93 research outputs found
A liquid helium target system for a measurement of parity violation in neutron spin rotation
A liquid helium target system was designed and built to perform a precision
measurement of the parity-violating neutron spin rotation in helium due to the
nucleon-nucleon weak interaction. The measurement employed a beam of low energy
neutrons that passed through a crossed neutron polarizer--analyzer pair with
the liquid helium target system located between them. Changes between the
target states generated differences in the beam transmission through the
polarizer--analyzer pair. The amount of parity-violating spin rotation was
determined from the measured beam transmission asymmetries. The expected
parity-violating spin rotation of order rad placed severe constraints
on the target design. In particular, isolation of the parity-odd component of
the spin rotation from a much larger background rotation caused by magnetic
fields required that a nonmagnetic cryostat and target system be supported
inside the magnetic shielding, while allowing nonmagnetic motion of liquid
helium between separated target chambers. This paper provides a detailed
description of the design, function, and performance of the liquid helium
target system.Comment: V2: 29 pages, 14 figues, submitted to Nucl. Instrum. Meth. B. Revised
to address reviewer comment
Characterization of a Li-6 loaded liquid organic scintillator for fast neutron spectrometry and thermal neutron detection
The characterization of a liquid scintillator incorporating an aqueous
solution of enriched lithium chloride to produce a scintillator with 0.40% Li-6
is presented, including the performance of the scintillator in terms of its
optical properties and neutron response. The scintillator was incorporated into
a fast neutron spectrometer, and the light output spectra from 2.5 MeV, 14.1
MeV, and Cf-252 neutrons were measured using capture-gated coincidence
techniques. The spectrometer was operated without coincidence to perform
thermal neutron measurements. Possible improvements in spectrometer performance
are discussed.Comment: Submitted to Applied Radiation and Isotopes. 11 pages, 7 figures, 3
tables. Revision addresses reviewers' comment
An Opinion Dynamics Model for the Diffusion of Innovations
We study the dynamics of the adoption of new products by agents with
continuous opinions and discrete actions (CODA). The model is such that the
refusal in adopting a new idea or product is increasingly weighted by neighbor
agents as evidence against the product. Under these rules, we study the
distribution of adoption times and the final proportion of adopters in the
population. We compare the cases where initial adopters are clustered to the
case where they are randomly scattered around the social network and
investigate small world effects on the final proportion of adopters. The model
predicts a fat tailed distribution for late adopters which is verified by
empirical data.Comment: 14 pages, 8 figures, revised text, a new section with empirical
evidence has been adde
A note on the Sagnac effect and current terrestrial experiments
We focus on the Sagnac effect for light beams in order to evaluate if the higher-order relativistic corrections of kinematic origin could be relevant for actual terrestrial experiments. Moreover, we discuss to what extent the analogy with the Aharonov-Bohm effect holds true in a fully relativistic framework. We show that the analogy with the Aharonov-Bohm is not true in general, but is recovered in a suitable low-order approximation, and that even though the Sagnac effect is influenced by both the position of the interferometer in the rotating frame and its extension, these effects are negligible for current terrestrial experiment
Formation of dense partonic matter in relativistic nucleus-nucleus collisions at RHIC: Experimental evaluation by the PHENIX collaboration
Extensive experimental data from high-energy nucleus-nucleus collisions were
recorded using the PHENIX detector at the Relativistic Heavy Ion Collider
(RHIC). The comprehensive set of measurements from the first three years of
RHIC operation includes charged particle multiplicities, transverse energy,
yield ratios and spectra of identified hadrons in a wide range of transverse
momenta (p_T), elliptic flow, two-particle correlations, non-statistical
fluctuations, and suppression of particle production at high p_T. The results
are examined with an emphasis on implications for the formation of a new state
of dense matter. We find that the state of matter created at RHIC cannot be
described in terms of ordinary color neutral hadrons.Comment: 510 authors, 127 pages text, 56 figures, 1 tables, LaTeX. Submitted
to Nuclear Physics A as a regular article; v3 has minor changes in response
to referee comments. Plain text data tables for the points plotted in figures
for this and previous PHENIX publications are (or will be) publicly available
at http://www.phenix.bnl.gov/papers.htm
Human toxocariasis: contribution by Brazilian researchers
In the present paper the main aspects of the natural history of human infection by Toxocara larvae that occasionally result in the occurrence of visceral and/or ocular larva migrans syndrome were reviewed. The contribution by Brazilian researchers was emphasized, especially the staff of the Tropical Medicine Institute of São Paulo (IMT)
Improving Genetic Prediction by Leveraging Genetic Correlations Among Human Diseases and Traits
Genomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to demonstrate that widespread pleiotropy among phenotypes can be utilised to improve genomic risk prediction. We show how a genetic predictor can be created as a weighted index that combines published genome-wide association study (GWAS) summary statistics across many different traits. We apply this framework to predict risk of schizophrenia and bipolar disorder in the Psychiatric Genomics consortium data, finding substantial heterogeneity in prediction accuracy increases across cohorts. For six additional phenotypes in the UK Biobank data, we find increases in prediction accuracy ranging from 0.7 for height to 47 for type 2 diabetes, when using a multi-trait predictor that combines published summary statistics from multiple traits, as compared to a predictor based only on one trait. © 2018 The Author(s)
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
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