedro
- Garc\ueda Luis
- Garcia-Mayol Luis
- Gaysina Leyla
- Gelersztein Elizabeth
- George L Bakris
- Georgiev Dimitar
- Gerasimos Filippatos
- Giebel Thomas
- Gillard Pieter
- Giorgio Battaglia Giovanni
- Gislason Gunnar
- Glandt Mariela
- Goldstein Gary
- Goluch Richard
- Gonz\ue1lez Albarr\ue1n Olga
- Gonz\ue1lez G\ue1lvez Guillermo
- Gonz\ue1lez Gonz\ue1lez Jos\ue9
- Gonz\ue1lez Fernando
- Gonzalez Edgar
- Gonzalez-Abreu Francisco
- Gordeev Ivan
- Gore Ashwini
- Gouet Didier
- Grachova Mariia
- Grant David
- Grossman Ehud
- Guan Tianjun
- Guerci Bruno
- Guerrot Dominique
- Guia Jose
- Gul Ibrahim
- Gulakova Drahomira
- Gumprecht Janusz
- Guo Weiying
- Guron Gregor
- Gushterova Valentina
- Guti\ue9rrez Ochoa Ramiro
- Guzm\ue1n Gustavo
- H Boonstra A
- H\uf8ivik Hans
- Habwe Violet
- Hagemeier Robert
- Hagenow Andreas
- Halabi Majdi
- Haller Hermann
- Halpern Stephen
- Hamamoto Yoshiyuki
- Hamasaki Akihiro
- Hamet Pavel
- Hamilton Maxine
- Hammoud Jamal
- Handelsman Stuart
- Hangaard J\uf8rgen
- Hanna Fahmy
- Hanusch Ursula
- Hao Chuanming
- Harcsa Eleonora
- Hart Randolph
- Hartman Israel
- Hasalova Zapletalova Jitka
- Hasnul Halimi Bin Wan Hasan Wan
- Hasslacher Christoph
- Hatazaki Masahiro
- Hatunic Mensud
- Hatziagelaki Erifili
- Hayashi Terumasa
- Heigerick Glenn
- Heitor Susana
- Hellberg Olof
- Hellgren Margareta
- Henein Sam
- Hern\ue1ndez Jaras Julio
- Hern\ue1ndez Eric
- Hernandez German
- Hernandez-Cassis Carlos
- Herrera Carlos
- Higashi Takayuki
- Hirohata Yoshihide
- Hissa Miguel
- Hoffmann Michal
- Hola Olga
- Holian John
- Honkasalo Mikko
- Honkasalo Mikko
- Horacek Thomas
- Horinouchi Shuji
- Hornova Lucie
- Houdova Jana
- Hougardy Jean-Michel
- Hrmova Helena
- Humaloja Kari
- Hung Cheng-Chieh
- Hwang YouCheol
- Ibarra Jaime
- Ibern\uf3n Meritxell
- Imoto Hirofumi
- Inagaki Akemi
- Inagaki Masayuki
- Ioannidis Ioannis
- Ipatko Irina
- Iranmanesh Ali
- Irizar Santana Sa\ufal
- Isayeva Anna
- Ishii Masao
- Ishiko Tamayo
- Jackson Timothy
- Jain Mahendra
- Jamerson Kenneth
- Jansen van Rensburg Dirkie
- Jaramillo Carlos
- Jaramillo Nicol\ue1s
- Jaroslaw Pacyk Grzegorz
- Jiang Fangfang
- Jiang Ju-Ying
- Jiang Sheng
- Jinnouchi Hideaki
- Johnson Karen
- Joshi Mukesh
- Joshi Shaifali
- Juhl Claus
- Juli\ue1n Segura de la Morena Jos\ue9
- Jungmair Wolfgang
- Kahal Hassan
- Kalashnikova Marina
- Kalathil Dhanya
- Kalina Akos
- Kanai Hidetoshi
- Kananen Kristiina
- Kanda Daisuke
- Kanehara Hideo
- Kang JunGoo
- Kantola Ilkka
- Karasek David
- Karlsson Thomas
- Kashima Masayuki
- Kato Kiyoe
- Katsuki Takeshi
- Kattah William
- Kawamitsu Katsunori
- Kawasaki Satsuki
- Kayali Zeid
- Kaye William
- Kazup Szilvia
- Kelly Allan
- Keltai Katalin
- Khalimov Yuriy
- Khan Bobby
- Khan Muhammad
- Khanh Tran
- Kharait Sourabh
- Kikuchi Fumi
- Kikuchi Hidetoshi
- Kilvert Anne
- Kim HyeSoon
- Kim InJoo
- Kim JaeHyeon
- Kim SinGon
- Kirschner Robert
- Kiss Julianna
- Klein Alexandre
- Klimontov Vadim
- Kloos Christof
- Klyuchkova Neli
- Kobalava Zhanna
- Kobayashi Kunihisa
- Koch Stanley
- Koch Thorsten
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- Krebs Jeremy
- Kreit Camil
- Krekels Marielle
- Kriauciuniene Dovile
- Krishna Arvind
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- Kuang Jian
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- Kuchar Jiri
- Kumbasar Abdulbaki
- Kurnatowska Ilona
- Kusano Yoshiro
- Kutejova Vlasta
- Kvitkova Lyudmila
- Kyriakidou Christina
- L Penne E
- L\uf3pez M\uf3nica
- L\uf6ndahl Magnus
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- Lahtela Jorma
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- Lakha Deepak
- Lamboy Beata
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- LE Meur Yannick
- Lee ByungWan
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- Lee Keung
- Lee Paul
- Lee WooJe
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- Leite Jr Maurilo
- LeJeune Derek
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- Lerman Sam
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- Long Gang
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- Lu Guoyuan
- Lu Weiping
- Lu Yibing
- Lubanda Hana
- Lucheva Mariya
- Ludvik Bernhard
- Luigi Cavalot Franco
- Luis M Ruilope
- Lurie Alexander
- M Barendregt J N
- M van Leendert Ruud J
- M\ue9ndez Machado Gustavo
- M\ufcller Joachim
- Ma Jianhua
- MacIsaac Richard
- Maddukuri Geetha
- Madero Rovalo Magdalena
- Madore Francois
- Madrzejewski Adam
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- Maletz Louis
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- Mandayam Sreedhar
- Mandviwala Mustafa
- Mankovsky Borys
- Mann Mah Peak
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- Mareev Vyacheslav
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- Markell Mariana
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- O Donovan Richard
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- O Meara Yvonne
- Ochodnicka Zuzana
- Ocicka-Kozakiewicz Anna
- Odugbesan A
- Ogiwara Takayuki
- Oguz Aytekin
- Ohashi Hiroshi
- Okamoto Hideki
- Okenka Libor
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- Osonoi Takeshi
- Ozdogan Oner
- P\ue9rez Manghi Federico
- Packham David
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- Pang Ip Tai
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- Paolino Bruno
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- Paschoalin Nathalia
- Paschoalin Raphael
- Pascual Santos Julio
- Passadakis Ploumis
- Patel Rajesh
- Patel Rakesh
- Paulweber Bernhard
- Paveliu Silvia
- Pech\ue8re-Bertschi Antoinette
- Pecoits Filho Roberto
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- Peixoto Aldo
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- R Winkelmann Bernhard
- Radulian Gabriela
- Radzeviciene Lina
- Raina Rupesh
- Rajiv Agarwal
- Ramanathan Kodangudi
- Ramos L\uf3pez Gabriel
- Ramos-Gonez Luis
- Rangelov Rangel
- Ranjith Naresh
- Rashkov Rosen
- Rasmussen Ole
- Rastogi Anjay
- Ratnasingam Jeyakantha
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- Red\uf3n Josep
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- Reisin Efrain
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- Sasaki Nobuhiro
- Satirapoj Bancha
- Sauque Reyna Leobardo
- Saxena Sanjeev
- Sch\uf6ll Norbert
- Sch\uf6nherr Hans-Robert
- Sch\ufcrholz Thomas
- Scheen Andr\ue9
- Schernthaner Gerit-Holger
- Schettler Volker
- Schiefke Ingolf
- Schlichthaar Heike
- Schneider Karoly
- Schousboe Karoline
- Schr\uf6ppel Bernd
- Schwartz Daniel
- Schwartz Doron
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- Seco Gilberto
- Seeber Mary
- Sekigami Taiji
- Sels\ue5s Hilde
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- Shi Bingyin
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- Silva Gil
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- Smirnov Ivan
- Smith Mark
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- Smuts Nine
- Sobajima Hiroshi
- Soe Kyaw
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- Solache Ortiz Gustavo
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- Solovev Oleg
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- Stefan D Anker
- Stefanidis Ioannis
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- Stoyanovska-Elencheva Bilyana
- Strack Georg
- Strand Jorma
- Strey Christopher
- Strongin Leonid
- Stryzhak Vasyl
- Su Qing
- Suarez Rosa
- Subramanian Bala
- Sue Kirkman M
- Sugitatsu Kazuya
- Sugiura Toshiyuki
- Sugiyama Toru
- Sulosaari Sakari
- Sun Zhuxing
- Suranyi Michael
- Suzuki Daisuke
- Suzuki Masaaki
- Swift Pauline
- Szerlip Harold
- Szilagyi Iosif
- Szocs Albert
- T Luik P
- T\ue4schner Heidrun
- Tagarev Zhivko
- Tamirisa Aparna
- Tanaka Asami
- Tanaka Seiichi
- Tang Shuifu
- Tanque Maribel
- Tarng Der-Cherng
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- Tellier Guy
- Temelkova-Kurktschieva Theodora
- Temizhan Ahmet
- Tengmark Bengt-Olov
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- Terront M\uf3nica
- Thomson Stephen
- Thorup Frode
- Tigen Mustafa
- Tirador Louie
- Tiuryn-Petrulewicz Agnieszka
- Tobe Sheldon
- Tomanek Pavel
- Tong Nanwei
- Tonolo Giancarlo
- Topliss Duncan
- Toursarkissian Nicole
- Tran Tuan-Huy
- Treger Richard
- Trevisan Roberto
- Trokis J
- Troya Maribel
- Trujillo Freddy
- Trullenque Gretel
- Tsch\uf6pe Diethelm
- Tsoukas George
- Tsunematsu Izumi
- Tu Shih-Te
- Turcu Liana
- Turk Thomas
- Tytus Richard
- Ujihara Makoto
- Ukhanova Olga
- Ulmer Achim
- Umpierrez Guillermo
- Urbach Daniel
- Urbach Dorothea
- Urbanaviciene Egle
- Urbonas Gediminas
- Urina Miguel
- Ustundag Sedat
- Vacaru Georgeta
- Valdes Martin
- Valdez Ortiz Rafael
- Valika Shujauddin
- Vallejos Augusto
- van Buren M
- van den Born Bert-Jan
- van der Giet Markus
- VAN Gaal Luc
- VAN Hoang Lam
- van Zyl Louis
- Vanbelleghem Hilde
- Vandeleur James
- Varleta Paola
- Vasas Szilard
- Vasconcellos Eduardo
- Vasileva Svetla
- Vega Damaris
- Velaviciene Audrone
- Vencio Sergio
- Verges Bruno
- Verlan Nadezhda
- Vi\uf1es Gloria
- Vijayaraman Arutchelvam
- Vila Lobos Ana
- Villagordoa Mesa Juan
- Villegas Iv\ue1n
- Vitou Louise
- Vlad Adrian
- Vlasenko Maryna
- Vorokhobina Natalya
- Wainstein Julio
- Wainstein Julio
- Walsh Michael
- Wan Ronald Ma Ching
- Wang Hao
- Wang Jianqin
- Wang Li
- Wang Lihua
- Wang Xinjun
- Wanner Christoph
- Wasilewska Katarzyna
- Wassermann Alfredo
- Wei Jiali
- Weisnagel Stanley
- Weissman Peter
- Whaley-Connell Adam
- Wierusz-Wysocka Bogna
- Wilderman Igor
- Winston Jonathan
- Wise Jonathan
- Wittert Gary
- Wnetrzak-Michalska Renata
- Wong Yuk-Ki
- Wu Chaoqing
- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Why Do Some Consumers Make Unhealthy Food Choices?
- Author
- Bellisle F.
- Claudia Dumitrescu
- Clifford J. Shultz
- Cotugna N.
- Drewnowski A.
- Drichoutis A.
- Dumitrescu C.
- Fischer C. A.
- Food Marketing Institute
- Food Marketing Institute
- Frazao E.
- Fullmer S.
- Grossman M.
- Hatcher L.
- Hearne S. A.
- Ippolito P. M.
- Ippolito P. M.
- Koplan J. P.
- Levi J.
- Levi J.
- Lin C.-T. J.
- Mancino L.
- Mathios A. D.
- McLean-Meyinsse P. E.
- National Center for Health Statistics
- Nunnally J. C.
- Putler D.
- Renée Shaw Hughner
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Selective polymerization of a new bifunctional monomer via free radical polymerization and oxidative route
- Author
- Abdolahi
- Abdollahi
- Alain S. Conejo-DĂĄvila
- Alejandro Vega-Rios
- Alkan
- Amalvy
- Anayansi Estrada-Monje
- Armando Zaragoza-Contreras
- Arsov
- Arunbabu
- Ayad
- Basavaraja
- Chan
- Chao
- Chen
- Claudia A. HernĂĄndez-Escobar
- Dai
- Dan
- Dumitrescu
- E. Armando Zaragoza-Contreras
- Farias-Mancilla
- GeniĂšs
- Guyot
- He
- Hirata
- Huang
- Ishizone
- Isis RodrĂguez-SĂĄnchez
- Jing
- Klein
- Krasovskii
- Kuroda
- Lee
- Li
- Liu
- Liu
- Liu
- Moreno-Villoslada
- Pehlivan
- PĂ©rez-Blanco
- Radja
- RamĂłn E. DĂaz de LeĂłn-GĂłmez
- Rao
- Rimbu
- Shao
- Shishov
- Sinha
- Vega-Rios
- Vega-Rios
- Weiss
- Yao
- Yelil Arasi
- Yu
- Zaragoza-Contreras
- Zaragoza-Contreras
- Zhu
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The history of optic chiasm from antiquity to the twentieth century
- Author
- A Barone
- A Chang
- A Graefe Von
- A Ieva Di
- A Nanda
- A Paluzzi
- A Vater
- A Vesalius
- A Vesalius
- AJ Newman
- Anca Sava
- Andrei IonuĆŁ Cucu
- Avicenna (Ibn Sina)
- B Gudden
- BV Gudden
- C Reeves
- C Singer
- CD OâMalley
- CG Gross
- Claudia Florida Costea
- CM Calkins
- CW Rucker
- CÄtÄlin BuzdugÄ
- D Turliuc
- DA Simpson
- DC Lindberg
- DM Turliuc
- E Clarke
- E Crivellato
- F DâAguilĂłn
- F Magendie
- F Vicq DâAzyr
- G Doesschate ten
- G Falloppio
- G Milos
- G Santoro
- Gabriela FlorenĆŁa Dumitrescu
- IG Panourias
- IP Howard
- IP Howard
- J Chandwick
- J Hirschberg
- J Murube
- J MĂŒller
- J Taylor
- JD Godman
- JD Schmahmann
- JE Donley
- JE Lebensohn
- JG Zinn
- JP McMurrich
- JS Glaser
- JT Goodrich
- JT Goodrich
- L Swanson
- M Loukas
- Mihaela Dana Turliuc
- MJ Ibåñez
- MM Mortazavi
- MM Shoja
- N Sarkies
- NF Maartens
- NJ Wade
- NJ Wade
- P Prioreschi
- R Darowski
- R Guillery
- RF Maestro Del
- RG Ellenbogen
- S Finger
- S Polyak
- SJA Ziggelaar
- SR Y Cajal
- SR Y Cajal
- SR Y Cajal
- V Medvei
- W Briggs
- WF Hoyt
- Ćerban Turliuc
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Defining the role of common variation in the genomic and biological architecture of adult human height
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- Abecasis Goncalo R
- Absher Devin
- Afzal Uzma
- Albrecht Eva
- Alizadeh B
- Altshuler D
- Altshuler D
- Ambite JL
- Amin Najaf
- Amouyel Philippe
- Anand S
- Anand S
- Anderson G
- Anderson Denise
- Ardissino D
- Ardissino D
- Ardissino D
- Arnold A
- Arscott Gillian M
- Arveiler Dominique
- Asselbergs Folkert W
- Asselta R
- Assimes Themistocles L
- Avery C
- Avila PC
- Bakker Stephan J. L
- Ball SG
- Balmforth AJ
- Bandinelli Stefania
- Baron Jeffrey
- Barrett Amy
- Barroso InĂȘs
- Basford M
- Beckmann Jacques S
- Beekman Marian
- Beilby John
- Bellis Claire
- Bennett Amanda J
- Berg R
- Berger K
- Berglund G
- Bergman Richard N
- Bergmann Sven
- Bernardi F
- BERNARDINELLI LUISA
- Berndt Sonja I
- Berne Christian
- Berzuini C
- Bielinski S
- Biffar Reiner
- Blangero John
- BlĂŒher Matthias
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle E
- Boerwinkle Eric
- Boezen HM
- Bolton Jennifer L
- Boomsma Dorret I
- Borecki Ingrid B
- Bornstein Stefan R
- Boston J
- Bottinger Erwin P
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Brambilla Paolo
- Braund PS
- Brown Gentry K
- Brown Morris J
- Bruinenberg M
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Burke W
- Burnett MS
- Burtt N
- Bush WS
- Buyske S
- Buyske Steven
- Buzkova P
- Böttcher Yvonne
- Cambien F
- Campbell Harry
- Carlson C
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- Carrell D
- Carty C
- Casari G
- Caspersen Ida H
- Cauchi Stéphane
- Caulfield Mark J
- Celli P
- Chakravarti Aravinda
- Chambers John C
- Chanock Stephen J
- Chasman Daniel I
- Chen L
- Chen Z
- Cheng I
- Chines Peter S
- Chisholm RL
- Choudary V
- Chu Audrey Y
- Churchill LR
- Chute C
- Clarke Robert
- Claudi Boehm Simone
- Clayton E
- Cochran B
- Cole S
- Collins Francis S
- Collins Rory
- Cooper Matthew
- Cooper Richard S
- Cornfield D
- Corrocher R
- Crane P
- Crawford D
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- Crawford Dana C
- Croteau Chonka Damien C
- Cupples L. Adrienne
- Daly MJ
- Danesh John
- Darbar D
- Daw E. Warwick
- Day Felix R
- de Andrade M
- De Bakker Paul I. W
- de Boer RA
- De Faire Ulf
- De Groot Lisette C. P. G. M.
- De Jong Pim A
- Dedoussis George
- Deelen Joris
- Deelman E
- Delgado Graciela
- Deloukas P
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- Demirkan Ayse
- Den Ruijter Hester M
- Denny JC
- Denny Josh C
- Devaney J
- Dhonukshe Rutten Rosalie
- Dimitriou Maria
- Ding K
- Do R
- Doney Alex S. F
- Duan Yanan
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- Durda P
- Dörr Marcus
- Ehret Georg B
- Eklund Niina
- Elosua R
- Elosua R
- Elosua R
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- Engert JC
- Engert JC
- Epstein SE
- Erbel Raimund
- Erdmann J
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- Wichmann H. Erich
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- Winkler Thomas W
- Wojczynski Mary K
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- Wong Andrew
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- Workalemahu Tsegaselassie
- Wright BJ
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- Yee J
- Yengo LoĂŻc
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- Zanen Pieter
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zheng W
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- Ziegler A
- Zonzin P
- Ărnlöv Johan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated âŒ2,000, âŒ3,700 and âŒ9,500 SNPs explained âŒ21%, âŒ24% and âŒ29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/ÎČ-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants
Genetic studies of body mass index yield new insights for obesity biology
- Author
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- Workalemahu Tsegaselassie
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- Ărnlöv J
- Ărnlöv Johan
- Ăsterholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Note: A full list of authors and affiliations appears at the end of the article.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p
Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
- Author
- Abbas Jalal
- Abbate Antonio
- Abdallah mouhamad
- Abdullakutty Jabir
- Abdullkutty Jabir
- Abhyanakar Atul D
- Aboyans Victor
- Abrantes José Antonio M
- Abu-Fadel Mazen
- Accini Mendoza Jose L
- Acevedo Monica
- Adamkova Vera
- Adamo Antony
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Aggarwal Rahul
- Aggarwal Rajesh K
- Agnetti Veronique
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A
- Aidar Ayoub José Carlos
- Airaksinen Juhani
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea YY
- Alan David
- Albert Seals
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M
- Alings Marco
- Alings Marco
- Alonso Martin Joaquin J
- Alonso Alvaro
- Alsweiler Caroline
- Alvarisqueta Andrés F
- Alves De Lima Alberto E
- Amarasekera Stanley
- Amarasena Naomali
- Amidon Thomas
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Anchante Hernandez Henry A
- Andersen Dorthe
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Anderson Jay
- Ando Kenji
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arambula Rafael Suarez
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Aroca Carlos Cotes
- Aroney Constantine
- Arstall Margaret A
- Asanin Milika R.
- Assi Nizar
- Aswegen Dina Van
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayaz Mohammad
- Aylward Philip E
- Aylward Philip E
- Aylward Philip E
- Aylward Philip E
- Azizad Masoud M
- BabiÄ Zdravko
- Badreddine Emmy
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Ball Eric
- Bang Lia E
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L
- Barbato Emanuele
- Barna Olga M
- Barone-Rochette Gilles
- Barr Craig
- Barraud Pauline
- Barrera Silva Sandra I
- Barrucco Robert
- Bartels Gerard L
- Basart Dirk
- Bashir Riyaz
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Bejuit Raphael
- Bekkouche Mhamed
- Belhassane Abdelkader
- Beltran Pascale
- Benbernou Fadela
- Benedicto Amparo
- Bengrait Nafissa
- Bengston James
- Bengus Cristina M
- Benov Haralambi O
- Berdan Lisa
- Berger Rudolf
- Berglund Stefan
- Berk Martin
- Berland Jacques
- Berli Mario A
- Berlowitz Michael
- Berman Brett
- Bernan Alisa
- Berthou Christelle
- Berti Sergio
- Bezault Madeleine
- Bhagwat Ajit
- Bhagwat Ravi
- Bhansali Prasant
- Bhatt Deepak L.
- Bhatt Deepak L.
- Binde Ronald
- Birchem Jessica
- Bittner Vera A.
- Bittner Vera A.
- Blanquicett Marco
- Blicharski Tomasz
- Blok Thomas
- Blonder Ronald
- Blumberg Eduardo DS
- Boccara Franck
- Bodanese Luiz C
- Bojovski Stojko
- Bokarev Igor
- Bokern Marcel JJA
- Bonfanti Alberto J Cadena
- Bono Julio OE
- Bordonava Anselmo P
- Borger-Van Der Burg Alida
- Borse Rohidas
- Bortnick Anna
- Bos Robert J
- Botelho Ana
- Botelho Roberto V
- Bouancheau Cecile
- Bougon Nathalie
- Bourgeois Ronald
- Brabham David
- Braganza Denise
- Braun- Dullaeus RĂŒdiger
- Bravo Mannucci Jorge E
- Breedveld Robert W
- Brennan J. Matthew
- Brigui Imane
- Brocklehurst Maddy
- Brodison Adrian
- Bronzwaer Patrick NA
- Brueren Bart RG
- Brégeault Marie-France
- Budaj Andrzej
- Budaj Andrzej
- Bugan Viliam
- Busmane Arija
- Bustamante Labarta Miguel H
- Busz-Papiez Benita
- Butler Rob
- Butters Julie
- Bystryk Leszek
- Böcker Dirk
- BĂžttcher Morten
- Caccavo Alberto
- Caetano Francisca
- Caime Guillermo D
- CalabrĂČ Paolo
- Calderon Ticona Jorge R
- Calvillo Jorge Carrillo
- Camacho Cosavalente Luis A
- Cambier Patrick
- Campos Pedro Fajardo
- CamprubĂ Potau Mercedes
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- Car SiniĆĄa
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- Carey Charles
- Carlos Pablo
- Carlson Eric
- Carnero Gabriela S
- Carrion Chambilla Jesus M
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- Cartasegna Luis R
- Carter Luther
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- Castadot Marc
- Castillo Leon Reynaldo P
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- Cerqueira Maria José AG
- Cestari Horacio G
- Cevc Matija
- Cha James
- Chachalis Geargios
- Chae In-Ho
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- Chalavarya Gopal
- Chaleff Fred
- Chandna Harish
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- Chang Mark
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- Chavez Ayala Carlos A
- Cheema Muhammad
- Chen Dandan
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- Cheng Shi-Chi
- Cheng Xiaoshu
- Chengyue Zhu
- Chiang Chern-En
- Chiang Chern-En
- Chizhov Petr
- Chopda Manoj
- Chopra Vijay K
- Chotnoparatpat Paiboon
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- Christopher Daniels
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- Cleveland David
- Clifford Piers
- Clifton Shaun
- Cobler Joanne
- Coching Raul Martin
- Codutti Oscar R
- Cohen Steven
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- Collins Nicholas
- Colombo Hugo R
- Colquhoun David
- Coman Ioan
- Commerford Patrick J
- Conrad Gary
- Constantine Godwin
- Constantinescu Mircea CA
- Convens Carl
- Cools Frank
- Corbett Clive
- Cornel Jan H
- Coronel Arroyo Julian A
- Correa Flores Roger M
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- Cortada Jordi Bruguera
- Costa Fernando
- Costamagna Osvaldo
- Coste Pierre
- CosĂn Sales Juan
- Cotruta Raluca
- Cottin Yves
- Coufal Zdenek
- Coulange Anthony
- Coverdale Steven GM
- Cristian Gabriel
- Cruz FernĂĄndez Jose M
- Cuccia Claudio
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- Cyster Henry P
- Czerski Tomasz
- Daboul Nizar
- Dagher Georges
- Dahl Charles
- Dai Kazuoki
- Dalby Anthony J
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- Danchin Nicolas
- Danchin Nicolas
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- Danchin Nicolas
- Dandillaya Ramprasad
- Daniels Christopher
- Das Srihari
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- Davidsen Flemming
- Davidson Laura
- Davies Richard
- Davis William
- De Berrazueta Fernåndez José R
- De Cesare Nicoletta B
- De La Tassa CĂ©sar MorĂs
- De Leon MarĂa Guerrero
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- De Salazar Dora I Molina
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- de Souza Juliana A
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- Delarche Nicolas
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- Deloatch Shalonda
- Demirtas Mustafa
- Dempsey Michael A.
- Denham Douglas
- Devarapalli Sai K
- Devaul Dawn
- DeVore Adam D.
- Diamantis Steve
- Diaz Ariel
- Diaz Rafael
- Diaz Rafael
- Diaz Rafael
- Dick Ronald
- Dickey Sheila
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- Dilic Mirza
- Dimkovic Sinisa
- Dimov Bojidar I
- Dincic Dragan V.
- Ding Chunhua
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- Dorobantu Maria
- Dorsel Thomas
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- Doty Daniel
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- Drexel Heinz
- Drexel Heinz
- Drouet Elodie
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- du Toit Theron Hendrik
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- Dukat Andrej
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- Dumitrescu Silviu
- Dupuis Robert
- Durak-Nalbantic Azra
- Durand Velasquez Julio R
- Duronto Ernesto A
- Dzupina Andrej
- Dzyak Georgiy
- DĂaz FernĂĄndez Jose Francisco
- DâUrso Michael
- Eagerton Donald
- Eapen Zubin
- East Cara
- Eaton Charles
- Ebrahim Iftikhar O
- Edelberg Jay M.
- Edward Kemala
- Egorova Liudmila
- Egydio Flavia
- Ehud Chorin
- Eisenberg Steven
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- Elias Mazen
- Elias Nizar
- Eliaschewitz Freddy G
- Elliott John
- Endsley Patricia
- Eppinger Arleen
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- Ersanli Murat
- Escudier Juan M
- Espinoza Andrey
- Etienne Alexis
- Fadlallah Hussein
- Faes Dirk
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- Fan Zhongcai
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- Farhat Naim
- Farrar Michael
- Faustino Douglas
- Fausto Ovando Sergio R
- Fazekas FrantiĆĄek
- Fazlibegovic Emir
- Feenema-Aardema Margriet
- Feenema-Aradema Margriet
- Feitosa Gilson S
- Fell David
- Feng Yi
- fenton Sarah
- Fernandez Ruiz Ricardo L
- Fernandez Mauricio
- Fernando Kaputella
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- Francis Adi
- Franek Edward
- Fras Zlatko
- Fras Zlatko
- French William J
- Frey Bernhard
- Friedman Dennis
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- Frost Lars
- Fu Guosheng
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- Fulop Peter
- Fulwani Mahesh C
- Furukawa Yutaka
- Gabor Kiss Robert
- Gache Cecile
- Galski Thomas
- Galvani Marcello
- Gamil Dawood
- Gapon Liudmila
- Garbelotto Raffaella
- Garcia Brasca Daniela F
- Garcia Duran Ruben O
- Garcia Lozada Henry J
- Garcia-Dorado David
- GarcĂa LledĂł JosĂ© Alberto
- Gardner Geraldine
- Garrahy Paul J
- Garrido Marcelo
- Garza RuĂz JosĂ© Angel
- Gavish Dov
- Ge Junbo
- Gelormini Joseph
- Gerber Jaime
- Gerber Robert
- Ghitis Arnold
- Ghlonti Ramaz
- Gibson Paul
- Gielen Stephan
- Giesler Gregory
- Gil-Extremera Blas
- Gilbert John M
- Gillespie Eve
- Gilmore Richard
- Gimple Lawrence
- Giordano Jorge A
- Giorgeto Flavio E
- Gislason Gunnar
- Giuliano Maria E
- Gniot Jacek
- Gobillot Caroline
- Goch Aleksander
- Goloborodko Borys
- Gomez Vilamajo Oscar A
- Gonsorcik Jozef
- Gonzalez-Juanatey Carlos
- Gonzalez-Juanatey Jose R
- GonzĂĄlez DĂaz Belinda
- GonzĂĄlez Salas Luis Gerardo
- Goodman Shaun G.
- Goodman Shaun G.
- Goodman Shaun G.
- Goodman Shaun G.
- Goraya Tauqir
- Gordeev Ivan
- Gordienko Alexander
- Gorny Jerzy
- Goronja Boris
- Gospodinov Maryana
- Gosselin Gilbert
- Gosselink Antonius TM
- Gotcheva Nina N
- Gotcheva Nina N
- Gouet Valerie
- Govinda Ravishankar A
- Goyal Naresh K
- Gremmler Uwe
- Grewal Jasprakash Singh
- Griffith Liddy
- Griffiths Huw
- Gring Christian
- Groenemeijer Bjorn E
- Groutars Reginald GEJ
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- Guardigli Gabriele
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- Guillou Severine
- Gullestad Lars
- Guneri Sema
- Guneri Sema
- Guo Ying
- Gupta Jugal
- Gurevich Victor
- Guy Douglas
- Guzman Pablo N
- GĂ€mperli Oliver
- Haddad Tariq
- Hagström Emil
- Hagström Emil
- Hagström Emil
- Hagström Emil
- Hahalis Georgios
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- Hansen Ole
- Haraguchi Takuya
- Harding Scott
- Harkut Pankaj
- Harrington Robert A.
- Harrington Robert A.
- Harris Barry
- Harris Bill
- Harrison Robert W.
- Hart Hamish
- Hasan Mian
- Hasin Yonathan
- Hata Yoshiki
- Hattler Brack
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- Healy Jan
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- Hemetsberger Rayyan
- Henderson David
- Henkin Yaakov
- Henry John
- Hepditch Anita
- Herath Jagath I
- Hermans Kurt
- Hermans Walter RM
- Hernandez Zuniga Jose D
- Herrman Johannes PR
- Hersbach Ferry MRJ
- Herzog William
- Hess Connie Ng
- Hidalgo Urbano Rafael Jesus
- Higashikata Toshinori
- Higuera Juan Diego
- Hii Chris LS
- Hirayama Atsushi
- Hirooka Keiji
- Hlatky Mark A.
- Hoag Gordon
- Hodes Zachary
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- Hoffman David
- Hominal Miguel Angel
- Hong Taekjong
- Hoogslag Pieter AM
- Hoppe Uta
- Horak David
- Horowitz John
- Horvath IvĂĄn
- Horwitz Phillip
- Hove Jens D
- Hrabar Adrian D
- Hranai Marian
- Hsiang Lin Wei
- Hsieh I-Chang
- Hsieh Ming-Jer
- Huang Lan
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- Huikuri Heikki
- Hunter John
- Hurtig Ulf
- Hussein Osamah
- Huynh Thao
- Hwang Juey- Jen
- Ilic Stevan
- Ilieva- Pandeva Katya A
- Ilya Masterov
- Ince Carlos
- Iqbal Syed MR
- Irimpen Anand
- Islam Othman
- Islam Shahidul
- Istratoaie Octavian
- Ito Kashima
- Ivanov Igor G
- Ivanova Raya
- Ivanovic Nikola
- Iyengar Shamanna S
- Iñiguez Andres
- Jacoby Douglas
- Jafar Zubair
- Jaffrani Naseem
- Jain Diwakar
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- Jeong Myung Ho
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- Jeserich Michael
- Jiang Weihong
- Jimenez Francisco Fuentes
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- Johansen Peter
- Johansen Peter Betton
- Jonas Michael
- Jones William Schuyler
- Jong Geert T
- Jordan Joseph Dedrick
- Jortveit Jarle
- Joshi Abhijeet B
- Joshi Parag
- Jovin Ion
- Jujjuru Srimannarayana
- Jukema J. Wouter
- Jukema J. Wouter
- Jukema Johan
- Jure Horacio O
- Jurgaitiene Ruta
- Jurgenson Tiina
- Kadr Honer
- Kaewsuwanna Pinij
- Kahali Dhiman
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- Kalil Renato
- Kamensky Gabriel
- Kamiya Haruo
- Kandasamy Balachandran
- Kanorsky Sergey
- Kapin Tibor
- Kaplan Refik
- Kapp Ilse E
- Karadzic Ana
- Karakas Mahir
- Karalis Ioannis
- Karlsberg Ronald
- Karpenko Oleksandr
- Karpenko Yuriy
- Karpov Yuri
- Karpov Yuri
- Karpov Yuriy
- Kartalis Athanasios
- Kasim Sazzli
- Kathryn Rohr
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- Katz Amos
- Kaucak Vladimir
- Kavaliauskiene Roma
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- Kawasaki Tomohiro
- Ke Yuannan
- Keating Friederike
- Kedev Sasko
- Kedev Sasko
- Keen William
- Kehasukcharoen Wirash
- Kelsey Sheryl F.
- Kerkar Prafulla
- Khabeishvili George
- Khaira Ajit S
- Khaisheva Larisa
- Khan Abul
- Khan Aziz
- Khasanov Niiaz
- Khera Amit
- Khintibidze Irakli
- Khlevchuk Tatiana
- Khurana Sandeep
- Kibarskis Aleksandras
- Kichukov Kostadin N
- Killat Holger
- Kim Chongjin
- Kim Hack-Lyoung
- Kim Hae Young
- Kim Hyo Soo
- Kim Hyo-Soo
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- Kim Sang-Hyun
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- Kimura Takeshi
- Kimura Takeshi
- King Marilyn
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- Kirma Cevat
- Kishi Koichi
- Kiss Robert Gabor
- Kjovkaroski Aleksandar
- Klancke Kim
- Klantsa Andriy
- Klausen Ib C
- Kline Geoffrey
- Klutstein Marc
- Knickelbine Thomas
- Knowles Joshua W.
- Knutson Thomas
- Koba Shinji
- Kobalava Zhanna
- Kobayashi John
- Koike Akihiro
- Koldas Lale
- Kolls Bradley J.
- Kondo Nicholas I
- Kong David F.
- Kopytsya Mykola
- Koren Michael
- Kormann Adrian
- Kornder Jan
- Kornowski Ran
- Korol Marek
- Kosinski Edward
- Kosmachova Elena
- Kostarska-Srokosz Edyta
- Kostis John
- Kotha Purushotham
- Kouz Simon
- Kovalskyi Ihor
- Kozuma Ken
- Kralova Katarina
- Krasowski Wlodzimierz
- Krawczyk Justine
- Krichmar Perry
- Kristensen Kjeld S
- Kristjan Arved
- Kubilius Raimondas
- Kuchar Jiri
- Kuhlman Peter
- KuliÄ Mehmed
- Kultursay Hakan
- Kumar Yerra Shiv
- Kumar Anil
- Kumar Priya
- Kumar Vinay
- Kumbla Mukund
- Kumkumian Greg
- Kuo Jen-Yuan
- Kurian John
- Kushnir Mykola
- Kutniy Oles
- Kuvin Jeffrey
- Kyiak Yulian
- Labeirie Julien
- Labroo Ajay
- Lai Christopher
- Lai Wen-Ter
- Lambert Charles
- Lamoureux Maud
- Landeo Javier Heredia
- Landmesser Ulf
- Landmesser Ulf
- Landzberg Joel
- Larry John
- Larsen John
- Laucevicius Aleksandras
- Laufs Ulrich
- Laxson David
- Lazov Petar V
- Leaes Paulo E
- Leclercq Florence
- Lecorps Guillaume
- Lecorps Guillaume
- Lee Kaeng
- Lee Kwan
- LefĂšvre Thierry
- Leggewie Stefan
- Lehman Sam J
- Leimbach Wayne
- Lekakis John
- Leo Alessandro De
- Leonard Parilak
- Leonardi Sergio
- Leone Attilio
- Lepage Serge
- Lepor Norman
- Leshchuk Oleh
- Lester F. Martin
- Leung Raymond
- Levite Howard
- Levy Terry
- Li Huanming
- Li Jianping
- Li Tianchang
- Li Xiang
- Li Xiaodong
- Li Ying
- Lianopoulos Emmanouil
- Liberman Alberto
- Liberopoulos Evangelos
- Liberopoulos Evangelos
- Liberopoulos Evangelos
- Libov Igor
- Licciardello Giovanni
- Lieber Ira
- Liem Anho AH
- Liew Houng B
- Lillis Linda
- Lin Jinxiu
- Lin Wenhua
- Lin Xuefeng
- Lindsey Jason
- Linhart Ales
- Link Chad
- Lip Gregory YH
- Lipko Jan Andrzej
- Lishner Michael
- Liu Ming-En
- Liu Shaowen
- Liu Xuebo
- Llamas EsperĂłn Guillermo Antonio
- Llerena Navarro Nassip C
- Llois Susana
- Loizeau Virginie
- Lomakin Nikita V
- Lomholdt Jens D
- Lominadze Zaza
- Lopes Renato D.
- Lopes Renato D.
- Lopes Renato D.
- Lopes Renato D.
- Lopez Rodrigo Botero
- Lorenzato Christelle
- Lorenzatti Alberto J
- Lotan Chaim
- Lottering Hanlie
- Lotun Kapildeo
- Loussararian Arthur
- Love Michael
- LovriÄ BenÄiÄ Martina
- Lozance Nensi
- Lu Qinghua
- Lubinski Andrzej
- Luca Giuseppe De
- Luciardi Hector L
- Lui Henry
- Lukenda Josip
- Luna Botia Diana C
- Luo Zhurong
- Lupkovics Geza
- Lupovitch Steven
- Luquez Hugo A
- Lutchmedial Sohrab
- Luyten Anne
- Lyamina Nadezhda
- Lysek Roman
- LĂłpez-Jaramillo Patricio
- MacDonald Paul
- Macdonell Alexander
- Mach Francois
- Machado Leandro
- Machecourt Jacques
- Machova Vilma
- Mackinnon Ignacio J
- Madrigal Jaime Carranza
- Mahaffey Kenneth W.
- Mahaffey Kenneth W.
- Mahajan Ajaykumar
- Mahal Sharan
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- MajercĂĄk Ivan
- Makoali Makotoko Ellen
- Malhotra Vinay
- Malis Mihaela
- Malozzi Christopher
- Malynovsky Yaroslav
- Manakshe Gajendra V
- Manenti Euler Roberto F Fernandes
- Mano Toshiaki
- Manolis Athanassios
- Mansourati Jacques
- Manvelian Garen
- Manzur Jatin Fernando G
- Marais H. John
- Marco Valgimigli
- Marcus Jill
- Markov Dimitar T
- Markov Valentin
- Marmor Alon
- Maron David J.
- MartĂnez SĂĄnchez Carlos Rodolfo
- Marusincova Ivana
- Marx Nikolaus
- Marx Nikolaus
- Marx Nikolaus
- Marx Roger
- MarĂn Francisco
- Maskon Oteh
- Massey Clara
- Masutani Motomaru
- Matei Adrian V
- Mathews Robin
- Mathur Rishabh
- Matiga Generoso
- Matthews Alexander
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- Mayurathan Gnanamoorthy
- Mazur Juraj
- McClanahan Mark A.
- Mcclure Sam
- Mcgarvey Joseph
- McGinniss Jennifer
- Mcgough Martin
- Mclaurin Brent
- Medrano Allende Juan C
- Mehta Rajendra H.
- Mehta Shamir
- Mejic-Krstulovic Stanka
- Meloni Chiara
- Mendis Sepalika
- Mendonça Carlos
- Mentz Robert J.
- Merkely Bela
- Mesquita Bastos Jose
- Metra Marco
- Metwally Lamia
- Michalaros Yorghos L
- Michaud Nicolas
- Michishita Ichiro
- Micko Karol
- Midzic Zlatko
- Miklaszewicz Beata
- Mileta Dean
- Militaru Constantin
- MiliÄiÄ Davor
- Mincheva Valentina M
- Minescu Bogdan
- Mintale Iveta
- Misonis Nerijus
- Mittal Suneet
- Moccetti Tiziano
- Mody Freny
- Mohart Ann Elizabeth
- Molchanova Olga
- Mollov Mihail N
- Monier Myriam
- Monraats Pascalle
- Montalescot Gilles
- Montaña Oscar R
- Montecinos Humberto
- Monteiro Minguel R
- Monteiro Pedro
- Montenegro Valdovinos Pablo Carlos
- Moodley Rajendran
- Morais Joao
- Morais Joao
- Morales Dante D.
- Morales Ulises
- Moran Joseph
- Moreira Humberto Graner
- Morel Olivier
- Moriarty Andrew
- Moriarty Katie
- Moriarty Patrick M.
- Moriarty Patrick M.
- Morino Yoshihiro
- Morisset Anne
- Morrello Christine
- Moryusef AngĂšle
- Mosseri Morris
- Mostovoy Yuriy
- Motovska Zuzana
- Moura Jorge Jose C
- Mourgues Maxime
- Mourtzinis Georgios
- Mrabti Asmaa
- Mthombeni Bicky
- Mudawi Telal
- Muenzel Thomas
- Mulkay Angel
- Munk Peter S
- Munusamy Vengatesh
- Murillo Fernando Civeira
- Murin Jan
- Murin Jan
- Murphy Judith
- Murphy Sherrill
- Muslibegovic Adis
- Musumeci Giuseppe
- Muthusamy Rangasamy
- Mutlu Bulent
- Mynhardt Joseph H
- Myshanych Halyna
- MĂ€rtsin Kaja
- MĂŒller Christian
- MĂŒller Christian
- MĂŒller GĂĄbor
- MĂŒller-Wieland Dirk
- Nacoud Ackar Alfredo
- Nager Paul
- Nagy Lajos
- Nahhas Ahed
- Nahuelpan Leonardo
- Nakao Koichi
- Nani Sebastian
- Naplava Robert
- Natour Mohammed
- Negron Miguel Sandra A
- Nelson William
- Neto Jose A Marin
- Neuenschwander Fernando
- Neustel Mark
- Nicol Peter
- Nicolau Jose C
- Nielsen Peter Kaiser
- Nielsen Tonny
- Nieminen Markku S
- Nieminen Markku S
- Nigro Frank
- Nijmeijer Remco
- Nikolaev Konstantin
- Nikolov Fedya P
- Nikolsky Eugenia
- Ninio Daniel
- Nishibe Akira
- Nishibe Akira
- Nociar Jan
- Nogareda Gustavo
- Norkiene Sigute
- Normand Mickael
- Novaretto Leonardo P
- Novo Salvatore
- Novoa Federico
- Novotny Vojtech
- Nuding Sebastian
- NygÄrd Ottar
- NĂșñez Fragoso Juan Carlos
- Ofer Havakuk
- Offers Elmar
- Okan Betim
- Olexa Peter
- Olivares Claudia
- Olivari Zoran
- Oliveira Janaina
- Oliver Richard
- Olsson Anders G.
- Omran Heyder
- Ong Tiong Kiam
- Ono Yujiro
- Oomen Antonius
- Oomman Abraham
- Oqueli Flores Romulo E
- Orcajo Norberto Alonso
- Orlikova Olga
- Osokina Natalya
- Ossei-Gerning Nicholas
- Ostadal Petr
- Ostadal Petr
- Ourliac Anne
- OâDonnell Philip J.
- Paganelli Franck
- Pagava Zurab
- Palimkar Priya
- Palka Juraj
- Palmer Bruce
- Palvarini Michela
- Panchal Vipul
- Pancholy Samir
- Pandey Amritanshu
- Pandurangi Ulhas
- Parada Jeffrey Castellanos
- Parepa Irinel R
- Park Hyeun (Tom)
- Parkhomenko Alexander
- Parkhomenko Alexander
- Parthenakis Frangkiskos
- Pasquini John
- Patange Dr. Aparna
- Patel Chetan B.
- Paterlini Gustavo A
- Patil Chandrakant
- Patil Sachin N
- Patki Nitin
- Patocchi Cristian A
- Patsilinakos Sotiris
- Pawar Sudhir
- Pawlowicz Lidia
- Payeras Antonio Coca
- Pearce Stephen
- Pederson Robert
- Pella Daniel
- Pellan Valerie
- Pellegrin Annamaria De
- Peng Daoquan
- Penny William
- Pepine Carl
- Pereira Edward
- Pereira Helder H
- Pereira Sabrina Bernardez
- Perez Ignacio Plaza
- Perez Luis
- Pericas Laia Matas
- Peris Vicente BodĂ
- Perkins Lynn
- Perlmutter Neal
- Perthuis Aurelie
- PerĆĄiÄ Viktor
- Pesant Yves
- Petranov Stanislav L
- Petrulioniene Zaneta
- PeÄin Ivan
- Piatti Piermarco
- Picault Patrick
- Picone Mark
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- Piovaccari Giancarlo
- Pirenne Bruno
- Piyayotai Dilok
- Podoleanu Cristian GC
- Podpera Ivo
- Poh Kian-Keong
- Pojskic Belma
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- Xu Xiping
- Xu Yizhou
- Yagensky Andriy
- Yakushin Sergey
- Yan Bryan PY
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yañez Mario
- Yee Ong Hean
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Yusoff Khalid
- Zahger Doron
- Zahr Firas
- Zaidman Cesar J
- Zainea Mark
- Zaman Azfar
- Zamorano Jose Luis
- Zapata Gerardo
- Zea Nunez Carlos A
- Zeiher Andreas M.
- Zeiher Andreas M.
- Zhang Ruiyan
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Shuiping
- Zhao Xingsheng
- Zheleznyy Volodymyr
- Zheng Yang
- Zheng Zeqi
- Zhong Yi
- Zhou Yujie
- Zhu Hong
- Zhu Jianhua
- Zirlik Andreas
- Zizka Jiri
- Zobouyan Isabelle
- Zong Wenxia
- Zrazhevsky Konstantin
- Zukermann Robert
- Zurakowski Aleksander
- Zvi Vered
- Zwart Peter
- Zweiker Robert
- Ădes IstvĂĄn
- Ć ikiÄ Jozica
- Ć tambuk Kresimir
- Ć uligoj NataĆĄa ÄerniÄ
- Ćœuran Ivan
- Publication venue
- American Heart Association
- Publication date
- 30/08/2022
- Field of study
Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18â924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfatal ischemic stroke, hospitalization for unstable angina). Associations between baseline apoB or apoB at 4 months and MACE were assessed in adjusted Cox proportional hazards and propensity scoreâmatched models. Results: Median follow-up was 2.8 years. In proportional hazards analysis in the placebo group, MACE incidence increased across increasing baseline apoB strata (3.2 [95% CI, 2.9â3.6], 4.0 [95% CI, 3.6â4.5], and 5.5 [95% CI, 5.0â6.1] events per 100 patient-years in strata 35â<50, and â€35 mg/dL, respectively). Compared with propensity scoreâmatched patients from the placebo group, treatment hazard ratios for alirocumab also decreased monotonically across achieved apoB strata. Achieved apoB was predictive of MACE after adjustment for achieved low-density lipoprotein cholesterol or nonâhigh-density lipoprotein cholesterol but not vice versa. Conclusions: In patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, MACE increased across baseline apoB strata. Alirocumab reduced MACE across all strata of baseline apoB, with larger absolute reductions in patients with higher baseline levels. Lower achieved apoB was associated with lower risk of MACE, even after accounting for achieved low-density lipoprotein cholesterol or nonâhigh-density lipoprotein cholesterol, indicating that apoB provides incremental information. Achievement of apoB levels as low as â€35 mg/dL may reduce lipoprotein-attributable residual risk after acute coronary syndrome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01663402.gov; Unique identifier: NCT01663402.URL: https://www